Abstract:
:Rhabdomyolysis, a syndrome of skeletal muscle breakdown with leakage of muscle contents, is frequently accompanied by myoglobinuria, and if sufficiently severe, acute renal failure with potentially life-threatening metabolic derangements may ensue. A diverse spectrum of inherited and acquired disorders affecting muscle membranes, membrane ion channels, and muscle energy supply causes rhabdomyolysis. Common final pathophysiological mechanisms among these causes of rhabdomyolysis include an uncontrolled rise in free intracellular calcium and activation of calcium-dependent proteases, which lead to destruction of myofibrils and lysosomal digestion of muscle fiber contents. Recent advances in molecular genetics and muscle enzyme histochemistry may enable a specific metabolic diagnosis in many patients with idiopathic recurrent rhabdomyolysis.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Warren JD,Blumbergs PC,Thompson PDdoi
10.1002/mus.10053subject
Has Abstractpub_date
2002-03-01 00:00:00pages
332-47issue
3eissn
0148-639Xissn
1097-4598pii
10.1002/mus.10053journal_volume
25pub_type
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