Mycophenolate mofetil in dermatology.

Abstract:

UNLABELLED:Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA), a medication used to treat psoriasis in the 1970s until side effects and the concern of carcinogenesis led to its discontinuation. The prodrug, MMF, emerged decades later in the transplant field. Dermatologists have since used MMF off-label to treat various inflammatory skin conditions, with most research concentrating on its use in psoriasis, autoimmune blistering disorders, dermatitides, and connective tissue disorders. The appeal of MMF is predicated upon its lymphocyte specificity and consequent decreased toxicity profile. These attributes may make it a preferable treatment option. Its use in the field of dermatology is currently limited by a lack of randomized controlled trials, potential unknown side effects, and cost of treatment. In reviewing both current literature and our own clinic records, MMF appears to be a promising therapeutic option for the treatment of cutaneous inflammatory diseases. LEARNING OBJECTIVE:After completing this learning activity, participants should be able to summarize the history and pharmacology of mycophenolate mofetil as an immunosuppressant; recognize its potential role in the treatment of dermatologic conditions, including general dosing guidelines, use in pregnancy and pediatrics, and potential adverse effects; and identify future considerations and developing areas of research regarding the use of mycophenolate mofetil in dermatology.

journal_name

J Am Acad Dermatol

authors

Orvis AK,Wesson SK,Breza TS Jr,Church AA,Mitchell CL,Watkins SW

doi

10.1016/j.jaad.2008.08.049

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

183-99; quiz 200-2

issue

2

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(08)01322-4

journal_volume

60

pub_type

杂志文章,评审
  • Ichthyosis follicularis with atrichia and photophobia (IFAP) syndrome in two unrelated female patients.

    abstract::The IFAP syndrome is characterized by the congenital onset of ichthyosis follicularis, absence of hair, and photophobia. A limited number of patients with the disorder have been described, and X-linked recessive inheritance has been proposed. Two unrelated female patients with a complete IFAP syndrome are reported. Bo...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2002.112930

    authors: Cambiaghi S,Barbareschi M,Tadini G

    更新日期:2002-05-01 00:00:00

  • Cutaneous vascular proliferations. Part III. Malignant neoplasms, other cutaneous neoplasms with significant vascular component, and disorders erroneously considered as vascular neoplasms.

    abstract::In this third and last part of our review of cutaneous vascular proliferations we include malignant vascular neoplasms and a group of heterogeneous cutaneous neoplasms characterized by a significant vascular component. We also review some disorders that, in our opinion, have been erroneously considered as vascular neo...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(98)70237-3

    authors: Requena L,Sangueza OP

    更新日期:1998-02-01 00:00:00

  • A novel nonepidermolytic palmoplantar keratoderma: a clinical and histopathologic study of six cases.

    abstract:BACKGROUND:Some hereditary palmoplantar keratodermas (PPK) have been defined at the molecular level. OBJECTIVE:Our purpose was to establish the cause of a hereditary PPK with unique histopathologic findings in the epidermis. METHODS:Investigative studies included light and electron microscopy and determination of gen...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(97)70208-1

    authors: Magro CM,Baden LA,Crowson AN,Bowden PE,Baden HP

    更新日期:1997-07-01 00:00:00

  • Annular atrophic lichen planus.

    abstract::We describe a case of generalized, asymptomatic, chronic annular lichen planus. The centers of the large annular lesions were atrophic and had lost their elasticity. Histologic examination revealed an absence of elastic fiber in the center. Electron microscopy revealed fragmented elastic fibers. Examination of early l...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(91)70212-k

    authors: Friedman DB,Hashimoto K

    更新日期:1991-08-01 00:00:00

  • Combination of psoralens and ultraviolet A and ultraviolet B in the treatment of psoriasis vulgaris: a bilateral comparison study.

    abstract::Forty-two adults with psoriasis vulgaris were treated total body thrice weekly with both ultraviolet B (UVB) and psoralens and ultraviolet A (PUVA) with the use of protocols shown to be effective with either treatment alone. Patients previously difficult to manage with either UVB or PUVA and at least 25% psoriasis wer...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0190-9622(84)80098-5

    authors: Momtaz-T K,Parrish JA

    更新日期:1984-03-01 00:00:00

  • Use of high-dose acyclovir in pityriasis rosea.

    abstract:BACKGROUND:The association of human herpesvirus 6 (HHV-6) and HHV-7 with pityriasis rosea suggests that systemic drugs directed against HHV may hasten recovery of patients with pityriasis rosea. OBJECTIVE:The purpose of this study was to verify the efficacy of oral acyclovir in the treatment of pityriasis rosea. METH...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2005.06.042

    authors: Drago F,Vecchio F,Rebora A

    更新日期:2006-01-01 00:00:00

  • Role of topical tretinoin in melanoma and dysplastic nevi.

    abstract::The retinoids have been investigated extensively as chemopreventive and therapeutic agents in a variety of neoplasms. They have been shown to inhibit the proliferation of transformed cell lines in vitro and transplanted tumors in vivo. In cultured murine melanoma cells, retinoids inhibit proliferation and induce diffe...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0190-9622(86)70239-9

    authors: Meyskens FL Jr,Edwards L,Levine NS

    更新日期:1986-10-01 00:00:00

  • Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: a comparative study.

    abstract::A panel of antibodies reactive in routinely fixed, paraffin-embedded tissue sections was compared with a panel of antibodies reactive in frozen sections for the immunophenotyping of cutaneous lymphoproliferative disorders. Three T cell-associated markers (UCHL1, MT-1, MT-2, six B cell-associated markers (MB-1, MB-2, L...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(90)70055-m

    authors: Cerroni L,Smolle J,Soyer HP,Martinez Aparicio A,Kerl H

    更新日期:1990-03-01 00:00:00

  • Outcomes research in your office.

    abstract::This article reviews the definition of outcomes research. It explores the reasons that outcomes research should be conducted by practicing physicians in both university and private practice settings. Methods for outcomes research with examples relevant to dermatologists are detailed. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(98)70164-1

    authors: Faust HB

    更新日期:1998-06-01 00:00:00

  • Body dysmorphic disorder symptoms among patients with acne vulgaris.

    abstract:BACKGROUND:Acne is one of the most common concerns of patients with body dysmorphic disorder (BDD), a psychiatric condition defined as a preoccupation with a slight or imagined defect in appearance that causes significant disruption in daily functioning. OBJECTIVE:We sought to screen for BDD symptoms among patients wi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2007.03.030

    authors: Bowe WP,Leyden JJ,Crerand CE,Sarwer DB,Margolis DJ

    更新日期:2007-08-01 00:00:00

  • Prospective study of cosmetic reactions: 1977-1980. North American Contact Dermatitis Group.

    abstract::This prospective study (1977-1980) of cosmetic adverse reactions by eleven dermatologists identified 487 cases of cosmetic-induced dermatitis. Approximately half of the cases were covert in nature. Eight percent were due to allergic contact dermatitis; the face, eye, and upper arm were the most involved sites. Skin ca...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(82)70080-5

    authors: Eiermann HJ,Larsen W,Maibach HI,Taylor JS

    更新日期:1982-05-01 00:00:00

  • A side-by-side comparison of carbon dioxide resurfacing lasers for the treatment of rhytides.

    abstract:BACKGROUND:The use of cutaneous resurfacing lasers to treat rhytides is widely accepted. Several carbon dioxide lasers, many using fundamentally different technologies, are available. OBJECTIVE:The purpose of this study was to compare the results obtained and side effects after treating rhytides with 3 different carbo...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0190-9622(98)70002-7

    authors: Gross EA,Rogers GS

    更新日期:1998-10-01 00:00:00

  • AAD Guidelines of Care: how did we get here and where are we going?

    abstract::In 1987 the American Academy of Dermatology began to create Guidelines of Care for clinical disease processes in dermatology. The format of the guidelines has changed dramatically over the past several years; now all of the recent guidelines are in the evidence-based style. These guidelines have been recognized nation...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2003.188

    authors: Van Voorhees AS

    更新日期:2003-06-01 00:00:00

  • Changes in the pattern of sun exposure and sun protection in young children from tropical Australia.

    abstract:BACKGROUND:Australia has one of the highest rates of skin cancer globally. Lifetime risk is associated with childhood sun exposure. OBJECTIVE:We sought to investigate whether skin cancer prevention programs have resulted in improvements in sun-exposure and sun-protection behavior among young children in tropical Austr...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2012.10.057

    authors: Smith A,Harrison S,Nowak M,Buettner P,Maclennan R

    更新日期:2013-05-01 00:00:00

  • Thalidomide: use and possible mode of action in reactional lepromatous leprosy and in various other conditions.

    abstract::The literature concerning the use and possible mode of action of thalidomide in reactional lepromatous leprosy and in various other conditions is reviewed. Although it has no action against the leprosy bacillus, its value in the treatment of the adverse reactions in this type of leprosy is well established, many lepro...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(82)70118-5

    authors: Barnhill RL,McDougall AC

    更新日期:1982-09-01 00:00:00

  • Superantigens in dermatology.

    abstract::Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against S...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2010.03.044

    authors: Macias ES,Pereira FA,Rietkerk W,Safai B

    更新日期:2011-03-01 00:00:00

  • A randomized, double-blind, placebo-controlled, phase I study of MEDI-545, an anti-interferon-alfa monoclonal antibody, in subjects with chronic psoriasis.

    abstract:BACKGROUND:Interferon-alfa (IFN-alpha) has been implicated in the pathogenesis of psoriasis. OBJECTIVE:To evaluate the safety profile of MEDI-545, a fully human anti-IFN-alpha monoclonal antibody and to explore its effect on the involvement of type I IFN-alpha activity in the maintenance of established plaque psoriasi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaad.2009.05.042

    authors: Bissonnette R,Papp K,Maari C,Yao Y,Robbie G,White WI,Le C,White B

    更新日期:2010-03-01 00:00:00

  • JAAD Grand Rounds quiz: A subcutaneous nodule on the right shoulder.

    abstract:LEARNING OBJECTIVES:At the conclusion of this learning activity, physician participants should be able to assess their own diagnostic and patient management skills and use the results of this exercise to help determine personal learning needs. Instructions: In answering each question, refer to the specific directions p...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2013.01.042

    authors: Hung CT,Wang WM

    更新日期:2015-11-01 00:00:00

  • Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma.

    abstract:BACKGROUND:Lentigo maligna (LM) is a relatively common tumor with increasing prevalence and substantial morbidity. A variety of treatment modalities are available, though margin-control surgery offers the highest cure rate. We were interested in comparing long-term outcomes of Mohs micrographic surgery (MMS) versus sta...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2007.02.011

    authors: Walling HW,Scupham RK,Bean AK,Ceilley RI

    更新日期:2007-10-01 00:00:00

  • Gluten intake and risk of psoriasis, psoriatic arthritis, and atopic dermatitis among United States women.

    abstract:BACKGROUND:Associations between gluten intake and psoriasis, psoriatic arthritis, and atopic dermatitis are poorly understood. OBJECTIVE:To determine whether increased gluten intake is associated with incident psoriasis, psoriatic arthritis, and atopic dermatitis. METHODS:Cohort studies among women in Nurses' Health ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2019.08.007

    authors: Drucker AM,Qureshi AA,Thompson JM,Li T,Cho E

    更新日期:2020-03-01 00:00:00

  • Ulcerated epithelioid hemangioendothelioma of the foot in childhood.

    abstract::Epithelioid hemangioendothelioma is an uncommon malignant vascular tumor usually involving soft tissue and, in rare cases, the skin. Histologically and biologically it is considered to be a borderline neoplasm between an angiolymphoid hyperplasia with eosinophilia and an epithelioid angiosarcoma. Here we describe an 1...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2003.416

    authors: Forschner A,Harms D,Metzler G,Sönnichsen K,Ulmer A,Rassner G,Fierlbeck G

    更新日期:2003-07-01 00:00:00

  • Apoeccrine sweat duct obstruction as a cause for Fox-Fordyce disease.

    abstract::The pathogenesis of Fox-Fordyce disease has been reported to be hyperkeratosis and obstruction of the upper hair follicle, where the duct of the apocrine sweat gland opens. We report a case of Fox-Fordyce disease with full clinical manifestation. It appeared to be caused by the obstruction of intraepidermal apoeccrine...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2003.93

    authors: Kamada A,Saga K,Jimbow K

    更新日期:2003-03-01 00:00:00

  • Hereditary epidermolytic palmoplantar keratoderma (Vörner type). Report of a familial case and review of the literature.

    abstract::A recent familial case of hereditary epidermolytic palmoplantar keratoderma (Vörner type) that was treated with orally administered etretinate is reported herein. A review of the literature with regard to the clinical, genetic, and laboratory features of this rare genodermatosis is also presented. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(87)70222-9

    authors: Kanitakis J,Tsoitis G,Kanitakis C

    更新日期:1987-09-01 00:00:00

  • Follicular mucinosis as a presenting sign of acute myeloblastic leukemia.

    abstract::Follicular mucinosis is often associated with mycosis fungoides and has been rarely observed to occur with other neoplastic and inflammatory conditions. We describe a 60-year-old patient with follicular mucinosis who later developed acute myelogenous leukemia. This is the first reported case of follicular mucinosis as...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(98)70462-1

    authors: Sumner WT,Grichnik JM,Shea CR,Moore JO,Miller WS,Burton CS

    更新日期:1998-05-01 00:00:00

  • Metastatic Crohn's disease: a review and approach to therapy.

    abstract::Metastatic Crohn's disease (CD) is a rare cutaneous manifestation of CD that was first described nearly 50 years ago. Many subsequent reports have defined its most common clinical and histopathologic features. The pathogenesis underlying metastatic CD is unknown but various hypotheses exist. An established standard th...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2014.04.002

    authors: Kurtzman DJ,Jones T,Lian F,Peng LS

    更新日期:2014-10-01 00:00:00

  • Immunosuppression in a homosexual man with Kaposi's sarcoma.

    abstract::The occurrence of Kaposi's sarcoma in young homosexual men is a recently reported condition. The same individuals are at risk for the development of Pneumocystis carinii pneumonia and other unusual infections. These associations suggest these persons are somehow immunocompromised. Evidence of current or prior cytomega...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(82)70076-3

    authors: Rasmussen EO,Cooper KD,Kang K,White CR Jr,Regan DH,Hanifin JM

    更新日期:1982-05-01 00:00:00

  • Skin metastasis of dermatofibrosarcoma protuberans with distinct morphological features, confirmed by COL1A1-PDGFB fusion gene analysis.

    abstract::We discuss a metastatic dermatofibrosarcoma protuberans on the occiput of a 53-year-old man whose initial tumor appeared on his forehead 23 years previously. The pathology of the tumor that recurred at the initial site was fibrosarcomatous dermatofibrosarcoma protuberans, whereas the metastatic tumor was a pigmented d...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2008.10.053

    authors: Kabumoto T,Fujiwara H,Kariya N,Tsujimoto T,Ito K,Ito M,Kobayashi H

    更新日期:2009-07-01 00:00:00

  • Local anesthesia in dermatologic surgery.

    abstract::With the growth of dermatologic surgery the appropriate use of local anesthesia is becoming an important issue. Thoughtful use of local anesthesia can improve the patient's experience and facilitate the surgical procedure. In this review we discuss historical and pharmacologic aspects of local anesthetic agents. Empha...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(88)70213-3

    authors: Grekin RC,Auletta MJ

    更新日期:1988-10-01 00:00:00

  • Potential mechanisms of minoxidil-induced hair growth in alopecia areata.

    abstract::In vivo, topical minoxidil therapy is associated with changes in the follicular epithelium, tissue and blood lymphocyte populations, lymphocyte blastogenic response to mitogens, and perifollicular vasculature. Biopsy specimens taken from areas of terminal hair regrowth show a dose-dependent increase in hair follicle l...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(87)70083-8

    authors: Fiedler-Weiss VC

    更新日期:1987-03-01 00:00:00

  • Use of complementary and alternative medicine among adults with skin disease: updated results from a national survey.

    abstract:BACKGROUND:In the United States, complementary and alternative medicine (CAM) is used for a variety of diseases, including those of the skin. An estimate of the prevalence of CAM use among adults with skin disease using the alternative health supplement of the 2002 National Health Interview Survey (NHIS) has been publi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2009.12.009

    authors: Fuhrmann T,Smith N,Tausk F

    更新日期:2010-12-01 00:00:00