Abstract:
:We treated 5 patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and multifocal bone lesions or diffuse bone marrow plasmacytic infiltration with high-dose therapy (HDT) and autologous blood stem cell transplantation. In all cases, the treatment produced remission of plasma cell proliferation associated with marked improvement in the patients' performance status, neurologic symptoms, and other manifestations of the syndrome. HDT with stem cell support should be investigated further as a therapeutic option in patients with POEMS syndrome and disseminated plasma cell dyscrasia.
journal_name
Bloodjournal_title
Bloodauthors
Jaccard A,Royer B,Bordessoule D,Brouet JC,Fermand JPdoi
10.1182/blood.v99.8.3057subject
Has Abstractpub_date
2002-04-15 00:00:00pages
3057-9issue
8eissn
0006-4971issn
1528-0020journal_volume
99pub_type
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