Abstract：
:Early endocytic membrane traffic is regulated by the small GTPase Rab5, which cycles between GTP- and GDP-bound states as well as between membrane and cytosol. The latter cycle depends on GDI, which functions as a Rab vehicle in the aqueous environment of the cytosol. Here, we report that formation of the GDI:Rab5 complex is stimulated by a cytosolic factor that we purified and then identified as p38 MAPK. We find that p38 regulates GDI in the cytosolic cycle of Rab5 and modulates endocytosis in vivo. Our observations reveal the existence of a cross-talk between endocytosis and the p38-dependent stress response, thus providing molecular evidence that endocytosis can be regulated by the environment.
journal_name
Mol Celljournal_title
Molecular cellauthors
Cavalli V,Vilbois F,Corti M,Marcote MJ,Tamura K,Karin M,Arkinstall S,Gruenberg Jdoi
10.1016/s1097-2765(01)00189-7subject
Has Abstractpub_date
2001-02-01 00:00:00pages
421-32issue
2eissn
1097-2765issn
1097-4164pii
S1097-2765(01)00189-7journal_volume
7pub_type
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