The utility of serology in diagnosing candidosis in non-neutropenic critically ill patients.

Abstract:

:This study was carried out to evaluate the utility of serological tests in the diagnosis of candidal infections in non-neutropenic critically ill patients. A prospective study was carried out in a 10-bed general intensive care unit; all patients with at least one organic sample with Candida spp. were included. A therapeutic-diagnostic algorithm was designed, and patients were treated or not, according to a classification. Blood samples were taken, and serological tests included: antigenaemia detection using two different commercial latex kits (Cand-Tec and Pastorex) and antibody detection by indirect haemagglutination (IHA) and indirect germ tube immunofluorescence (IFA). A total of 56% of antibody tests (IHA 45% and IFA 64%) and 26% of antigen tests (Cand-Tec 36% and Pastorex 17%) were positive. The sensitivity and specificity of these tests with respect to systemic candidosis were 37% and 78%, respectively, for antibodies, and 0% and 90% for antigens. There was statistical significance for mortality and low levels of antibodies; Candida glabrata was detected by IFA and Candida tropicalis by Cand-Tec. Serological tests may help to define the prognosis of these patients and to support the detection of specific Candida species.

journal_name

Mycoses

journal_title

Mycoses

authors

Ibàñez-Nolla J,Torres-Rodríguez JM,Nolla M,León MA,Mèndez R,Soria G,Díaz RM,Marrugat J

doi

10.1046/j.1439-0507.2001.00616.x

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

47-53

issue

1-2

eissn

0933-7407

issn

1439-0507

journal_volume

44

pub_type

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