The KP4 killer protein gene family.

Abstract:

:Killer protein 4 (KP4) is a well studied viral toxin secreted by the maize smut fungus Ustilago maydis that kills sensitive Ustilago strains as well as inhibits Fusarium and plant root growth by inhibiting calcium uptake. Numerous small, cysteine-rich proteins have been shown to play a critical role in fungal-plant-bacterial associations. The discovery of six KP4-like genes in F. verticillioides precipitated efforts to understand their function and evolutionary origin. Analysis of publicly available genomic sequence identified 31 additional KP4-like genes from a range of Ascomycota, a Basidiomycota, and the moss Physcomitrella patens. Sequence comparison and phylogenetic analysis indicate that the viral KP4 and the moss and fungal KP4-like genes evolved from a common ancestor providing evidence for lateral gene transfer between kingdoms. Six genes of the 37 total genes are predicted to encode a protein with two, non-identical KP4-like domains in tandem separated by 29-56 amino acids. The results suggest that two independent events led to the dual-domain KP4 genes present in different lineages of the Ascomycota. Understanding the nature and function of KP4-like proteins in mycotoxin-producing species like Fusarium may help to limit plant diseases and increase food safety and food production.

journal_name

Curr Genet

journal_title

Current genetics

authors

Brown DW

doi

10.1007/s00294-010-0326-y

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

51-62

issue

1

eissn

0172-8083

issn

1432-0983

journal_volume

57

pub_type

杂志文章
  • The minimum domain of Pho81 is not sufficient to control the Pho85-Rim15 effector branch involved in phosphate starvation-induced stress responses.

    abstract::The phosphate regulatory mechanism in yeast, known as the PHO pathway, is regulated by inorganic phosphate to control the expression of genes involved in the acquisition of phosphate from the medium. This pathway is also reported to contribute to other nutritional responses and as such it affects several phenotypic ch...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s00294-005-0583-3

    authors: Swinnen E,Rosseels J,Winderickx J

    更新日期:2005-07-01 00:00:00

  • Implications of maintenance of mother-bud neck size in diverse vital processes of Saccharomyces cerevisiae.

    abstract::The mother-bud neck is defined as the boundary between the mother cell and bud in budding microorganisms, wherein sequential morphological events occur throughout the cell cycle. This study was designed to quantitatively investigate the morphology of the mother-bud neck in budding yeast Saccharomyces cerevisiae. Obser...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s00294-018-0872-2

    authors: Kubo K,Okada H,Shimamoto T,Kimori Y,Mizunuma M,Bi E,Ohnuki S,Ohya Y

    更新日期:2019-02-01 00:00:00

  • Identification of paternal mitochondrial DNA sequences in the nucleus-cytoplasm hybrids of tetraploid and hexaploid wheat with D and D2 plasmons from Aegilops species.

    abstract::Mitochondrial (mt) DNA structures were studied in 12 nucleus-cytoplasm (NC) hybrids of tetraploid and hexaploid wheat in which nuclear genomes of the recurrent paternal wheat parents were combined with D and D2 plasmons from Aegilops species. RFLP analysis of 15 mtDNA regions indicated the presence of the paternal seq...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s002940000153

    authors: Tsukamoto N,Asakura N,Hattori N,Takumi S,Mori N,Nakamura C

    更新日期:2000-11-01 00:00:00

  • Composition of the spindle pole body of Saccharomyces cerevisiae and the proteins involved in its duplication.

    abstract::The microtubule-organizing center (MTOC) is the organelle that manages the distribution of microtubule filaments in the cell. It includes such centers of microtubule organization as basal bodies, nucleus-associated bodies, spindle pole bodies and centrosomes. The centrosome is the MTOC in most animal cells. Despite th...

    journal_title:Current genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s00294-001-0263-x

    authors: Helfant AH

    更新日期:2002-02-01 00:00:00

  • Genetic effects of photoactivated psoralens during meiosis in DNA repair mutant pso3-1 of Saccharomyces cerevisiae.

    abstract::The influence of the DNA repair gene PSO3 on photoactivated psoralen-induced meiotic recombination, gene conversion, reverse mutation, and on survival, was assayed in diploid strains of Saccharomyces cerevisiae homozygous for the wild-type or the pso3-1 mutant allele. Sporulation was normal in the pso3-1 diploid. Wild...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00712961

    authors: Pothin HS,da Silva KV,Brendel M,Henriques JA

    更新日期:1994-01-01 00:00:00

  • Cloning and characterization of the nuclear gene encoding plastid glyceraldehyde-3-phosphate dehydrogenase from the marine red alga Gracilaria verrucosa.

    abstract::The single-copy nuclear gene (GapA), encoding the plastid-localized glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of the marine red alga Gracilaria verrucosa, has been cloned and sequenced. The GapA transcriptional initiation site was located 49 bp upstream of the start codon, and a putative TATA box was found 54 b...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00326308

    authors: Zhou YH,Ragan MA

    更新日期:1994-07-01 00:00:00

  • Partial sequence of the mitochondrial genome of the crustacean Daphnia pulex.

    abstract::A 4062-nucleotide (nt) fragment of the mitochondrial genome of the crustacean Daphnia pulex was sequenced and found to contain the complete genes for eight tRNAs and five proteins (ATP6, ATP8, COII, COIII, ND3) and the partial sequence of COI. In combination with data described previously, approximately 50% of the D. ...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s002940050175

    authors: Crease TJ,Little TJ

    更新日期:1997-01-01 00:00:00

  • A direct study of the relative synthesis of petite and grande mitochondrial DNA in zygotes from crosses involving suppressive petite mutants of Saccharomyces cerevisiae.

    abstract::Work in recent years has produced indirect evidence to support the view that the phenomenon of suppressiveness in yeast is the result of the ability of the petite mtDNA to out-replicate the wild-type genome. We have developed a method, based on fluorography of gels containing restriction fragments of radioactively lab...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00418122

    authors: Chambers P,Gingold E

    更新日期:1986-01-01 00:00:00

  • Localization of yeast glucoamylase genes by PFGE and OFAGE.

    abstract::Chromosomes of two closely related yeast strains, the amylolytic Saccharomyces diastaticus and the non-amylolytic Saccharomyces cerevisiae, were resolved by pulsed field gel electrophoresis (PFGE) and orthological field alteration gel electrophoresis (OFAGE). Electrophoretic karyotypes of these two strains are identic...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00405847

    authors: Pretorius IS,Marmur J

    更新日期:1988-07-01 00:00:00

  • Expression of Tri15 in Fusarium sporotrichioides.

    abstract::In the fungus Fusarium sporotrichioides, biosynthesis of trichothecene mycotoxins requires at least three genetic loci: a core 12-gene cluster, a smaller two-gene cluster, and a single-gene locus. Here, we describe the Tri15 gene, which represents a fourth locus involved in trichothecene biosynthesis. Tri15 is predict...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s00294-003-0467-3

    authors: Alexander NJ,McCormick SP,Larson TM,Jurgenson JE

    更新日期:2004-03-01 00:00:00

  • Characterization of hch, the Podospora anserina homolog of the het-c heterokaryon incompatibility gene of Neurospora crassa.

    abstract::The het-c locus controls heterokaryon formation in Neurospora crassa. It is subject to balancing selection operating to maintain polymorphism at that locus in natural populations. We have isolated hch, the het-c homolog from the related species Podospora anserina (hch for het-c homolog), in order to determine if this ...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s002940000130

    authors: Saupe SJ,Clavé C,Sabourin M,Bégueret J

    更新日期:2000-07-01 00:00:00

  • Cointegration of transforming DNAs in Aspergillus nidulans: a model using autonomously-replicating plasmids.

    abstract::Transforming DNAs form cointegrates in Aspergillus nidulans by homologous and non-homologous recombination as well as by end-to-end ligation of linear fragments. This process has been studied by means of a model in which the linkage of a marker gene to the origin of autonomous replication AMA1 was selected for. Recomb...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00310500

    authors: Aleksenko AY

    更新日期:1994-10-01 00:00:00

  • The evolution of peptide mating pheromones in fission yeast.

    abstract::In fungi, sexual reproduction primarily depends on the interaction between peptide pheromones and their receptors. Most ascomycete fungi produce two classes of peptide mating pheromones, a simple peptide and a modified peptide. These peptides are recognized by their corresponding receptors on the surface of cells of t...

    journal_title:Current genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s00294-019-00968-w

    authors: Seike T

    更新日期:2019-10-01 00:00:00

  • Identification and characterization of CEN12 in the budding yeast Saccharomyces cerevisiae.

    abstract::In this paper we report the cloning, sequencing and functional characterization of CEN12 and an associated autonomously replicating sequence (ARS) from the budding yeast Saccharomyces cerevisiae. In the course of studying a dynamin-related gene, DNM1, we previously physically mapped the gene to chromosome 12. Genetic ...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00518162

    authors: Gammie AE,Rose MD

    更新日期:1995-11-01 00:00:00

  • Inheritance and alteration of transforming DNA during an induced parasexual cycle in the imperfect fungus Cladosporium fulvum.

    abstract::Protoplasts of a pAN7-1-transformed isolate of Cladosporium fulvum race 4, harbouring a tandem duplication of the vector, and an untransformed race 5 isolate were fused, without selection for the presence of vector sequences. Fusion products were allowed to haploidize spontaneously. The inheritance of pAN7-1 sequences...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00312643

    authors: Arnau J,Oliver RP

    更新日期:1993-05-01 00:00:00

  • Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole.

    abstract::For a comprehensive evaluation of genes that have their expression modulated during exposure of the mycelia to voriconazole, we performed a large-scale analysis of gene expression in Aspergillus fumigatus using a microarray hybridization approach. By comparing the expression of genes between the reference time and aft...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s00294-006-0073-2

    authors: da Silva Ferreira ME,Malavazi I,Savoldi M,Brakhage AA,Goldman MH,Kim HS,Nierman WC,Goldman GH

    更新日期:2006-07-01 00:00:00

  • Characterization and prevalence of a circular mitochondrial plasmid in senescence-prone isolates of Neurospora intermedia.

    abstract::Genetic and molecular analyses of the phenomenon of senescence-i.e., irreversible loss of growth and reproductive potential upon subculturing-in Neurospora intermedia strain M1991-60A, collected from Maddur in southern India, showed the presence of plasmid pMaddur1, which is homologous to the senescence-inducing circu...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s00294-004-0558-9

    authors: D'Souza AD,Sultana S,Maheshwari R

    更新日期:2005-03-01 00:00:00

  • Pentose-phosphate pathway in Saccharomyces cerevisiae: analysis of deletion mutants for transketolase, transaldolase, and glucose 6-phosphate dehydrogenase.

    abstract::Deletion mutants for the yeast transketolase gene TKL1 were constructed by gene replacement. Transketolase activity was below the level of detection in mutant crude extracts. Transketolase protein could be detected as a single protein band of the expected size by Western-blot analysis in wild-type strains but not in t...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00351843

    authors: Schaaff-Gerstenschläger I,Zimmermann FK

    更新日期:1993-11-01 00:00:00

  • Identification of an ADPG-dependent trehalose synthase in Saccharomyces.

    abstract::Uridine diphosphoglucose is not the sole donor for trehalose synthesis in yeast cells: an ADPG-dependent trehalose synthase, has been identified in mutant strains with undetectable UDPG-dependent trehalose-6-P synthase activity. Genetic and chromatographic studies indicate that the two activities correspond to differe...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00393399

    authors: Paschoalin VM,Silva JT,Panek AD

    更新日期:1989-08-01 00:00:00

  • Biochemical properties of bacterial reverse transcriptase-related (rvt) gene products: multimerization, protein priming, and nucleotide preference.

    abstract::Cellular reverse transcriptase-related (rvt) genes represent a novel class of reverse transcriptases (RTs), which are only distantly related to RTs of retrotransposons and retroviruses, but, similarly to telomerase RTs, are immobilized in the genome as single-copy genes. They have been preserved by natural selection t...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s00294-018-0844-6

    authors: Yushenova IA,Arkhipova IR

    更新日期:2018-12-01 00:00:00

  • Comparison of ribosomal DNA ITS regions among geographic isolates of Cenococcum geophilum.

    abstract::Cenococcum geophilum is an ecologically important mycorrhizal fungus with a global distribution and a wide host range. It has been difficult to study since it forms only sterile mycelia and, occasionally, sclerotial bodies. Because of its lack of morphological variability, its taxonomy and phylogenetic origins have un...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s002940050449

    authors: Shinohara ML,LoBuglio KF,Rogers SO

    更新日期:1999-06-01 00:00:00

  • Disruption of the cyclosporin synthetase gene of Tolypocladium niveum.

    abstract::Cyclosporin A is a potent and clinically-important immunosuppressive drug (SandimmunR). It is produced by the fungus Tolypocladium niveum. A transformation system for T. niveum ATCC34921 based on hygromycin selection was established. In order to obtain a T. niveum promoter, the cyclophilin gene was isolated using the ...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00309935

    authors: Weber G,Leitner E

    更新日期:1994-11-01 00:00:00

  • Physical mapping of genetic determinants on yeast mitochondrial DNA affecting the apparent size of the Var 1 polypeptide.

    abstract::The var1 locus on yeast mitochondria) DNA is defined by a set of alleles that affect the apparent size (Mr 40,000-44,000) of a mitochondria) translation product (var1), a protein of the mitochondria) 38S ribosomal subunit. Using petite deletion and restriction endonuclease site mapping, we have defined the physical lo...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00445691

    authors: Vincent RD,Perlman PS,Strausberg RL,Butow RA

    更新日期:1980-07-01 00:00:00

  • Isolation of transcripts preferentially expressed during fruit body primordia differentiation in the basidiomycete Agrocybe aegerita.

    abstract::An Agrocybe aegerita cDNA library, constructed from fruit body primordia poly(A)+ RNAs, was screened by differential colony hybridization. Clones which preferentially hybridized to poly(A)+ RNA sequences from fruit body primordia, versus poly(A)+ RNAs from mycelium, were isolated. Eight of these clones (EMAa-1 to EMAa...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00326234

    authors: Salvado JC,Labarère J

    更新日期:1991-08-01 00:00:00

  • Cold-sensitive mutation in Neurospora crassa affecting the production of 17S ribosomal RNA from ribosomal precursor RNA.

    abstract::The cold-sensitive mutant strain of Neurospora crassa, crib-1 (PJ30201) has a conditional defect in ribosome biosynthesis. At 10 °C this mutant underproduces the small (37S) ribosomal subunit. Experiments were done to study rRNA synthesis in crib-1 after a shift from the permissive (25 °C) to the nonpermissive tempera...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00376778

    authors: Russell PJ,Selker EU,Jackson JA

    更新日期:1981-09-01 00:00:00

  • Cloning and analysis of the nuclear gene MRP-S9 encoding mitochondrial ribosomal protein S9 of Saccharomyces cerevisiae.

    abstract::The Saccharomyces cerevisiae nuclear gene MRP-S9 was identified as part of the European effort in sequencing chromosome II. MRP-S9 encodes for a hydrophilic and basic protein of 278 amino acids with a molecular mass of 32 kDa. The C-terminal part (aa 153-278) of the MRP-S9 protein exhibits significant sequence similar...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/BF00311878

    authors: Kötter P,Entian KD

    更新日期:1995-06-01 00:00:00

  • Intra-specific and inter-specific conservation of mating-type genes from the discomycete plant-pathogenic fungi Pyrenopeziza brassicae and Tapesia yallundae.

    abstract::In previous work, four genes involved in mating-type determination were cloned from reference strains of Pyrenopeziza brassicae; three genes, PAD1, PMT1, and PHB1 (re-named henceforth as MAT-1-1, MAT-1-4, and MAT1-3, respectively), are encoded by the MAT-1 idiomorph, and one gene, PHB2 (re-named MAT-2), by the corresp...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s002940050503

    authors: Singh G,Dyer PS,Ashby AM

    更新日期:1999-11-01 00:00:00

  • Expression and molecular properties of a new laccase of the white rot fungus Phlebia radiata grown on wood.

    abstract::Laccases are phenol-oxidizing, multicopper enzymes produced by fungi, plants, insects and bacteria. Fungal laccases are involved in ecologically important processes such as decomposition of lignocellulose (wood and plant material). In this work, in order to find out the role of fungal laccases upon wood colonisation a...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s00294-006-0090-1

    authors: Mäkelä MR,Hildén KS,Hakala TK,Hatakka A,Lundell TK

    更新日期:2006-11-01 00:00:00

  • Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity.

    abstract::Studies on replicative and chronological aging in Saccharomyces cerevisiae have greatly advanced our understanding of how longevity is regulated in all eukaryotes. Chronological lifespan (CLS) of yeast is defined as the age-dependent viability of non-dividing cell populations. A number of nutrient sensing and signal t...

    journal_title:Current genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s00294-017-0697-4

    authors: Zhang N,Cao L

    更新日期:2017-10-01 00:00:00

  • Primary structure and transcription patterns of RPL36, a ribosomal protein-encoding gene of the mycoparasitic fungus, Trichoderma hamatum.

    abstract::We report the isolation and expression profiles of a single-copy gene from the mycoparasitic fungus Trichoderma hamatum encoding a 60 S cytoplasmic ribosomal protein. The gene, named RPL36, was cloned through its nutrient-mediated expression, using mRNA differential screening. Its predicted ORF, interrupted by two int...

    journal_title:Current genetics

    pub_type: 杂志文章

    doi:10.1007/s002940100192

    authors: Fekete C,Posta K,Hornok L

    更新日期:2001-05-01 00:00:00