Abstract:
INTRODUCTION:There remains a need for a non-invasive, low-cost and easily accessible way of identifying women at risk of developing hypertensive disorders in pregnancy. This study evaluated the predictive value of longitudinal salivary uric acid measurement. MATERIAL AND METHODS:Pregnant women (n = 137) from 20 weeks of gestation were recruited at St Richards Hospital, Chichester, UK, for this prospective cohort study. Weekly samples of salivary uric acid were analyzed until delivery. Information regarding pregnancy and labor were obtained from the patient's record after delivery. Independent t tests were used to compare mean levels of salivary uric acid in women with hypertensive complications and adverse fetal outcomes with women with normal pregnancies. Main outcome measures were preeclampsia, pregnancy-induced hypertension, spontaneous preterm delivery and small-for-gestational-age babies. RESULTS:From 21 weeks of gestation until delivery, levels of salivary uric acid increased significantly in women who subsequently developed preeclampsia and pregnancy-induced hypertension compared with women with normal pregnancies (preeclampsia-mean at gestational age 21-24, 95% confidence interval [95% CI] [mean GA21-24 ): 108 [63-185] vs 47 (39-55) µmol/L; P = .005; pregnancy-induced hypertension-mean GA21-24 : 118 [54-258] vs 47 [39-55] µmol/L; P = .004). In women who had spontaneous preterm delivery, salivary uric acid levels increased significantly from 29 to 32 weeks of gestation compared with women with normal pregnancies (mean GA29-32 : 112 (57-221) vs 59 (50-71) µmol/L; P = .04). In women who had babies small-for-gestational-age <10th percentile and small-for-gestational-age <3rd percentile, differences in salivary uric acid levels were insignificant. CONCLUSIONS:Elevated levels of salivary uric acid precede the onset of preeclampsia, pregnancy-induced hypertension and preterm delivery. Salivary uric acid may prove to be an early biomarker of hypertensive complications of pregnancy and spontaneous preterm delivery.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Püschl IC,Bonde L,Reading IC,Maguire P,Macklon NS,Van Rijn BBdoi
10.1111/aogs.13888subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1339-1345issue
10eissn
0001-6349issn
1600-0412journal_volume
99pub_type
杂志文章abstract::In a double-blind, randomized study, 50 patients undergoing conization were treated with either lysine-vasopressin (LVP) or its longer-acting analogue Glypressin. Bleeding during the operation and side effects were studied. The hemostatic effect appeared better with LVP than with Glypressin. One postoperative bleeding...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016348609161488
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:Antenatal anemia is a major public health problem in the UK, yet there is limited high quality evidence for associated poor clinical outcomes. The objectives of this study were to estimate the incidence and clinical outcomes of antenatal anemia in a Scottish population. MATERIAL AND METHODS:A retrospectiv...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Alteration in the vaginal flora has been associated with adverse pregnancy outcomes. The objective of this study was to examine the impact of changes in individual microflora on genital immunity among low-risk pregnant women in early pregnancy. DESIGN:Cross-sectional study. SETTING:Large, tertiary care, aca...
journal_title:Acta obstetricia et gynecologica Scandinavica
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doi:10.1111/j.1600-0412.2011.01082.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of early maternal feeding on maternal satisfaction and gastrointestinal complications on patients following simple and complicated caesarean delivery (CD). METHODS:A prospective, randomised study was designed including 179 women undergoing first or repeated CD. Women who were assigned ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1080/00016340701778849
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:No population-based study has evaluated the effects of third trimester ultrasound screening on prognosis. OBJECTIVE:To study the effects of routine ultrasound screening in the third trimester on perinatal/infant mortality, prevalence of small for gestational age infants (SGA) and low Apgar score. STUDY DES...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1111/j.0001-6349.2005.00649.x
更新日期:2005-12-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
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doi:10.1111/aogs.13354
更新日期:2018-07-01 00:00:00
abstract::Dehydroepiandrosterone sulfate (DHAS) is now used for a dynamic test of placental function by many obstetricians. While practicing this test, the authors found that DHAS markedly promoted so-called "cervical ripening". To study this problem, DHAS of 50 or 100 mg in multiple doses were injected into 132 Japanese pregna...
journal_title:Acta obstetricia et gynecologica Scandinavica
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doi:10.3109/00016347809156518
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abstract:BACKGROUND:To compare a 48 hour non surgical policy in the management of spontaneous abortion with a policy of routine, universal uterine curettage. METHODS:A prospective, observational study on 354 women admitted to hospital with spontaneous abortion. Of these, 225 who had retained products of conception were treated...
journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016341003605693
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abstract::1914 women were asked to count fetal movements for 15 minutes every evening from the 28th week of pregnancy until parturition. An individual lowest limit for number of fetal movements was calculated from the first five counts. The women were instructed to contact the maternity ward for fetal evaluation as soon as thei...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348609158402
更新日期:1986-01-01 00:00:00
abstract::Bromocriptine given for prolonged times at high doses has been found to induce tumors in the uterus in aged rats. To elucidate the possible tumorigenic effect of long-term treatment with bromocriptine in humans, 35 women treated with this drug for chronic parkinsonism were studied. For each patient a gynecological ana...
journal_title:Acta obstetricia et gynecologica Scandinavica
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doi:10.3109/00016348509154693
更新日期:1985-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348609157347
更新日期:1986-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章
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更新日期:1998-07-01 00:00:00
abstract::Endometriosis is estimated to affect up to 50% of infertile women, and severity of endometriosis stage appears to correlate with reduced fertility. Ovarian endometriomas are found in up to 44% of women with endometriosis, and are significantly associated with the presence of pelvic deep infiltrating endometriosis, ova...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347509156760
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journal_title:Acta obstetricia et gynecologica Scandinavica
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348809029873
更新日期:1988-01-01 00:00:00
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doi:10.1111/j.1600-0412.2011.01309.x
更新日期:2012-02-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To determine the performance of trained midwives in second trimester ultrasound screening for fetal structural abnormalities in a low-risk population. DESIGN:Retrospective study. SETTING:University Department of Obstetrics and Gynecology. POPULATION:About 13,882 women with singleton pregnancies. METHODS:T...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340902934688
更新日期:2009-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347709158350
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Our aim was to estimate the prevalence of stress urinary incontinence 4 years after the first delivery and analyze its risk factors. METHODS:A retrospective cohort survey was conducted in a French university hospital. The 669 primiparous women who delivered in our department in 1996 a singleton in a vertex ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2004.00457.x
更新日期:2004-10-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349209007940
更新日期:1992-01-01 00:00:00
abstract::With the object of examining the diagnostic accuracy of and pain reaction to endocervical curettage (ECC) either by using a new instrument, Vabra mc cervix, or with a conventional 3 mm metal curette, 298 patients with histologically verified cervical intraepithelial neoplasia (CIN) or cytological suspicion have been i...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016348809004171
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:This study compared healing of the scars after cesarean section during the first postpartum year using a single- or double-layer suturing technique. Scarring was assessed by a transvaginal ultrasound. We explored the appearance and localization of uterine scars with regard to the obstetric history. Our aim...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aogs.13714
更新日期:2020-01-01 00:00:00
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journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00