Abstract:
BACKGROUND:There are few studies of cardiac autonomic nervous activity (CANA) in patients with congenital heart disease. Methods and Results-We evaluated CANA in 54 patients after closure of an atrial/ventricular septal defect (group A), 54 patients after successful right ventricular outflow tract reconstruction (RVOTR) (group B1), 35 RVOTR patients with residual stenosis (group B2), and 47 controls. Cardiac parasympathetic nervous activity (PSNA) was estimated by heart rate (HR) change after cholinergic blockade, HR variability, and arterial baroreflex sensitivity (BRS). Cardiac sympathetic nervous activity was estimated by the heart-to-mediastinum (123)I-metaiodobenzylguanidine activity ratio (H/M) and HR increase after isoproterenol infusion (ss). HR response (DeltaHR) and peak oxygen uptake (VO(2)) were measured by exercise test. There was no difference in ss among study groups. Group A exhibited mildly impaired PSNA, which recovered 1 year after surgery, and no change in H/M. Impaired PSNA and low H/M were found in groups B1 and B2 compared with controls (P<0.001), although the PSNA tended to recover 1 year after re-RVOTR. In group B1, PSNA and ss were related to DeltaHR, and BRS correlated inversely with the number of surgical procedures and age at RVOTR and positively correlated with the follow-up period, whereas DeltaHR correlated with peak VO(2) (P<0.01 to 0.001). CONCLUSIONS:After RVOTR, postsynaptic ss-sensitivity is maintained and is important in DeltaHR during exercise, as is PSNA, although ventricular sympathetic denervation is common. Impaired PSNA immediately after RVOTR improves with improved DeltaHR and results in future amelioration of aerobic capacity, whereas ventricular sympathetic reinnervation is uncertain.
journal_name
Circulationjournal_title
Circulationauthors
Ohuchi H,Suzuki H,Toyohara K,Tatsumi K,Ono Y,Arakaki Y,Echigo Sdoi
10.1161/01.cir.102.22.2732subject
Has Abstractpub_date
2000-11-28 00:00:00pages
2732-8issue
22eissn
0009-7322issn
1524-4539journal_volume
102pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Sensitivity to apoptotic signals, the clearance rate of apoptosis, and the apoptotic ultrastructure have not been studied in cells of the in vivo adult heart. METHODS AND RESULTS:To minimize the systemic influence, soluble Fas ligand was injected directly into in vivo rat hearts and livers (as the control) ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000018651.89208.69
更新日期:2002-06-25 00:00:00
abstract:BACKGROUND:A family history of premature coronary artery disease (CAD) in a first-degree relative is an independent risk factor for coronary disease. Both genetic and environmental influences are likely to be responsible and may interact, but their relative importance is unclear. METHODS AND RESULTS:We studied endothe...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.10.3378
更新日期:1997-11-18 00:00:00
abstract:BACKGROUND:Pulmonary regurgitation frequently occurs after surgical correction of tetralogy of Fallot. To date, reliable quantitation of pulmonary regurgitation has not been possible, and therefore the clinical significance of pulmonary regurgitation is controversial. Nuclear magnetic resonance (NMR) velocity mapping a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.88.5.2257
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Early risk assessment is important in patients with unstable coronary artery disease, ie, unstable angina or non-Q-wave myocardial infarction. Some previous small studies have indicated that patients with unstable angina and elevation of troponin T (tn-T) have worse short-term and long-term prognoses. In thi...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.93.9.1651
更新日期:1996-05-01 00:00:00
abstract::Separate effects of perfusion hypothermia, potassium arrest, and procaine arrest were studied in 150 hearts using the isolated rat heart preparation. Aortic flow rate (AFR), coronary flow rate (CFR), and heart rate (HR) were measured before and after ischemic periods of 90 to 300 min. Prior to the ischemic period, the...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:We investigated whether decreased myofilament calcium contractile activation may, in part, contribute to heart failure. METHODS AND RESULTS:Calcium concentration required for 50% activation and Hill coefficient for fibers from nonfailing and failing human hearts at pH 7.1 were not different. Maximum calcium...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.14.1679
更新日期:2000-04-11 00:00:00
abstract::Long-term clinical and laboratory findings in three children who required mitral valve replacement below age four years are reported. In each instance a second valve replacement was necessary approximately 8 1/2 years after the initial one, following a two and one-half fold increase in body weight. Inadequate mitral v...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.57.5.981
更新日期:1978-05-01 00:00:00
abstract::This review discusses the role of growth factors on the proliferation of smooth muscle cells (SMCs) in injured arteries. We have used a variety of procedures to injure rat carotid arteries and noted that removal of endothelium followed by platelet adherence does not always initiate SMC replication. Furthermore, thromb...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00
abstract::The existence of a brain renin-angiotensin system (RAS) as one of various tissue RASs is now firmly established. Angiotensin-containing pathways within brain areas involved in central blood pressure regulation have been described. Evidence from biochemical, neurophysiologic, pharmacologic, and most recently, molecular...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1988-06-01 00:00:00
abstract::The continuity equation suggests that a ratio of velocities at two different cardiac valves is inversely proportional to the ratio of cross-sectional areas of the valves. To determine whether a ratio of mitral/aortic valve orifice velocities is useful in determining aortic valve area in patients with aortic stenosis, ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.73.5.964
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:The enzyme 11beta-hydroxysteroid dehydrogenase (11beta-HSD) prevents inappropriate activation of the nonselective mineralocorticoid receptors by glucocorticoids. Renal activity of 11beta-HSD is decreased in patients with apparent mineralocorticoid excess (SAME), licorice-induced hypertension, and essential h...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.25.3129
更新日期:2001-06-26 00:00:00
abstract:BACKGROUND:Vasoplegic syndrome is a form of vasodilatory shock that can occur after cardiopulmonary bypass (CPB). We hypothesized that the severity and duration of the decline in mean arterial pressure immediately after CPB is begun can be used as a predictor of patients will develop vasoplegia in the immediate post-CP...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.814533
更新日期:2009-10-27 00:00:00
abstract:BACKGROUND:Dilated cardiomyopathy is an important cause of morbidity and mortality among patients with congestive heart failure. Hemodynamic and prognostic characterization are critical in guiding selection of medical and surgical therapies. METHODS AND RESULTS:A cohort of 102 patients with the clinical diagnosis of d...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.6.2772
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Vasomotor reactivity may contribute to the pathophysiology of ischemic injury. The atherosclerotic vessel may be particularly susceptible to vasoconstriction because of the damaged endothelial layer with resultant loss of vasodilatory factors. While dietary omega 3 fatty acids have been proposed to protect a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.3.1393
更新日期:1991-09-01 00:00:00
abstract::Global ventricular function was evaluated by both multiple gated cardiac blood pool scans (MUGA) and contrast ventriculograms in a group of 17 patients with suspected coronary artery disease. The contrast ventriculograms were analyzed frame by frame to generate a volume versus time curve for each patient, while the tr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.6.1024
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:Decreased renal function has been found to be an independent risk factor for cardiovascular outcomes in patients with chronic heart failure (CHF) with markedly reduced left ventricular ejection fraction (LVEF). The aim of this analysis was to evaluate the prognostic importance of renal function in a broader ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.580506
更新日期:2006-02-07 00:00:00
abstract:BACKGROUND:During the initial phase of an ischemic insult, left ventricular (LV) performance depends on the complex interaction between oxygen deprivation, vascular turgor, and accumulation of metabolites. In experimental preparations, low-flow ischemia decreases systolic shortening and increases diastolic LV distensib...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.88.2.461
更新日期:1993-08-01 00:00:00
abstract::Endocardial catheter mapping was performed in 15 patients in sinus rhythm who had no evidence of structural heart disease and normal left ventricles. Mapping was performed with the use of 10 mm interelectrode distance from various left ventricular endocardial sites. In 10 patients a quantitative analysis of electrogra...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.70.1.37
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Paroxysmal atrial fibrillation (AF) naturally progresses toward chronic AF at an estimated rate of 15% to 30% over a 1- to 3-year period. Pulmonary vein (PV) isolation is increasingly performed for the treatment of drug-refractory paroxysmal AF. The long-term data on clinical outcome after circumferential PV...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.946806
更新日期:2010-12-07 00:00:00
abstract:BACKGROUND:During rest and exercise, patients with heart failure hyperventilate; therefore, the diaphragm can be viewed as undergoing constant moderate-intensity exercise. Accordingly, we hypothesized that heart failure elicits adaptations in the diaphragm similar to those elicited by endurance exercise in the limb mus...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.4.910
更新日期:1997-02-18 00:00:00
abstract::Experimental studies of animals have previously demonstrated the validity of [1-11C]acetate as a tracer of oxidative metabolism for use with positron emission tomography. The present study was undertaken to define in normal human volunteers the relation between myocardial clearance kinetics of [1-11C]acetate, and the ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.4.863
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Ultrasonic angioplasty was recently shown to ablate thrombi and atherosclerotic plaques in vitro and to recanalize occluded arteries in experimental animal models. The goal of the present study was to examine the clinical feasibility of ultrasonic angioplasty. METHODS AND RESULTS:Intraoperative ultrasonic a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.6.1976
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:C-type natriuretic peptide (CNP) is a newly identified peptide that is structurally related to atrial natriuretic peptide (ANP). Although it has been suggested that CNP is released from the endothelium for the regulation of local vascular tone, no data are available concerning the vasodilatory response to CN...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.90.3.1210
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Paroxysmal atrial fibrillation (PAF) can be eliminated with continuous circular lesions (CCLs) around the pulmonary veins (PVs), but it is unclear whether all PVs are completely isolated. METHODS AND RESULTS:Forty-one patients with symptomatic PAF underwent 3D mapping, and all PV ostia were marked on the 3D...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000144459.37455.EE
更新日期:2004-10-12 00:00:00
abstract:BACKGROUND:Autoimmune mechanisms have been implicated in the pathogenesis of chronic ongoing myocarditis. To investigate this relation, we used an A/J mouse model inoculated with coxsackievirus B3 and determined whether myocarditis would be transferred to normal hearts that were heterotopically transplanted. METHODS A...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.12.3348
更新日期:1996-12-15 00:00:00
abstract::The purpose of this investigation was to determine whether blood vessels could develop de novo between an extracardiac artery and a collateral-dependent zone of the heart and to quantify the nutritive blood flow afforded by the new vessels. We also adapted the preparation so that angiogenically active agents could be ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.82.4.1449
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Data on outcomes after Stanford type A aortic dissection in patients with Marfan syndrome are limited. We investigated the primary surgery and long-term results in patients with Marfan syndrome who suffered aortic dissection. METHODS AND RESULTS:Among 1324 consecutive patients with aortic dissection type A,...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.113.005865
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Cardiac troponin I (cTnI), a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Small studies report that cTnI is elevated in severe heart failure (HF) and may predict adverse outcomes. METHODS AND RESULTS:The present study e...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000084543.79097.34
更新日期:2003-08-19 00:00:00
abstract:BACKGROUND:Household air pollution is the third largest risk factor for global disease burden, but direct links with cardiovascular disease mortality are limited. This study aimed to evaluate the relationship between household fuel use and cardiovascular disease mortality. METHODS AND RESULTS:The Golestan Cohort Study...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.115.020288
更新日期:2016-06-14 00:00:00
abstract:BACKGROUND:The Lewis-F344 rat cardiac transplantation model produces cardiac allografts with chronic rejection characterized by arteriosclerotic lesions composed of macrophages and smooth muscle cells. Modulation of the inflammatory response with a diet deficient in essential fatty acids protects against the developmen...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.3.457
更新日期:1995-08-01 00:00:00