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Hyperprolactinemia in cases of infertility and amenorrhea.

Abstract：

:Of 17 patients with longstanding (3--15 years, mean 7.7 years) amenorrhea and hyperprolactinemia, 8 developed their amenorrhea after the use of oral contraceptives (Group I) and 9 became amenorrhoic spontaneously (Group II). There were no differences between the groups with respect to the basal serum levels of FSH, LH, low polar estrogens (estradiol-17 beta + estrone) and prolactin. Tomography revealed pituitary adenoma in four patients. One of these developed symptoms of her tumor during pregnancy; the symptoms disappeared after delivery. The other patients with tumors are checked twice a year and have not yet received any treatment. The patients with no detectable tumors were treated with bromocriptine starting with 1.25 X 3 daily. The peripheral serum levels of prolactin, FSH, LH, low polar estrogens and progesterone were determined once a week and if the prolactin levels remained high, the bromocriptine dose was increased. All these patients started to menstruate as soon as prolactin returned to normal levels (below 25 micrograms/l). All patients who wished to became pregnant, i.e. 6 patients. Three were delivered by cesarean section, one had a normal delivery and two are still pregnant. There was no difference between Group I and Group II in the dose required or in the duration of treatment before menstruation started. Three cases of galactorrhea were found. :Of 17 patients with longstanding amenorrhea and hyperprolactinemia (3-15 years, mean 7.7 years), 8 developed their amenorrhea after the use of oral contraceptives (Group 1) and 9 became amenorrheic spontaneously (Group 2). There were no differences between the groups with respect to the basal serum levels of (FSH) follicle stimulating hormone; (LH) luteinizing hormone; (LPE) low polar estrogens (estradiol-17 beta and estrone); and prolactin. Tomography revealed pituitary adenoma in 4 patients; 1 developed symptoms of her tumor during pregnancy and they subsided following delivery. The others with tumors are checked twice/year and have not yet received treatment. The patients with no detectable tumors were treated with bromocriptine starting with 1.25x 3 daily. The peripheral serum levels of prolactin, FSH, LH, LPE, and progesterone were determined once a week and if the prolactin levels remained high, the bromocriptine dosage was increased. All patients began to menstruate once the prolactin returned to normal levels (below 25 mcg/l). Those patients who desired to become pregnant (N=6) subsequently did. 3 were delivered by cesarean section, 1 had a normal delivery, and 2 are still pregnant. There were no differences between Group 1 and 2 in the dose required or in the duration of treatment before menstruation started. 3 cases of galactorrhea were found.

journal_name

Acta Obstet Gynecol Scand

journal_title

Acta obstetricia et gynecologica Scandinavica

authors

Furuhjelm M,Rydner T,Carlström K

doi

10.3109/00016348009154630

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

137-41

issue

eissn

0001-6349

issn

1600-0412

journal_volume

pub_type

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Hyperprolactinemia in cases of infertility and amenorrhea.