Turbidometric characterization of the postantifungal effect: comparative studies with amphotericin B, 5-fluorocytosine and miconazole on Candida albicans.

Abstract:

:The phenomenon of persistent suppression of Candida albicans yeast cell growth after short drug exposures (postantifungal effect, PAFE) was determined by performing comparative studies using different concentrations of 5-fluorocytosine (5-FC), amphotericin B (AMPH) and miconazole (MCZ). An in vitro turbidometric method was used to measure cell growth and to quantitate the PAFE after removal of the drug by dilution following exposure to C. albicans yeast cells for 0.5 h, 1 h or 2 h. The PAFE was determined by the difference in time (h) required for growth of the control and test cultures to increase to the 0.5 absorbance level following removal of the antifungal agent. A PAFE was demonstrated with each agent and generally the length of the PAFE was dependent upon the concentration of the drug and the time of exposure. An exposure time of 0.5 h resulted in PAFEs ranging from 0.6 to 16.7 h with 5-FC, 0 to 16.5 h with AMPH and 0.1 to 14.1 h with MCZ. In most instances exposure of the cells to each drug for 1 or 2 h resulted in slightly longer PAFEs, respectively. Longer PAFEs were induced with lower concentrations of 5-FC as compared to AMPH and MCZ. The data from such PAFE assays may be useful for determining in vivo treatment regimens, since longer PAFEs may allow for intermittent dosing instead of continuous drug administration.

journal_name

Mycoses

journal_title

Mycoses

authors

Scalarone GM,Mikami Y,Kurita N,Ichihara Y,Yazawa K,Miyaji M

doi

10.1111/j.1439-0507.1991.tb00663.x

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

297-302

issue

7-8

eissn

0933-7407

issn

1439-0507

journal_volume

34

pub_type

杂志文章

相关文献

MYCOSES文献大全
  • A case of sporotrichosis treated successfully with oral fluconazole 200 mg once weekly.

    abstract::A case of fixed cutaneous sporotrichosis that developed on the extensor aspect of the left wrist of an 83-year-old woman was treated once a week with 200 mg of oral fluconazole. This dermatological lesion healed within 4 months, leaving a scar. No side-effects were seen. At the time of writing, 7 months after the end ...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.1994.tb00427.x

    authors: Yoshida M,Hiruma M,Tezuka T

    更新日期:1994-07-01 00:00:00

  • Small-dose itraconazole pulse therapy in the treatment of onychomycosis.

    abstract::The aim was to evaluate efficacy and tolerance of a short-schedule treatment regimen using a small dose of itraconazole in pulse intermittently. The open study evaluated the pulse therapy consisting of monthly 1-week cycles of oral itraconazole 200 mg daily for 2-3 consecutive months in 42 patients with onychomycosis....

    journal_title:Mycoses

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1439-0507.1997.tb00258.x

    authors: Wu J,Wen H,Liao W

    更新日期:1997-12-01 00:00:00

  • Scutular tinea of the scrotum: report of two cases.

    abstract::Infections caused by dermathophytes in the scrotal skin are uncommon especially due to Microsporum gypseum, which may form scutular or favus-like lesions. We report two patients with this type of tinea: one immune suppressed by HIV infection and another immunocompetent without comorbidity. In the literature we found o...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.2005.01097.x

    authors: Prochnau A,de Almeida HL Jr,Souza PR,Vetoratto G,Duquia RP,Defferrari R

    更新日期:2005-05-01 00:00:00

  • Is there a need for autopsies in the management of fungal disease?

    abstract::The autopsy rates in Germany became low like in other European, American and Asian countries. Main reasons for this development are the lack of acceptance of autopsy in the society as well as in the medical profession, the introduction of a requirement for consent, unclear legal position, the public health system, pre...

    journal_title:Mycoses

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0507.2007.01486.x

    authors: Knoke M,Bernhardt H,Schwesinger G

    更新日期:2008-07-01 00:00:00

  • Fungicidal activity and morphological alterations of Candida albicans induced by echinocandins: study of strains with reduced caspofungin susceptibility.

    abstract::Caspofungin is a member of the echinocandin class of antifungal compounds that inhibit 1,3-β-d-Glucan synthase. As patient exposure to caspofungin (CAS) broadens, the number of infecting strains with reduced susceptibility to this drug is expected to rise. In the present study, the in vitro effects of varying concentr...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.2009.01834.x

    authors: Dunyach C,Drakulovski P,Bertout S,Jouvert S,Reynes J,Mallié M

    更新日期:2011-07-01 00:00:00

  • The role of Candida infections as an adverse effect upon head and neck cancer patients undergoing therapeutic radiation and the effect of antimycotic treatment.

    abstract::Oral, pharyngeal and esophageal infections caused by Candida species occur very frequently when it comes to radiation therapy for head and neck cancer. In clinical terms oral candidosis is most often characterized by pseudomembranes or erythema. The erythematous form of oral candidosis has in particular to be distingu...

    journal_title:Mycoses

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0507.1989.tb02308.x

    authors: Poland JM

    更新日期:1989-01-01 00:00:00

  • [Differentiation and characterization of yeasts pathogenic for humans (Candida albicans, Exophiala dermatitidis) and algae pathogenic for animals (Prototheca spp.) using Fourier transform infrared spectroscopy (FTIR) in comparison with conventional method

    abstract::Due to the Fourier-Transform Infrared Spectroscopy (FT-IR) of strain specific traits demonstrated to be a suitable and efficient method for diagnostic and epidemiological determinations for the yeasts Candida albicans, Exophiala dermatitidis and the chlorophylless algae of the genus Prototheca. FT-IR leads in a rapid ...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.1998.tb00587.x

    authors: Schmalreck AF,Tränkle P,Vanca E,Blaschke-Hellmessen R

    更新日期:1998-01-01 00:00:00

  • Multicentre surveillance study on feasibility, safety and efficacy of antifungal combination therapy for proven or probable invasive fungal diseases in haematological patients: the SEIFEM real-life combo study.

    abstract:UNLABELLED:This multicentre observational study evaluated the feasibility, efficacy and toxicity of antifungal combination therapy (combo) as treatment of proven or probable invasive fungal diseases (IFDs) in patients with haematological malignancies. Between January 2005 and January 2010, 84 cases of IFDs (39 proven a...

    journal_title:Mycoses

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/myc.12161

    authors: Candoni A,Caira M,Cesaro S,Busca A,Giacchino M,Fanci R,Delia M,Nosari A,Bonini A,Cattaneo C,Melillo L,Caramatti C,Milone G,Scime' R,Picardi M,Fanin R,Pagano L,SEIFEM GROUP (Sorveglianza Epidemiologica Infezioni Fungine

    更新日期:2014-06-01 00:00:00

  • Evaluation of the new AspID polymerase chain reaction assay for detection of Aspergillus species: A pilot study.

    abstract::The newly developed AspID PCR assay for detection of Aspergillus spp. was evaluated with an interlaboratory quality control programme panel and human bronchoalveolar lavage fluid (BALF) samples. With the quality control programme, 8 out of 9 panel members were correctly identified. With the clinical study, 36 BALF sam...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/myc.12757

    authors: Prattes J,Hoenigl M,Zinke SE,Heldt S,Eigl S,Johnson GL,Bustin S,Stelzl E,Kessler HH

    更新日期:2018-06-01 00:00:00

  • Diagnostic value of serum galactomannan, (1,3)-β-d-glucan, and Aspergillus fumigatus-specific IgA and IgG assays for invasive pulmonary aspergillosis in non-neutropenic patients.

    abstract::Detection of serum galactomannan (GM) and (1,3)-β-d-glucan (BG) is considered useful for non-culture diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients. Only few studies evaluated these seromarkers in non-neutropenic patients suspected of having IPA. The aim of this study was to evaluate both ...

    journal_title:Mycoses

    pub_type: 杂志文章,多中心研究

    doi:10.1111/myc.12765

    authors: Dobias R,Jaworska P,Tomaskova H,Kanova M,Lyskova P,Vrba Z,Holub C,Svobodová L,Hamal P,Raska M

    更新日期:2018-08-01 00:00:00

  • Prophylaxis of fungal infections with itraconazole during remission-induction therapy.

    abstract::Deep fungal infections are an increasing problem in the treatment of acute leukemias and malignant lymphomas. Risk factors are known but unavoidable. Because of diagnostic difficulties most patients are treated empirically with intravenous amphotericin B. This drug's toxicity increases morbidity and mortality. An oral...

    journal_title:Mycoses

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1439-0507.1989.tb02298.x

    authors: Prentice AG,Bradford GR

    更新日期:1989-01-01 00:00:00

  • Tinea capitis due to Microsporum gypseum in an adult.

    abstract::A case of tinea capitis due to Microsporum gypseum in an adult is described. An otherwise healthy 69-year-old woman presented two large patches of slightly erythematous scaling alopecia localized on the vertex and on the left parietal region of the scalp. The only subjective sign was itching. A mycological culture was...

    journal_title:Mycoses

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0507.1998.tb00331.x

    authors: Offidani A,Simoncini C,Arzeni D,Cellini A,Amerio P,Scalise G

    更新日期:1998-05-01 00:00:00

  • Preanalytical conditions for broth microdilution antifungal susceptibility of Microsporum spp.

    abstract::Dermatophytoses caused by the genus Microsporum require a long-duration therapy compared to infections caused by other genera. Treatment of these cutaneous infections includes topical and systemic antifungal agents. Tinea capitis and tinea unguium caused by M. canis and M. gypseum are the most difficult-to-treat derma...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.2008.01503.x

    authors: Biancalana FS,Telles PF,Lyra L,Schreiber AZ

    更新日期:2008-07-01 00:00:00

  • Susceptibility of yeast isolates from defined German patient groups to 5-fluorocytosine.

    abstract::Susceptibility and development of resistance to 5-fluorocytosine (5-FC) in Candida strains isolated from defined German groups of probands was investigated. 5-FC susceptibility was determined in a microdilution assay in yeast nitrogen base after 24 h of incubation at 37 degrees C. The range of 5-FC concentration inves...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.1992.tb00839.x

    authors: Weber S,Polak A

    更新日期:1992-07-01 00:00:00

  • Short-course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania.

    abstract:BACKGROUND:Cryptococcal meningitis accounts for 15% of all AIDS mortality globally. Most cases in low- and middle-income countries are treated with fluconazole monotherapy, which is associated with a high mortality. New available therapies are needed. Short-course amphotericin B has been shown to be a safe and efficien...

    journal_title:Mycoses

    pub_type: 临床试验,杂志文章

    doi:10.1111/myc.12995

    authors: Katende A,Mbwanji G,Faini D,Nyuri A,Kalinjuma AV,Mnzava D,Hullsiek KH,Rhein J,Weisser M,Meya DB,Boulware DR,Letang E,KIULARCO Study Group.

    更新日期:2019-12-01 00:00:00

  • Evaluation of CHROMagar Candida for rapid screening of clinical specimens for Candida species.

    abstract::CHROMagar Candida is a new differential culture medium that allows selective isolation of yeasts and simultaneously identifies colonies of Candida albicans, Candida glabrata, Candida tropicalis and Candida krusei. We evaluated this medium and compared it with a reference medium, Sabouraud glucose agar, for the presump...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1046/j.1439-0507.1999.00406.x

    authors: Willinger B,Manafi M

    更新日期:1999-04-01 00:00:00

  • Ecthyma-like phaeohyphomycosis caused by Cladosporium cladosporioides.

    abstract::A case of cutaneous phaeohyphomycosis caused by Cladosporium cladosporioides in a 50-year-old housewife is described. The clinical presentation was an ecthyma-like crusted lesion on the back of her left hand. Scanning electron microscopy of the culture showed the conidiophores and the limoniform or ellipsoidal conidia...

    journal_title:Mycoses

    pub_type: 信件

    doi:10.1111/j.1439-0507.2009.01745.x

    authors: Duquia RP,de Almeida HL Jr,Vettorato G,Rocha NM,de Castro LA

    更新日期:2010-11-01 00:00:00

  • Effect of reducing agents on proteolytic and keratinolytic activity of enzymes of Microsporum gypseum.

    abstract::The effect of sodium sulphite, cysteine, glutathione, mercaptoethanol and dithioerythritol (0.1-10 mmol l-1) on the activity of proteases of Microsporum gypseum was studied using azocasein, cross-linked bovine serum albumin and keratin as substrates. With the substrate without disulphide bonds (casein) no stimulation ...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.1992.tb00892.x

    authors: Kunert J

    更新日期:1992-11-01 00:00:00

  • Production of extracellular collagenolytic proteinases by Histoplasma capsulatum var. duboisii and Histoplasma capsulatum var. capsulatum in the yeast phase.

    abstract::Yeast cultures of Histoplasma capsulatum var. duboisii and H. capsulatum var. capsulatum in collagen containing defined, semi-defined and complex media produced extracellular collagenolytic proteinases, assayed using 4-phenylazo-benzyloxycarbonyl-L-propyl-L-leucyl- glycyl-L-propyl-D-arginine, a specific collagenase su...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.1991.tb00860.x

    authors: Okeke CN,Müller J

    更新日期:1991-11-01 00:00:00

  • A 20-year survey of tinea faciei.

    abstract::Tinea faciei is an uncommon dermatophytosis affecting the glabrous skin of the face. Between 1988 and 2007 at the Dermatology Department of Cagliari University, 107 cases of tinea faciei have been diagnosed, involving 72 females and 35 males, aged 2-72 years. Incidence peaks were observed between 6 and 15 years (48.59...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.2009.01748.x

    authors: Nicola A,Laura A,Natalia A,Monica P

    更新日期:2010-11-01 00:00:00

  • Podopompholyx due to pemphigus vulgaris and Trichophyton rubrum infection. Report of an unusual case.

    abstract::We report the case of a 48-year old man who after a disease-free interval of 7 years developed a relapse of pemphigus vulgaris (PV) presenting as pompholyx of the left foot. The patient was first thought to suffer from a dyshidrosic form of tinea pedis due to Trichophyton rubrum. Although the concomitant occurrence of...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.1994.tb00790.x

    authors: Borradori L,Harms M

    更新日期:1994-03-01 00:00:00

  • Development of a nested PCR assay for the detection of Fusarium solani DNA and its evaluation in the diagnosis of invasive fusariosis using an experimental mouse model.

    abstract::Fusarium infections are increasingly being encountered in immunocompromised patients. Fusarium solani accounts for nearly half of these infections. A specific nested PCR (nPCR) assay has been developed by using DNA isolated from several Fusarium species and other common fungi. Furthermore, DNA samples isolated from br...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.2008.01657.x

    authors: Ahmad S,Khan ZU,Theyyathel AM

    更新日期:2010-01-01 00:00:00

  • [Treatment of superficial mycoses in the tropics. Results of a double-blind study in the Karonga District, Malawi].

    abstract::A double-blind trial was undertaken in Karonga District, Northern Malawi comparing Whitfield's cream (3% salicylic acid and 6% benzoylic acid) and clotrimazole cream in the treatment of dermatophyte infections of the skin. To date, 138 patients have been reviewed; 65 of these patients received Whitfield's cream and 73...

    journal_title:Mycoses

    pub_type: 临床试验,杂志文章

    doi:

    authors: Pönnighaus JM,Gooskens V,Clayton Y,Mkandawire P,Sterne J

    更新日期:1994-01-01 00:00:00

  • Distribution of dermatophytes and other related fungi in Jaipur city, with particular reference to soil pH.

    abstract::Screening of 217 soil samples of different habitats, such as PG study centre, garden, farmhouse, nursery, roadside, hostel, animal habitat, bird habitat, marriage garden, temple, vegetable market and house dust, was carried out for the presence of dermatophytes and related fungi in relation to soil pH. A total of 461 ...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.2009.01751.x

    authors: Jain N,Sharma M

    更新日期:2011-01-01 00:00:00

  • Reactive oxygen species and the bacteriostatic and bactericidal effects of isoconazole nitrate.

    abstract::Bacterial superinfections often occur in dermatomycoses, resulting in greatly inflamed or eczematous skin. The objective of this study was to evaluate the antibacterial efficacy of isoconazole nitrate (ISN), a broad-spectrum antimicrobial imidazole, commonly used to treat dermatomycoses. Several gram-positive bacteria...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/myc.12055

    authors: Czaika VA,Siebenbrock J,Czekalla F,Zuberbier T,Sieber MA

    更新日期:2013-05-01 00:00:00

  • Case report. Fatal Aspergillus flavus pericarditis in a patient with acute myeloblastic leukaemia.

    abstract::We report a case of Aspergillus flavus pericarditis treated with fluconazole for oral candidosis. The patient with acute myeloblastic leukaemia developed tachypnoea after antileukaemic chemotherapy. Pericardial effusion was seen in the echocardiogram. Aspergillus flavus was isolated from the pericardial fluid. The pat...

    journal_title:Mycoses

    pub_type: 信件

    doi:10.1046/j.1439-0507.2000.00540.x

    authors: Gökahmetoğlu S,Koç AN,Patiroğlu T

    更新日期:2000-01-01 00:00:00

  • Tinea pedis acquired in mosques?

    abstract::We present four cases of interdigital tinea pedis in Italian tourists which was probably acquired in Turkish mosques and holy Muslim places. In all patients mycological examinations were positive for Trichophyton rubrum. All patients were successfully treated with bifonazole cream (one application/day for three weeks)...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/myc.12775

    authors: Veraldi S,Esposito L,Gorani A

    更新日期:2018-11-01 00:00:00

  • Effectiveness of treatment of severe tinea pedis with 1% terbinafine cream in members of the Japanese self-defense forces.

    abstract::A clinical study was conducted to determine the efficacy of terbinafine cream in severe cases of tinea pedis. The subjects were 21 men, members of the Japanese Self-Defense Forces who were judged to have severe symptoms of tinea pedis. The description 'severe' was defined as 'considered to require the concurrent inter...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1046/j.1439-0507.1999.00487.x

    authors: Noguchi H,Hiruma M,Kawada A

    更新日期:1999-01-01 00:00:00

  • Pseudomembranous-like tinea of the scrotum: report of six cases.

    abstract::Six cases of tinea of the scrotum with atypical clinical features were observed in the dermatology department of our hospital between 2001 and 2007. The age of onset ranged from 14 to 26 years. Unusual clinical presentations of pseudomembranous-like disease were observed in every patient. Causative agents were Microsp...

    journal_title:Mycoses

    pub_type: 信件

    doi:10.1111/j.1439-0507.2008.01557.x

    authors: Lu S,Xi LY,Zhang JM,Lu CM

    更新日期:2009-05-01 00:00:00

  • Persistent oral candidosis by non-albicans Candida strains including Candida glabrata in a human immunodeficiency virus-infected patient observed over a period of 6 years.

    abstract::A 38-year-old woman infected with human immunodeficiency virus (HIV) presented with persistent oral candidosis in which non-albicans Candida strains were the predominant yeasts in most of the examinations performed over a period of 6 years. Oral treatment with fluconazole had no effect on clinical signs of oral candid...

    journal_title:Mycoses

    pub_type: 杂志文章

    doi:10.1111/j.1439-0507.1998.tb00347.x

    authors: Hoegl L,Thoma-Greber E,Röcken M,Korting HC

    更新日期:1998-09-01 00:00:00