Dolasetron versus ondansetron for the treatment of postoperative nausea and vomiting.

Abstract:

:The management of postoperative nausea and vomiting (PONV) remains a persistent problem. Despite the use of prophylactic antiemetics, breakthrough nausea and vomiting still frequently occur. There have been no published studies comparing dolasetron and ondansetron for the treatment of PONV. This was a prospective, randomized, double-blind, active-controlled study in adult outpatient surgery patients. We screened 559 consecutive adult surgery patients, with 92 patients randomized to either ondansetron or dolasetron. The objectives of the study were 1) to determine whether treatment of PONV with ondansetron 4 mg IV or dolasetron 12.5 mg IV would result in better outcomes in patients undergoing day surgery and 2) to compare the cost of drugs used for treating PONV. Thirty-three (70%) of 47 patients given ondansetron required rescue medication, compared with 18 (40%) of 45 patients given dolasetron (P < 0.004). Dolasetron was approximately 40% less expensive than ondansetron, and the costs of the study drug plus rescue antiemetics were 30% less in the dolasetron group than in the ondansetron group. Dolasetron provided greater efficacy for antiemetic treatment because of the need for less rescue therapy. Because of the decreased use of rescue antiemetics and acquisition cost at our hospital, costs in the dolasetron group were less than costs in the ondansetron group.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Meyer TA,Roberson CR,Rajab MH,Davis J,McLeskey CH

doi

10.1213/01.ANE.0000144421.96275.D1

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

373-7

issue

2

eissn

0003-2999

issn

1526-7598

pii

100/2/373

journal_volume

100

pub_type

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