MicroRNAs in common diseases and potential therapeutic applications.

Abstract:

:1. Evidence gathered in recent years has revealed microRNAs (miRNAs) fine-tune gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation and apoptosis. 2. The present review summarizes current knowledge of miRNA pathways in the pathogenesis of cancer, cardiac diseases, neurodegenerative diseases, diabetes, autoimmune/inflammatory diseases and infection. 3. There is considerable potential to target miRNAs as a novel approach in the treatment of human diseases. Currently, miRNA-based therapies are being examined in both animal models and human clinical trials.

authors

Tsai LM,Yu D

doi

10.1111/j.1440-1681.2009.05269.x

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

102-7

issue

1

eissn

0305-1870

issn

1440-1681

pii

CEP5269

journal_volume

37

pub_type

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