In vivo and in vitro effects of atrial natriuretic peptide on renin release.

abstract：:1. The present study was undertaken to investigate the effects of aerobic physical exercise on membrane function in mild essential hypertension. 2. Hypertensive patients were divided into an exercise group (n = 8) and a non-exercise (control) group (n = 8). Physical exercise within the intensity of the anaerobic thres...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tsuda K,Yoshikawa A,Kimura K,Nishio I

更新日期：2003-05-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) has become a major disease that threatens human health. Neurotransmitters and the amygdala are found to be critical in the development and maintenance of PTSD. We aim to investigate the role of glycyrrhizin in treating PTSD. Contextual fear extinction and elevated plus maze test w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lai S,Shi L,Jiang Z,Lin Z

更新日期：2020-01-01 00:00:00

abstract：:1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Falckh PH,Harkin LA,Head RJ

更新日期：1992-08-01 00:00:00

abstract：:1. Several selective antagonists are available to differentiate between muscarinic receptors. 2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors. 3. Reasons for differences between affinity constants determined in functional and binding studies a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mitchelson F,Choo LK,Darroch S

更新日期：1989-06-01 00:00:00

abstract：:1. The administration of coumarin resulted in a two-fold increase in the entry of 51Cr-labelled rat plasma protein into otherwise normal tissues. 2. Prior treatment of rats with coumarin allowed about 50% more radio-labelled protein to enter the tissues immediately after thermal injury than occurred with thermal injur...

journal_title：Clinical and experimental pharmacology & physiology

authors： Piller NB

更新日期：1976-11-01 00:00:00

abstract：:1. The intravenous administration of nicergoline (5 mg) was followed by a rapid and sustained lowering of blood pressure; less rapid effects were bradycardia and an elevation of cardiac output. These delayed effects are consistent with an indirect action on the alpha-adrenoreceptors of the central nervous system. 2. F...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boismare F,Lefrançois J

更新日期：1980-03-01 00:00:00

abstract：:1. We investigated the effect of exercise on plasma adrenomedullin, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations and studied the relationship between these peptides and haemodynamic parameters in nine patients with old myocardial infarction (MI) and in eight normal subjects. 2. T...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morimoto A,Nishikimi T,Takaki H,Okano Y,Matsuoka H,Takishita S,Kitamura K,Miyata A,Kangawa K,Matsuo H

更新日期：1997-05-01 00:00:00

abstract：:1. Stimulation of the mesolimbic dopamine system, by micro-injection of the substance P analogue [pGlu5,MePhe8,Sar9] substance P (DiMe-C7) into the ventral tegmental area induced a prolonged increase in blood pressure and circulating levels of vasopressin. 2. In the present study, this treatment produced a significant...

journal_title：Clinical and experimental pharmacology & physiology

authors： van den Buuse M,Wilks DP,Cornish JL

更新日期：1998-07-01 00:00:00

abstract：:1. Taurine and homocysteine are metabolites of methionine. Hyperhomocysteinaemia is one of the risk factors for cardiovascular disease. Although taurine may be a cardiovascular cytoprotective substance, we hypothesized that it may antagonize the effects of homocysteine on myocardial mitochondrial function. 2. We studi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chang L,Zhao J,Xu J,Jiang W,Tang CS,Qi YF

更新日期：2004-04-01 00:00:00

abstract：:1. The purpose of this study was to determine whether hepatic mitochondria of guinea-pigs with spontaneous diabetes mellitus differ from those of non-diabetic guinea-pigs in the oxidation of fatty acids, the activity of beta-hydroxybutyrate dehydrogenase, or respiration-linked oxidative phosphorylation. During the cou...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nevalainen TO,White WJ,Lang CM,Munger BL

更新日期：1978-05-01 00:00:00

abstract：:1. Adrenaline can enhance the stimulation-induced release of transmitter noradrenaline in sympathetically innervated tissues by activating prejunctional beta-adrenoceptors. 2. Adrenaline incorporated into sympathetic transmitter stores by neuronal uptake can be subsequently released as a co-transmitter and can then ac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Majewski H,Tung LH,Rand MJ

更新日期：1981-09-01 00:00:00

abstract：:1. We examined the effects of torasemide (0.3 and 1 mg/kg i.v.) on renal haemodynamics and function employing renal clearance and stop-flow techniques in anaesthetized dogs and compared these with furosemide (1 and 3 mg/kg i.v.). 2. Torasemide and furosemide did not influence renal haemodynamics, in the renal clearanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Uchida T,Hayashi K,Suzuki Y,Matsumura Y

更新日期：1991-07-01 00:00:00

abstract：:1. The endothelin (ET) system and NADPH oxidase play important roles in the regulation of cardiovascular function, as well as in the pathogenesis of hypertension and other cardiovascular diseases. 2. Endothelins activate NADPH oxidases and thereby increase superoxide production, resulting in oxidative stress and cardi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dammanahalli KJ,Sun Z

更新日期：2008-01-01 00:00:00

abstract：:Preeclampsia is a complication affecting pregnant women worldwide, which leads to maternal and fetal morbidity and mortality. In this study, we evaluated the efficacy of ferulic acid (FA) on an Nω -nitro-L-arginine methyl ester hydrochloride (L-NAME) induced rat model of preeclampsia. L-NAME was administered to pregna...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gong W,Wan J,Yuan Q,Man Q,Zhang X

更新日期：2017-10-01 00:00:00

abstract：:1. Structural changes in resistance vessels were studied sequentially (a) by hindquarter perfusion and (b) by planimetry of renal arterioles less than or equal to 20 micrometers radius, for 10 weeks during development of DOCA (deoxycorticosterone acetate)/salt hypertension in uninephrectomized rats and 5 weeks after c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Vial JH,Yong AC,Boyd GW

更新日期：1982-05-01 00:00:00

abstract：:The effects of the calcium antagonists verapamil and nifedipine on mean arterial blood pressure, heart rate and pressor responses to a range of alpha-adrenoceptor agonists were examined in male normotensive New Zealand white rabbits and in rabbits with perinephritis hypertension. Verapamil and nifedipine caused a grea...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hamilton CA,Jardine E,Sumner DJ,Reid JL

更新日期：1987-02-01 00:00:00

abstract：:1. The aim of this study was to compare the effect of acute versus chronic ADH administration on the handling of sodium, potassium and water by the nephron. Simultaneous clearance and free-flow micropuncture experiments were performed on rats, infused with hypotonic Ringer solution, following either 1-3 h ('acute') or...

journal_title：Clinical and experimental pharmacology & physiology

authors： Field MJ,Seow F,Lawrence JR

更新日期：1989-02-01 00:00:00

abstract：:1. The objectives of the study were to establish that inhibition of neuronal differentiation in culture (assessed by neurite outgrowth) can be used as a broad spectrum in vitro measure of neurotoxicity. 2. To establish whether a rapid measure of neurite outgrowth could be used. Thus the study examined the relationship...

journal_title：Clinical and experimental pharmacology & physiology

authors： Abdulla EM,Calaminici M,Campbell IC

更新日期：1995-05-01 00:00:00

abstract：:1. This study was designed to elucidate the effects of guar gum, a dietary fibre, on changes in prostanoid contents induced by 1,2-dimethylhydrazine, a carcinogenic agent, in rat colonic mucosa. 2. Prostanoid contents were determined using high performance liquid chromatography; five prostanoids, namely 6-keto-prostag...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kanamori S,Sugiyama S,Goto H,Hayakawa T,Shimomura Y,Ozawa T

更新日期：1995-10-01 00:00:00

abstract：:1. Mechanisms involved in the plasma extravasation observed following thermal injury of rat dorsal skin were investigated. 2. Heat applied to the dorsal skin of anaesthetized rats by a temperature-controlled skin heater (1 cm diameter) for 5 min induced temperature-dependent plasma protein extravasation at 48-48.5 deg...

journal_title：Clinical and experimental pharmacology & physiology

authors： Waller J,Siney L,Hoult JR,Brain SD

更新日期：1997-11-01 00:00:00

abstract：:1. The effect of pretreatment with nifedipine on naloxone-stimulated corticotrophin-releasing hormone (CRH)-induced adrenocorticotrophin (ACTH) release in humans was investigated. The mean peak plasma ACTH and cortisol levels and the mean peak change in cortisol levels from basal were significantly lower in the nifedi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hockings GI,Grice JE,Walters MM,Jackson RV

更新日期：1991-05-01 00:00:00

abstract：:1. For the past decade, using radioligand binding, contractility and immunohistochemical techniques, we have been characterizing vascular smooth muscle (VSM) adrenoceptors in four functionally different canine blood vessels, namely the dog aorta (DAO), dog mesenteric artery (DMA), dog mesenteric vein (DMV) and dog sap...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kwan DC

更新日期：1999-10-01 00:00:00

abstract：:1. This study was undertaken to evaluate the preventive effects of locally administered argatroban, a competitive inhibitor of thrombin-induced platelet activation, on restenosis after balloon angioplasty. 2. A hydrogel-coated balloon catheter was immersed three times in argatroban/saline solution (1 mg/mL) for 60 s, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Imanishi T,Arita M,Tomobuchi Y,Hamada M,Hano T,Nishio I

更新日期：1997-11-01 00:00:00

abstract：:1. Effects of FR139317, an endothelin ETA receptor antagonist, on renal haemodynamic and excretory responses to acute nitric oxide (NO) blockade were examined using anaesthetized rats. 2. Intrarenal arterial infusion of NG-nitro-L-arginine (NOARG), the NO synthase inhibitor, at a rate of 40 micrograms/kg per min, prod...

journal_title：Clinical and experimental pharmacology & physiology

authors： Matsumura Y,Kuro T,Hashimoto N,Taira S

更新日期：1998-06-01 00:00:00

abstract：:MicroRNA plays an integral role in the development of atherosclerosis. Our study aimed to investigate the roles of miR-599 in lipopolysaccharide (LPS)-induced endothelial damage in human umbilical vein endothelial cells (HUVECs). HUVECs were transfected with a miR-599 mimic and negative control, and then exposed to LP...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang J,Du A,Wang H,Li Y

更新日期：2020-08-01 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is an endogenously produced nitric oxide synthase (NOS) inhibitor. L-Arginine can be metabolised by NOS and arginase, and arginase is the first step in polyamine production necessary for cellular proliferation. We tested the hypothesis that ADMA would inhibit NOS but not arginase act...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen B,Strauch K,Jin Y,Cui H,Nelin LD,Chicoine LG

更新日期：2014-07-01 00:00:00

abstract：:1. It is a central thesis of this review that in clinical and experimental pharmacology and physiology the goal of statistical analysis should be to minimize the risk of making any false-positive inferences from the results of an experiment (experimentwise Type I error). 2. It is common in clinical and experimental ph...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J

更新日期：1991-06-01 00:00:00

abstract：:1. A comparison has been made of the effects of three acetylcholine antagonists--hexamethonium, tubocurarine and pancuronium--on maximal tetani of limb muscles of cats under chloralose anaesthesia. In most experiments, the indirectly stimulated soleus muscle was studied, but observations were also made on the tibialis...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bowman WC,Webb SN

更新日期：1976-11-01 00:00:00

abstract：:1. We tested the hypothesis that increasing myocardial cyclic GMP levels would reduce myocardial O2 consumption and areas of low O2 supply/consumption balance, using zaprinast, a selective cyclic GMP-phosphodiesterase inhibitor. 2. The study was conducted in three groups (vehicle, 10(-3) and 3 x 10(-3) mol/L zaprinast...

journal_title：Clinical and experimental pharmacology & physiology

authors： Weiss HR,Rodriguez E,Tse J,Scholz PM

更新日期：1994-08-01 00:00:00

abstract：:1. Pericytes are cells of microvessels (arterioles, capillaries and venules) that wrap around endothelial cells. They are most abundant on venules and are common on capillaries. 2. The pericyte population is highly variable between different tissues and organs, probably in a manner reflecting postarteriolar hydrostati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sims DE

更新日期：2000-10-01 00:00:00