Abstract：
:Five week old, commercially available large white pigs were vaccinated with either a single dose or two doses of a recombinant porcine adenovirus expressing the glycoprotein D gene from pseudorabies virus (PRV). Pigs were monitored for the development of serum neutralizing antibodies to PRV and challenged 3 weeks after final vaccination. Prior to challenge, pigs given 2 doses of the vaccine demonstrated boosted levels of antibody compared with those given a single dose, and all surviving pigs had increased neutralization titres over pre-challenge levels. Following challenge, pigs were monitored for clinical signs of disease, with blood and nasal swabs collected for virus isolation. All control animals became sick with elevated temperatures for 6 days post challenge, whereas; vaccinated animals displayed an increase in body temperature for only 2-3 days. Control pigs and those given a single dose all lost condition, but the group given 2 doses remained healthy. At postmortem, gross lesions of pneumonia only occurred in control animals and those given a single dose of vaccine. Histology carried out on the brains of all animals demonstrated a difference in severity of infection and frequency of immunohistochemical antigen detection between test animals, with control and single dose groups being most severely affected and pigs given 2 doses the least. Virus isolation studies demonstrated that no viraemia could be detected, but virus was found in nasal swabs from some animals in both groups of vaccinates following challenge.
journal_name
Vaccinejournal_title
Vaccineauthors
Hammond JM,Jansen ES,Morrissy CJ,van der Heide B,Goff WV,Williamson MM,Hooper PT,Babiuk LA,Tikoo SK,Johnson MAdoi
10.1016/s0264-410x(01)00084-6subject
Has Abstractpub_date
2001-06-14 00:00:00pages
3752-8issue
27eissn
0264-410Xissn
1873-2518pii
S0264-410X(01)00084-6journal_volume
19pub_type
杂志文章相关文献
VACCINE文献大全abstract：INTRODUCTION:It is suspected that Web 2.0 web sites, with a lot of user-generated content, often support viewpoints that link autism to vaccines. METHODS:We assessed the prevalence of the views supporting a link between vaccines and autism online by comparing YouTube, Google and Wikipedia with PubMed. Freedom of speec...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.01.078
更新日期：2015-03-17 00:00:00
abstract：:In Bangladesh, full vaccination rates among children living in rural hard-to-reach areas and urban streets are low. We conducted a quasi-experimental pre-post study of a 12-month mobile phone intervention to improve vaccination among 0-11 months old children in rural hard-to-reach and urban street dweller areas. Softw...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2015.11.024
更新日期：2016-01-04 00:00:00
abstract：OBJECTIVE:Rotavirus is the most common cause of severe diarrhea in children. Two rotavirus vaccines (RotaTeq and Rotarix) have been licensed in Taiwan. We have investigated whether routine infant immunization with either vaccine could be cost-effective in Taiwan. METHODS:We modeled specific disease outcomes including ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.01.023
更新日期：2009-03-04 00:00:00
abstract：:Capsular polysaccharides are important virulence factors of Streptococcus pneumoniae. The polysaccharide has been used as a component of vaccines against pneumococcal diseases either as plain polysaccharide or better conjugated to a protein. The last one is the vaccine of choice to target child protection. The immune ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.09.047
更新日期：2012-11-19 00:00:00
abstract：:A short-term toxicity study was performed to investigate local reactions and haematological changes after intramuscular (i.m.) injection of meningococcal vaccine with a concentration of 25 or 50 micrograms protein ml-1. In these meningococcal vaccines up to 75 micrograms Zwittergent ml-1 was used to form a protein-det...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(88)90142-9
更新日期：1988-10-01 00:00:00
abstract：:Varicella-zoster virus (VZV) is the causative agent of varicella and zoster. The varicella vaccine was developed to control VZV infection in children. The currently available Oka vaccine strain is the only live varicella vaccine approved by the World Health Organization. We previously cloned the complete genome of the...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2014.11.001
更新日期：2016-01-04 00:00:00
abstract：:HIV-1 specific cellular immune responses play a significant part in controlling HIV-1 viral replication and are an important component of an HIV-1 vaccine induced immune response. We reported earlier that recombinant DNA vaccine delivered intramuscularly, and recombinant Listeria monocytogenes, delivered orally induce...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.08.016
更新日期：2006-05-22 00:00:00
abstract：:Enterohemorrhagic Escherichia coli (EHEC) comprise an important group of enteric pathogens causing hemorrhagic colitis and hemolytic uremic syndrome. These bacteria need EspA (E) as a conduct for Tir (T) delivery to the host cell and surface arrayed intimin (I) which docks the bacterium to the translocated Tir. This p...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2010.07.061
更新日期：2010-10-04 00:00:00
abstract：:Enterovirus type 71 (EV71) and coxsackievirus A 16 (CA16) are recognized as the major pathogens responsible for human hand-foot-mouth disease. To develop a bivalent EV71-CA16 vaccine, rhesus macaques immunized with two doses of this vaccine via the intradermal route were challenged with EV71 or CA16, and their clinica...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.12.057
更新日期：2020-02-18 00:00:00
abstract：:Vaccination with viral-based vaccines continues to hold promise for the prevention of malaria. Whilst antigen-specific T cell responses are considered a major aim of such an approach, a role for induced NK cells as anti-malarial effector cells, or in shaping T cell responses, has received less attention. In this study...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2009.09.132
更新日期：2009-12-10 00:00:00
abstract：:Vaccine induced responses are often weaker in those individuals most susceptible to infection, namely the very young and the elderly, highlighting the need for safe and effective vaccine adjuvants. Herein we evaluated different archaeosome formulations as an adjuvant to the H1N1 influenza hemagglutinin protein and com...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.07.010
更新日期：2019-11-08 00:00:00
abstract：BACKGROUND:By the time clinical symptoms of Alzheimer's disease (AD) manifest in patients there is already substantial tau pathology in the brain. Recent evidence also suggests that tau pathology can become self-propagating, further accelerating disease progression. Over the last decade several groups have tested the e...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2017.03.020
更新日期：2017-04-11 00:00:00
abstract：:Successful vaccination of mice against an otherwise lethal challenge with the Peru strain of Trypanosoma cruzi necessitates the induction of a strong cell mediated immune response. Previously, immunization of mice with the paraflagellar rod proteins from Trypanosoma cruzi90% reduction in parasitemia in immunized mice ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(99)00380-1
更新日期：2000-01-31 00:00:00
abstract：:After 16 years of no vaccination against pertussis in Sweden, mass vaccination of infants and catch-up vaccination of children up to 10 years with a monocomponent pertussis toxoid vaccine was performed in the Greater Gothenburg area of Sweden between 1995 and 1999. At the end of the project in February 1999, 56% of al...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2011.01.021
更新日期：2011-03-16 00:00:00
abstract：BACKGROUND:Persons with primary immunodeficiency disorders (PIDD) who receive oral poliovirus vaccine (OPV) or are household contacts of OPV recipients are at risk of excreting immunodeficiency-associated vaccine-derived polioviruses (iVDPVs). iVDPVs can be transmitted and cause paralytic polio. The objective of this s...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2012.06.017
更新日期：2012-08-03 00:00:00
abstract：:Extensive glycosylation and variable loops of the HIV envelope protein (Env) are reported to shield some neutralizing epitopes. Here, we investigated the immunogenicity of mutated HIV Envs presented in virus-like particles (VLPs). We immunized mice with simian human immunodeficiency virus (SHIV) VLPs containing mutant...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.01.107
更新日期：2007-05-10 00:00:00
abstract：:Some important vaccines, including ones against tuberculosis (Tb) and foot-and-mouth disease (FMD), are not used in many developed countries because there is no simple way to differentiate between vaccine-induced immunity and infection. Eliminating major protein antigens has not succeeded in the cases of Tb, FMD and s...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2005.01.008
更新日期：2005-03-18 00:00:00
abstract：:This study sought to explore how parents respond to competing media messages about vaccine safety. Six focus groups with mothers of infants were shown television vignettes of typical pro- and anti-vaccination claims. Thematic analysis of transcripts was undertaken. Mothers expressed surprise and concern about alleged ...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2006.05.010
更新日期：2006-11-30 00:00:00
abstract：:The baculovirus-insect cell expression system is a well known tool for the production of complex proteins. The technology is also used for commercial manufacture of various veterinary and human vaccines. This review paper provides an overview of how this technology can be applied to produce a multitude of vaccine cand...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2012.01.016
更新日期：2012-02-27 00:00:00
abstract：:The IgG isotype response in Balb/c mice infected with FMDV or immunized with different vaccine formulations using inactivated virus particles as antigen was analyzed at various times post-inoculation. For this purpose an ELISA based on polyclonal antibodies for detection and quantification of mouse IgG isotypes with F...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/0264-410x(95)00078-f
更新日期：1995-07-01 00:00:00
abstract：:The efficacy of a novel inactivated Lawsonia intracellularis vaccine, Porcilis® Lawsonia, was compared to that of a commercially available live attenuated vaccine in three experimental vaccination-challenge studies in pigs. The efficacy of the new vaccine was further tested under field conditions on a farm with a hist...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.02.067
更新日期：2019-04-03 00:00:00
abstract：:A novel recombinant hepatitis B vaccine, trademarked Sci-B-Vac, was evaluated for safety, tolerability and immunogenicity in an open label trial performed in Singapore. The experimental vaccine, derived from Chinese hamster ovary (CHO) cells, consists of hepatitis B surface antigen (HBsAg) particles harbouring all thr...
journal_title：Vaccine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0264-410x(92)90391-v
更新日期：1992-01-01 00:00:00
abstract：:Potential vaccine strategies against otitis media are to prevent (1) symptomatic infections in the middle ear and/or (2) carriage of pneumococci and thereby subsequent middle ear infections. The possibility of using immunity to virulence proteins of pneumococci to elicit immunity against pneumococci has been examined....
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(00)00285-1
更新日期：2000-12-08 00:00:00
abstract：:The purpose of the NIAID/FDA joint workshop, "correlates of immunity for pneumococcal conjugate vaccines (PCVs)," was to discuss the present understanding of protective immunity against invasive pneumococcal disease and identify in vitro measures that may represent immunologic correlates in future clinical trials. Ani...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/s0264-410x(03)00025-2
更新日期：2003-05-16 00:00:00
abstract：:When the hypothesis of a link between vaccination and a possible adverse outcome arises, further investigation is required to confirm or refute the suspicion. Given the rarity of most serious adverse effects, a case-control approach will often be chosen. This paper discusses aspects of the design, analysis and interpr...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/s0264-410x(02)00147-0
更新日期：2002-06-07 00:00:00
abstract：BACKGROUND:Diabetes is associated with higher risk of hospitalization, morbidity, and mortality from influenza. We assessed influenza vaccination coverage among adults aged ≥ 18 years with diabetes during the 2007-08 through 2017-18 influenza seasons and identified factors independently associated with vaccination duri...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2020.08.008
更新日期：2020-09-29 00:00:00
abstract：:Meningococcal disease is a serious medical condition that can prove fatal within hours in otherwise healthy individuals. Disease incidence is highest in infants, yet there is no broadly protective quadrivalent vaccine that covers this age group. A new investigational quadrivalent meningococcal glycoconjugate vaccine a...
journal_title：Vaccine
pub_type： 杂志文章,评审
doi：10.1016/j.vaccine.2009.07.036
更新日期：2009-09-18 00:00:00
abstract：:Chitosan is a polysaccharide capable of augmenting immune responses with a proven safety record in animals and humans. These properties make it a potentially attractive agent for the prevention and treatment of infectious disease. Infection by respiratory syncytial virus (RSV) is the leading cause of serious lower res...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2019.06.003
更新日期：2019-07-09 00:00:00
abstract：:At the Netherlands Vaccine Institute (NVI) a vaccine against Neisseria meningitidis serogroup B organisms based on different porA subtypes contained in outer membrane vesicles (OMVs) is in advanced stage of development and will be evaluated in clinical trial studies in the near future. In order to meet the expected de...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2007.06.008
更新日期：2007-08-21 00:00:00
abstract：:Across the developing world peste des petits ruminants virus places a huge disease burden on agriculture, primarily affecting the production of small ruminant. The disease is most effectively controlled by vaccinating sheep and goats with live attenuated vaccines that provide lifelong immunity. However, the current va...
journal_title：Vaccine
pub_type： 杂志文章
doi：10.1016/j.vaccine.2014.10.050
更新日期：2015-01-09 00:00:00
