In vitro effects of gliotoxin, a natural proteasome inhibitor, on the infectivity and proteolytic activity of Toxoplasma gondii.

Abstract:

:We examined the in vitro effect of increasing gliotoxin concentrations on the infectivity of Toxoplasma gondii for NIH-3T3 murine fibroblasts and on Toxoplasma chymotrypsin-like activity, which is specific to the proteasome. Parasite penetration of host cells was not modified by a high gliotoxin concentration (1 microM), but replication was markedly decreased (approximately 50% inhibition by 0.5 microM gliotoxin). Gliotoxin reduced the chymotrypsin-like activity of the Toxoplasma proteasome, but five times less potently than in HeLa cells.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Paugam A,Creuzet C,Dupouy-Camet J,Roisin P

doi

10.1007/s00436-002-0644-1

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

785-7

issue

8

eissn

0932-0113

issn

1432-1955

journal_volume

88

pub_type

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