Abstract:
:The receptors for the complement anaphylatoxins C3a and C5a are expressed by glial cells and neurons in normal and inflamed brain. Previous studies demonstrated modest elevations in mRNA expression of these receptors in a model of focal cerebral ischemia. Using a similar model system for both mice and rats, we report markedly different patterns of anaphylatoxin receptor mRNA expression in cerebral ischemia. C5a receptor expression was dramatically elevated within 3 h after middle cerebral artery occlusion, while C3aR expression was reduced to 25% of control animals. By 24 h post-occlusion, expression of both receptors was higher than at any other time point examined. This increased expression at late time points after occlusion is most likely the result of massive infiltration of leukocytes expressing the receptors. We also observed increased receptor mRNA expression in sham-operated animals, indicating that the procedures used for arterial occlusion affects mechanisms regulating receptor expression. This latter result highlights the importance of including this important control group in ischemic model systems for proper interpretation of changes in gene expression.
journal_name
Gliajournal_title
Gliaauthors
Barnum SR,Ames RS,Maycox PR,Hadingham SJ,Meakin J,Harrison D,Parsons AAdoi
10.1002/glia.10069subject
Has Abstractpub_date
2002-04-15 00:00:00pages
169-73issue
2eissn
0894-1491issn
1098-1136pii
10.1002/glia.10069journal_volume
38pub_type
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