MicroRNAs in common diseases and potential therapeutic applications.

abstract：:The effect of indomethacin suppositories on both acute urinary colic and urinary calculus, resistant or refractory to conventional therapy with analgesics and spasmolytics was investigated. Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics ha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Al-Waili NS

更新日期：1986-03-01 00:00:00

abstract：:This study describes the pharmacodynamic interaction between propofol and remifentanil. Sixty patients who were scheduled for elective surgery under general anaesthesia (30 males/30 females) were enrolled. Patients were randomly allocated to receive one of 15 combinations of drug levels. Baseline electroencephalograms...

journal_title：Clinical and experimental pharmacology & physiology

authors： Choe S,Choi BM,Lee YH,Lee SH,Lee EK,Kim KS,Noh GJ

更新日期：2017-01-01 00:00:00

abstract：:1. The present study sought to explain the mechanism leading to reduced availability of propranolol when given after a priming dose in the single-pass perfused rat liver. 2. Extracellular sucrose space (as a measure of sinusoidal relaxation) in perfused rat liver before and after propranolol or propranolol and N(G)-ni...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu X,Zou Y,Khlentzos AM,Yang Y,Nikolovski J,Weiss M,Roberts MS

更新日期：2010-10-01 00:00:00

abstract：:1. Salt intake is not only known to play an important role in determining blood pressure (BP) but has been shown to have other deleterious effects independent of BP. 2. Epidemiological and animal studies have provided evidence that salt intake may have an adverse effect on stroke mortality independent of BP. 3. Signif...

journal_title：Clinical and experimental pharmacology & physiology

authors： Antonios TF,MacGregor GA

更新日期：1995-03-01 00:00:00

abstract：:1. Gastric emptying studies in small laboratory animals are hampered by the deficiency of a technique that is non-invasive and repeatable. The aim of the present study was to adapt the non-invasive [13C]-octanoic acid breath test, which has been validated in humans, to assess both liquid and solid gastric emptying in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Symonds EL,Butler RN,Omari TI

更新日期：2000-09-01 00:00:00

abstract：:1. The present study was undertaken to elucidate the effects of parecoxib, a novel cyclo-oxygenase (COX)-2 inhibitor, on spontaneous and prostaglandin-induced contractions of uterine smooth muscle. 2. Non-pregnant adult Wistar rats were decapitated and dissected to isolate myometrial strips. The tissue was mounted in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ayar A

更新日期：2007-08-01 00:00:00

abstract：:Placental growth factor (PlGF) is decreased in early gestation of pregnant women who subsequently develop pre-eclampsia. In this study, pre-emptive treatment with PlGF to prevent pre-eclampsia was evaluated in an in vivo rodent model of experimental pre-eclampsia (EPE) induced by TNF-α and in an in vitro model of huma...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chau K,Bobek G,Xu B,Stait-Gardner T,Price W,Hennessy A,Makris A

更新日期：2020-01-01 00:00:00

abstract：:1. Resveratrol (RSV), a polyphenol in red wine, exhibits cardioprotective effects in vitro, such as inhibition of angiotensin II- or phenylephrine-induced cardiomyocyte hypertrophy in rat neonatal myocyte cultures and suppression of cardiac fibroblast proliferation. The aim of the present study was to investigate the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang DL,Zhang HG,Xu YL,Gao YH,Yang XJ,Hao XQ,Li XH

更新日期：2010-02-01 00:00:00

abstract：:1. The possibility that the anticonvulsant activity of the benzodiazepines, diazepam and clobazam, is related to changes in EEG parameters, particularly beta activity, was investigated in amygdaloid kindled rats. 2. The effects of diazepam (1, 2, 4, 8 and 16 mumols/kg), administered intraperitoneally (i.p.), clobazam ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Harris QL,Lewis SJ,Young NA,Vajda FJ,Jarrott B

更新日期：1988-10-01 00:00:00

abstract：:This study investigates the effect of chronic consumption of a high-fat diet rich in corn oil (CO-HFD) on atrial cells ultrastructure, antioxidant levels and markers of intrinsic cell death of both control and type 1 diabetes mellitus (T1DM)-induced rats. Adult male rats (10 rats/group) were divided into four groups: ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Eid RA,Eleawa SM,Alkhateeb MA,Aldera H,Zaki MSA,Al-Shraim M,Saeed MA,El-Kott AF,Alaa Eldeen M,Alassiri M,Alshehri MM,Salem Al-Shudiefat AA,Khalil MA

更新日期：2019-12-01 00:00:00

abstract：:Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. Plasma renin activity (PRA)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Isbil-Buyukcoskun N,Ilcol YO,Cansev M,Hamurtekin E,Ozluk K,Ulus IH

更新日期：2008-09-01 00:00:00

abstract：:1. The present review describes the actions of sensory neuropeptides on the contractility of the rat and guinea-pig prostate gland and discusses the differences in sensitivity of the smooth muscle of the prostates taken from these species to these neuropeptides. 2. Nerve fibres immunoreactive for the tachykinins subst...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ventura S,Lau WA,Buljubasich S,Pennefather JN

更新日期：2000-11-01 00:00:00

abstract：:1. Renin mRNA is present in the kidney and, in lower concentrations, in many extrarenal tissues and serves as an index of renin gene activity, as well as potential renin or prorenin synthesis in cell populations within those tissues. Unfortunately the quantity can be very low. 2. A new, highly sensitive technique is d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lou YK,Smith DL,Robinson BG,Morris BJ

更新日期：1991-05-01 00:00:00

abstract：:1. The influence of the intact kidney on blood pressure, extracellular fluid volume (ECF, ferrocyanide space) and ECF volume distribution was studied in rats 60 days after constriction of the contralateral renal artery. 2. Renal artery constriction increased both blood pressure and ECF levels. The rise of both variabl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kunes J,Jelínek J

更新日期：1979-09-01 00:00:00

abstract：:1. Positive inotropic effect of taurine and improvement of cardiac performance of failing heart are mediated through the modulation of Ca2+ movement through the sarcolemma. 2. Cardioprotection with glutamate and aspartate is related to enhanced anaerobic energy formation in mitochondria coupled with succinate formatio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pisarenko OI

更新日期：1996-08-01 00:00:00

abstract：:1. This study investigated the effect of atrial natriuretic peptide on renin release from the kidney. The in vitro direct effect was examined in the animal experiment using renal cortical slices of rat, and the in vivo effect was observed in the human infusion study. 2. In the in vitro experiments, alpha-human atrial ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ishimitsu T,Hirata Y,Matsuoka H,Ishii M,Sugimoto T,Kangawa K,Matsuo H

更新日期：1992-10-01 00:00:00

abstract：:1. Schizophrenia is a chronic, disabling brain disease that affects approximately 1% of the world's population. It is characterized by delusions, hallucinations and formal thought disorder, together with a decline in socio-occupational functioning. While the causes for schizophrenia remain unknown, evidence from famil...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mowry BJ,Nancarrow DJ

更新日期：2001-01-01 00:00:00

abstract：:1. The efficacy of coumarin (1,2-benzopyrone) was examined for the regulation of hyperthyroidism in female rats. 2. Coumarin was administered (10 mg/kg per day for 15 days) to l-thyroxine (L-T(4))-induced hyperthyroid as well as to euthyroid rats and changes in serum concentrations of thyroid hormones and in associate...

journal_title：Clinical and experimental pharmacology & physiology

authors： Panda S,Kar A

更新日期：2007-11-01 00:00:00

abstract：:Prostaglandin (PG) efflux into ureteral (UE) and venous effluents (VE) of rabbit isolated perfused kidneys was determined by superfusion bioassay and radioimmunoassay (RIA), in response to injections of arginine-vasopressin (AVP), the non-pressor vasopressin analogue 1-deamino-8-D-arginine vasopressin (dDAVP) and arac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miller MJ,Westlin WF,McNeill H,McGiff JC

更新日期：1986-08-01 00:00:00

abstract：:1. Pyruvate has been shown to enhance the contractile performance of cardiac muscle when provided as an alternative substrate to glucose. The aims of the present study were to determine whether the inotropic effects of pyruvate are due to increased mobilization of intracellular Ca2+ ([Ca2+]i) and to compare the effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mellors LJ,Kotsanas G,Wendt IR

更新日期：1999-11-01 00:00:00

abstract：:1. Treatment with angiotensin-converting enzyme (ACE) inhibitors slows the rate of progression of nephropathy in the spontaneously hypertensive rat (SHR) with streptozotocin-induced diabetes. Paradoxically, however, chronic ACE inhibitor therapy has been reported to be associated with induction of ACE in the plasma. W...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hodge G,Makarious MM,Charlesworth JA,Duggan KA

更新日期：1997-06-01 00:00:00

abstract：:1. Altered calcium regulation has been observed in experimental and human hypertension. In this study erythrocyte (RBC) intracellular calcium concentration ([Ca2+]i) was compared in conscious spontaneously hypertensive rats (SHR) and their normotensive controls (WKY) at rest and after injection of the dihydropyridine ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris MJ,David-Dufilho M,Devynck MA

更新日期：1988-04-01 00:00:00

abstract：:1. Ghrelin is a multifunctional peptide hormone that affects various processes, including growth hormone and insulin release, appetite regulation, gut motility, metabolism and cancer cell proliferation. Ghrelin is produced in the stomach and in other normal and pathological cell types. It may act as an endocrine or au...

journal_title：Clinical and experimental pharmacology & physiology

authors： Seim I,Amorim L,Walpole C,Carter S,Chopin LK,Herington AC

更新日期：2010-01-01 00:00:00

abstract：:1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site- and event-specific fashion. 2. We characterized cardioprotective actions of the adenosine deaminase inhibitor erythro-2...

journal_title：Clinical and experimental pharmacology & physiology

authors： Willems L,Headrick JP

更新日期：2005-03-01 00:00:00

abstract：:1. Subpressor calcium infusion for 1 h, which raised calcium levels to the upper limit of normal in normal subjects, increased plasma and urinary levels of atrial natriuretic peptide (ANP). 2. Heart rate fell, presumably due to carotid baroreflex stimulation (supported by the fall in noradrenaline) and the resultant f...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finn WL,Gordon RD,Seneviratne BI,Tunny TJ,Klemm SA

更新日期：1992-05-01 00:00:00

abstract：:1. Hepatocyte growth factor (HGF) has the therapeutic potential to improve renal fibrosis and proteinuria in rodents with chronic kidney disease. In contrast, long-term administration of human HGF to normal rats reportedly elicits proteinuria. Thus, the role of HGF during proteinuria remains contentious. The aim of th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mizuno S,Ikebuchi F,Fukuta K,Kato T,Matsumoto K,Adachi K,Abe T,Nakamura T

更新日期：2011-03-01 00:00:00

abstract：:1. The vascular contractile effects of polymorphonuclear leucocytes (PMN) isolated from control rabbits and from rabbits made atherosclerotic by 1% cholesterol feeding for 8 weeks were examined. 2. Rings of control rabbit thoracic aorta with or without endothelium were mounted at 2 g tension in 10 mL organ baths and w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sobey CG,Hart JL,Woodman OL

更新日期：1994-02-01 00:00:00

abstract：:1. Amino acid neurotransmitters are critical for controlling the activity of most central neurons, including sympathetic preganglionic neurons (SPN), the spinal cord neurons involved in controlling blood pressure and other autonomic functions. 2. In studies reviewed here, SPN were identified either by retrograde traci...

journal_title：Clinical and experimental pharmacology & physiology

authors： Llewellyn-Smith IJ

更新日期：2002-05-01 00:00:00

abstract：:1. Plasma concentration and atrial content of atrial natriuretic factor (ANF) were measured in rats with chronic renal failure induced by subtotal nephrectomy. 2. Plasma ANF was higher, and atrial ANF content lower in rats with renal failure when compared with sham-operated controls. 3. Plasma renin activity (PRA) and...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hodsman GP,Jackson B,Debrevi LM,Ogawa K,Johnston CI

更新日期：1987-03-01 00:00:00

abstract：:1. This paper reports on the in vitro and in vivo characteristics of a non-peptide vasopressin V1 receptor antagonist 1-(1-[4-(3-acetylaminopropoxy)benzoyl]-4-piperidyl)-3,4-dihydro-2( 1H)- quinolinone (OPC-21268). 2. OPC-21268 caused a concentration-dependent displacement of the selective V1 receptor antagonist radio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Burrell LM,Phillips PA,Stephenson J,Risvanis J,Hutchins AM,Johnston CI

更新日期：1993-05-01 00:00:00