Abstract：
:As yeast colonies ceased growth, cells at the edge of these colonies transited from the cell division cycle into meiosis at high efficiency. This transition occurred remarkably synchronously and only at late stages of colony maturation. The transition occurred on medium containing acetate or low concentrations of glucose, but not on medium containing high glucose. The repression by high glucose was overcome when IME1 was overexpressed from a plasmid. Experiments with different growth media imply that meiosis in colonies is triggered by changes in the nutrient environment as colonies mature. HAP2 is required to sporulate in any carbon source, whereas GRR1 is required for glucose repression of sporulation. CLN3 is required to repress meiosis in colonies but not in liquid cultures, indicating that the regulators that mediate the transition to meiosis in colonies are not identical to the regulators that mediate this transition in liquid cultures.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Purnapatre K,Honigberg SMdoi
10.1007/s00294-002-0331-xsubject
Has Abstractpub_date
2002-10-01 00:00:00pages
1-8issue
1eissn
0172-8083issn
1432-0983journal_volume
42pub_type
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