Keloidal scars: a review with a critical look at therapeutic options.

abstract：:Since first reported in 1982, published anecdotal reports have appeared with increasing frequency of patients in whom autoimmune connective tissue diseases developed after mammary augmentation with silicone gel-filled elastomer envelope-type prostheses. Although scleroderma has been reported most often, other diagnose...

journal_title：Journal of the American Academy of Dermatology

authors： Houpt KR,Sontheimer RD

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:The plasma concentration of bleomycin after injection of bleomycin into warts is unknown, as is the long-term stability of bleomycin solution. OBJECTIVE:Our purpose was to measure plasma bleomycin concentration after injection of bleomycin into warts, to relate histologic and immunocytochemical changes in w...

journal_title：Journal of the American Academy of Dermatology

authors： James MP,Collier PM,Aherne W,Hardcastle A,Lovegrove S

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Often after biopsy a skin cancer appears to resolve clinically and a repeat biopsy may be done on the area in question before proceeding with further treatment. OBJECTIVE:Our purpose was to assess the value of a subsequent biopsy in the treatment of skin cancers previously diagnosed by biopsy results. METH...

journal_title：Journal of the American Academy of Dermatology

authors： Torres A,Seeburger J,Robison D,Glogau R

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The use of cutaneous resurfacing lasers to treat rhytides is widely accepted. Several carbon dioxide lasers, many using fundamentally different technologies, are available. OBJECTIVE:The purpose of this study was to compare the results obtained and side effects after treating rhytides with 3 different carbo...

journal_title：Journal of the American Academy of Dermatology

authors： Gross EA,Rogers GS

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Onychomycosis is a common nail infection, often resulting in nail plate damage and deformity. Topical lacquer treatments have negligible efficacy. Oral treatments, although more efficacious, are limited by drug interactions and potential hepatotoxicity. OBJECTIVE:We investigated the safety and efficacy of e...

journal_title：Journal of the American Academy of Dermatology

authors： Elewski BE,Rich P,Pollak R,Pariser DM,Watanabe S,Senda H,Ieda C,Smith K,Pillai R,Ramakrishna T,Olin JT

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Patients with cutaneous lupus erythematosus (LE) and a history of disease- related photoaggravation, confirmed by phototesting, may not respond to photoprotection and/or medical intervention. Ultraviolet B-hardening therapy may improve tolerance for environmental ultraviolet radiation (UVR) in photosensitive...

journal_title：Journal of the American Academy of Dermatology

authors： Sanders CJ,Lam HY,Bruijnzeel-Koomen CA,Sigurdsson V,van Weelden H

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Butenafine hydrochloride, a benzylamine derivative with potent antifungal activity, has been used in Japan to treat superficial fungal diseases. OBJECTIVE:We evaluated the safety and efficacy of twice-daily butenafine versus its vehicle in the treatment of interdigital tinea pedis in a multicenter, randomiz...

journal_title：Journal of the American Academy of Dermatology

authors： Savin R,De Villez RL,Elewski B,Hong S,Jones T,Lowe N,Lucky A,Reyes B,Stewart D,Willis I

更新日期：1997-02-01 00:00:00

abstract：:A 40-year-old man with severe psoriasis developed painless muscle stiffness coinciding with four successive courses of etretinate therapy. Peripheral nerve block extinguished the increased muscle tone. Our patient's symptoms resembled those of the stiff-man syndrome. Increased muscle tone is a potential side effect of...

journal_title：Journal of the American Academy of Dermatology

authors： Ellis CN,Gilbert M,Cohen KA,Albers JW,Ball RD,Albin RL,Silverman A,Voorhees JJ

更新日期：1986-05-01 00:00:00

abstract：:The great diversity of wounds and the broad range of available dressings complicate the selection of proper chronic wound treatment. Choosing the right treatment is the essential step in the healing process. In this review, we focus on chronic nonhealing ulcers, which are a critical problem in clinical practice, and c...

journal_title：Journal of the American Academy of Dermatology

authors： Skórkowska-Telichowska K,Czemplik M,Kulma A,Szopa J

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Dermatomyositis is associated with significant morbidity and occasional mortality. Currently there is no consensus on treatment for patients with dermatomyositis. OBJECTIVE:Our purpose was to review the clinical features and response to therapy of patients with dermatomyositis and compare these data with pr...

journal_title：Journal of the American Academy of Dermatology

authors： Dawkins MA,Jorizzo JL,Walker FO,Albertson D,Sinal SH,Hinds A

更新日期：1998-03-01 00:00:00

abstract：:Clinical trials are critical for the development of new therapies in dermatology, and their results help determine US Food and Drug Administration (FDA) approval and guide care. Of special relevance is the clinical trial efficacy end point, the metric from which statistically significant outcome is derived. Clinicians...

journal_title：Journal of the American Academy of Dermatology

authors： Wei EX,Kirsner RS,Eaglstein WH

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Women with stage I malignant melanoma (MM) have a survival advantage over men as judged by univariate analysis. However, on multivariate analysis, gender was found to be an independent predictor of survival in only 8 of 14 published studies. OBJECTIVE:This study attempts to explain the disparate findings fo...

journal_title：Journal of the American Academy of Dermatology

authors： Vossaert KA,Silverman MK,Kopf AW,Bart RS,Rigel DS,Friedman RJ,Levenstein M

更新日期：1992-03-01 00:00:00

abstract：:The retinoids have been investigated extensively as chemopreventive and therapeutic agents in a variety of neoplasms. They have been shown to inhibit the proliferation of transformed cell lines in vitro and transplanted tumors in vivo. In cultured murine melanoma cells, retinoids inhibit proliferation and induce diffe...

journal_title：Journal of the American Academy of Dermatology

authors： Meyskens FL Jr,Edwards L,Levine NS

更新日期：1986-10-01 00:00:00

abstract：:Desmoplastic malignant melanoma is a rare neoplasm consisting primarily of spindle-shaped melanoma cells embedded in a fibrous stroma, with approximately 6% of cases occurring in the lip. A literature search revealed that most reported cases occur in sun-exposed areas in older men. Few cases of desmoplastic malignant ...

journal_title：Journal of the American Academy of Dermatology

authors： Hui JI,Linden KG,Barr RJ

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Conventional therapy of severe bullous pemphigoid (BP) relies on the use of high-dose systemic corticosteroids with or without adjuvants, notably immunosuppressive agents. This approach can result in debilitating and potentially fatal side effects, hence the need to explore alternative therapies. Intravenous...

journal_title：Journal of the American Academy of Dermatology

authors： Engineer L,Ahmed AR

更新日期：2001-01-01 00:00:00

abstract：:This is the second reported case of minocycline-induced Sweet's syndrome (and the first such case to appear in the American literature). The syndrome developed in a 32-year-old man 10 days after minocycline therapy for acne was begun and resolved rapidly after discontinuation of the medication and start of oral predni...

journal_title：Journal of the American Academy of Dermatology

authors： Thibault MJ,Billick RC,Srolovitz H

更新日期：1992-11-01 00:00:00

abstract：:Unlike other mammals that molt hair seasonally, human beings have scalp hair follicles that exhibit an asynchronized pattern of cycling, with the growth and subsequent shedding of each hair being independent of others around it. This mosaic cycling behavior is established early and continues throughout life. We descri...

journal_title：Journal of the American Academy of Dermatology

authors： Thai KE,Sinclair RD

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Effective medical treatment for patients with severe hidradenitis suppurativa (HS) is limited. OBJECTIVES:We sought to measure the impact of wide local excision on quality of life in HS Hurley grade III patients and to examine the rate of postoperative complications, disease recurrences, and satisfaction wi...

journal_title：Journal of the American Academy of Dermatology

authors： Posch C,Monshi B,Quint T,Vujic I,Lilgenau N,Rappersberger K

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Molluscum contagiosum (MC) is a common and at times severely disfiguring cutaneous viral infection in patients with human immunodeficiency virus (HIV) infection. OBJECTIVE:The purpose of this study was to describe the clinical course of MC in patients with HIV infection and to examine the relation between p...

journal_title：Journal of the American Academy of Dermatology

authors： Schwartz JJ,Myskowski PL

更新日期：1992-10-01 00:00:00

abstract：:The occurrence of Langerhans cell histiocytosis (LCH) and malignancy in the same patient is rare. When LCH occurs concomitantly with acute leukemia, distinct temporal patterns often exist; acute myelogenous leukemia (AML) typically succeeds LCH, whereas acute lymphocytic leukemia (ALL) usually precedes it. We report a...

journal_title：Journal of the American Academy of Dermatology

authors： Chiles LR,Christian MM,McCoy DK,Hawkins HK,Yen AH,Raimer SS

更新日期：2001-12-01 00:00:00

abstract：:Unilateral dermatomal superficial telangiectasia (UDST) may be congenital or acquired. Acquired UDST may occur coincident with physiologic states of estrogen increase, including puberty and pregnancy in women and adrenarche in men. Acquired UDST may also occur in estrogenized pathologic states such as chronic hepatic ...

journal_title：Journal of the American Academy of Dermatology

authors： Wilkin JK,Smith JG Jr,Cullison DA,Peters GE,Rodriquez-Rigau LJ,Feucht CL

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Nephrogenic systemic fibrosis is a fibrosing disorder associated with gadolinium (Gd)-based contrast agents dosed during renal insufficiency. OBJECTIVE:In two patients, Gd deposition in tissue affected by nephrogenic systemic fibrosis was quantified using inductively coupled plasma mass spectrometry. The pr...

journal_title：Journal of the American Academy of Dermatology

authors： High WA,Ranville JF,Brown M,Punshon T,Lanzirotti A,Jackson BP

更新日期：2010-01-01 00:00:00

abstract：:In a 4-year-old boy with steriod-resistant syndrome and extreme hyperlipidemia, an intense pruritic papular eruption developed on the trunk, buttocks, and extensor surface of the extremities. Findings from a skin biopsy specimen were consistent with an eruptive xanthoma. The patient was treated with gemfibrozil (Lopid...

journal_title：Journal of the American Academy of Dermatology

authors： Teltscher J,Silverman RA,Stork J

更新日期：1989-11-01 00:00:00

abstract：:We describe a 3-year-old male patient with an unusual congenital lesion on the plantar surface of the left foot that had been asymptomatic until shortly before presentation. Histologic examination of the plaque revealed a thinner keratin layer, increased pigmentation, and a pilosebaceous unit with a visible vellus hai...

journal_title：Journal of the American Academy of Dermatology

authors： Dragan L,Lorincz AL,Medenica MM,Phillips SB

更新日期：1999-05-01 00:00:00

abstract：UNLABELLED:Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA), a medication used to treat psoriasis in the 1970s until side effects and the concern of carcinogenesis led to its discontinuation. The prodrug, MMF, emerged decades later in the transplant field. Dermatologists have since used MMF off-lab...

journal_title：Journal of the American Academy of Dermatology

authors： Orvis AK,Wesson SK,Breza TS Jr,Church AA,Mitchell CL,Watkins SW

更新日期：2009-02-01 00:00:00

abstract：:Cytodestructive or surgical therapy for patients with anogenital warts is frequently associated with recurrence. In February 1997, the US Food and Drug Administration approved imiquimod as a 5% cream for the treatment of anogenital warts. Activity of the drug results primarily from interferon alfa and other cytokine i...

journal_title：Journal of the American Academy of Dermatology

authors： Carrasco D,vander Straten M,Tyring SK

更新日期：2002-10-01 00:00:00

abstract：:Our objective was to determine the percutaneous absorption of hydrocortisone in psoriatic skin. [14C]-Hydrocortisone formulated as a 0.5% cream was applied to sharply defined erythematous plaques with silvery scales on the dorsal forearm of four hospitalized psoriatic patients. An average 2.32 +/- 1.4 (SD) percent of ...

journal_title：Journal of the American Academy of Dermatology

authors： Wester RC,Bucks DA,Maibach HI

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating moderate to severe psoriasis in a phase II trial. OBJECTIVES:We sought to compare efficacy and safety of guselkumab with adalimumab and placebo in patients with psoriasis treated for 1 year. METHODS:Patients were randomized to gu...

journal_title：Journal of the American Academy of Dermatology

authors： Blauvelt A,Papp KA,Griffiths CE,Randazzo B,Wasfi Y,Shen YK,Li S,Kimball AB

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Facial erythema is a clinical hallmark of rosacea and often causes social and psychological distress. Although facial erythema assessments are a common endpoint in rosacea clinical trials, their reliability has not been evaluated. OBJECTIVE:The objective of this study was to evaluate the inter- and intrarat...

journal_title：Journal of the American Academy of Dermatology

authors： Tan J,Liu H,Leyden JJ,Leoni MJ

更新日期：2014-10-01 00:00:00

abstract：:Direct-to-consumer teledermatology is radically changing the way some patients obtain dermatologic care. Many direct-to-consumer teledermatology services offer care to patients younger than 18 years, but policies and standards are nonuniform. For pediatric patients, direct-to-consumer teledermatology is a substantial ...

journal_title：Journal of the American Academy of Dermatology

authors： Fogel AL,Teng J,Sarin KY

更新日期：2016-11-01 00:00:00