E587 antigen is upregulated by goldfish oligodendrocytes after optic nerve lesion and supports retinal axon regeneration.

abstract：:Astrocytes can experience large intracellular Na+ changes following the activation of the Na+-coupled glutamate transport. The present study investigated whether cytosolic Na+ changes are transmitted to mitochondria, which could therefore influence their function and contribute to the overall intracellular Na+ regulat...

journal_title：Glia

authors： Bernardinelli Y,Azarias G,Chatton JY

更新日期：2006-10-01 00:00:00

abstract：:In multiple sclerosis (MS), one strategy to reduce disability is enhancement of endogenous repair by remyelinating oligodendrocytes derived from oligodendrocyte progenitor cells (OP). An important prerequisite is determining the abundance of OP relative to oligodendrocytes in normal human central nervous system (CNS),...

journal_title：Glia

authors： Jennings A,Carroll W

更新日期：2010-09-01 00:00:00

abstract：:Reorganization of the adult dentate gyrus following unilateral entorhinal cortex lesion (ECL) is a well-established model for studying mechanisms of trauma-induced neuronal plasticity. The lesion induces deafferentiation of the outer molecular layer, which is accompanied by a strong astroglial reaction. This glial res...

journal_title：Glia

authors： Schröder W,Hager G,Kouprijanova E,Weber M,Schmitt AB,Seifert G,Steinhäuser C

更新日期：1999-11-01 00:00:00

abstract：:We evaluated the intracellular and extracellular biological role of S100B protein with respect to microglia. S100B, which belongs to the multigenic family of Ca2+-binding proteins, is abundant in astrocytes where it is found diffusely in the cytoplasm and is associated with membranes and cytoskeleton constituents. S10...

journal_title：Glia

authors： Adami C,Sorci G,Blasi E,Agneletti AL,Bistoni F,Donato R

更新日期：2001-02-01 00:00:00

abstract：:Neurons in organotypic hippocampal slice cultures (OHSCs) are known to preserve morphological and physiological features of the in vivo situation; however, little is known about the properties of microglial cells under these in vitro conditions. In this study, we addressed the question whether microglial cells in OHSC...

journal_title：Glia

authors： Hailer NP,Jarhult JD,Nitsch R

更新日期：1996-12-01 00:00:00

abstract：:Microglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic "modal shifts", purinergic receptors have central roles. When microglia sense ATP/ADP leaked from injured cells by P2Y(12) receptors, they are transformed into a moving phenotype, showing process ...

journal_title：Glia

authors： Koizumi S,Ohsawa K,Inoue K,Kohsaka S

更新日期：2013-01-01 00:00:00

abstract：:Injury to the adult brain results in the formation of a glial scar that involves both activated astroglia and microglia/macrophages. Although reactive gliosis has been linked to failure of axonal regeneration in the adult mammalian CNS, the spatio-temporal pattern of the postlesion responses in morphology and distribu...

journal_title：Glia

authors： Stichel CC,Müller HW

更新日期：1994-02-01 00:00:00

abstract：:The mechanisms involved in oligodendroglial cell death in human demyelinating diseases are only partly understood. Here, we demonstrate that the BH3 only protein Puma, but not Noxa, is essential for oligodendroglial cell death in toxic demyelination induced by the copper chelator cuprizone. Primary oligodendrocytes de...

journal_title：Glia

authors： Hagemeier K,Lürbke A,Hucke S,Albrecht S,Preisner A,Klassen E,Hoffmann E,Cui QL,Antel J J,Brück W,Klotz L,Kuhlmann T

更新日期：2013-10-01 00:00:00

abstract：:Recent evidence suggested that ATP acting via ionotropic (P2X) and metabotropic (P2Y) purinergic receptors might be involved in signaling between glial cells and within glial-neuronal networks. In contrast to their neuronal counterpart, the identity of P2X receptors in CNS glial cells is largely unknown. In the presen...

journal_title：Glia

authors： Kukley M,Barden JA,Steinhäuser C,Jabs R

更新日期：2001-10-01 00:00:00

abstract：:Axonal signals activate myelinogenesis via regulation of the extent to which oligodendrocyte (OLG) processes wrap around the axon. The cytoskeleton in OLG processes is actively involved in myelination and is a putative target for axonal regulation of myelination. The axon-associated neuregulins may regulate the cytosk...

journal_title：Glia

authors： LoPresti P,Muma NA,De Vries GH

更新日期：2001-08-01 00:00:00

abstract：:The effects of microglia-conditioned medium (MCM) on the inducible Nrf2 system in astrocyte-rich cultures were investigated by determination of glutathione (GSH) levels, γglutamylcysteine ligase (γGCL) activity, the protein levels of Nrf2, Keap1, the modulatory subunit of γGCL (γGCL-M) and activated MAP kinases (ERK1/...

journal_title：Glia

authors： Correa F,Ljunggren E,Mallard C,Nilsson M,Weber SG,Sandberg M

更新日期：2011-05-01 00:00:00

abstract：:We have examined the migratory capacity of Schwann cells from the distal stump of a 1-week transected sciatic nerve of adult rat for a distance of 10 mm. The distal stump was introduced into the open end of a silicone chamber packed with artificial fibrin sponge (Gelaspon) soaked in phosphate-buffered saline (control ...

journal_title：Glia

authors： Dubový P,Svízenská I

更新日期：1992-01-01 00:00:00

abstract：:We recently showed that trisialoganglioside (GT1b) induces cell death of dopaminergic neurons in rat mesencephalic cultures (Chung et al., Neuroreport 12:611-614, 2001). The present study examines the in vivo neurotoxic effects of GT1b on dopaminergic neurons in the substantia nigra (SN) of Sprague-Dawley rats. Seven ...

journal_title：Glia

authors： Ryu JK,Shin WH,Kim J,Joe EH,Lee YB,Cho KG,Oh YJ,Kim SU,Jin BK

更新日期：2002-04-01 00:00:00

abstract：:Gamma-secretase is an aspartyl protease composed of four proteins: presenilin (PS), nicastrin (Nct), APH1, and PEN2. These proteins assemble into a membrane complex that cleaves a variety of substrates within the transmembrane domain. The gamma-secretase cleavage products play an important role in various biological p...

journal_title：Glia

authors： Nadler Y,Alexandrovich A,Grigoriadis N,Hartmann T,Rao KS,Shohami E,Stein R

更新日期：2008-04-01 00:00:00

abstract：:Isolated acellular nerve segments protected from migration of Schwann cells and the acellular nerve segments joined with the distal nerve stumps were prepared by a repeated freeze-thaw procedure in the rat sciatic nerves. The presence of laminin-1 and -2, as well as alpha6 and beta1 integrin chains, was detected by in...

journal_title：Glia

authors： Dubový P,Svízenská I,Klusáková I,Zítková A,Houst'Ava L,Haninec P

更新日期：2001-01-01 00:00:00

abstract：:Williams-Beuren syndrome (WBS) is a microdeletion disorder with cognitive phenotype. NSUN5 gene, which encodes a cytosine-5 RNA methyltransferase, is located in WBS deletion locus. To investigate the influence of NSUN5 deletion on cognitive behaviors, we produced single-gene Nsun5 knockout (Nsun5-KO) mice. Here, we re...

journal_title：Glia

authors： Zhang T,Chen P,Li W,Sha S,Wang Y,Yuan Z,Shen B,Chen L

更新日期：2019-04-01 00:00:00

abstract：:The myelin basic protein gene (Mbp) encodes for the major myelin structural proteins and it is included in the Golli-Mbp gene complex. Previously, we observed MBP-like proteins in the human central nervous system (CNS) at developmental stages preceding myelination. In an effort to distinguish between Golli (HOG5 and H...

journal_title：Glia

authors： Tosic M,Rakic S,Matthieu J-,Zecevic N

更新日期：2002-03-01 00:00:00

abstract：:The neuronal doctrine, developed a century ago regards neuronal networks as the sole substrate of higher brain function. Recent advances in glial physiology have promoted an alternative hypothesis, which places information processing in the brain into integrated neuronal-glial networks utilizing both binary (neuronal ...

journal_title：Glia

authors： Nedergaard M,Verkhratsky A

更新日期：2012-07-01 00:00:00

abstract：:The consequences of sublytic terminal complement complex (TCC) assembly on Schwann cell proliferation and apoptosis were examined by using purified complement proteins (C5*-9) or antibody-sensitized Schwann cells in the presence of a serum that was depleted of the seventh component of complement (C7dHS) and reconstitu...

journal_title：Glia

authors： Dashiell SM,Rus H,Koski CL

更新日期：2000-04-01 00:00:00

abstract：:Radial glial cells play an essential role through their function as guides for neuronal migration during development. Disruption of metabotropic glutamate receptor 5 (mGluR5) function retards the growth of radial glial processes in vitro. Neuregulins (NRG) are activated by proteolytic cleavage and regulate (radial) gl...

journal_title：Glia

authors： Louhivuori LM,Turunen PM,Louhivuori V,Yellapragada V,Nordström T,Uhlén P,Åkerman KE

更新日期：2018-01-01 00:00:00

abstract：:Painful neuropathy is one of the most common complications of diabetes, one hallmark of which is tactile allodynia (pain hypersensitivity to innocuous stimulation). The underlying mechanisms of tactile allodynia are, however, poorly understood. Emerging evidence indicates that, following nerve injury, activated microg...

journal_title：Glia

authors： Tsuda M,Ueno H,Kataoka A,Tozaki-Saitoh H,Inoue K

更新日期：2008-03-01 00:00:00

abstract：:We have used C6 glial cells (2B clone), early and late passage, as well as advanced passages (8-17) of glial cells derived from aged (18-month-old) mouse cerebral hemispheres (MACH), as model systems for studying glial properties. In this study passages 20-24 were considered "early" and passages 73-90 were considered ...

journal_title：Glia

authors： Lee K,Kentroti S,Billie H,Bruce C,Vernadakis A

更新日期：1992-01-01 00:00:00

abstract：:Type I interferons (IFNs), IFN-α and IFN-β, represent the major effector cytokines of the host immune response against viruses and other intracellular pathogens. These cytokines are produced via activation of numerous pattern recognition receptors, including the Toll-like receptor signaling network, retinoic acid-indu...

journal_title：Glia

authors： Blank T,Prinz M

更新日期：2017-09-01 00:00:00

abstract：:When the brain is damaged, astrocytes often cause hyperplasia resulting in glial scar formation at the injured sites. Endothelins (ETs) have been shown to be involved in the pathophysiologic responses of astrocytes, including proliferation. In this study, we examined the mechanisms underlying the ET-induced astrocytic...

journal_title：Glia

authors： Koyama Y,Yoshioka Y,Matsuda T,Baba A

更新日期：2003-08-01 00:00:00

abstract：:Complement has been implicated as a potential effector mechanism in neurodegeneration; yet the precise role of complement in this process remains elusive. In this report, we have utilized the cuprizone model of demyelination-remyelination to examine the contribution of complement to disease. C1q deposition was observe...

journal_title：Glia

authors： Briggs DT,Martin CB,Ingersoll SA,Barnum SR,Martin BK

更新日期：2007-11-01 00:00:00

abstract：:The possible consequences of activating bradykinin (Bk) receptors on identified astrocyte subtypes derived from rat cortex have been investigated in terms of: 1) mobilization of intracellular Ca2+; and 2) electrophysiological response. Bk induced a rapid, transient rise in intracellular Ca2+ in 63% of cortical type-1-...

journal_title：Glia

authors： Stephens GJ,Cholewinski AJ,Wilkin GP,Djamgoz MB

更新日期：1993-12-01 00:00:00

abstract：:This article reviews how the uptake of neurotransmitter by glial amino acid transporters limits the spatial spread of transmitter to preserve the independent operation of nearby synapses, temporally shapes postsynaptic currents, and regulates the effects of tonic transmitter release. We demonstrate the importance of a...

journal_title：Glia

authors： Marcaggi P,Attwell D

更新日期：2004-08-15 00:00:00

abstract：:Water balance between cells and extracellular compartments is essential for proper functioning of the central nervous system, as demonstrated by its perturbations in pathological conditions. Aquaporin 4 (AQP4) is the predominant water channel in brain and spinal cord, where it is present mainly on astrocytic endfeet c...

journal_title：Glia

authors： Vitellaro-Zuccarello L,Mazzetti S,Bosisio P,Monti C,De Biasi S

更新日期：2005-08-01 00:00:00

abstract：:Recent studies have suggested that Nkx6.2/Gtx and Nkx2.2 homeodomain transcription factors are involved in the regulation of oligodendrocyte maturation and/or myelination which occur predominantly in postnatal stages. However, their cellular specificity in postnatal central nervous system has not been characterized an...

journal_title：Glia

authors： Cai J,Zhu Q,Zheng K,Li H,Qi Y,Cao Q,Qiu M

更新日期：2010-03-01 00:00:00

abstract：:The poor regenerative ability of neurons of the central nervous system in mammals, as compared with their counterpart in fish or amphibians, is thought to stem from differences in their immediate nonneuronal environment and its response to axonal injury. We describe one aspect of the environmental response to axonal i...

journal_title：Glia

authors： Cohen I,Sivron T,Lavie V,Blaugrund E,Schwartz M

更新日期：1994-01-01 00:00:00