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Hsp27-induced MMP-9 expression is influenced by the Src tyrosine protein kinase yes.

Abstract：

:The small heat shock protein hsp27 is associated with aggressive tumor behavior in certain subsets of breast cancer patients. Previously we demonstrated that hsp27 overexpression in breast cancer cells increased in vitro and in vivo invasiveness, suggesting that hsp27 influences the metastatic process. To investigate this role for hsp27, we have utilized MDA-MB-231 breast cancer cells that overexpress hsp27 and cDNA expression array technology. We demonstrate that hsp27 overexpression up-regulates MMP-9 expression and activity and down-regulates Yes expression. Furthermore, our results suggest that Yes may be involved in regulating MMP-9 expression, as well as in vitro invasion. Reconstitution of Yes expression by transfection into hsp27-overexpressing cells decreased MMP-9 expression, and increased in vitro invasiveness, abrogating the phenotype conferred by hsp27 overexpression. Therefore, our results provide a new potential mechanism by which hsp27 affects the metastatic cascade-through regulation of MMP-9 and Yes expression.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hansen RK,Parra I,Hilsenbeck SG,Himelstein B,Fuqua SA

doi

10.1006/bbrc.2001.4548

subject

Has Abstract

pub_date

2001-03-23 00:00:00

pages

186-93

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)94548-6

journal_volume

282

pub_type

杂志文章

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