Antinociceptive interaction between spinal clonidine and lidocaine in the rat formalin test: an isobolographic analysis.

Abstract:

UNLABELLED:Clinical and basic science studies suggest that spinal alpha-2-adrenergic receptor agonists and local anesthetics produce analgesia, but interaction between alpha-2-adrenergic receptor agonists and local anesthetics in the persistent pain model has not been examined. In the present study, using isobolographic analysis, we investigated the antinociceptive interaction of intrathecal clonidine and lidocaine in the rat formalin test. Sprague-Dawley rats were implanted with chronic lumbar intrathecal catheters, and were tested for paw flinch by formalin injection. Biphasic painful behavior was counted. Intrathecal clonidine (3-12 nmol) was administered 15 min before formalin, and intrathecal lidocaine (375-1850 nmol) was administered 5 min before formalin. To examine the interaction of intrathecal clonidine and lidocaine, an isobolographic design was used. Spinal administration of clonidine produced dose-dependent suppression of the biphasic responses in the formalin test. Spinal lidocaine resulted in dose-dependent transient motor dysfunction and the motor dysfunction recovered to normal at 10-15 min after administration. Spinal lidocaine produced dose-dependent suppression of phase-2 activity in the formalin test. Isobolographic analysis showed that the combination of intrathecal clonidine and lidocaine synergistically reduced Phase-2 activity. We conclude that intrathecal clonidine synergistically interacts with lidocaine in reducing the nociceptive response in the formalin test. IMPLICATIONS:Preformalin administration of intrathecal clonidine and lidocaine dose-dependently produced antinociception in the formalin test. The combination of clonidine and lidocaine, synergistically produced suppression of nociceptive response in the persistent pain model.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Hao S,Takahata O,Iwasaki H

doi

10.1097/00000539-200103000-00034

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

733-8

issue

3

eissn

0003-2999

issn

1526-7598

journal_volume

92

pub_type

杂志文章
  • Pro- and anticonvulsant effects of anesthetics (Part I)

    abstract::Many inhaled anesthetics and intravenous analgesics have been alleged to produce both proconvulsant and anticonvulsant activity in humans. The reasons for these contrasting actions on the CNS are poorly understood at the present time. However, biologic variability plays an important role in determining individual pati...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/00000539-199003000-00013

    authors: Modica PA,Tempelhoff R,White PF

    更新日期:1990-03-01 00:00:00

  • Acute toxicity of ropivacaine compared with that of bupivacaine.

    abstract::The acute central nervous and cardiovascular effects of the local anesthetics ropivacaine and bupivacaine were compared in 12 volunteers in a randomized double-blind manner with use of intravenous infusions at a rate of 10 mg/min up to a maximal dose of 150 mg. The volunteers were all healthy men. They were familiariz...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Scott DB,Lee A,Fagan D,Bowler GM,Bloomfield P,Lundh R

    更新日期:1989-11-01 00:00:00

  • Autotriggering during pressure support ventilation due to cardiogenic oscillations.

    abstract::Newer generation anesthesia machines are equipped with a pressure support mode of ventilation, which can be used to support spontaneous ventilation in anesthetized patients. The Drager Apollo anesthesia machine uses an inspiratory limb hot-wire flow sensor to measure inspiratory flow rates. Detected flow rates that ex...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ane.0b013e3181a9d75a

    authors: Sheikh E,Maguire DP,Gratch D

    更新日期:2009-08-01 00:00:00

  • Paravertebral blockade for day-case breast augmentation: a randomized clinical trial.

    abstract:BACKGROUND:Bilateral breast augmentation is an increasingly popular day-case procedure. Local infiltration with sedation is routinely used for its ease of application compared with the more complex and potentially riskier paravertebral blockade (PVB). We hypothesized that ropivacaine injected by experienced anesthesia ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0b013e318264ba33

    authors: Gardiner S,Rudkin G,Cooter R,Field J,Bond M

    更新日期:2012-11-01 00:00:00

  • Hydroxyethyl Starch 130/0.4 and Its Impact on Perioperative Outcome: A Propensity Score Matched Controlled Observation Study.

    abstract:BACKGROUND:Adverse effects of hydroxyethyl starches (HESs) have been verified in patients suffering from sepsis or kidney disease, but not in surgical patients at large. The investigation aimed to determine whether the use of HES 130/0.4 was associated with the incidence of acute postinterventional adverse events compa...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0000000000002778

    authors: Pagel JI,Rehm M,Kammerer T,Hulde N,Speck E,Briegel J,Reinholz F,Crispin A,Hofmann-Kiefer KF

    更新日期:2018-06-01 00:00:00

  • The effect of maternal cocaine exposure on neonatal rat cardiac function.

    abstract::Fetal cocaine exposure has been associated with a variety of cardiovascular dysfunctions in humans. We treated pregnant rats with either saline or cocaine at 60 mg/kg by gastric lavage for the entire gestational period and for 14 days after parturition. We then performed high-frequency transthoracic echocardiography t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ane.0000074792.87311.db

    authors: Sun LS,Takuma S,Lui R,Homma S

    更新日期:2003-09-01 00:00:00

  • Diagnostic Accuracy of Point-of-Care Gastric Ultrasound.

    abstract:BACKGROUND:Pulmonary aspiration of gastric contents is associated with significant perioperative morbidity and mortality. Previous studies have investigated the validity, reliability, and possible clinical impact of gastric ultrasound for the assessment of gastric content at the bedside. In the present study, we examin...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ANE.0000000000003372

    authors: Kruisselbrink R,Gharapetian A,Chaparro LE,Ami N,Richler D,Chan VWS,Perlas A

    更新日期:2019-01-01 00:00:00

  • Effect of volatile anesthetics on vecuronium-induced neuromuscular blockade in children.

    abstract::We studied 60 children undergoing elective surgery to evaluate the effect of interactions between vecuronium and isoflurane or halothane on the potency and duration of neuromuscular blockade, as measured by electromyography. Vecuronium was first administered by a logarithm-based cumulative method (14, 22, 35, 56, 89 m...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/00000539-199003000-00003

    authors: Pittet JF,Melis A,Rouge JC,Morel DR,Gemperle G,Tassonyi E

    更新日期:1990-03-01 00:00:00

  • Ultrasound-guided peripheral nerve stimulator placement in two soldiers with acute battlefield neuropathic pain.

    abstract::Acute peripheral neuropathic pain after combat-related polytrauma is a common occurrence in the United States military that is often refractory to current drugs and regional anesthesia. Both spinal cord and peripheral nerve stimulation are successfully used for chronic neuropathic pain states, but are not reported for...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/ANE.0b013e318247f6b2

    authors: Kent M,Upp J,Spevak C,Shannon C,Buckenmaier C 3rd

    更新日期:2012-04-01 00:00:00

  • Modern wireless telecommunication technologies and their electromagnetic compatibility with life-supporting equipment.

    abstract::Hospitals rely on pagers and ordinary telephones to reach staff members in emergency situations. New telecommunication technologies such as General Packet Radio Service (GPRS), the third generation mobile phone system Universal Mobile Telecommunications System (UMTS), and Wireless Local Area Network (WLAN) might be ab...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000180216.83554.00

    authors: Wallin MK,Marve T,Hakansson PK

    更新日期:2005-11-01 00:00:00

  • Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis.

    abstract:BACKGROUND:Recent research suggests that 6% hydroxyethyl starch (HES) 130/0.4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy. METHODS:We performed a systematic review and...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1213/ANE.0b013e318236b4d6

    authors: Gattas DJ,Dan A,Myburgh J,Billot L,Lo S,Finfer S,CHEST Management Committee.

    更新日期:2012-01-01 00:00:00

  • Effect of naloxone infusion on analgesia and respiratory depression after epidural fentanyl.

    abstract::The efficacy of two dosage regimens of intravenous naloxone were compared to avoid nonrespiratory side effects and respiratory depression and yet to preserve analgesia (maximum tolerance to periostial pressure over the tibia) after administration of 200 micrograms epidural fentanyl. Three groups of eight patients were...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章

    doi:

    authors: Gueneron JP,Ecoffey Cl,Carli P,Benhamou D,Gross JB

    更新日期:1988-01-01 00:00:00

  • A vein entry indicator device for facilitating peripheral intravenous cannulation in children: a prospective, randomized, controlled trial.

    abstract:BACKGROUND:Vascular access is often technically difficult in children because of the small caliber and impalpability of the veins. In this study, we sought to determine if use of the Vein Entry Indicator Device (VEIDtrade mark) in children facilitates peripheral venous access. METHODS:Two-hundred-two healthy (ASA grad...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e318185cdab

    authors: Simhi E,Kachko L,Bruckheimer E,Katz J

    更新日期:2008-11-01 00:00:00

  • Bunegin-Albin catheter improves air retrieval and resuscitation from lethal venous air embolism in upright dogs.

    abstract::Three types of catheters, the Arrow multi-orifice catheter, the American Edwards 7 Fr Swan-Ganz catheter and the Cook Bunegin-Albin multi-orifice CVP catheter were evaluated for their ability to retrieve venous air emboli and effect on the success rate of resuscitation from venous air emboli. The catheters were insert...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Colley PS,Artru AA

    更新日期:1989-03-01 00:00:00

  • The effect of peripheral resistance on impedance cardiography measurements in the anesthetized dog.

    abstract::In the vasodilated and septic patient, the impedance method of measuring cardiac output (CO) may underestimate the true value. In this study, we sought to determine whether impedance CO (COIC) measurements are influenced by total peripheral resistance (TPR). In eight anesthetized and ventilated dogs, a high-precision ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000150602.40554.EB

    authors: Critchley LA,Peng ZY,Fok BS,James AE

    更新日期:2005-06-01 00:00:00

  • Central poststroke pain: a review of pathophysiology and treatment.

    abstract:BACKGROUND:Central poststroke pain (CPSP) is a disabling morbidity occurring in 8%-14% of patients with stroke. It is infrequently recognized and difficult to manage. OBJECTIVE:We systematically reviewed the pathophysiology and treatment of CPSP. METHODS:We conducted a Medline search using the key words "central post...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ane.0b013e31819d644c

    authors: Kumar B,Kalita J,Kumar G,Misra UK

    更新日期:2009-05-01 00:00:00

  • Incidence, Prediction, and Causes of Unplanned 30-Day Hospital Admission After Ambulatory Procedures.

    abstract:BACKGROUND:Unanticipated hospital admission is regarded as a measure of adverse perioperative patient care. However, previously published studies for risk prediction after ambulatory procedures are sparse compared to those examining readmission after inpatient surgery. We aimed to evaluate the incidence and reasons for...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究

    doi:10.1213/ANE.0000000000004852

    authors: Teja B,Raub D,Friedrich S,Rostin P,Patrocínio MD,Schneider JC,Shen C,Brat GA,Houle TT,Yeh RW,Eikermann M

    更新日期:2020-08-01 00:00:00

  • The effects of intravenous lidocaine administration on the minimum alveolar concentration of isoflurane in cats.

    abstract::Lidocaine decreases the minimum alveolar concentration (MAC) of inhaled anesthetics and has been used clinically to reduce the requirements for other anesthetic drugs. In this study we examined the effects of lidocaine on isoflurane MAC in cats. Six cats were studied. In Experiment 1, the MAC of isoflurane was determi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/01.ANE.0000139350.88158.38

    authors: Pypendop BH,Ilkiw JE

    更新日期:2005-01-01 00:00:00

  • Cardiac electrophysiologic effects of pancuronium.

    abstract::A microelectrode examination of guinea pig left ventricular papillary muscle was performed to determine whether there was a direct effect of pancuronium on cardiac cells and, if so, to attempt to ascertain the mechanism of this effect. Electrical events were measured before and during superfusion with pancuronium, epi...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Jacobs HK,Lim S,Salem MR,Rao TL,Mathru M,Smith BD

    更新日期:1985-07-01 00:00:00

  • Efficacy of high-frequency jet ventilation in cardiac tamponade.

    abstract::To evaluate the effects of high-frequency jet ventilation (HFJV) (f = 60, 120 breaths/min) and conventional mechanical ventilation (CMV) (f = 10, 20) during equivalent conditions of cardiac tamponade, stroke index (SI), intrapericardial pressure (IPP), airway pressure (P(aw)), and cardiac pressures were measured in an...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199004000-00006

    authors: Goto K,Goto H,Benson KT,Unruh GK,Arakawa K

    更新日期:1990-04-01 00:00:00

  • The effect of sedation on intracranial pressure in patients with an intracranial space-occupying lesion: remifentanil versus propofol.

    abstract:BACKGROUND:In this study, we compared the effect of light sedation with remifentanil versus propofol on intracranial (ICP) and cerebral perfusion pressure (CPP) of patients undergoing stereotactic brain tumor biopsy under regional anesthesia. METHODS:This was a prospective, open-label, randomized, and controlled study...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1213/ane.0b013e3181a3ea3a

    authors: Girard F,Moumdjian R,Boudreault D,Chouinard P,Bouthilier A,Ruel M

    更新日期:2009-07-01 00:00:00

  • Arteriovenous concentration differences of propofol during and after a stepdown infusion.

    abstract::To compare the arterial and venous concentration differences of propofol, six healthy adult patients received a propofol infusion by the Bristol three-stage manual stepdown technique. Both the mean arterial and venous concentrations of propofol remained relatively stable during the 40-min infusion. Simultaneous blood ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:10.1213/00000539-199412000-00021

    authors: Wang YP,Cheng YJ,Fan SZ,Liu CC

    更新日期:1994-12-01 00:00:00

  • A comparison of costs and efficacy of ondansetron and droperidol as prophylactic antiemetic therapy for elective outpatient gynecologic procedures.

    abstract::Ondansetron and droperidol are both effective prophylactic antiemetics for gynecologic outpatient procedures. However, increased drowsiness, delayed discharge, and postdischarge restlessness may occur with droperidol, and ondansetron is costly. In this prospective, randomized, double-blind, placebo-controlled study in...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199608000-00018

    authors: Tang J,Watcha MF,White PF

    更新日期:1996-08-01 00:00:00

  • Exposure to halothane and enflurane affects learning function of murine progeny.

    abstract::This study was conducted to assess the learning function of murine progeny born of mothers that had received either 1% or 2% halothane or 2% or 4% enflurane, on days 6 and 10 or days 14 and 17 or gestation. Their timed performance at the age of 6 to 7 weeks was compared in a maze with that of control mice of similar a...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章

    doi:

    authors: Chalon J,Tang CK,Ramanathan S,Eisner M,Katz R,Turndorf H

    更新日期:1981-11-01 00:00:00

  • Clinical uses of the Bonfils Retromolar Intubation Fiberscope: a review.

    abstract::The Bonfils Retromolar Intubation Fiberscope is a rigid, straight fiberoptic device with a 40-degree curved tip, which facilitates targeted intubation. Bonfils, using a retromolar approach to intubate tracheas of children with Pierre Robin syndrome, was first described in 1983. After an initial steep learning curve, t...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,评审

    doi:10.1213/ANE.0b013e318265bae2

    authors: Thong SY,Wong TG

    更新日期:2012-10-01 00:00:00

  • Intraoperative moderate acute normovolemic hemodilution associated with a comprehensive blood-sparing protocol in off-pump coronary surgery.

    abstract:UNLABELLED:We evaluated the blood-sparing effects of intraoperative moderate acute normovolemic hemodilution (ANH) combined with intraoperative tranexamic acid treatment and shed blood reinfusion in patients undergoing off-pump coronary artery bypass (OPCAB). One-hundred consecutive OPCAB patients (baseline hematocrit ...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000113238.35409.fe

    authors: Casati V,Benussi S,Sandrelli L,Grasso MA,Spagnolo S,D'Angelo A

    更新日期:2004-05-01 00:00:00

  • A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis.

    abstract:UNLABELLED:The optimal dose and timing of 5-HT(3) antagonist administration for prophylaxis against postoperative nausea and vomiting (PONV) remains controversial. Although 5-HT(3) antagonists seem to be most effective when administered near the end of surgery, there are no data on the comparative efficacy or costs ass...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-200006000-00017

    authors: Zarate E,Watcha MF,White PF,Klein KW,Sa Rego M,Stewart DG

    更新日期:2000-06-01 00:00:00

  • An evaluation of the efficacy of aspirin and benzydamine hydrochloride gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study.

    abstract::Postoperative sore throat (POST), although a minor complication, remains a source of postoperative morbidity. We compared the efficacy of dispersible aspirin gargle to benzydamine hydrochloride (a topical nonsteroidal anti inflammatory drug) gargles for prevention of POST. We enrolled 60 consecutive female patients, 1...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1213/01.ane.0000231637.28427.00

    authors: Agarwal A,Nath SS,Goswami D,Gupta D,Dhiraaj S,Singh PK

    更新日期:2006-10-01 00:00:00

  • Vomiting after adenotonsillectomy in children: a comparison of ondansetron, dimenhydrinate, and placebo.

    abstract:UNLABELLED:We compared the effectiveness of ondansetron, dimenhydrinate, and placebo for the prevention of postoperative vomiting in children after adenotonsillectomy. In a randomized, placebo-controlled, double-blind study, 74 children, 2-10 yr of age scheduled for adenotonsillectomy as outpatients were given a single...

    journal_title:Anesthesia and analgesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000539-199803000-00008

    authors: Hamid SK,Selby IR,Sikich N,Lerman J

    更新日期:1998-03-01 00:00:00

  • Optimization of Endotracheal Tube Cuff Pressure by Monitoring CO2 Levels in the Subglottic Space in Mechanically Ventilated Patients: A Randomized Controlled Trial.

    abstract:BACKGROUND:Many of the complications of mechanical ventilation are related to inappropriate endotracheal tube (ETT) cuff pressure. The aim of the current study was to evaluate the effectiveness of automatic cuff pressure closed-loop control in patients under prolonged intubation, where presence of carbon dioxide (CO2) ...

    journal_title:Anesthesia and analgesia

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1213/ANE.0000000000002358

    authors: Efrati S,Bolotin G,Levi L,Zaaroor M,Guralnik L,Weksler N,Levinger U,Soroksky A,Denman WT,Gurman GM

    更新日期:2017-10-01 00:00:00