Rhabdomyolysis: a review.

Abstract:

:Rhabdomyolysis, a syndrome of skeletal muscle breakdown with leakage of muscle contents, is frequently accompanied by myoglobinuria, and if sufficiently severe, acute renal failure with potentially life-threatening metabolic derangements may ensue. A diverse spectrum of inherited and acquired disorders affecting muscle membranes, membrane ion channels, and muscle energy supply causes rhabdomyolysis. Common final pathophysiological mechanisms among these causes of rhabdomyolysis include an uncontrolled rise in free intracellular calcium and activation of calcium-dependent proteases, which lead to destruction of myofibrils and lysosomal digestion of muscle fiber contents. Recent advances in molecular genetics and muscle enzyme histochemistry may enable a specific metabolic diagnosis in many patients with idiopathic recurrent rhabdomyolysis.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Warren JD,Blumbergs PC,Thompson PD

doi

10.1002/mus.10053

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

332-47

issue

3

eissn

0148-639X

issn

1097-4598

pii

10.1002/mus.10053

journal_volume

25

pub_type

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