Abstract:
:Two topical formats containing clotrimazole [500 mg single dose vaginal tablet (VT) or 10% single dose vaginal cream (VC) for intravaginal use] combined with additional clotrimazole cream for topical application to the vulval area (Canesten 1 Combi, Bayer AG, Leverkusen, Germany) were compared with oral fluconazole 150 mg single dose treatment of vulvovaginal mycosis (VVM) in a single-blind clinical study. The objective of the study was to demonstrate the equivalent efficacy of the clotrimazole combination therapies (VT + 1% cream and VC + 2% cream), and fluconazole 150 mg oral capsule (Diflucan 1, Pfizer Gmbh, Karlsruhe, Germany) in terms of overall response defined as clinical cure and mycological resolution. Overall, combination therapies containing either clotrimazole 500 mg VTs or clotrimazole 10% VC were as effective as a single dose fluconazole 150 mg oral tablet in treating VVM with rates for overall response being 66%, 61% and 60%, respectively, after 14 days. There were no significant differences in the time to onset of symptom relief in the clotrimazole 500 mg tablet group and clotrimazole 10% VC compared with fluconazole 150 mg oral capsules. Only 50% of 88 patients across treatment groups with mycological recurrence also experienced return of symptoms over the entire 8 week follow-up period. All treatments administered were safe and well-tolerated and the number of patients experiencing adverse events was low.
journal_name
Mycosesjournal_title
Mycosesauthors
Mendling W,Krauss C,Fladung Bdoi
10.1111/j.1439-0507.2004.00970.xsubject
Has Abstractpub_date
2004-04-01 00:00:00pages
136-42issue
3-4eissn
0933-7407issn
1439-0507pii
MYC970journal_volume
47pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
MYCOSES文献大全abstract::For the first time in the history of German mycology, a multicenter study for identification of dermatophytes, yeasts and molds was conducted under the auspices of the German Speaking Mycological Society and the German Dermatological Society. A total of 1,008 dermatological offices and dermatology hospitals as well as...
journal_title:Mycoses
pub_type: 杂志文章,多中心研究
doi:
更新日期:2000-01-01 00:00:00
abstract::A case is presented of an 8-year-old boy suffering from disseminated verrucous lesions with some purulent drainage on his right foot, shank, thigh, scrotum, penis, perianal area and abdomen. Epidermophyton floccosum was isolated from these lesions. The patient was treated with oral ketoconazole for 4 months and the le...
journal_title:Mycoses
pub_type: 信件
doi:
更新日期:2001-01-01 00:00:00
abstract::Resistotyping was used to characterise 106 strains of Candida albicans classified as to whether they came from deep or superficial infections. The data were analysed by logistic regression analysis. There was a statistically significant difference between the two groups of strains. After removal of variables by the lo...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1995.tb00006.x
更新日期:1995-01-01 00:00:00
abstract::The autopsy rates in Germany became low like in other European, American and Asian countries. Main reasons for this development are the lack of acceptance of autopsy in the society as well as in the medical profession, the introduction of a requirement for consent, unclear legal position, the public health system, pre...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.2007.01486.x
更新日期:2008-07-01 00:00:00
abstract::Systematic studies about pet guinea pigs with dermatophytosis are rare. The aim of this study was to evaluate clinical signs, therapy and zoonotic risk of pet guinea pigs with dermatophytosis. Questionnaires from both owners (n = 74) of pet guinea pigs with dermatophytosis and their veterinarians (n = 101) were analys...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2012.02228.x
更新日期:2013-03-01 00:00:00
abstract::Mucor is a fungus, which give rise to opportunistic infection in immunocompromised patients. We described a 55-year-old immunocompetent woman with cutaneous mucormycosis after scorpion sting. Mucormycosis may happen in patients with intact immunity and is not allocated only to patients with immune deficiency. ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12066
更新日期:2013-09-01 00:00:00
abstract::We present four cases of interdigital tinea pedis in Italian tourists which was probably acquired in Turkish mosques and holy Muslim places. In all patients mycological examinations were positive for Trichophyton rubrum. All patients were successfully treated with bifonazole cream (one application/day for three weeks)...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12775
更新日期:2018-11-01 00:00:00
abstract::Scedosporium prolificans infections of normal hosts usually require extensive debridement and sometimes amputation to effect cure, due to the intrinsic resistance of this species to available antifungal agents. Newer agents have not tested favourably. Variable results are obtained with voriconazole, and 100% resistanc...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.2003.00878.x
更新日期:2003-06-01 00:00:00
abstract::The authors report a case of subcutaneous mucormycosis in a diabetic patient with verrucous lesions in the fourth finger of the right hand. Initially diagnosed as a fixed cutaneous sporotrichosis case, success was obtained with the use of potassium iodide with healing of the lesion in a period of nearly 5 months. At p...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.1990.33.5.241
更新日期:1990-05-01 00:00:00
abstract::Mucormycosis, previously termed as zygomycosis, is caused by fungi belonging to the order Mucorales and is a very severe disease in immunocompromised patients with an often unfavourable outcome. Given the high morbidity and mortality of mucormycosis, establishing a timely diagnosis followed by immediate treatment is o...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/myc.12203
更新日期:2014-09-01 00:00:00
abstract::Anaphylactic reactions to food containing allergens in the consumption or preparation of food are well known. However, allergy in the preparation of sausages has rarely been described. In the present study a 26-year-old-butcher was investigated who had a severe anaphylactic reaction developing sneezing, rhinitis, conj...
journal_title:Mycoses
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract::Among fungi, Curvularia inaequalis is a rare pathogen. We report the first case of non-invasive fungal rhinosinusitis caused by this species. Endoscopic sinus surgery revealed massive polyposis and the presence of viscous eosinophilic mucus that allowed the growth of the fungus. We diagnosed eosinophilic fungal rhinos...
journal_title:Mycoses
pub_type: 信件
doi:10.1111/j.1439-0507.2008.01671.x
更新日期:2010-01-01 00:00:00
abstract::We aimed to estimate the total number of serious fungal infections occurring yearly in Belgium. The number of cryptococcal infections was retrieved from the National Reference Center for Mycosis. Populations at risk and fungal infections frequencies in these populations were used to estimate incidence or prevalence of...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12389
更新日期:2015-10-01 00:00:00
abstract::Of 1400 pupils from two public primary schools in Ekpoma, Edo State, Nigeria, who were screened for dermatophyte infection, 188 (13.4%) were infected. The causative agents isolated included Microsporum audouinii in 88 (46.8%), Trichophyton mentagrophytes in 48 (25.5%), T. rubrum in 40 (21.3%), T. tonsurans in four (2....
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1996.tb00143.x
更新日期:1996-07-01 00:00:00
abstract::Posaconazole represents an antifungal extended-spectrum triazole whose absolute bioavailability following oral drug administration is considerably variable. Special conditions including increased gastric pH values, malabsorption syndrome, diarrhoea, intake on an empty stomach and some concomitantly administered potent...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2010.01984.x
更新日期:2011-01-01 00:00:00
abstract::A total of 122 Candida spp. strains, isolated from a group of 100 patients hospitalized in the Santa Casa de Misericordia of Belo Horizonte were assayed for in vitro susceptibility to amphotericin B, fluconazole, itraconazole, ketoconazole and flucytosine using a microbroth technique proposed by the National Committee...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1046/j.1439-0507.1999.00522.x
更新日期:1999-01-01 00:00:00
abstract::A valid and reliable measure that captures onychodystrophy disease severity is important for both clinical and research applications. Three hundred and twenty-two patients at two Veterans Affairs Medical Centers with clinical evidence of onychodystrophy suggesting onychomycosis (at least 25% in a distal subungual patt...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2007.01444.x
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Histoplasmosis is a frequent fungal infection in HIV/AIDS patients, with high morbimortality rates when diagnosis and treatment are delayed. Antibody detection, which is faster than the gold standard culture test, hastens the laboratory investigation. OBJECTIVES:To evaluate the role of WB for antibody detec...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/myc.12877
更新日期:2019-03-01 00:00:00
abstract::In patients with vulvovaginal mycosis systemic treatment is being discussed for eradication of possible fungal reservoirs, therefore, the efficacy and toleration of fluconazole, a triazole-derivative, has been investigated in the course of an open, comparative study. 104 patients with clinical, microscopic and cultura...
journal_title:Mycoses
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::The effect of three azole antifungals on inducible nitric oxide (iNOS) activity in different mouse and human cells was evaluated. The iNOS activity was determined by L-citrulline and nitrite measurement. In the murine macrophage cell line RAW 264.7, in mouse peritoneal macrophages (MPM) and in human colorectal adenoca...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1997.tb00200.x
更新日期:1997-09-01 00:00:00
abstract::The aim was to evaluate efficacy and tolerance of a short-schedule treatment regimen using a small dose of itraconazole in pulse intermittently. The open study evaluated the pulse therapy consisting of monthly 1-week cycles of oral itraconazole 200 mg daily for 2-3 consecutive months in 42 patients with onychomycosis....
journal_title:Mycoses
pub_type: 临床试验,杂志文章
doi:10.1111/j.1439-0507.1997.tb00258.x
更新日期:1997-12-01 00:00:00
abstract::Studies on the prevalence of tinea pedis, a frequently encountered dermatophytic infection, have been conducted mostly in swimmers although people who regularly practise other types of physical activities may also have a high rate of clinical or subclinical infection. This investigation was undertaken to establish the...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1993.tb00685.x
更新日期:1993-01-01 00:00:00
abstract::The in vitro and in vivo tolerance of sertaconazole gel, a new topical azole antifungal, was studied. Ketoconazole gel (Panfungol) was used as a reference substance. The methods applied for tolerance assessment were the bovine corneal opacity and permeability test for the in vitro assay and a modified Draize test for ...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1996.tb00085.x
更新日期:1996-01-01 00:00:00
abstract::Cutaneous infections by Zygomycetes may have underestimated clinical consequences. Apophysomyces elegans is a Zygomycete that rarely causes disease in humans. However, it has been reported with increasing frequency in warm climate zones as a result of infection in healthy patients after injury to the cutaneous barrier...
journal_title:Mycoses
pub_type: 信件
doi:10.1111/j.1439-0507.2009.01698.x
更新日期:2010-05-01 00:00:00
abstract::Dermatophytoses are of worldwide distribution. Epidemiological studies concerning dermatophyte infections have been performed in many countries and differences in the incidence and the aetiological agents have been reported in different geographical locations. This study was undertaken to investigate the prevailing sp...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2007.01403.x
更新日期:2007-11-01 00:00:00
abstract::Oral terbinafine (Lamisil, Novartis Pharma AG, Basel, Switzerland) is an effective therapy for fungal infections of the skin and nails. A post-marketing surveillance study was undertaken to evaluate the clinical efficacy and safety of oral terbinafine. A total of 454 patients with clinically and mycologically confirme...
journal_title:Mycoses
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1439-0507.1999.00515.x
更新日期:1999-01-01 00:00:00
abstract::Interdigital ulcer is an exceptionally rare condition while erosio interdigitalis blastomycetica is common for candidiasis. Four Chinese patients with Candida interdigital ulcers were reported. The exudates were examined directly and cultured for fungi. Skin biopsies were stained with haematoxylin-eosin and periodic a...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.2011.02023.x
更新日期:2011-11-01 00:00:00
abstract::Cytostatic chemotherapy of hematological malignancies if often complicated by neutropenia, which increases the risk of infections, especially if the neutrophil count is below 500/ml. Frequently, fever is the first and in most patients the only sign of an infection. Unexplained fever is defined as follows: temperature ...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::The in vitro hair perforation test as described by Ajello and George, was applied to eight species of Chrysosporium and one species each of Microsporum and Trichophyton. Six of them were found to perforate hair while four were negative. Chr. keratinophilum, M. gypseum and Tr. vanbreuseghemii were able to perforate and...
journal_title:Mycoses
pub_type: 杂志文章
doi:10.1111/j.1439-0507.1989.tb02255.x
更新日期:1989-07-01 00:00:00
abstract::A case of tinea capitis due to Microsporum gypseum in an adult is described. An otherwise healthy 69-year-old woman presented two large patches of slightly erythematous scaling alopecia localized on the vertex and on the left parietal region of the scalp. The only subjective sign was itching. A mycological culture was...
journal_title:Mycoses
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0507.1998.tb00331.x
更新日期:1998-05-01 00:00:00