Abstract:
:Detection of serum galactomannan (GM) and (1,3)-β-d-glucan (BG) is considered useful for non-culture diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients. Only few studies evaluated these seromarkers in non-neutropenic patients suspected of having IPA. The aim of this study was to evaluate both tests together with the Aspergillus fumigatus-specific serum IgG and IgA (IgAG) test for serological IPA diagnosis in non-neutropenic patients. Sera from 87 patients suspected of having IPA were retrospectively analysed. Patients were categorised into groups of proven IPA (n = 10), putative IPA (n = 31) and non-IPA colonisation (n = 46). When the GM, BG and IgAG assays were used for patients included in the study, the sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 48.8%/91.3%/83.3%/66.7%, 82.9%/73.9%/73.9%/82.9% and 75.6%/95.7%/93.9%/81.5%, respectively. Thus, the highest specificity and PPV were confirmed for the IgAG assay. Improvements in the sensitivity and NPV were achieved by "at least one positive" analysis with the GM and BG assays, with the sensitivity/specificity/PPV/NPV values being 85.0%/69.6%/71.4%/84.2%. Nevertheless, the highest sensitivity and NPV were achieved by the "at least one positive" analysis combining the GM, BG and IgAG tests (97.6% and 96.8%, respectively). The involvement of the IgAG assay could improve IPA diagnosis in non-neutropenic patients by increasing the sensitivity and NPV when combined with the GM or BG assays. Furthermore, improvement was achieved by combining the GM, BG and IgAG assays using the "at least one positive test" strategy, especially if doubt exists.
journal_name
Mycosesjournal_title
Mycosesauthors
Dobias R,Jaworska P,Tomaskova H,Kanova M,Lyskova P,Vrba Z,Holub C,Svobodová L,Hamal P,Raska Mdoi
10.1111/myc.12765subject
Has Abstractpub_date
2018-08-01 00:00:00pages
576-586issue
8eissn
0933-7407issn
1439-0507journal_volume
61pub_type
杂志文章,多中心研究相关文献
MYCOSES文献大全abstract::Interdigital ulcer is an exceptionally rare condition while erosio interdigitalis blastomycetica is common for candidiasis. Four Chinese patients with Candida interdigital ulcers were reported. The exudates were examined directly and cultured for fungi. Skin biopsies were stained with haematoxylin-eosin and periodic a...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2011.02023.x
更新日期:2011-11-01 00:00:00
abstract::This report analyses the frequency, the pattern and the severity of mycotic infection in a necropsy series of 103 bone marrow transplantations. Fungal infection was documented in 33 (32%) of all death cases. The risk of mycotic infection was increased in patients with graft failure and after retransplantation. At post...
journal_title:Mycoses
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::An in vitro microassay for the measurement of Candida albicans hyphal-form growth inhibition by myelomonocytic cells is described. The assay is rapid, easy-to-perform and objective. A Candida strain capable of in vitro dimorphic transition from yeast to hyphal form has been employed. The assay is based on the incorpor...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1991.tb00631.x
更新日期:1991-03-01 00:00:00
abstract::Candida species constitute the majority of nosocomial fungal pathogens in non-neutropenic patients. Candida infections are still connected with substantial mortality. Recent epidemiological observations indicate a shift to non-albicans species, especially because of a rise of infections caused by C. glabrata, which fr...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.2008.01527.x
更新日期:2008-01-01 00:00:00
abstract::A case of localized cutaneous cryptococcosis successfully treated with oral itraconazole is reported. The patient, a 63-year-old Japanese housewife, had had an erythematous and partly eroded lesion in the area of her right earlobe for about 10 months. No findings suggesting a primary focus of Cryptococcus infection we...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.1990.33.9-10.455
更新日期:1990-09-01 00:00:00
abstract::Different commercial enzyme-linked immunsorbent assays (ELISA) were evaluated in a preliminary study for diagnosis of systemic candidosis: Biomerica and Virotech GmbH, which allowed immunoglobulin G detection, and Platelia, which associated total antibody to antigen detection. They were tested with a home-made ELISA a...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.2002.00775.x
更新日期:2002-12-01 00:00:00
abstract::The effect of four media or media combinations on the growth and the in vitro susceptibility to amphotericin B, 5-fluorocytosine, fluconazole and itraconazole of 51 isolates of Cr. neoformans was studied. The drug concentration producing a 50% decrease in OD405 (IC50) was determined in microtiter format. The following...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1996.tb00125.x
更新日期:1996-05-01 00:00:00
abstract::Eight cases of imported mycetomata in The Netherlands are reviewed. Seven of these were cultured; only one isolate, Actinomadura madurae, belonged to a species commonly known as an agent of mycetoma. The remaining strains either belonged to very rare species, such as Phialophora cyanescens, or could not be identified ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1993.tb00693.x
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVES:Candidaemia carries a mortality of up to 40% and may be related to increasing complexity of medical care. Here, we determined risk factors for the development of candidaemia. METHODS:We conducted a prospective, multi-centre, case-control study over 12 months. Cases were aged ≥18 years with at least one bloo...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13211
更新日期:2020-11-13 00:00:00
abstract:BACKGROUND:Light microscopy to study the infection of fungi in skin specimens is time-consuming and requires automation. OBJECTIVE:We aimed to design and explore the application of an automated microscope for fungal detection in skin specimens. METHODS:An automated microscope was designed, and a deep learning model w...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13209
更新日期:2020-11-10 00:00:00
abstract::The report deals with three patients, who developed paracoccidioidomycosis in Europe after having been in South America 50, 25 and 38 years before, respectively. The conditions for the long period of quiescent infection and for the late manifestations are discussed. ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.0933-7407.2003.00914.x
更新日期:2003-01-01 00:00:00
abstract::Aspergillus infections are major causes of morbidity and mortality among immunocompromised patients. This study was designed to investigate the galactomannan assay optical density (OD) indices relative to the culture results in bronchoscopic samples obtained from neutropenic and non-neutropenic patients. Galactomannan...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12126
更新日期:2014-03-01 00:00:00
abstract::Although case series of talaromycosis have been reported in China, their detailed clinical and microbiological characteristics have never been systematically profiled. In this study, we report the clinical characteristics, molecular epidemiology, rapid identification and antifungal susceptibilities of talaromycosis in...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12887
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Invasive pulmonary aspergillosis (IPA) is a complication of respiratory bacterial and viral infections such as coronavirus disease 2019 (COVID-19). PATIENTS/METHODS:In University Hospital La Paz (Madrid, Spain), we reviewed the clinical and demographic characteristics of 10 patients with positive severe acu...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13155
更新日期:2020-08-04 00:00:00
abstract::The amount of protein released into liquid culture medium and weight loss were taken as measures of wool degradation by Trichophyton simii and Aspergillus niger. Protein released into the culture medium was observed to be greater after T. simii treatment than after A. niger treatment. Sulphitolysis was shown by T. sim...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1996.tb00103.x
更新日期:1996-11-01 00:00:00
abstract::The effect of sodium sulphite, cysteine, glutathione, mercaptoethanol and dithioerythritol (0.1-10 mmol l-1) on the activity of proteases of Microsporum gypseum was studied using azocasein, cross-linked bovine serum albumin and keratin as substrates. With the substrate without disulphide bonds (casein) no stimulation ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1992.tb00892.x
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Sporotrichosis is a subcutaneous mycosis caused by Sporothrix species that affects humans and animals. Little information on the genetic diversity and population structure of the pathogen is available for Brazil, which is needed to design effective strategies to tackle the advance of sporotrichosis in endemi...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13230
更新日期:2020-12-18 00:00:00
abstract::Although conventional identification of pathogenic fungi is based on the combination of tests evaluating their morphological and biochemical characteristics, they can fail to identify the less common species or the differentiation of closely related species. In addition these tests are time consuming, labour-intensive...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12365
更新日期:2015-10-01 00:00:00
abstract::Infections caused by dermathophytes in the scrotal skin are uncommon especially due to Microsporum gypseum, which may form scutular or favus-like lesions. We report two patients with this type of tinea: one immune suppressed by HIV infection and another immunocompetent without comorbidity. In the literature we found o...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2005.01097.x
更新日期:2005-05-01 00:00:00
abstract::The authors carried out research into anti-Malassezia precipitating antibodies in the population, specifying the distribution by age and sex. A total of 868 serum specimens from subjects of both sexes, aged between 0 and 80 years, were studied. An immunoelectroprecipitation reaction was used using a M. furfur culture ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1998.tb00337.x
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Acute myeloid leukaemia (AML) patients are at high risk of invasive aspergillosis (IA) after first induction chemotherapy (CHT). Although IA risk factors have been identified, few data are available on impact of IA, occurring during induction phase, on overall AML outcome. PATIENTS AND RESULTS:The end point...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13147
更新日期:2020-10-01 00:00:00
abstract::Scedosporium prolificans is a saprophytic fungus responsible for an increasing number of infections among immunocompromised hosts. Most disseminated S. prolificans infections prove fatal due to persistent neutropenia, and inherited resistance to currently available antifungal drugs. The authors report a fatal case of ...
journal_title:Mycoses
pub_type: 信件
doi:10.1111/j.1439-0507.2009.01765.x
更新日期:2011-01-01 00:00:00
abstract::A 45-year-old woman was found to have cerebral phaeohyphomycosis caused by an Exophiala species. The portal of entry of the fungus remained unknown. Despite surgery and antimycotic therapy the patient died from circulation failure. The fungus is compared to several related Exophiala species. ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1991.tb00651.x
更新日期:1991-05-01 00:00:00
abstract::The treatment of systemic candidal infection in neutropenic patients continues to be a major problem, and only 20% of patients survive despite treatment with amphotericin B (Amph B). Granulocyte colony-stimulating factor (G-CSF) is a haemopoietic glycoprotein that appears to control the survival, cycle, activation, pr...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1994.tb00783.x
更新日期:1994-03-01 00:00:00
abstract::Terbinafine was remarkably effective in tinea barbae due to Trichophyton rubrum on the cheek in front of the right ear in a 75-year-old man. This patient also showed tinea pedis and unguium, but these were due to Trichophyton mentagrophytes and were unrelated to the tinea in the cheek. This patient showed an atypical ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1998.tb00382.x
更新日期:1998-01-01 00:00:00
abstract::The work reported here is the first nationwide, multicenter surveillance study conducted in Korea to obtain data on fluconazole susceptibility of Candida albicans (C. albicans) isolates. A total of 1137 isolates of C. albicans obtained from 17 university hospitals in South Korea during the 6-month period, July through...
journal_title:Mycoses
pub_type: 信件,多中心研究
doi:10.1111/j.1439-0507.2006.01329.x
更新日期:2007-03-01 00:00:00
abstract::Deep fungal infections are an increasing problem in the treatment of acute leukemias and malignant lymphomas. Risk factors are known but unavoidable. Because of diagnostic difficulties most patients are treated empirically with intravenous amphotericin B. This drug's toxicity increases morbidity and mortality. An oral...
journal_title:Mycoses
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1439-0507.1989.tb02298.x
更新日期:1989-01-01 00:00:00
abstract::A 29-year-old female suffering from full-blown AIDS received fluconazole 400 mg day-1 for a long period for treatment of oral candidosis, pseudomembranous type. She had previously received this drug repeatedly for the same reason, yet manifest disease persisted. She was therefore put on parenteral amphotericin B, whic...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1994.tb00282.x
更新日期:1994-01-01 00:00:00
abstract::This work presents the epidemiology of dermatomycoses and their etiological agents of people living in the Lódź region, Central Poland, over the years 1987-1996. The analysis involved subjects referred by physicians to three major mycological laboratories in Lódź (covering the entire mycological diagnostics of the Lód...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.1999.00454.x
更新日期:1999-01-01 00:00:00
abstract::An atypical strain of Microsporum canis was isolated in our laboratory, which was characterized by a variety of polymorphous macroconidia. These are demonstrated by illustrations. Based on our observation and literature, the relationship between Microsporum canis and Microsporum distortum is discussed. Epidemiologic a...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1989.tb02167.x
更新日期:1989-01-01 00:00:00