Abstract:
OBJECTIVES:Candidaemia carries a mortality of up to 40% and may be related to increasing complexity of medical care. Here, we determined risk factors for the development of candidaemia. METHODS:We conducted a prospective, multi-centre, case-control study over 12 months. Cases were aged ≥18 years with at least one blood culture positive for Candida spp. Each case was matched with two controls, by age within 10 years, admission within 6 months, admitting unit, and admission duration at least as long as the time between admission and onset of candidaemia. RESULTS:A total of 118 incident cases and 236 matched controls were compared. By multivariate analysis, risk factors for candidaemia included neutropenia, solid organ transplant, significant liver, respiratory or cardiovascular disease, recent gastrointestinal, biliary or urological surgery, central venous access device, intravenous drug use, urinary catheter and carbapenem receipt. CONCLUSIONS:Risk factors for candidaemia derive from the infection source, carbapenem use, host immune function and organ-based co-morbidities. Preventive strategies should target iatrogenic disruption of mucocutaneous barriers and intravenous drug use.
journal_name
Mycosesjournal_title
Mycosesauthors
Keighley CL,Pope A,Marriott DJE,Chapman B,Bak N,Daveson K,Hajkowicz K,Halliday C,Kennedy K,Kidd S,Sorrell TC,Underwood N,van Hal S,Slavin MA,Chen SCdoi
10.1111/myc.13211subject
Has Abstractpub_date
2020-11-13 00:00:00eissn
0933-7407issn
1439-0507pub_type
杂志文章相关文献
MYCOSES文献大全abstract::Invasive fungal disease (IFD) causes increasing morbidity and mortality in haematological cancer patients. Reliable cost data for treating IFD in German hospitals is not available. Objective of the study was to determine the institutional cost of treating the IFD. Data were obtained by retrospective chart review in Ge...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2012.02193.x
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:We aimed to implement and to assess the impact of the antifungal stewardship programme (AFSp) on prescription appropriateness of antifungals, management and outcomes of candidaemia patients, and antifungal consumption and costs at our solid organ transplant (SOT) institute. METHODS:Local epidemiology of invasi...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13098
更新日期:2020-07-01 00:00:00
abstract::Two topical formats containing clotrimazole [500 mg single dose vaginal tablet (VT) or 10% single dose vaginal cream (VC) for intravaginal use] combined with additional clotrimazole cream for topical application to the vulval area (Canesten 1 Combi, Bayer AG, Leverkusen, Germany) were compared with oral fluconazole 15...
journal_title:Mycoses
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1439-0507.2004.00970.x
更新日期:2004-04-01 00:00:00
abstract::Histoplasmosis is an important systemic mycosis in the Americas, Asia, and Africa. Increasingly cases are recognised in nonendemic areas. Proper management requires recognition of the clinical syndromes caused by Histoplasma capsulatum infection, familiarity with the uses and limitations of the diagnostic tests, an un...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.2006.01253.x
更新日期:2006-07-01 00:00:00
abstract::Using intraperitoneal (i. p.) infection of mice with Candida albicans we determined which parameters might be useful for characterization of virulence in this model. Upon i. p. infection of mice with two reference strains striking differences in lethality were detected. These differences in virulence corresponded with...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1999.tb00007.x
更新日期:1999-12-01 00:00:00
abstract::The effect of sodium sulphite, cysteine, glutathione, mercaptoethanol and dithioerythritol (0.1-10 mmol l-1) on the activity of proteases of Microsporum gypseum was studied using azocasein, cross-linked bovine serum albumin and keratin as substrates. With the substrate without disulphide bonds (casein) no stimulation ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1992.tb00892.x
更新日期:1992-11-01 00:00:00
abstract::The aim of this study was to evaluate the pharmacokinetics and efficacy of posaconazole (PSC) in combination with granulocyte colony-stimulating factor (G-CSF) in a neutropaenic murine model of disseminated zygomycosis (mucormycosis) due to Rhizopus microsporus. Male BALB/c mice were rendered neutropaenic with cycloph...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2010.01958.x
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Mycetoma is a pathological process in which fungal or actinomycotic agents of exogenous origin produce grains. In the absence of data on the global burden, it is important to map mycetoma cases, which are useful to implement control strategies. OBJECTIVE:The objective of this study was to map mycetoma cases...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13037
更新日期:2020-03-01 00:00:00
abstract::We describe an African histoplasmosis case in a 65-year-old Belgian living in Zaire for 46 years. Microscopic bone marrow examination showed Histoplasma. It was confirmed by cultures and hamster inoculation. Autopsy revealed a fungal dissemination by Histoplasma duboisii. ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1991.tb00620.x
更新日期:1991-01-01 00:00:00
abstract::Vulvovaginal candidiasis (VVC) is a hormonal-dependent infection but in contrast to sporadic VVC, therapy of recurrent vulvovaginal candidiasis (RVVC) is still unsolved. Long-term administration of medroxyprogesterone acetate was evaluated for the management of RVVC. Overall, 20 patients were treated with Depo-Provera...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12593
更新日期:2017-04-01 00:00:00
abstract::Histological changes of vaginal and ectocervical mucosa in women of reproductive age suffering from vaginal candidosis are described. The epithelial surface is covered with adherent masses composed of desquamated and destroyed epithelial cells and leucocytes impregnated with proteinaceous fluid and penetrated by pseud...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1992.tb00823.x
更新日期:1992-03-01 00:00:00
abstract::The prevalence of onychomycosis differs according to geographic area and over time and is influenced by several factors. The epidemiology of onychomycosis in Italy is still unclear. To evaluate the prevalence of onychomycosis in a representative sample of the Italian population a group of Dermatologists and General Pr...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12396
更新日期:2015-11-01 00:00:00
abstract::Candida albicans was maintained in various culture media and incubated with different concentrations of the antifungal agent rilopirox. After fixation, dehydration and embedding in Spurr's medium, the cells were analysed at the ultrastructural level to investigate morphological aspects of the antifungal mode of action...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1993.tb00727.x
更新日期:1993-11-01 00:00:00
abstract::The annual incidence of cryptococcosis during 1981-2000 was determined in subscribers of a large integrated health care program in Northern California and in those among them who were HIV positive. The incidence of cryptococcosis had been measured in this setting in the previous decade. The 20-year incidence per milli...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2004.01082.x
更新日期:2005-03-01 00:00:00
abstract::Pathogenicity of fungi is connected with their ability to easily penetrate the host tissues, survive in the infected host organism and use the elements of the host tissues as nutrients. Hence, the co-occurrence of pathogenic properties with the high enzymatic activity, which is manifested through the production of var...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2009.01696.x
更新日期:2010-05-01 00:00:00
abstract::CHROMagar Candida is a new differential culture medium that allows selective isolation of yeasts and simultaneously identifies colonies of Candida albicans, Candida glabrata, Candida tropicalis and Candida krusei. We evaluated this medium and compared it with a reference medium, Sabouraud glucose agar, for the presump...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.1999.00406.x
更新日期:1999-04-01 00:00:00
abstract::Paracoccidioides brasiliensis is a thermally dimorphic fungus agent of paracoccidioidomycosis, a deep-seated systemic infection of humans with high prevalence in Latin America. Until now no vaccine has been reported. Ionizing radiation can be used to attenuate pathogens for vaccine development and we have successfully...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2007.01389.x
更新日期:2007-09-01 00:00:00
abstract::Pityriasis versicolor (p.v.) is a superficial mycosis occurring frequently on the face. Epidemiological and clinical data regarding cases of p.v. on the face over a period of 11 years are discussed and some explanation given for conditions which favour facial involvement. This study underlines that face lesions of p.v...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1991.tb00674.x
更新日期:1991-07-01 00:00:00
abstract::Adherence of Candida has been implicated as the first step in the pathogenesis of oral candidosis, and germ tube formation, a contributory attribute. While chlorhexidine gluconate is by far the most common antiseptic mouthwash prescribed in dentistry, its intraoral concentration fluctuates considerably because of the ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2010.01915.x
更新日期:2011-09-01 00:00:00
abstract::The in vitro antifungal activity of D0870 against eight isolates of fluconazole-resistant Candida albicans was compared with that of itraconazole, ketoconazole and miconazole. The colorimetric MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide] assay was used to assess the antifungal activities. The...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1998.tb00709.x
更新日期:1998-12-01 00:00:00
abstract::To date, there has been only one published report on the infectious sclerokeratitis caused by Metarhizium anisopliae, which is an entomopathogenic fungus. Regarding corneal infection, three reports have been published to date. Although the prognoses of the corneal infections are favourable, prognosis when scleral infe...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/myc.12279
更新日期:2015-02-01 00:00:00
abstract::A case of tinea capitis due to Microsporum gypseum in an adult is described. An otherwise healthy 69-year-old woman presented two large patches of slightly erythematous scaling alopecia localized on the vertex and on the left parietal region of the scalp. The only subjective sign was itching. A mycological culture was...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.1998.tb00331.x
更新日期:1998-05-01 00:00:00
abstract::Studies of the genetic diversity of Candida albicans strains and the correlation between the antifungal susceptibility and gene diversity of C. albicans were carried out and the results were found to be inconsistent. To investigate antifungal susceptibility and genotypes of C. albicans strains from patients with vulvo...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2008.01539.x
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Invasive mould infections (IMIs) are very rare in patients with lymphoid malignancies. However, IMIs, mostly due to Aspergillus species, have been increasingly reported in such patients receiving ibrutinib (IBR). There is paucity of information regarding non-Aspergillus invasive mould infections (NAIMIs) in ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.13120
更新日期:2020-08-01 00:00:00
abstract::The aim of this study was to investigate a possible effect of optical brighteners on the growth of dermatophytes. Typical strains of Trichophyton rubrum, T. mentagrophytes, Microsporum canis and Epidermophyton floccosum were grown on agar plates containing two different brighteners of stilbenedisulfonic acid type in c...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.2003.00857.x
更新日期:2003-04-01 00:00:00
abstract::To evaluate caspofungin in high-risk invasive aspergillosis (IA) patient, a retrospective review of patient characteristics, antifungal therapies and clinical outcomes on hospitalised patients at sites in Russia, Canada, Germany, and Thailand was performed. Fifty-five patients were included, six with proven and 49 wit...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2010.01861.x
更新日期:2011-07-01 00:00:00
abstract::The prevalence of atopic dermatitis (AD) has been increasing. Whereas AD symptoms are obvious and easy to recognise, the etiopathogenesis remains not fully elucidated. Recently, the role of microorganisms and their impact on the immunology of AD have been discussed. In this review, we summarise a possible role of Mala...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/myc.12913
更新日期:2019-07-01 00:00:00
abstract::Anti-Candida antibodies were determined in 2053 sera with an indirect hemagglutination test (HAT; Labor Diagnostika, Heiden, Germany) and with an enzyme immunoassay (ELISA) which detects IgG antibodies (Institut Virion, Würzburg, Germany). Antigen diagnostics was performed with the Cand-Tec-test (Ramco, Houston, USA)....
journal_title:Mycoses
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The Aspergillus fumigatus group splits into the anamorphic A. fumigatus series and the teleomorphic Neosartorya fischeri series. The species A. fumigatus Fresenius is the most common species within the A. fumigatus series. Forty-seven clinical isolates out of the A. fumigatus group were obtained from patients with dis...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1997.tb00248.x
更新日期:1997-12-01 00:00:00
abstract::Fifty-four patients with human immunodeficiency virus (HIV) infection were studied to assess the load of oral carriage of Candida spp. The mean oral Candida carriage density (30,305.93 +/- 56,643.93 CFU ml(-1)) in HIV patients was significantly higher than that seen in the control population (93.48 +/- 358.48 CFU ml(-...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2008.01534.x
更新日期:2009-01-01 00:00:00