Abstract:
:Several factors affect the viability of biosensor design. A computer-based model is being developed to enable the sources and effect of noise and variability within the sensor to be analysed. The work now presented details the modelling of the biochemical aspect of the biosensor model-the immunoassay. The equilibrium equations that describe the chemical reactions that occur when a sample containing the analyte is added to the immunosensor are cast as a sum of squares function that can be minimized using an optimization procedure. The optimization returns the concentrations of each species at equilibrium and the procedure is incorporated within a Monte Carlo simulation, which allows the variations in the resulting concentrations to be determined. Three classes of optimization technique are considered, classical regression techniques and two intelligent optimization techniques: simulated annealing and genetic algorithms. Several methods of imposing constraints are implemented and the issue of local minima is discussed. Classical regression procedures were found to be superior to the intelligent optimizations examined.
journal_name
Physiol Measjournal_title
Physiological measurementauthors
Keating SM,Flanagan MTdoi
10.1088/0967-3334/22/3/318subject
Has Abstractpub_date
2001-08-01 00:00:00pages
625-34issue
3eissn
0967-3334issn
1361-6579journal_volume
22pub_type
杂志文章abstract::This review describes recent developments in microfabricated flow cytometers and related microfluidic devices that can detect, analyze, and sort cells or particles. The high-speed analytical capabilities of flow cytometry depend on the cooperative use of microfluidics, optics and electronics. Along with the improvemen...
journal_title:Physiological measurement
pub_type: 杂志文章,评审
doi:10.1088/0967-3334/26/3/R02
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:The ratio of the partial pressure of arterial oxygen to fraction of inspired oxygen is a key component of the sequential organ failure assessment score that operationally defines sepsis. But, it is calculated infrequently due to the need for the acquisition of an arterial blood gas. So, we sought to find an o...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/ab5154
更新日期:2019-12-03 00:00:00
abstract:OBJECTIVE:Observational studies suggest that obesity might have a Mendelian origin, but it is not clear if gene expression patterns observed in obese subjects are secondary to genetic traits or not. APPROACH:Here we test a transcriptomic signature of obesity previously identified by our group on a large cohort of twin...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aab85a
更新日期:2018-04-26 00:00:00
abstract::The paper presents a method for adaptive decomposition of an electrical bio-impedance (BI) signal into two components: cardiac and respiratory. The decomposition of a BI signal is not a trivial process because of the non-stationarity of the signal components and overlapping of their harmonic spectra. An application sp...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/29/6/S02
更新日期:2008-06-01 00:00:00
abstract::False alarm (FA) rates as high as 86% have been reported in intensive care unit monitors. High FA rates decrease quality of care by slowing staff response times while increasing patient burdens and stresses. In this study, we proposed a rule-based and multi-channel information fusion method for accurately classifying ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/8/1298
更新日期:2016-08-01 00:00:00
abstract::The most common method of clinical measurement of arterial blood pressure is by means of the cuff sphygmomanometer. This instrument has provided fundamental quantitative information on arterial pressure in individual subjects and in populations and facilitated estimation of cardiovascular risk related to levels of blo...
journal_title:Physiological measurement
pub_type: 历史文章,杂志文章,评审
doi:10.1088/0967-3334/31/1/R01
更新日期:2010-01-01 00:00:00
abstract::Electrical impedance spectroscopy has been developed as a potential method for the diagnosis of carcinoma in epithelial tissues. An understanding of the influence of structural changes in the tissue on the properties measured using this technique is essential for interpreting measured data and optimization of probe de...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/26/3/010
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Atrial fibrillation (AF) causes marked risk for patients, while silent fibrillation may remain unnoticed if not suspected and screened. Development of comfortable yet accurate beat-to-beat heart rate (HR) monitoring with good AF detection sensitivity would facilitate screening and improve treatment. The purpo...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aac9a9
更新日期:2018-06-27 00:00:00
abstract::Epidemiological studies have associated the negative effects of sedentary time and sedentary patterns on health indices. However, these studies have used methodologies that do not directly measure the sedentary state. Recent technological developments in the area of motion sensors have incorporated inclinometers, whic...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/33/11/1887
更新日期:2012-11-01 00:00:00
abstract::The effect of composition on the dielectric properties of hydrogels for biomedical applications is experimentally investigated. The hydrogels, containing hydroxyethylcellulose (HEC), are characterized by means of the impedance spectroscopy technique. The real and imaginary parts of the electrical impedance of the hydr...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/31/10/S02
更新日期:2010-10-01 00:00:00
abstract::Non-invasive in vivo neutron activation analysis (NAA) was used to measure the fluorine concentration in 35 people in Hamilton, Ontario, Canada. Measurement and precision data of this second generation NAA system were determined in 2013, and the results were compared with the performance of a first generation system u...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/36/3/465
更新日期:2015-03-01 00:00:00
abstract::The relation between the right-side (RS) electrical impedance phase angle (PA) and segmental PA in five configurations at 50 kHz was analyzed in 23 peritoneal dialysis male patients before complete drainage of the abdominal cavity. The impedance vector (Z/H) components were standardized by the height H of the subjects...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/29/9/N01
更新日期:2008-09-01 00:00:00
abstract::Virtual shunt describes the overall loss of O2 content between the alveolar gas and arterial blood. Clinicians indirectly estimate the magnitude of the virtual shunt by monitoring peripheral blood oxygen saturation (SpO2) using non-invasive pulse oximetry. An inherent limitation of this method is the variable precisio...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/36/5/967
更新日期:2015-05-01 00:00:00
abstract::Plethysmographic measurement of airway resistance (R(aw)) has been determined by single-point analysis, usually at 50% of maximum inspiratory flow (MIF). Computer-assisted (best fit) analysis, however, allows R(aw) to be calculated by applying a regression line to any portion of the plethysmograph pressure-flow loop. ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/23/2/304
更新日期:2002-05-01 00:00:00
abstract::There is a lack of studies that examine the dynamics of heat-induced shrinkage of organ tissues. Clinical procedures such as radiofrequency ablation, microwave ablation or high-intensity focused ultrasound, use heat to treat diseases such as cancer and cardiac arrhythmia. When heat is applied to tissues, shrinkage occ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/1/55
更新日期:2014-01-01 00:00:00
abstract::Polysomnography (PSG) has been extensively studied for sleep staging, where sleep stages are usually classified as wake, rapid-eye-movement (REM) sleep, or non-REM (NREM) sleep (including light and deep sleep). Respiratory information has been proven to correlate with autonomic nervous activity that is related to slee...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/12/2529
更新日期:2014-12-01 00:00:00
abstract::A major problem confronting application of impedance techniques to studies of disease is the extraction of intrinsic properties of the tissue from the measured impedances, which unavoidably involve geometric factors as well. Amongst the foremost are the sizes and locations of the measuring electrode arrays, and this p...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/34/11/1513
更新日期:2013-11-01 00:00:00
abstract::Muscle injuries in the lower limb are common among professional football players. Classification is made according to severity and is diagnosed with radiological assessment as: grade I (minor strain or minor injury), grade II (partial rupture, moderate injury) and grade III (complete rupture, severe injury). Tetrapola...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/36/1/27
更新日期:2015-01-01 00:00:00
abstract::This study was done to introduce new parameters derived by time frequency analysis of heart rate variability data. Four simulation experiments were carried out to compare the short-time Fourier transform (STFT) analysis method to the traditional overall spectral analysis method. Sinusoidal signals were generated with ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/21/2/303
更新日期:2000-05-01 00:00:00
abstract::In recent AASM practice, parameter actimetry is cited to measure total sleep time in obstructive sleep apnoea patients, when polysomnography is not available. An actigraph was therefore compared to polysomnographic data in 28 subjects with known sleep disordered breathing. Total sleep time (TST), sleep period time (SP...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/31/12/005
更新日期:2010-12-01 00:00:00
abstract::The use of artificial neural networks (ANNs) to interpret sleep monitoring signals is described. Recordings from ten infants with apparent life threatening episodes were assigned into training feedforward R-PROP networks. In order to separate good signal from artefact, 60 second time frames of SaO2 and TcPO2 signals w...
journal_title:Physiological measurement
pub_type: 临床试验,杂志文章
doi:10.1088/0967-3334/21/3/401
更新日期:2000-08-01 00:00:00
abstract::In this study, we designed and tested a new algorithm, which we call the 'restricted parabola', to identify the optimum atrioventricular (AV) delay in patients with biventricular pacemakers. This algorithm automatically restricts the hemodynamic data used for curve fitting to the parabolic zone in order to avoid inadv...
journal_title:Physiological measurement
pub_type: 杂志文章,随机对照试验
doi:10.1088/0967-3334/36/9/1889
更新日期:2015-09-01 00:00:00
abstract::The state-dependent portion of cardio-vagal baroreflex control is called baroreflex hyteresis: we observe hysteresis when RR interval and carotid diameter depend on both the direction and value of arterial pressure. The elasticity of arterial walls, as well as the responsiveness of central command reset controls the r...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/31/6/009
更新日期:2010-06-01 00:00:00
abstract::Electrical impedance tomography (EIT) is a recent imaging technique based on electrical impedance, offering the possibility of measuring pulmonary perfusion. In the present study the influence of several pulmonary haemodynamical parameters on the EIT signal were investigated. First, the influence on the systolic wave ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/19/2/013
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:The healing of wounds is critical in protecting the human body against environmental factors. The mechanisms involving protein expression during this complex physiological process have not been fully elucidated. APPROACH:Here, we use reverse-phase protein microarrays (RPPA) involving 94 phosphoproteins to st...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/1361-6579/aaee19
更新日期:2018-12-07 00:00:00
abstract::A new method to image and quantify intra-abdominal haemorrhage using electrical impedance tomography (EIT) was tested in vivo. Supine peritoneal dialysis patients were monitored using an 8-electrode hemiarray placed on the anterior abdomen. EIT measurements were recorded using the EPack II data acquisition system befo...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/32/2/001
更新日期:2011-02-01 00:00:00
abstract::Capillary refill time (CRT) is a simple means of cardiovascular assessment which is widely used in clinical care. Currently, CRT is measured through manual assessment of the time taken for skin tone to return to normal colour following blanching of the skin surface. There is evidence to suggest that manually assessed ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/37/1/83
更新日期:2016-01-01 00:00:00
abstract::Part I of this series showed that the five-element circuit model accurately mimics impedances measured using multi-frequency electrical impedance myography (MFEIM), focusing on changes brought on by disease. This paper addresses two requirements which must be met if the method is to qualify for clinical use. First, th...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/34/2/223
更新日期:2013-02-01 00:00:00
abstract::Electrical impedance tomography (EIT) could be significantly advantageous to continuous monitoring of lung development in newborn and, in particular, preterm infants as it is non-invasive and safe to use within the intensive care unit. It has been demonstrated that accurate boundary form of the forward model is import...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/35/6/1149
更新日期:2014-06-01 00:00:00
abstract::Acupuncture (ACU) is known to be effective in ischemia treatment, and glutamate (GLU) excitotoxicity is an important factor in neuronal cell death. We observed the effect of ACU on cerebral blood flow (%CBF) and DeltaGLU (the changes in GLU release) in the ischemic stroke rat model of diabetic mellitus (DM). A global ...
journal_title:Physiological measurement
pub_type: 杂志文章
doi:10.1088/0967-3334/31/5/003
更新日期:2010-05-01 00:00:00