Morphine kinetics and kidney transplantation: morphine removal is influenced by renal ischemia.

Abstract:

:Morphine plasma concentrations were determined in six patients receiving kidney transplants from living-related donors, and nine patients receiving kidney transplants from cadavers. The total cold ischemic time was about 2 hr for kidneys from living-related donors and 14 hr for those from cadavers. After an intravenous bolus dose of morphine, plasma morphine concentrations decreased to a plateau that lasted for several hours; morphine elimination resumed when the transplanted kidney began to clear creatinine. The duration of the total cold ischemic time was significantly related to both the duration of the plateau in morphine concentration (P = 0.008) and the first postoperative day creatinine clearance (P = 0.021). Morphine elimination half-life after the plateau was related to first postoperative day creatinine clearance (P less than 0.001). It was concluded that morphine elimination depended upon intact renal function.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Sear J,Moore A,Hunniset A,Baldwin D,Allen M,Hand C,McQuay H,Morris P

subject

Has Abstract

pub_date

1985-11-01 00:00:00

pages

1065-70

issue

11

eissn

0003-2999

issn

1526-7598

journal_volume

64

pub_type

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