Triple anesthetic combination: propofol-midazolam-alfentanil.

Abstract:

:The hypnotic effects of propofol, midazolam, alfentanil, and their binary and triple combinations, were studied in 130 unpremedicated patients in a randomized, double-blind fashion. The ability to open eyes on verbal command was used as an end-point. Dose-response curves for the three drugs given separately and in combination were determined with a probit procedure and the ED50 values were compared with an isobolographic analysis. The ratios of a single-drug fractional dose (ED50 = 1.0) to a combined fractional dose (in fractions of single-drug ED50 values) indicating the degree of superadditivity (synergism) were: 1.4 (P < 0.05) for propofol-alfentanil, 1.8 (P < 0.0005) for midazolam-propofol, 2.8 (P < 0.0001) for midazolam-alfentanil, and 2.6 (P < 0.0001) for propofol-midazolam-alfentanil. The results indicate that the propofol-midazolam-alfentanil interaction produces a profound hypnotic synergism which is not significantly different from that of the binary midazolam-alfentanil combination.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Vinik HR,Bradley EL Jr,Kissin I

doi

10.1213/00000539-199402000-00026

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

354-8

issue

2

eissn

0003-2999

issn

1526-7598

journal_volume

78

pub_type

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