Systolic and diastolic dysfunction in patients with clinical diagnosis of dilated cardiomyopathy. Relation to symptoms and prognosis.


BACKGROUND:Dilated cardiomyopathy is an important cause of morbidity and mortality among patients with congestive heart failure. Hemodynamic and prognostic characterization are critical in guiding selection of medical and surgical therapies. METHODS AND RESULTS:A cohort of 102 patients with the clinical diagnosis of dilated cardiomyopathy who underwent echocardiographic examination between 1986 and 1990 was identified and followed up through July 1, 1991. Patients with moderate or severe symptoms had lower indices of systolic function and greater left atrial and right ventricular dilation. Mitral inflow Doppler signals were characterized by a restrictive left ventricular filling pattern. In multivariate logistic regression analysis, deceleration time, ejection fraction, and peak E velocity were independently associated with symptom status. Over a mean follow-up of 36 months, 35 patients died. Kaplan-Meier estimated survival at 1, 2, and 4 years was 84%, 73%, and 61%, respectively, and was significantly poorer than that of an age- and sex-matched population. The subgroup with an ejection fraction < 0.25 and deceleration time < 130 milliseconds had a 2-year survival of only 35%. The subgroup with ejection fraction < 0.25 and deceleration time > 130 milliseconds had an intermediate 2-year survival of 72%, whereas patients with an ejection fraction > or = 0.25 had 2-year survivals > or = 95% regardless of deceleration time. In multivariate analysis, ejection fraction and systolic blood pressure were independently predictive of subsequent mortality. Mitral deceleration time was significant in univariate analysis. CONCLUSIONS:In patients with the clinical diagnosis of dilated cardiomyopathy, markers of diastolic dysfunction correlated strongly with congestive symptoms, whereas variables of systolic function were the strongest predictors of survival. Consideration of both ejection fraction and deceleration time allowed identification of subgroups with divergent long-term prognoses.






Rihal CS,Nishimura RA,Hatle LK,Bailey KR,Tajik AJ




Has Abstract


1994-12-01 00:00:00












  • Impact of prolonged cyclooxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised C-reactive protein: a randomized placebo-controlled study.

    abstract:BACKGROUND:The impact of cyclooxygenase (COX)-2 antagonist treatment on acute coronary risk is controversial. We investigated the effect of prolonged COX-2 inhibition on inflammatory profile and endothelial function in patients with ischemic heart disease and high serum C-reactive protein (CRP) values. METHODS AND RES...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bogaty P,Brophy JM,Noel M,Boyer L,Simard S,Bertrand F,Dagenais GR

    更新日期:2004-08-24 00:00:00

  • Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

    abstract:BACKGROUND:The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out to identify novel and functionally important endothelial lncRNAs. METHODS:Epigenetically controlled lncRNAs in human umbilical vein endothelia...


    pub_type: 杂志文章


    authors: Leisegang MS,Fork C,Josipovic I,Richter FM,Preussner J,Hu J,Miller MJ,Epah J,Hofmann P,Günther S,Moll F,Valasarajan C,Heidler J,Ponomareva Y,Freiman TM,Maegdefessel L,Plate KH,Mittelbronn M,Uchida S,Künne C,Stello

    更新日期:2017-07-04 00:00:00

  • Attenuation of exercise-induced myocardial ischemia in dogs with recruitment of coronary vasodilator reserve by nifedipine.

    abstract::There is now evidence that under resting conditions coronary vasodilator reserve exists even in the presence of myocardial ischemia. Therefore, we tested the hypothesis that a vasodilator reserve may exist during exercise so that during exercise-induced ischemia a reduction in coronary constrictor tone can be produced...


    pub_type: 杂志文章


    authors: Heusch G,Guth BD,Seitelberger R,Ross J Jr

    更新日期:1987-02-01 00:00:00

  • Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block.

    abstract:BACKGROUND:Three distinct cardiac arrhythmia disorders, the long-QT syndrome, Brugada syndrome, and conduction system disease, have been associated with heterozygous mutations in the cardiac voltage-gated sodium channel alpha-subunit gene (SCN5A). We present clinical, genetic, and biophysical features of 2 new SCN5A mu...


    pub_type: 杂志文章


    authors: Wang DW,Viswanathan PC,Balser JR,George AL Jr,Benson DW

    更新日期:2002-01-22 00:00:00

  • Slowing Progression of Cardiovascular Calcification With SNF472 in Patients on Hemodialysis: Results of a Randomized Phase 2b Study.

    abstract:BACKGROUND:The high cardiovascular morbidity and mortality in patients with end-stage kidney disease could be partially caused by extensive cardiovascular calcification. SNF472, intravenous myo-inositol hexaphosphate, selectively inhibits the formation and growth of hydroxyapatite. METHODS:This double-blind, placebo-c...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Raggi P,Bellasi A,Bushinsky D,Bover J,Rodriguez M,Ketteler M,Sinha S,Salcedo C,Gillotti K,Padgett C,Garg R,Gold A,Perelló J,Chertow GM

    更新日期:2020-03-03 00:00:00

  • Report of the Inter-Society Commission for Heart Disease Resources. Optimal resource guidelines for radioactive tracer studies of the heart and circulation.

    abstract::The status of radioactive tracer studies in cardiovascular diagnosis is summarized. Planning guidelines are suggested for a hospital nuclear medical service including a central nuclear medical facility and satellite units, and resource criteria are given for professional personnel including training and duties, equipm...


    pub_type: 杂志文章


    authors: Adelstein SJ,Jansen C,Wagner HN Jr

    更新日期:1975-07-01 00:00:00

  • Vascular injury, repair, and restenosis after percutaneous transluminal angioplasty in the atherosclerotic rabbit.

    abstract:BACKGROUND:Several nonatherosclerotic animal models of restenosis exist and are used for the evaluation of the vascular response to angioplasty-induced injury. However, few studies have evaluated the response of an atherosclerotic vessel to angioplasty. The present study examined the radiographic, histological, immunoh...


    pub_type: 杂志文章


    authors: Wilensky RL,March KL,Gradus-Pizlo I,Sandusky G,Fineberg N,Hathaway DR

    更新日期:1995-11-15 00:00:00

  • Echophonocardiographic studies of the contribution of the atrioventricular valves to the first heart sound.

    abstract::The movements of the mitral, tricuspid and aortic valves have been recorded echocardiographically and related to the first heart sound (S1) in patients with various hemodynamic and conduction abnormalities. Closure of the mitral and tricuspid valves has been studied with respect to the corresponding atrioventricular p...


    pub_type: 杂志文章


    authors: Mills PG,Chamusco RF,Moos S,Craige E

    更新日期:1976-12-01 00:00:00

  • Female mice lacking estrogen receptor beta display prolonged ventricular repolarization and reduced ventricular automaticity after myocardial infarction.

    abstract:BACKGROUND:Major gender-based differences in the incidence of ventricular tachyarrhythmia after myocardial infarction have been shown in humans. Although the underlying mechanisms are unclear, earlier studies suggest that estrogen receptor-mediated effects play a major role in this process. METHODS AND RESULTS:We exam...


    pub_type: 杂志文章


    authors: Korte T,Fuchs M,Arkudas A,Geertz S,Meyer R,Gardiwal A,Klein G,Niehaus M,Krust A,Chambon P,Drexler H,Fink K,Grohé C

    更新日期:2005-05-10 00:00:00

  • Troglitazone inhibits voltage-dependent calcium currents in guinea pig cardiac myocytes.

    abstract:BACKGROUND:It has been suggested that intracellular Ca2+ overload in cardiac myocytes leads to the development of diabetic cardiomyopathy. Troglitazone, an insulin-sensitizing agent, is a promising therapeutic agent for diabetes and has been shown to prevent diabetes-induced myocardial changes. To elucidate the underly...


    pub_type: 杂志文章


    authors: Nakajima T,Iwasawa K,Oonuma H,Imuta H,Hazama H,Asano M,Morita T,Nakamura F,Suzuki J,Suzuki S,Kawakami Y,Omata M,Okuda Y

    更新日期:1999-06-08 00:00:00

  • Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.

    abstract:BACKGROUND:We tested the hypothesis that nuclear factor-kappaB (NF-kappaB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans. METHODS AND RESULTS:We conducted a randomized, double-blind, placebo-controlled crossover study in 14 nondiabetic overweight or obese (body mass index > ...


    pub_type: 杂志文章,随机对照试验


    authors: Pierce GL,Lesniewski LA,Lawson BR,Beske SD,Seals DR

    更新日期:2009-03-10 00:00:00

  • Long-term survival after acute myocardial infarction is lower in more deprived neighborhoods.

    abstract:BACKGROUND:As part of the Worcester Heart Attack Study, a community-wide study examining changes over time in the incidence and long-term case-fatality rates of greater Worcester, Mass, residents hospitalized with confirmed acute myocardial infarction (AMI), we investigated the hypothesis that census tract-level socioe...


    pub_type: 杂志文章


    authors: Tonne C,Schwartz J,Mittleman M,Melly S,Suh H,Goldberg R

    更新日期:2005-06-14 00:00:00

  • Prognostic significance of the electrocardiogram after Q wave myocardial infarction. The Framingham Study.

    abstract::The prognostic value of abnormalities on the electrocardiogram (ECG) present 1 year after initial myocardial infarction (MI) is examined in relation to reinfarction and coronary death throughout 32 years (mean, 10.1 years) of follow-up in the Framingham Heart Study. Resting 12-lead ECGs were available in 251 survivors...


    pub_type: 杂志文章


    authors: Wong ND,Levy D,Kannel WB

    更新日期:1990-03-01 00:00:00

  • Regression of left ventricular hypertrophy after surgical therapy for aortic stenosis is associated with changes in extracellular matrix gene expression.

    abstract:BACKGROUND:Regression of left ventricular hypertrophy (LVH) after surgical correction for aortic stenosis is not fully understood on the molecular level. The aim of this study was to examine whether there is an association between LVH regression and extracellular matrix (ECM) gene expression. METHODS AND RESULTS:A sta...


    pub_type: 杂志文章


    authors: Walther T,Schubert A,Falk V,Binner C,Kanev A,Bleiziffer S,Walther C,Doll N,Autschbach R,Mohr FW

    更新日期:2001-09-18 00:00:00

  • Incremental value of the preoperative echocardiogram to predict mortality and major morbidity in coronary artery bypass surgery.

    abstract:BACKGROUND:Although echocardiography is commonly performed before coronary artery bypass surgery, there has yet to be a study examining the incremental prognostic value of a complete echocardiogram. METHODS AND RESULTS:Patients undergoing isolated coronary artery bypass surgery at 2 hospitals were divided into derivat...


    pub_type: 杂志文章,多中心研究


    authors: Afilalo J,Flynn AW,Shimony A,Rudski LG,Agnihotri AK,Morin JF,Castrillo C,Shahian DM,Picard MH

    更新日期:2013-01-22 00:00:00

  • Right ventricular/arterial coupling in the patient with left ventricular assistance.

    abstract:BACKGROUND:Improvements are known to occur in right ventricular (RV) ejection fraction after the use of a left ventricular assist device (LVAD); less is known, however, about the mechanism of this improvement. The concept of ventricular/arterial coupling was applied to investigate whether systolic pump function or afte...


    pub_type: 杂志文章


    authors: Morita S,Kormos RL,Mandarino WA,Eishi K,Kawai A,Gasior TA,Deneault LG,Armitage JM,Hardesty RL,Griffith BP

    更新日期:1992-11-01 00:00:00

  • Effect of potassium cardioplegia on myocardial ischemia and post arrest ventricular function.

    abstract::To assess the effects of moderate potassium cardioplegia (37 mEq/l KCl) on the severity of myocardial ischemia during arrest and on post arrest ventricular function, 32 isolated, isovolumic feline hearts were studied before, during and 1 hour after ischemic arrest. Normothermia (37 degrees C) was maintained in the rem...


    pub_type: 杂志文章


    authors: Schaff HV,Dombroff R,Flaherty JT,Bulkley BH,Hutchins GM,Goldman RA,Gott VL

    更新日期:1978-08-01 00:00:00

  • Measles virus nucleoprotein induces a regulatory immune response and reduces atherosclerosis in mice.

    abstract:BACKGROUND:Recent studies clearly suggest that regulatory T cells play a critical role in the control of the immunoinflammatory response in atherosclerosis and substantially limit lesion development. Measles virus infection or vaccination is associated with immune depression, in part through the induction of an antiinf...


    pub_type: 杂志文章


    authors: Ait-Oufella H,Horvat B,Kerdiles Y,Herbin O,Gourdy P,Khallou-Laschet J,Merval R,Esposito B,Tedgui A,Mallat Z

    更新日期:2007-10-09 00:00:00

  • Feasibility, safety, and therapeutic efficacy of human induced pluripotent stem cell-derived cardiomyocyte sheets in a porcine ischemic cardiomyopathy model.

    abstract:BACKGROUND:Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are a promising source of cells for regenerating myocardium. However, several issues, especially the large-scale preparation of hiPS-CMs and elimination of undifferentiated iPS cells, must be resolved before hiPS cells can be used clinical...


    pub_type: 杂志文章


    authors: Kawamura M,Miyagawa S,Miki K,Saito A,Fukushima S,Higuchi T,Kawamura T,Kuratani T,Daimon T,Shimizu T,Okano T,Sawa Y

    更新日期:2012-09-11 00:00:00

  • Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.

    abstract:BACKGROUND:Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS:We genera...


    pub_type: 杂志文章


    authors: Hoffmann CJ,Harms U,Rex A,Szulzewsky F,Wolf SA,Grittner U,Lättig-Tünnemann G,Sendtner M,Kettenmann H,Dirnagl U,Endres M,Harms C

    更新日期:2015-05-19 00:00:00

  • Increased morning incidence of myocardial infarction in the ISAM Study: absence with prior beta-adrenergic blockade. ISAM Study Group.

    abstract::The time of acute myocardial infarction was determined in all 1,741 patients of the ISAM (Intravenous Streptokinase in Acute Myocardial Infarction) Study, based on onset of clinical symptoms and evaluation of plasma CK-MB enzyme time-activity curves. The incidence of myocardial infarction was markedly increased betwee...


    pub_type: 杂志文章


    authors: Willich SN,Linderer T,Wegscheider K,Leizorovicz A,Alamercery I,Schröder R

    更新日期:1989-10-01 00:00:00

  • Body mass index: a risk factor for unstable angina and myocardial infarction in patients with angiographically confirmed coronary artery disease.

    abstract:BACKGROUND:In patients with coronary artery disease (CAD), acute thrombosis frequently occurs in coronary arteries with only mild or moderate stenoses. Obesity increases the risk of atherosclerosis, but it is not known whether it also increases the risk of coronary thrombosis. We hypothesized that body mass index (BMI)...


    pub_type: 杂志文章


    authors: Wolk R,Berger P,Lennon RJ,Brilakis ES,Somers VK

    更新日期:2003-11-04 00:00:00

  • Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections.

    abstract:BACKGROUND:Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown. METHODS AND RESULTS:Activation of hypoxia-inducible factor-1 (HIF-1), t...


    pub_type: 杂志文章


    authors: Kempf VA,Lebiedziejewski M,Alitalo K,Wälzlein JH,Ehehalt U,Fiebig J,Huber S,Schütt B,Sander CA,Müller S,Grassl G,Yazdi AS,Brehm B,Autenrieth IB

    更新日期:2005-03-01 00:00:00

  • Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice.

    abstract:BACKGROUND:Enteroviridae such as coxsackievirus B3 (CVB3) are important infectious agents involved in viral heart disease, hepatitis, and pancreatitis, but no specific antiviral therapy is available. METHODS AND RESULTS:The aim of the present study was to evaluate the impact of RNA interference on viral replication, c...


    pub_type: 杂志文章


    authors: Merl S,Michaelis C,Jaschke B,Vorpahl M,Seidl S,Wessely R

    更新日期:2005-04-05 00:00:00

  • Pace mapping using body surface potential maps to guide catheter ablation of accessory pathways in patients with Wolff-Parkinson-White syndrome.

    abstract::BACKGROUND. A pace mapping technique using body surface potential maps (BSPMs) was developed to guide the positioning of an ablation catheter at the ventricular insertion point of accessory pathways (AP) in patients with the Wolff-Parkinson-White syndrome (WPW). METHODS AND RESULTS. The study was performed on 30 WPW p...


    pub_type: 杂志文章


    authors: Dubuc M,Nadeau R,Tremblay G,Kus T,Molin F,Savard P

    更新日期:1993-01-01 00:00:00

  • Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodarone.

    abstract:BACKGROUND:Patients surviving ventricular fibrillation (VF) or sustained ventricular tachycardia (VT) are at a high risk of death due to a recurrence of arrhythmia. The implantable cardioverter defibrillator (ICD) terminates VT or VF, but it is not known whether this device prolongs life in these patients compared with...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Connolly SJ,Gent M,Roberts RS,Dorian P,Roy D,Sheldon RS,Mitchell LB,Green MS,Klein GJ,O'Brien B

    更新日期:2000-03-21 00:00:00

  • Persantine-aspirin reinfarction study. Design, methods and baseline results. By the persantine-aspirin reinfarction study research group.

    abstract::The Persantine-Aspirin Reinfarction Study (PARIS) was a randomized, controlled, double-blind study of dipyridamole (Persantine) and aspirin in secondary prevention of coronary heart disease. Two thousand twenty-six men and women with myocardial infarction (MI) documented by electrocardiographic findings, clinical hist...


    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1980-09-01 00:00:00

  • Colchicine treatment for recurrent pericarditis. A decade of experience.

    abstract:BACKGROUND:The most troublesome complication of acute pericarditis is recurrent episodes of pericardial inflammation, occurring in 15% to 32% of cases. The cause of the recurrence is usually unknown, although in some cases it may be traced to viral infection or may be a consequence of coronary artery bypass grafting. T...


    pub_type: 杂志文章,多中心研究


    authors: Adler Y,Finkelstein Y,Guindo J,Rodriguez de la Serna A,Shoenfeld Y,Bayes-Genis A,Sagie A,Bayes de Luna A,Spodick DH

    更新日期:1998-06-02 00:00:00

  • Prevalence of hypertension in Mexico City and San Antonio, Texas.

    abstract:BACKGROUND:Few data are available on the prevalence of hypertension in Mexico. METHODS AND RESULTS:We compared the prevalence of mild hypertension (systolic blood pressure > or = 140 mm Hg and/or diastolic blood pressure > or = 90 mm Hg and/or use of antihypertensive medications) in 1500 low-income Mexican Americans w...


    pub_type: 杂志文章


    authors: Haffner S,González Villalpando C,Hazuda HP,Valdez R,Mykkänen L,Stern M

    更新日期:1994-09-01 00:00:00

  • Left ventricular function during intra-aortic balloon pumping assessed by multigated cardiac blood pool imaging.

    abstract::The effectiveness of intra-aortic balloon pumping in augmenting ventricular performance during acute myocardial ischemic syndromes was determined by noninvasive multigated cardiac blood pool imaging. Nine patients with unstable angina refractory to medical therapy and nine patients with acute myocardial infarction com...


    pub_type: 杂志文章


    authors: Nichols AB,Pohost GM,Gold HK,Leinbach RC,Beller GA,McKusick KA,Strauss HW,Buckley MJ

    更新日期:1978-09-01 00:00:00