Active substances against trypomastigote forms of Trypanosoma cruzi and microorganisms are produced in sequence by Talaromyces flavus.

Abstract:

:The conditions for the sequential production of antibiotic activity by Talaromyces flavus were determined. The highest level of activity against Trypanosoma cruzi was obtained from the aqueous extract of the Czapeck's fermentative culture after 48 hours, with lysis of 97.58% of the trypomastigote forms of Trypanosoma cruzi (red blood cells remained normal). The antimicrobial activity was detected in the extracts of fermentative cultures from different media just after 144 hours of incubation. Maximum activities against Micrococcus luteus, Staphylococcus aureus and Candida albicans were present in chloroform, butanolic and water extracts, in this order, when Talaromyces flavus was cultivated at pH 5.0. The minimal inhibitory concentration (MIC) of extracts of Takeuchi's cultures were determined.

journal_name

Microbiol Res

journal_title

Microbiological research

authors

Freitas TP,Furtado NA,Bastos JK,Said S

doi

10.1078/0944-5013-00148

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

201-6

issue

3

eissn

0944-5013

issn

1618-0623

pii

S0944-5013(04)70078-6

journal_volume

157

pub_type

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