Cardiac electrophysiologic effects of pancuronium.

Abstract:

:A microelectrode examination of guinea pig left ventricular papillary muscle was performed to determine whether there was a direct effect of pancuronium on cardiac cells and, if so, to attempt to ascertain the mechanism of this effect. Electrical events were measured before and during superfusion with pancuronium, epinephrine, propranolol, and verapamil; alone and in various combinations. Pancuronium prolonged the duration of the action potential (AP); increased resting potential (Em), AP magnitude, and rate of rise of the AP (dV/dt); and resulted in spontaneity in 12% of the muscles. Epinephrine and pancuronium combined caused spontaneity in 80% of the muscles and oscillatory behavior. Additionally, this combination decreased AP magnitude, Em, and dV/dt in several preparations--a pattern of response similar to that seen in ouabain-treated myocardial cells under the influence of catecholamines. These changes were always reversed by verapamil or by perfusion with a drug-free medium, and were usually reversed by propranolol. The data suggest a combined pancuronium/epinephrine induced increase in cardiac membrane permeability to Ca2+.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Jacobs HK,Lim S,Salem MR,Rao TL,Mathru M,Smith BD

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

693-9

issue

7

eissn

0003-2999

issn

1526-7598

journal_volume

64

pub_type

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