Can intravenous antifungal therapy be safely used in the outpatient parenteral antimicrobial therapy (OPAT) setting?


:Outpatient parenteral antimicrobial therapy (OPAT) is an established treatment option for patients with a variety of infections who require a period of intravenous therapy, are clinically stable, and do not require continuous monitoring. Many patients with fungal infections require prolonged therapy due to resistance or intolerance to oral antifungal agents. Despite the widespread use of OPAT by infection specialists, antifungal agents appear infrequently used in this setting. We suggest that with appropriate patient selection, patients with fungal infections could successfully be treated on OPAT.






Rae N,Kenny C,Muldoon EG




Has Abstract


2019-03-01 00:00:00














  • Susceptibility of Trichophyton rubrum to griseofulvin.

    abstract::Two hundred and seventy isolates of Trichophyton rubrum from 182 patients were subjected to susceptibility testing with griseofulvin according to Granade & Artis. A slight modification of the method concerning homogenization procedures gave better growth of controls in our investigation. In 245 cases an MIC could be d...


    pub_type: 杂志文章


    authors: Scholz R,Meinhof W

    更新日期:1991-09-01 00:00:00

  • Isolation of Cryptococcus neoformans from pigeon (Columba livia) droppings in Mexico City.

    abstract::To determine the ecological and epidemiological significance of pigeon excrement in cryptococcosis in Mexico City, 251 samples of pigeon droppings were studied. These were collected from houses, public buildings, churches, parks and pigeon nests. Each sample was suspended 1:10 in isotonic saline solution and then cult...


    pub_type: 杂志文章


    authors: Castanón-Olivares LR,López-Martínez R

    更新日期:1994-09-01 00:00:00

  • Management of human immunodeficiency virus-associated cryptococcal meningitis: Current status and future directions.

    abstract::Cryptococcal meningitis (CM) is one of the most common opportunistic infections of acquired immunodeficiency syndrome (AIDS), as well as an important cause of hospitalisation and death. In recent years, the mortality of CM has remained high in HIV/AIDS population, with up to 30%, including within developed countries. ...


    pub_type: 杂志文章,评审


    authors: Wu X,Shen Y

    更新日期:2019-10-01 00:00:00

  • Case Reports. Chronic and acute Aspergillus meningitis.

    abstract::Cerebral aspergillosis usually occurs in severely immunocompromized hosts, is difficult to diagnose, and has a poor prognosis. After 14 months of chronic meningitis, ventriculitis, choroid plexitis, and lumbar arachnoiditis, which was complicated by acute hydrocephalus, Aspergillus, suspected to be from the candidus g...


    pub_type: 信件


    authors: Moling O,Lass-Floerl C,Verweij PE,Porte M,Boiron P,Prugger M,Gebert U,Corradini R,Vedovelli C,Rimenti G,Mian P

    更新日期:2002-12-01 00:00:00

  • Screening examination and treatment of Trichophyton tonsurans infection in judo athletes affiliated with the University Judo Federation of Tokyo.

    abstract::In Japan, Trichophyton tonsurans infection has become an increasing problem among combat sports participants. We investigated the prevalence of T. tonsurans infection in athletes affiliated to judo clubs in the 21 First Division universities that were registered with the University Judo Federation of Tokyo in 2008. St...


    pub_type: 杂志文章


    authors: Hirose N,Suganami M,Ogawa YS,Hiruma M,Ogawa H

    更新日期:2011-07-01 00:00:00

  • Case of femoral pseudarthrosis due to Scedosporium apiospermum in an immunocompetent patient with successful conservative treatment and review of literature.

    abstract::Scedosporium apiospermum is a ubiquitous filamentous fungus, commonly found in soil, sewage and polluted waters. It is rarely pathogenic but can cause a broad spectrum of clinical diseases, which can be localised or disseminate to distant organs. The disseminated form of the disease is mostly seen among immunocompromi...


    pub_type: 杂志文章,评审


    authors: Dinh A,Demay O,Rottman M,Gaudot F,Bougnoux ME,Bouchand F,Coignard H,Rouzaud C,Davido B,Duran C,Nich C

    更新日期:2018-06-01 00:00:00

  • Small-dose itraconazole pulse therapy in the treatment of onychomycosis.

    abstract::The aim was to evaluate efficacy and tolerance of a short-schedule treatment regimen using a small dose of itraconazole in pulse intermittently. The open study evaluated the pulse therapy consisting of monthly 1-week cycles of oral itraconazole 200 mg daily for 2-3 consecutive months in 42 patients with onychomycosis....


    pub_type: 临床试验,杂志文章


    authors: Wu J,Wen H,Liao W

    更新日期:1997-12-01 00:00:00

  • Tinea incognito in children: 54 cases.

    abstract::The incidence of tinea incognito (TI) appears to have increased over recent years, although no large series of cases has been reported in children. The aim of this study was to analyse the main epidemiological, clinical and microbiological characteristics of TI diagnosed in children in comparison with other tineas. We...


    pub_type: 杂志文章


    authors: del Boz J,Crespo V,Rivas-Ruiz F,de Troya M

    更新日期:2011-05-01 00:00:00

  • Case report. Monascus purpureus--a new fungus of allergologic relevance.

    abstract::Anaphylactic reactions to food containing allergens in the consumption or preparation of food are well known. However, allergy in the preparation of sausages has rarely been described. In the present study a 26-year-old-butcher was investigated who had a severe anaphylactic reaction developing sneezing, rhinitis, conj...


    pub_type: 杂志文章


    authors: Hipler UC,Wigger-Alberti W,Bauer A,Elsner P

    更新日期:2002-02-01 00:00:00

  • Anti-Malassezia furfur antibodies in the population.

    abstract::The authors carried out research into anti-Malassezia precipitating antibodies in the population, specifying the distribution by age and sex. A total of 868 serum specimens from subjects of both sexes, aged between 0 and 80 years, were studied. An immunoelectroprecipitation reaction was used using a M. furfur culture ...


    pub_type: 杂志文章


    authors: Faggi E,Pini G,Campisi E,Gargani G

    更新日期:1998-09-01 00:00:00

  • Molecular-based assessment of diversity and population structure of Sporothrix spp. clinical isolates from Espírito Santo-Brazil.

    abstract:BACKGROUND:Sporotrichosis is a subcutaneous mycosis caused by Sporothrix species that affects humans and animals. Little information on the genetic diversity and population structure of the pathogen is available for Brazil, which is needed to design effective strategies to tackle the advance of sporotrichosis in endemi...


    pub_type: 杂志文章


    authors: da Cruz Bahiense Rocha I,Terra PPD,Cardoso de Oliveira R,Lubianca Zanotti R,Falqueto A,de Camargo ZP,Rodrigues AM,Gonçalves SS

    更新日期:2020-12-18 00:00:00

  • Disseminated histoplasmosis in acquired immunodeficiency syndrome patients in Uberaba, MG, Brazil.

    abstract::Histoplasmosis occurs in approximately 5% of acquired immunodeficiency syndrome (AIDS) patients in endemic areas and often evolves to a disseminated picture if diagnosis is delayed and/or CD4 count falls below 150 cells x mm(3) without high active antiretroviral therapy (HAART). This report presents clinical features ...


    pub_type: 杂志文章


    authors: Mora DJ,dos Santos CT,Silva-Vergara ML

    更新日期:2008-03-01 00:00:00

  • Use of cell surface protein typing for genotyping of azole-resistant and -susceptible Aspergillus fumigatus isolates in Iran.

    abstract::Aspergillus fumigatus is the leading cause of mortality in severely immunocompromised individuals. Understanding pathogen dispersion and relatedness is essential for determining the epidemiology of nosocomial infections. Therefore, the aim of this study was to investigate the diversity and putative origins of clinical...


    pub_type: 杂志文章


    authors: Falahatinejad M,Vaezi A,Fakhim H,Abastabar M,Shokohi T,Zahedi N,Ansari S,Meis JF,Badali H

    更新日期:2018-02-01 00:00:00

  • Sinocranial aspergillosis: a form of central nervous system aspergillosis in south India.

    abstract::Of the 21 patients with aspergillosis of central nervous system seen during the years 1990-1997, 16 (76%) had aspergillosis of sino-cranial origin. The occupation in patients with sino-cranial aspergillosis was either agricultural or manual work and predisposing risk factors were present in only two (12.5%) patients. ...


    pub_type: 杂志文章


    authors: Murthy JM,Sundaram C,Prasad VS,Purohit AK,Rammurti S,Laxmi V

    更新日期:2001-01-01 00:00:00

  • Usefulness of serum galactomannan in initiating and modifying antifungal therapy in children with cancer and persistent high-risk febrile neutropenia.

    abstract:BACKGROUND:Invasive fungal disease is a major cause of morbidity and mortality in children with cancer and high-risk febrile neutropenia (HRFN). Repeated serum galactomannan (sGM) measurements have been described as an effective tool to guide therapy in adults under suspicion of invasive aspergillosis. However, the uti...


    pub_type: 杂志文章


    authors: Delgado-Araneda M,Valenzuela R,de la Maza V,Rabello M,Álvarez AM,Contardo V,Zubieta M,Gutierrez V,Claverie X,Torres JP,Salgado C,Tordecilla J,Varas M,Avilés CL,Venegas M,Villarroel M,Santolaya ME

    更新日期:2020-08-01 00:00:00

  • Activated CD8+ T cells are involved in elimination of Candida albicans from the livers of mice.

    abstract::We have investigated the course of infection of Balb/c mice with Candida albicans. After intravenous infection of mice, the yeasts were evenly distributed in the liver sections. There was a 90% reduction in the yeasts found within 7 days after infection. This reduction was accompanied by an increase in the number of p...


    pub_type: 杂志文章


    authors: Kretschmar M,Jung C,Fontagnier E,Quade B,Nichterlein T,Hof H

    更新日期:1997-01-01 00:00:00

  • Antifungal susceptibility and genotypes of Candida albicans strains from patients with vulvovaginal candidiasis.

    abstract::Studies of the genetic diversity of Candida albicans strains and the correlation between the antifungal susceptibility and gene diversity of C. albicans were carried out and the results were found to be inconsistent. To investigate antifungal susceptibility and genotypes of C. albicans strains from patients with vulvo...


    pub_type: 杂志文章


    authors: Liu XP,Fan SR,Bai FY,Li J,Liao QP

    更新日期:2009-01-01 00:00:00

  • An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital.

    abstract::Multidrug-resistant Candida auris has emerged as a cause of insidious hospital outbreaks and complicated infections. We present the analysis of an ongoing C. auris outbreak including the largest published series of C. auris bloodstream infection. All C. auris-positive patients from April-2016 to January-2017 were incl...


    pub_type: 杂志文章


    authors: Ruiz-Gaitán A,Moret AM,Tasias-Pitarch M,Aleixandre-López AI,Martínez-Morel H,Calabuig E,Salavert-Lletí M,Ramírez P,López-Hontangas JL,Hagen F,Meis JF,Mollar-Maseres J,Pemán J

    更新日期:2018-07-01 00:00:00

  • Cure of orthopaedic infection with Scedosporium prolificans, using voriconazole plus terbinafine, without the need for radical surgery.

    abstract::Scedosporium prolificans infections of normal hosts usually require extensive debridement and sometimes amputation to effect cure, due to the intrinsic resistance of this species to available antifungal agents. Newer agents have not tested favourably. Variable results are obtained with voriconazole, and 100% resistanc...


    pub_type: 杂志文章


    authors: Gosbell IB,Toumasatos V,Yong J,Kuo RS,Ellis DH,Perrie RC

    更新日期:2003-06-01 00:00:00

  • Confocal laser scanning microscopy as a new valuable tool in the diagnosis of onychomycosis - comparison of six diagnostic methods.

    abstract::Onychomycosis is common and can mimic several different nail disorders. Accurate diagnosis is essential to choose the optimum antifungal therapy. The aim of this study was to evaluate the use of confocal laser scanning microscopy (CLSM) and optical coherence tomography (OCT) as new non-invasive diagnostic tools in ony...


    pub_type: 杂志文章


    authors: Rothmund G,Sattler EC,Kaestle R,Fischer C,Haas CJ,Starz H,Welzel J

    更新日期:2013-01-01 00:00:00

  • Antifungal susceptibility of Candida species isolated from patients with candidemia in southern Taiwan, 2007-2012: impact of new antifungal breakpoints.

    abstract::The Clinical and Laboratory Standard Institute (CLSI) revised the clinical breakpoints (CBPs) for the azoles and echinocandins against Candida species in 2012. We aimed to report the epidemiology of candidemia and antifungal susceptibility of Candida species and evaluate the impact of new CBPs on antifungal susceptibi...


    pub_type: 杂志文章


    authors: Chen YC,Kuo SF,Chen FJ,Lee CH

    更新日期:2017-02-01 00:00:00

  • Detection of Candida dubliniensis in oropharyngeal samples from human immunodeficiency virus infected and non-infected patients and in a yeast culture collection.

    abstract::The incidence of Candida dubliniensis in oropharyngeal swabs of 132 human immunodeficiency virus (HIV)-positive and 89 HIV-negative patients was determined. The samples were plated onto CHROMagar Candida medium and 82 strains, presumptively identified as C. albicans or C. dubliniensis, were further investigated (tempe...


    pub_type: 杂志文章


    authors: Faggi E,Pini G,Campisi E,Martinelli C,Difonzo E

    更新日期:2005-05-01 00:00:00

  • Our recommendations for avoiding exposure to fungi outside the hospital for patients with haematological cancers.

    abstract::Despite several chemotherapeutic and preventative advances, opportunistic fungal infections remain common unintended consequences of cancer treatment. Currently, cancer patients spend most of their time between treatments at home, where they can inadvertently come across potential hazards from environmental and food s...


    pub_type: 杂志文章,评审


    authors: Ariza-Heredia EJ,Kontoyiannis DP

    更新日期:2014-06-01 00:00:00

  • Paracoccidioidomycosis: a series of 66 patients with oral lesions from an endemic area.

    abstract::Paracoccidioidomycosis (PCM) is the most important systemic mycosis in Latin America. It has been regarded as a multifocal disease, with oral lesions as the prominent feature. To provide useful information concerning the diagnosis and management of the disease, this study describes demographic and clinical data from t...


    pub_type: 杂志文章


    authors: Brazão-Silva MT,Andrade MF,Franco T,Ribeiro RI,Silva Wdos S,Faria G,Faria PR,Cardoso SV,Loyola AM

    更新日期:2011-07-01 00:00:00

  • Pityriasis versicolor of the face.

    abstract::Pityriasis versicolor (p.v.) is a superficial mycosis occurring frequently on the face. Epidemiological and clinical data regarding cases of p.v. on the face over a period of 11 years are discussed and some explanation given for conditions which favour facial involvement. This study underlines that face lesions of p.v...


    pub_type: 杂志文章


    authors: Terragni L,Lasagni A,Oriani A

    更新日期:1991-07-01 00:00:00

  • The aetiological agents of superficial cutaneous mycoses in Jos, Plateau State of Nigeria.

    abstract::A survey of superficial skin mycoses was carried out among miners and office workers employed in different establishments in Jos, Nigeria. Mycotic infection was demonstrable by microscopy and culture in 45 (10.4%) subjects: 20 males and 25 females. Malassezia furfur was the predominant aetiological agent, followed by ...


    pub_type: 杂志文章


    authors: Ayanbimpe GH,Bello CS,Gugnani HC

    更新日期:1995-05-01 00:00:00

  • Distribution of keratinophilic fungi in desert soil of Kuwait.

    abstract::Forty soil samples from different desert localities in Kuwait were surveyed for keratinophilic and geophilic dermatophytic fungi. Sixteen species classified in 9 genera were recovered on wool baits. Chrysosporium species were the most common fungi: Chr. tropicum (60%), Chr. pannicola (32.5%), Chr. queenslandicum (27.5...


    pub_type: 杂志文章


    authors: al-Musallam AA

    更新日期:1989-06-01 00:00:00

  • Oral candidosis and associated Candida species in HIV-infected Cambodians exposed to antimycotics.

    abstract::Although human immundeficiency virus (HIV) infection is endemic in Southeast Asia, data on oral mycotic flora in this disease in Asians are sparse. The aim of this study was to determine the prevalence of Candida species in HIV-infected Cambodians with oral candidosis, unexposed (group 1) and exposed to antimycotics (...


    pub_type: 杂志文章


    authors: Schmidt-Westhausen AM,Bendick C,Reichart PA,Samaranayake LP

    更新日期:2004-10-01 00:00:00

  • Impact of invasive aspergillosis occurring during first induction therapy on outcome of acute myeloid leukaemia (SEIFEM-12B study).

    abstract:BACKGROUND:Acute myeloid leukaemia (AML) patients are at high risk of invasive aspergillosis (IA) after first induction chemotherapy (CHT). Although IA risk factors have been identified, few data are available on impact of IA, occurring during induction phase, on overall AML outcome. PATIENTS AND RESULTS:The end point...


    pub_type: 杂志文章


    authors: Candoni A,Farina F,Perruccio K,Di Blasi R,Criscuolo M,Cattaneo C,Delia M,Zannier ME,Dragonetti G,Fanci R,Martino B,Del Principe MI,Fianchi L,Vianelli N,Chierichini A,Garzia M,Petruzzellis G,Nadali G,Verga L,Busca A

    更新日期:2020-10-01 00:00:00

  • Cutaneous purulent aspergillosis in a young man with chronic granulomatous disease.

    abstract::We describe a case of cutaneous purulent aspergillosis in a 19-year-old man with chronic granulomatous disease (CGD) treated successfully with a 6-month regimen of itraconazole. The therapeutic effect of the drug was seen after 1 month of administration. Surgical treatment of the skin lesions, although first planned, ...


    pub_type: 杂志文章


    authors: Chatzipanagiotou S,Takou K,Perogamvros A

    更新日期:1998-11-01 00:00:00