Abstract:
:Several factors affect the viability of biosensor design. A computer-based model is being developed to enable the sources and effect of noise and variability within the sensor to be analysed. The work now presented details the modelling of the biochemical aspect of the biosensor model-the immunoassay. The equilibrium equations that describe the chemical reactions that occur when a sample containing the analyte is added to the immunosensor are cast as a sum of squares function that can be minimized using an optimization procedure. The optimization returns the concentrations of each species at equilibrium and the procedure is incorporated within a Monte Carlo simulation, which allows the variations in the resulting concentrations to be determined. Three classes of optimization technique are considered, classical regression techniques and two intelligent optimization techniques: simulated annealing and genetic algorithms. Several methods of imposing constraints are implemented and the issue of local minima is discussed. Classical regression procedures were found to be superior to the intelligent optimizations examined.
journal_name
Physiol Measjournal_title
Physiological measurementauthors
Keating SM,Flanagan MTdoi
10.1088/0967-3334/22/3/318subject
Has Abstractpub_date
2001-08-01 00:00:00pages
625-34issue
3eissn
0967-3334issn
1361-6579journal_volume
22pub_type
杂志文章abstract::This study compared sitting time measured by a questionnaire (International Physical Activity Questionnaire; IPAQ) with concurrently measured objective sitting time from an accelerometer-based measure of thigh inclination (activPAL).Adults (n = 69), wore an activPAL for a week, and then completed the long-form 7 d rec...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/11/2319
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:In this research, we introduce a new methodology for atrial fibrillation (AF) diagnosis during sleep in a large population sample at risk of sleep-disordered breathing. APPROACH:The approach leverages digital biomarkers and recent advances in machine learning (ML) for mass AF diagnosis from overnight-hours o...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/abb8bf
更新日期:2020-11-06 00:00:00
abstract::In order to detect minute amounts of glucose in diluted urine, we applied the Raman spectroscopy method. To simulate abnormal diluted urine in a toilet bowl, we diluted normal urine ten-fold with water and added glucose up to 8 mg dl(-1). Data were collected using a low-resolution Raman spectrometer that was preproces...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/28/5/011
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:An artefact-free electrocardiogram (ECG) is essential during cardiac arrest to decide therapy such as defibrillation. Mechanical cardiopulmonary resuscitation (CPR) devices cause movement artefacts that alter the ECG. This study analyzes the effectiveness of mechanical CPR artefact suppression filters to rest...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab9e53
更新日期:2020-11-06 00:00:00
abstract::Electrical impedance tomography (EIT) could be significantly advantageous to continuous monitoring of lung development in newborn and, in particular, preterm infants as it is non-invasive and safe to use within the intensive care unit. It has been demonstrated that accurate boundary form of the forward model is import...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/6/1149
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:Accurate bladder size estimation is an important clinical parameter that assists physicians, enabling them to provide better treatment for patients who are suffering from urinary incontinence. Electrical impedance tomography (EIT) is a non-invasive medical imaging method that estimates organ boundaries assumi...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/abaa56
更新日期:2020-12-18 00:00:00
abstract:OBJECTIVE:In this paper, a support vector machine (SVM) approach using statistical features, P wave absence, spectrum features, and length-adaptive entropy are presented to classify ECG rhythms as four types: normal rhythm, atrial fibrillation (AF), other rhythm, and too noisy to classify. APPROACH:The proposed algori...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aac7aa
更新日期:2018-06-25 00:00:00
abstract::The use of artificial neural networks (ANNs) to interpret sleep monitoring signals is described. Recordings from ten infants with apparent life threatening episodes were assigned into training feedforward R-PROP networks. In order to separate good signal from artefact, 60 second time frames of SaO2 and TcPO2 signals w...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/21/3/401
更新日期:2000-08-01 00:00:00
abstract::Twenty-nine patients were monitored overnight for breathing distress patterns during postoperative analgesia. Nasal flow apnoea monitoring and pulse oximetry data were recorded at 50 Hz. Respiratory inductive plethysmography (RIP) tracked tidal volume (TV) thoracoabdominal motion, and supplemented the flow monitoring ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/20/2/307
更新日期:1999-05-01 00:00:00
abstract::Skinfold anthropometry is a widely practiced technique often with little appreciation of its limitations. The large residual error appearing in any regressions of body density versus sums of skinfolds is primarily due to biological causes, in particular the non-constancy of the ratio of subcutaneous to total body fat....
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/19/3/008
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:PaCO2 affects cerebral blood flow (CBF) and its regulatory mechanisms, but the effects of CO2 measurement technique on cerebrovascular parameters are unknown. In order to determine if the two most commonly used approaches, face mask (FM) or nasal cannulae (NC), are interchangeable or not, we tested the hypoth...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aa6f9f
更新日期:2017-06-22 00:00:00
abstract::In this paper we present the concept, the design and the test procedure for a DSP-based high-precision and high-performance wide-band (up to 10 MHz) bioimpedance analyser module for application in EIT or bioimpedance spectroscopy. The module implements a digital concept with appropriate signal conditioning hardware fo...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/22/1/303
更新日期:2001-02-01 00:00:00
abstract::Previous studies have used isokinetic dynamometry to assess joint torques and angles during passive extension of the knee, often without reporting upon methodological errors and reliability outcomes. In addition, the reliability of the techniques used to measure passive knee extension torque-angle and the extent to wh...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/34/11/1483
更新日期:2013-11-01 00:00:00
abstract::Tetrapolar linear arrays are commonly used in geophysics to explore the vertical distribution of resistivity values in a geological section of a specific point on the earth. This technique, known as vertical electric sounding (VES), uses different electrode configurations. For our experiments, we utilized its more pop...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/18/1/007
更新日期:1997-02-01 00:00:00
abstract::Using the cross-sectional images taken with the zoom-in micro-tomography technique, we measured trabecular thicknesses of femur bones in postmortem rats. Since the zoom-in micro-tomography technique is capable of high resolution imaging of a small local region inside a large subject, we were able to measure the trabec...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/5/008
更新日期:2005-10-01 00:00:00
abstract::The paper describes the development of an electrical impedance tomography (EIT) system for gynecologic research. The GIT (gynecological impedance tomography) system has 48 electrodes and is embedded on a small space (30 mm diameter and 20 mm height) inside of the vaginal probe. The system provides real-time (one shot ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/33/5/849
更新日期:2012-05-01 00:00:00
abstract::This study investigates the cerebral hemodynamic changes during a routine sleep-deprived video-electroencephalogram (SD-VEEG) in healthy children. Forty-two children with normal intelligence were examined. The children were 5-14 years of age, and their electroencephalograms (EEGs) were within the normal range. Each su...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/7/981
更新日期:2016-07-01 00:00:00
abstract::A coordinated study of the dispersal of water between the various body compartments (stomach and gut, blood stream and tissue) and the similar dispersal kinetics of ethanol and its metabolism has been carried out involving two healthy volunteers using flowing afterglow mass spectrometry, FA-MS, and selected ion flow t...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/4/011
更新日期:2005-08-01 00:00:00
abstract::Electrocardiograms (ECGs) recorded from patients in intensive care were investigated to quantify any relationship between ECG signal quality and false monitoring alarms. False alarms are a considerable problem for nursing and medical staff as they distract from clinical care, and are also a problem for patients as the...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/8/1383
更新日期:2016-08-01 00:00:00
abstract::Electrical impedance endotomography (EIE) is a modality of impedance imaging where the electrodes are located on an insulating core placed at the centre of the region of interest. The absence of a physical limit to the medium surrounding the probe enables the use of remote electrodes. The present study compares the fe...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/4/001
更新日期:2005-08-01 00:00:00
abstract::Electrical impedance is one of the most often used parameters for characterizing material properties, especially in biomedical applications. Electrical impedance spectroscopy (EIS), used for revealing both resistive and capacitive characteristics, is good for use in tissue characterization. In this study, a portable a...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/32/9/010
更新日期:2011-09-01 00:00:00
abstract::The effect of composition on the dielectric properties of hydrogels for biomedical applications is experimentally investigated. The hydrogels, containing hydroxyethylcellulose (HEC), are characterized by means of the impedance spectroscopy technique. The real and imaginary parts of the electrical impedance of the hydr...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/31/10/S02
更新日期:2010-10-01 00:00:00
abstract::It has previously been shown that extreme changes in ambient air temperature can affect whole-body bioelectrical impedance. The purpose of this study was to determine if more moderate changes in ambient air temperature, such as those experienced in most laboratory settings, would also affect bioelectric impedance anal...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/25/1/011
更新日期:2004-02-01 00:00:00
abstract::The assessment and diagnosis of lower limb peripheral arterial occlusive disease (PAOD) is important since it can lead progressively to disabling claudication, ischaemic rest pain and gangrene. Historically, the first assessment has been palpation of the peripheral pulse since it can become damped, delayed and diminis...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/5/018
更新日期:2005-10-01 00:00:00
abstract::The aim of the study was to investigate whether body mass index (BMI) influences the estimation of extracellular volume (ECV) in hemodialysis (HD) patients when using segmental bioimpedance analysis (SBIA) compared to wrist-to-ankle bioimpedance analysis (WBIA) during HD with ultrafiltration (UF). Twenty five HD patie...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/26/2/009
更新日期:2005-04-01 00:00:00
abstract::Temporal changes in the impedance spectra of bioelectrodes in contact with skin provide useful data for comparisons between differing electrode materials and skin preparation methods. Traditional impedance measuring systems employ swept frequency methods which will distort results in the impedance spectra of a sample ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/20/1/008
更新日期:1999-02-01 00:00:00
abstract::Virtual shunt describes the overall loss of O2 content between the alveolar gas and arterial blood. Clinicians indirectly estimate the magnitude of the virtual shunt by monitoring peripheral blood oxygen saturation (SpO2) using non-invasive pulse oximetry. An inherent limitation of this method is the variable precisio...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/36/5/967
更新日期:2015-05-01 00:00:00
abstract::Electrical impedance spectroscopy has been developed as a potential method for the diagnosis of carcinoma in epithelial tissues. An understanding of the influence of structural changes in the tissue on the properties measured using this technique is essential for interpreting measured data and optimization of probe de...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/3/010
更新日期:2005-06-01 00:00:00
abstract::There has been a surge of interest in using electrical impedance tomography (EIT) for monitoring regional lung ventilation, however, EIT is an ill-conditioned problem, and errors/noise in the boundary voltages can have an undesirable effect on the quality of the final image. Most EIT systems in clinical usage use seri...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/34/6/659
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The performance of a novel unobtrusive system based on capacitively-coupled electrocardiography (ccECG) combined with different respiratory measurements is evaluated for the detection of sleep apnea. APPROACH:A sleep apnea detection algorithm is proposed, which can be applied to electrocardiography (ECG) and...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/abdf3d
更新日期:2021-01-22 00:00:00