Abstract:
:This study was carried out to evaluate the utility of serological tests in the diagnosis of candidal infections in non-neutropenic critically ill patients. A prospective study was carried out in a 10-bed general intensive care unit; all patients with at least one organic sample with Candida spp. were included. A therapeutic-diagnostic algorithm was designed, and patients were treated or not, according to a classification. Blood samples were taken, and serological tests included: antigenaemia detection using two different commercial latex kits (Cand-Tec and Pastorex) and antibody detection by indirect haemagglutination (IHA) and indirect germ tube immunofluorescence (IFA). A total of 56% of antibody tests (IHA 45% and IFA 64%) and 26% of antigen tests (Cand-Tec 36% and Pastorex 17%) were positive. The sensitivity and specificity of these tests with respect to systemic candidosis were 37% and 78%, respectively, for antibodies, and 0% and 90% for antigens. There was statistical significance for mortality and low levels of antibodies; Candida glabrata was detected by IFA and Candida tropicalis by Cand-Tec. Serological tests may help to define the prognosis of these patients and to support the detection of specific Candida species.
journal_name
Mycosesjournal_title
Mycosesauthors
Ibàñez-Nolla J,Torres-Rodríguez JM,Nolla M,León MA,Mèndez R,Soria G,Díaz RM,Marrugat Jdoi
10.1046/j.1439-0507.2001.00616.xsubject
Has Abstractpub_date
2001-01-01 00:00:00pages
47-53issue
1-2eissn
0933-7407issn
1439-0507journal_volume
44pub_type
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