当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > The use of topical diphenylcyclopropenone for the treatment of extensive alopecia areata.

The use of topical diphenylcyclopropenone for the treatment of extensive alopecia areata.

Abstract：

BACKGROUND:Highly variable results of topical diphenylcyclopropenone (DPCP) in the treatment of alopecia areata have been reported so far. OBJECTIVE:The purposes of our study were to evaluate the efficacy and tolerability of DPCP in the treatment of chronic, extensive alopecia areata and to assess the long-term overall benefit of treatment. METHODS:Fifty-six patients with chronic, extensive alopecia areata were enrolled in an open-label clinical trial. After sensitization with 2% DPCP, progressively higher concentrations beginning at 0.001% were applied weekly for 6 to 12 months to one side of the scalp. RESULTS:Fifty-two of 56 patients completed therapy. Total regrowth of terminal hair was achieved in 25 of 52 patients (48%) at 6 months. The most frequent side effect was an eczematous reaction at the site of application. Notably, persistent response was observed in 60% of these patients after 6 to 18 months of follow-up (mean, 12 months). CONCLUSION:Topical DPCP treatment for alopecia areata is effective and well tolerated and provides prolonged therapeutic benefits.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Cotellessa C,Peris K,Caracciolo E,Mordenti C,Chimenti S

doi

10.1067/mjd.2001.109309

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

73-6

issue

1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(01)90560-2

journal_volume

44

pub_type

临床试验,杂志文章

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