Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature.

Abstract:

:Diabetes insipidus (DI) is an uncommon perioperative complication that can occur secondary to medications or surgical manipulation and can cause significant hypovolemia and electrolyte abnormalities. We reviewed and evaluated the current literature and identified 24 cases of DI related to medications commonly used in anesthesia such as propofol, dexmedetomidine, sevoflurane, ketamine, and opioids. This review summarizes the case reports and frequency of DI with each medication and presents possible pathophysiology. Medication-induced DI should be included in the differential diagnosis when intraoperative polyuria is identified. Early identification, removal of the agent, and treatment of intraoperative DI are critical to minimize complications.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Van Decar LM,Reynolds EG,Sharpe EE,Harbell MW,Kosiorek HE,Kraus MB

doi

10.1213/ANE.0000000000005344

subject

Has Abstract

pub_date

2021-01-06 00:00:00

eissn

0003-2999

issn

1526-7598

pii

00000539-990000000-00037

pub_type

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