Abstract:
INTRODUCTION:Breast cancer is exceptionally associated with anti-collapsin response mediator protein 5 (anti-CRMP5) antibody or demyelinating neuropathy. This paraneoplastic antibody is itself not associated with demyelinating neuropathy. METHODS:Herein we describe a patient with a predominantly sensory ataxic demyelinating neuropathy associated with an IgG-kappa monoclonal gammopathy of uncertain significance (MGUS). Further investigations led to identification of anti-CRMP5 antibodies. An initial search for a malignancy proved negative. No immunomodulatory therapy was administered. RESULTS:The patient developed breast carcinoma 2 years after the initial neurological symptoms, which was effectively treated by surgery, chemotherapy, hormone therapy, and radiotherapy. At neurological follow-up, 16 months after cancer treatment, she remained in remission and had made substantial neurological recovery. Electrophysiology showed significant amelioration, and serum anti-CRMP5 antibodies were undetectable. MGUS paraprotein level was unchanged. CONCLUSION:This case widens the range of paraneoplastic manifestations of breast carcinoma to include anti-CRMP5 antibody-positive sensory ataxic demyelinating neuropathy, which, in this patient, improved after cancer treatment.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Samarasekera S,Rajabally YAdoi
10.1002/mus.22036subject
Has Abstractpub_date
2011-05-01 00:00:00pages
764-6issue
5eissn
0148-639Xissn
1097-4598journal_volume
43pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract:INTRODUCTION:The aim of this work was to determine the effect of chronic alcohol exposure on peripheral nerves in a nutritionally balanced rat model of alcoholism. METHODS:Three different strains of adult male rats were pair-fed for 8 weeks with isocaloric liquid diets containing 0% or 37% ethanol. Nerve conduction st...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23744
更新日期:2013-08-01 00:00:00
abstract::The physiological and phenotypic properties of motor units in the cat soleus muscle were studied after 4 months of inactivity induced by spinal cord isolation (SI). The soleus of some SI cats were stimulated for 30 min/day during an isometric (SI-I), shortening (SI-S), or lengthening (SI-L) phase of a simulated step c...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10190
更新日期:2002-08-01 00:00:00
abstract:INTRODUCTION:Pneumothorax is a potentially serious complication of electromyography (EMG). Data on the frequency of pneumothorax after EMG are lacking. The purpose of this study was to determine the frequency, timing, and risk factors for iatrogenic pneumothorax after EMG. METHODS:Cases of pneumothorax after EMG were ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24883
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:The risk of cancer in patients diagnosed with myotonic dystrophy (DM) is reported for the homogeneous Utah population. METHODS:Clinical data accessed from the largest Utah healthcare providers have been record-linked to the Utah Population Database, a population-based resource also linked to the Utah Canc...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25145
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:Stretch injuries in peripheral nerves can cause pain, paralysis, and loss of sensation. Although optimal treatment depends on the degree of injury, it is difficult to determine the severity of induced nerve damage. METHODS:The load-deformation curves of rat median nerves were generated from monotonic load...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23443
更新日期:2012-12-01 00:00:00
abstract:INTRODUCTION:There have been few reports on subtypes of Guillain-Barré syndrome (GBS) in children. We compared clinical and laboratory findings of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). METHODS:One hundred forty children with GBS were included. Based on...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25992
更新日期:2018-05-01 00:00:00
abstract::Immunocytochemical analysis of muscle specimens from 5 patients with acute quadriplegic myopathy indictes that depletion of either fast or slow myosin occurs in this disorder. The initial lesion consists of focal myosin loss in nonatrophic fibers. Other structural proteins (actin, titin, nebulin) are spared or affecte...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199703)20:3<316::AID-MUS8>
更新日期:1997-03-01 00:00:00
abstract::Cardiotrophin-1 (CT-1) has potent survival-promoting effects on motor neurons in vitro and in vivo and may be effective in treating motor neuron diseases (MND). We investigated the effects of CT-1 treatment in wobbler mouse MND. Wobbler mice were randomly assigned to receive subcutaneously injected CT-1 (1 mg/kg, n = ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.1068
更新日期:2001-06-01 00:00:00
abstract::Ion channels are complex proteins that span the lipid bilayer of the cell membrane, where they orchestrate the electrical signals necessary for normal function of the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. The role of ion channel defects in the pathogenesis of numerous disorder...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.10164
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:We aimed at evaluating the differential involvement of large myelinated Aβ-, small myelinated Aδ-, and unmyelinated C-fibers in patients with diabetic polyneuropathy and how they contribute to neuropathic pain. METHODS:We collected clinical and diagnostic test variables in 133 consecutive patients with diab...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.27080
更新日期:2021-01-01 00:00:00
abstract::To determine the contributions of neural and mechanical mechanisms to the limits in the range of motion (ROM) about a joint, we studied the effects of 30 sessions of static stretch training on the characteristics of the plantar-flexor muscles in 12 subjects. Changes in the maximal ankle dorsiflexion and the torque pro...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10549
更新日期:2004-02-01 00:00:00
abstract::We prospectively evaluated thalidomide-induced neuropathy using electrodiagnostic studies. Sixty-seven men with metastatic androgen-independent prostate cancer in an open-label trial of oral thalidomide underwent neurologic examinations and nerve conduction studies (NCS) prior to and at 3-month intervals during treatm...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/mus.1109
更新日期:2001-08-01 00:00:00
abstract::Diagnosis of multifocal motor neuropathy (MMN), a syndrome characterized by progressive asymmetric weakness with intact sensation, is important because the disorder often responds to treatment. Multifocal partial motor conduction block (PMCB) has been emphasized as a cardinal feature in the diagnosis of this syndrome,...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880170211
更新日期:1994-02-01 00:00:00
abstract::Single muscle fibers were prepared from biopsy specimens of Duchenne muscular dystrophy (DMD), normal, and neuromuscular disease controls. Single muscle cells were classified as type 1, type 2, or intermediate by the skinned fiber method. The intermediate fiber was most abundant in DMD, comprising 29% of fibers examin...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880050511
更新日期:1982-05-01 00:00:00
abstract::The frequency of muscle involvement in TSP/HAM is not known, nor is the precise role that HTLV-1 and the diverse cytokines play in the genesis of HTLV-1-associated diseases. In order to better define the frequency and characteristics of the skeletal muscle involvement in TSP/HAM, we studied 11 affected patients. EMG w...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880170812
更新日期:1994-08-01 00:00:00
abstract::The presence of differences in motor unit activity across contraction types and between hands suggests that the magnitude of fluctuations in motor output is only weakly related when these conditions are compared. Twenty right-handed young (24.1 +/- 5.3 years) and old (72.5 +/- 4.9 years) adults performed three levels ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20326
更新日期:2005-06-01 00:00:00
abstract::We compared the diaphragmatic electromyographic (EMG) recordings from 32 patients with known neuromuscular disease and respiratory symptoms (23 neuropathies, 9 myopathies) to recordings from 23 normal subjects. Turns analysis of 219-ms sections, or epochs, of the EMG demonstrated a significant overlap between diagnost...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199807)21:7<954::aid-mus18
更新日期:1998-07-01 00:00:00
abstract::We report a patient with clinical vermiform motor activity, muscle cramps, delayed relaxation of grip, and continuous motor unit discharges who developed mild symmetric symptoms in the upper extremities following a viral infection. Treatment with carbamazepine produced considerable symptomatic improvement. Needle elec...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110310
更新日期:1988-03-01 00:00:00
abstract::Normative values of muscle fiber conduction velocity depend on the conditions in which conduction velocity is measured due to the velocity recovery function (VRF) of muscle fibers. In this study the VRF of the compound muscle action potential (CMAP) was assessed following doublet and triplet stimulation in order to in...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20801
更新日期:2007-08-01 00:00:00
abstract::Central fatigue is a subjective phenomenon which can be examined using transcranial magnetic stimulation (TMS). To assess central fatigue, we compared TMS and peripheral electrical stimulations in patients with central nervous system (CNS) lesions and controls before and after an exhaustive task. The recovery times of...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199611)19:11<1429::AID-MUS
更新日期:1996-11-01 00:00:00
abstract:INTRODUCTION:Far-field potentials (FFPs) from muscles other than the abductor digiti minimi (ADM) may interfere with motor unit number estimation (MUNE) from that muscle. METHODS:We identified the origin of each surface motor unit potential (SMUP) during hypothenar MUNE using the multiple point stimulation method in 2...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23746
更新日期:2013-08-01 00:00:00
abstract::Genetic testing is rapidly becoming an increasingly significant part of the diagnostic armamentarium of neuromuscular clinicians. Although technically easy to order, the results of such testing, whether positive or negative, have potentially enormous consequences for the individual tested and for family members. As a ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.25400
更新日期:2016-12-01 00:00:00
abstract::Masseter (MR) and blink reflexes (BL) were investigated in 51 patients with internuclear ophthalmoplegia (INO) due to multiple sclerosis (28) and lacunar infarction (23). The MR was abnormal in 20 of 23 cases with bilateral INO and in 21 of 28 with unilateral INO. The R1 component of the BL (BL-R1) was abnormal in 7 o...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880140406
更新日期:1991-04-01 00:00:00
abstract:INTRODUCTION:Neuralgic amyotrophy (NA) often imposes diagnostic problems. Recently, MRI and high-resolution ultrasound (HRUS) have proven useful in diagnosing peripheral nerve disorders. METHODS:We performed a chart and imaging review of patients who were examined using neuroimaging and who were referred because of cl...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25147
更新日期:2016-12-01 00:00:00
abstract::In an attempt to determine the relative importance of the nerve cell body and of the axon in initiating and controlling axonal regeneration, nerve cell bodies were irradiated and the ability of the distal axon to sprout was examined. Mice were subjected to either 25 or 50 Gray (Gy) of x-irradiation localized to the lu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110513
更新日期:1988-05-01 00:00:00
abstract::Macroelectromyography is used to study the electrical activity of the entire motor unit. The amplitude of the motor unit action potential (MUP), recorded from a bared cannula, is dependent on the number and size of muscle fibers in the motor unit. In most situations of reinnervation the local fiber density (FD) as rec...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Protein synthesis in soleus and extensor digitorum longus (EDL) muscles was measured in vitro to test the hypothesis that the lack of muscle protein accumulation in dystrophic conditions could be caused by a reduced sensitivity to insulin. We demonstrate that physiological insulin concentrations stimulate protein synt...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880060709
更新日期:1983-09-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal disease with limited treatment options. Controlled studies are a necessary part of Phase II and Phase III assessments of proposed therapies. Due to the relatively small number of patients with ALS, several study designs have been proposed to improve the efficiency of Phas...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21358
更新日期:2009-06-01 00:00:00
abstract:INTRODUCTION:Are there electrophysiological findings that predict response to intravenous immunoglobulin (IVIg) in patients with lower motor neuron (LMN) syndromes without multifocal conduction block (MCB)? METHODS:We enrolled 9 patients with LMN syndromes without MCB to receive 18 weeks of IVIg therapy. Response was ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21914
更新日期:2011-04-01 00:00:00
abstract:UNLABELLED:Contemporary natural history data in Duchenne muscular dystrophy (DMD) is needed to assess care recommendations and aid in planning future trials. METHODS:The Cooperative International Neuromuscular Research Group (CINRG) DMD Natural History Study (DMD-NHS) enrolled 340 individuals, aged 2-28 years, with DM...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究
doi:10.1002/mus.23807
更新日期:2013-07-01 00:00:00