Fluconazole-resistant oral candidosis in a repeatedly treated female AIDS patient.

Abstract:

:A 29-year-old female suffering from full-blown AIDS received fluconazole 400 mg day-1 for a long period for treatment of oral candidosis, pseudomembranous type. She had previously received this drug repeatedly for the same reason, yet manifest disease persisted. She was therefore put on parenteral amphotericin B, which led to clinical, but not mycological, cure in the short term. IC30 testing revealed a minimum inhibitory concentration (MIC) > 128 micrograms ml-1 for fluconazole. The isolate, however, was susceptible in vitro to ketoconazole, itraconazole and amphotericin B. The same antimicrobial susceptibility pattern was found with a second isolate obtained later. Resistance to fluconazole might become a major problem in HIV-infected patients receiving this drug for long periods.

journal_name

Mycoses

journal_title

Mycoses

authors

Thomas-Greber E,Korting HC,Bogner J,Goebel FD

doi

10.1111/j.1439-0507.1994.tb00282.x

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

35-8

issue

1-2

eissn

0933-7407

issn

1439-0507

journal_volume

37

pub_type

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