Transcription of the RelB gene is regulated by NF-kappaB.

abstract：:Acute myeloid leukemia 1 (AML1) gene on chromosome 21 is involved in several chromosomal translocations, including t(8;21) and t(16;21), that produce chimeric fusion proteins AML1-eight twenty-one (ETO) and AML-myeloid transforming gene chromosome 16 (MTG16), which contribute to leukemogenesis. The molecular basis for...

journal_title：Oncogene

authors： Qiu J,Wong J,Tweardy DJ,Dong S

更新日期：2006-06-29 00:00:00

abstract：:Thymidine kinase (TK) is a nucleotide salvage pathway enzyme whose activity is highly dependent on the growth state and cell cycle phase of a cell. Cells in the resting or quiescent (G0) phase express very low levels of TK mRNA and protein. When quiescent cells are stimulated to enter the cell cycle by the addition of...

journal_title：Oncogene

authors： Kauffman MG,Rose PA,Kelly TJ

更新日期：1991-08-01 00:00:00

abstract：:Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cance...

journal_title：Oncogene

authors： Lee GH,Yoo KC,An Y,Lee HJ,Lee M,Uddin N,Kim MJ,Kim IG,Suh Y,Lee SJ

更新日期：2018-04-01 00:00:00

abstract：:A cloned line of S + L- mink lung cells (A clone), which exhibited a flat morphology, was superinfected with a novel dual-tropic virus (E1BX-MuLV) showing a broad host range and a B-tropism. These cells gave rise to transformed cells with two phenotypes: those which were still anchorage-dependent (AD), and those which...

journal_title：Oncogene

authors： Gao CL,Wang LC,Vass WC,Seth A,Chang KS

更新日期：1988-09-01 00:00:00

abstract：:Activating the protein-tyrosine kinase activity of v-Src rapidly induced expression of the two 'primary response' genes, TIS10 and Egr-1, in Balb/c 3T3 cells. Depleting cells of protein kinase C (PKC) by prolonged exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA), blocked v-Src-induced TIS10 expression, but had n...

journal_title：Oncogene

authors： Qureshi SA,Joseph CK,Rim M,Maroney A,Foster DA

更新日期：1991-06-01 00:00:00

abstract：:Although cell invasion is a necessary early step in cancer metastasis, its regulation is not well understood. We have previously shown, in human prostate cancer, that transforming growth factor beta (TGFbeta)-mediated increases in cell invasion are dependent upon activation of the serine/threonine kinase, p38 MAP kina...

journal_title：Oncogene

authors： Xu L,Chen S,Bergan RC

更新日期：2006-05-18 00:00:00

abstract：:The E2F1 transcription factor, which is deregulated in most human cancers by mutations in the p16-cyclin D-Rb pathway, has both oncogenic and tumor-suppressive properties. This is dramatically illustrated by the phenotype of an E2F1 transgenic mouse model that spontaneously develops tumors in the skin and other epithe...

journal_title：Oncogene

authors： Russell JL,Weaks RL,Berton TR,Johnson DG

更新日期：2006-02-09 00:00:00

abstract：:The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in response to nerve growth factor (NGF). To assess the importance of adaptor proteins and Ras in NGF control of phosphoinositide 3-OH kinase (PI 3-kinase), specific receptor mutations in Trk ha...

journal_title：Oncogene

authors： Hallberg B,Ashcroft M,Loeb DM,Kaplan DR,Downward J

更新日期：1998-08-13 00:00:00

abstract：:We have analysed the importance of proper substrate methylation by S-adenosylmethionine-dependent methyltransferases for cell survival and cell cycle progression. We show that treatment of cells with the methyltransferase inhibitor adenosine dialdehyde (AdOx) causes cell cycle arrest and death in different cell types....

journal_title：Oncogene

authors： Schwerk C,Schulze-Osthoff K

更新日期：2005-10-27 00:00:00

abstract：:Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in...

journal_title：Oncogene

authors： Fuchs SY,Spiegelman VS,Kumar KG

更新日期：2004-03-15 00:00:00

abstract：:The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has a significant role in initiating EBV-associated lymphoproliferative disease and EBV-related malignancies. In view of clinical features related to the type of EBV latency, LMP1 may influence invasiveness of EBV associated tumors categorized as ty...

journal_title：Oncogene

authors： Kim KR,Yoshizaki T,Miyamori H,Hasegawa K,Horikawa T,Furukawa M,Harada S,Seiki M,Sato H

更新日期：2000-03-30 00:00:00

abstract：:Death receptor 5 (DR5) is a receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). TRAIL is a promising candidate for cancer therapeutics due to its ability to induce apoptosis selectively in cancer cells. Here, we report that histone deacetylase inhibitors (HDACIs) such as trichostatin A (TSA),...

journal_title：Oncogene

authors： Nakata S,Yoshida T,Horinaka M,Shiraishi T,Wakada M,Sakai T

更新日期：2004-08-19 00:00:00

abstract：:DNA double-strand breaks (DSBs), the most hazardous DNA lesions, may result in genomic instability, a hallmark of cancer cells. The main DSB repair pathways are non-homologous end joining (NHEJ) and homologous recombination (HR). In mammalian cells, NHEJ, which can lead to inaccurate repair, predominates. HR repair (H...

journal_title：Oncogene

authors： Shahar OD,Raghu Ram EV,Shimshoni E,Hareli S,Meshorer E,Goldberg M

更新日期：2012-07-26 00:00:00

abstract：:The Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor E2-related factor 2 (NRF2)pathway has a central role in cellular antioxidant defense. NRF2 activation due to KEAP1 or NRF2 mutations occurs frequently in many cancers, suggesting that NRF2 inhibition could be a promising therapeutic strategy. However, no p...

journal_title：Oncogene

authors： Choi EJ,Jung BJ,Lee SH,Yoo HS,Shin EA,Ko HJ,Chang S,Kim SY,Jeon SM

更新日期：2017-09-14 00:00:00

abstract：:B-Myb, a highly conserved member of the Myb oncoprotein family, is a 110 kDa sequence-specific DNA binding protein expressed in virtually all proliferating cells. B-myb expression reaches its maximum at the G1/S phase boundary and during the S phase of the cell cycle. We have previously shown that B-Myb activity is ce...

journal_title：Oncogene

authors： Charrasse S,Carena I,Brondani V,Klempnauer KH,Ferrari S

更新日期：2000-06-15 00:00:00

abstract：:Forkhead box O class transcription factors are homeostasis regulators that control cell death, longevity and therapy-resistance. In neuroblastoma (NB), nuclear FOXO3 correlates with stage M disease and poor prognosis. To analyze whether FOXO3 contributes to drug-resistance in this childhood cancer, we investigated how...

journal_title：Oncogene

authors： Rupp M,Hagenbuchner J,Rass B,Fiegl H,Kiechl-Kohlendorfer U,Obexer P,Ausserlechner MJ

更新日期：2017-11-02 00:00:00

abstract：:The human RON and its mouse homologue stk are members of the MET family of tyrosine kinase receptors. We have previously shown that the RON gene is over-expressed in human breast carcinomas. As cat mammary tumours have been proposed as a suitable model for aggressive human breast cancer, we identified the feline stk g...

journal_title：Oncogene

authors： De Maria R,Maggiora P,Biolatti B,Prat M,Comoglio PM,Castagnaro M,Di Renzo MF

更新日期：2002-03-07 00:00:00

abstract：:The E6 proteins of specific cancer-associated human papillomaviruses (HPVs) complex with and mediate degradation of the cellular anti-oncogene p53 in vitro. A critical property of p53 is its ability to stimulate transcription from promoters containing its recognition sequence. HPV E6, mutant p53 proteins, and several ...

journal_title：Oncogene

authors： Mansur CP,Marcus B,Dalal S,Androphy EJ

更新日期：1995-02-02 00:00:00

abstract：:Alu sequences are the most abundant short interspersed repeated elements in the human genome. Here we show that in a cell culture model of colorectal cancer (CRC) progression, we observe accumulation of Alu RNA that is associated with reduced DICER1 levels. Alu RNA induces epithelial-to-mesenchymal transition (EMT) by...

journal_title：Oncogene

authors： Di Ruocco F,Basso V,Rivoire M,Mehlen P,Ambati J,De Falco S,Tarallo V

更新日期：2018-02-01 00:00:00

abstract：:Common fragile sites are specific genomic loci that form constrictions and gaps on metaphase chromosomes under conditions that slow, but do not arrest, DNA replication. These sites have been shown to have a role in various chromosomal rearrangements in tumors. Different DNA damage response proteins were shown to regul...

journal_title：Oncogene

authors： Ozeri-Galai E,Schwartz M,Rahat A,Kerem B

更新日期：2008-04-03 00:00:00

abstract：:The role of thromboxane A(2) (TxA(2)) in smoking-associated lung cancer is poorly understood. This study was conducted to study the role of TxA(2) in smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-promoted cell survival and growth in human lung cancer cells. We found that NNK increased TxA(2) ...

journal_title：Oncogene

authors： Huang RY,Li MY,Hsin MK,Underwood MJ,Ma LT,Mok TS,Warner TD,Chen GG

更新日期：2011-01-06 00:00:00

abstract：:Studies on human papillomavirus type 16 have demonstrated that the product of the early gene, E7, plays a key role in the immortalization and malignant transformation of the host cell. Several of the biological activities of HPV16 E7 are mediated by inactivation of the members of the pocket protein family, pRb, p107 a...

journal_title：Oncogene

authors： Caldeira S,de Villiers EM,Tommasino M

更新日期：2000-02-10 00:00:00

abstract：:We have isolated a human cDNA clone encoding a novel protein of 22 kDa that is a human counterpart of the rat oncoprotein PTTG. We show that the corresponding gene (hpttg) is overexpressed in Jurkat cells (a human T lymphoma cell line) and in samples from patients with different kinds of hematopoietic malignancies. An...

journal_title：Oncogene

authors： Domínguez A,Ramos-Morales F,Romero F,Rios RM,Dreyfus F,Tortolero M,Pintor-Toro JA

更新日期：1998-10-29 00:00:00

abstract：:We showed earlier that p300/CBP plays an important role in G1 progression by negatively regulating c-Myc and thereby preventing premature G1 exit. Here, we have studied the mechanism by which p300 represses c-Myc and show that in quiescent cells p300 cooperates with histone deacetylase 3 (HDAC3) to repress transcripti...

journal_title：Oncogene

authors： Sankar N,Baluchamy S,Kadeppagari RK,Singhal G,Weitzman S,Thimmapaya B

更新日期：2008-09-25 00:00:00

abstract：:Based on observations suggesting a role for the tumor suppressor protein p53 in regulating expression of the 67-kDa laminin receptor precursor, 37LRP, we analysed the 37LRP promoter activity in a wild-type p53 (wt p53) ovarian carcinoma cell line and in a cisplatin-resistant subline with mutated p53. We observed an in...

journal_title：Oncogene

authors： Modugno M,Tagliabue E,Ardini E,Berno V,Galmozzi E,De Bortoli M,Castronovo V,Ménard S

更新日期：2002-10-24 00:00:00

abstract：:Embryonic stem (ES) cells have provided a valid model to understand early events of mammalian lineage specification and differentiation, leading to important insights into the mechanisms that control embryogenesis at the molecular and cellular levels. Furthermore, ES cells have recently evoked great scientific interes...

journal_title：Oncogene

authors： Minchiotti G

更新日期：2005-08-29 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common and malignant carcinoma worldwide, and the incidence and mortality are increasing rapidly. Immunotherapy targeting programmed death 1/programmed death ligand 1 (PD-L1) signaling has shown prominent clinical effects in treating NSCLC; however, a poor understa...

journal_title：Oncogene

authors： Wang J,Jia Y,Zhao S,Zhang X,Wang X,Han X,Wang Y,Ma M,Shi J,Liu L

更新日期：2017-11-09 00:00:00

abstract：:SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that includes HACS1. HACS1 encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and has...

journal_title：Oncogene

authors： Claudio JO,Zhu YX,Benn SJ,Shukla AH,McGlade CJ,Falcioni N,Stewart AK

更新日期：2001-08-30 00:00:00

abstract：:We describe the cytogenetic and molecular characterization of a t(1;13)(q22;q12) constitutional rearrangement occurring in a patient with a relatively benign form of neuroblastoma, called ganglioneuroblastoma. Somatic cell hybrids were generated between mouse 3T3 cells and a lymphoblastoid cell line from this patient,...

journal_title：Oncogene

authors： Michalski AJ,Cotter FE,Cowell JK

更新日期：1992-08-01 00:00:00

abstract：:Tumor suppressor genes and the immune system are critical players in inhibiting cancer initiation and/or progression. However, little is known about whether a tumor suppressor gene can function through both immune-dependent and -independent mechanisms. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally ...

journal_title：Oncogene

authors： Liu-Chittenden Y,Jain M,Gaskins K,Wang S,Merino MJ,Kotian S,Kumar Gara S,Davis S,Zhang L,Kebebew E

更新日期：2017-06-22 00:00:00