Autoimmune response in chronic ongoing myocarditis demonstrated by heterotopic cardiac transplantation in mice.


BACKGROUND:Autoimmune mechanisms have been implicated in the pathogenesis of chronic ongoing myocarditis. To investigate this relation, we used an A/J mouse model inoculated with coxsackievirus B3 and determined whether myocarditis would be transferred to normal hearts that were heterotopically transplanted. METHODS AND RESULTS:Inbred 3-week-old A/J mice were inoculated intraperitoneally with coxsackievirus B3 (Nancy strain; 2 x 10(4) plaque-forming units) and housed for > 60 days. The presence of the viral genome in the myocardium was determined by the polymerase chain reaction with primers specific for the 5' end of the coxsackievirus B3 genome performed at 40, 50, or 60 days after inoculation. Normal A/J mouse hearts were transplanted into the same strain of mice without myocarditis (group A) and into mice with chronic ongoing myocarditis (group B). The hearts were evaluated histologically 2 weeks after transplantation. Conventional histological examination of infiltrated T cells and macrophages was performed, and the expression of intercellular adhesion molecule-1, major histocompatibility complex (MHC) class I antigen, and MHC class II antigen was evaluated by immunoenzymatic staining. The concentrations of interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor (TNF-alpha) in the grafts were measured with an ELISA. The viral RNA genomes were not detected in the mice with chronic ongoing myocarditis, but their transplanted hearts did show myocarditis. In the hearts with induced myocarditis, infiltrated mononuclear cells consisted of CD4+ T cells, CD8+ T cells (CD4+ cell number > CD8+ cell number), and macrophages. Intercellular adhesion molecule-1, MHC class I antigen, and MHC class II antigen were expressed in the vascular endothelial cells and myocardial cells in and around the infiltrated lesions. The concentrations of IL-1 alpha and TNF-alpha in group B were significantly higher than those in group A (group A versus group B: IL-1 alpha, 125 +/- 35 versus 180 +/- 34 pg/mL; TNF-alpha, 45 +/- 15 versus 96 +/- 40 pg/mL; P < .05). CONCLUSIONS:Results suggest that an autoimmune response may play a key role in the progression of chronic ongoing myocarditis.






Nakamura H,Yamamura T,Umemoto S,Fukuta S,Shioi T,Matsumori A,Sasayama S,Matsuzaki M




Has Abstract


1996-12-15 00:00:00












  • Pathogenesis of edema in constrictive pericarditis. Studies of body water and sodium, renal function, hemodynamics, and plasma hormones before and after pericardiectomy.

    abstract:BACKGROUND:The pathogenesis of sodium and water accumulation in chronic constrictive pericarditis is not well understood and may differ from that in patients with chronic congestive heart failure due to myocardial disease. This study was undertaken to investigate some of the mechanisms. METHODS AND RESULTS:Using stand...


    pub_type: 杂志文章


    authors: Anand IS,Ferrari R,Kalra GS,Wahi PL,Poole-Wilson PA,Harris PC

    更新日期:1991-06-01 00:00:00

  • Assessment of systemic right ventricular function in patients with transposition of the great arteries using the myocardial performance index: comparison with cardiac magnetic resonance imaging.

    abstract:BACKGROUND:Assessment of systemic right ventricular (RV) function is a key point in the follow-up of patients with transposition of the great arteries (TGA). Current echocardiographic assessment of RV function is at best an estimate, and cardiac magnetic resonance (CMR) is considered the gold standard. However, this te...


    pub_type: 杂志文章


    authors: Salehian O,Schwerzmann M,Merchant N,Webb GD,Siu SC,Therrien J

    更新日期:2004-11-16 00:00:00

  • Beneficial effects of pimobendan on exercise tolerance and quality of life in patients with heart failure. Results of a multicenter trial. The Pimobendan Multicenter Research Group.

    abstract:BACKGROUND:This multicenter trial was conducted to determine the efficacy and safety of pimobendan, an inotropic agent with calcium-sensitizing properties and activity as a phosphodiesterase inhibitor, in patients with heart failure. METHODS AND RESULTS:One hundred ninety-eight ambulatory patients with symptoms of mod...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Kubo SH,Gollub S,Bourge R,Rahko P,Cobb F,Jessup M,Brozena S,Brodsky M,Kirlin P,Shanes J

    更新日期:1992-03-01 00:00:00

  • Does length or eccentricity of coronary stenoses influence the outcome of transluminal dilatation?

    abstract::In 526 patients undergoing a first percutaneous transluminal coronary angioplasty (PTCA) of a single native vessel, we studied the influence of length and eccentricity of the lesion on complications and primary success. Long stenoses (greater than or equal to 5 mm, n = 153) did not differ from short stenoses (less tha...


    pub_type: 杂志文章


    authors: Meier B,Gruentzig AR,Hollman J,Ischinger T,Bradford JM

    更新日期:1983-03-01 00:00:00

  • Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: electrophysiologic and anatomic correlation.

    abstract::In this report we describe electrophysiologic and histologic findings in hearts and endocardially resected preparations from patients with sustained ventricular tachycardias in the chronic phase of myocardial infarction. We recorded simultaneously from 64 endocardial sites during tachycardia in 72 patients that were o...


    pub_type: 杂志文章


    authors: de Bakker JM,van Capelle FJ,Janse MJ,Wilde AA,Coronel R,Becker AE,Dingemans KP,van Hemel NM,Hauer RN

    更新日期:1988-03-01 00:00:00

  • Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age.

    abstract:BACKGROUND:People who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure. METHODS AND RESULTS:We studied blood pressure in 346 British men and ...


    pub_type: 杂志文章


    authors: Law CM,Shiell AW,Newsome CA,Syddall HE,Shinebourne EA,Fayers PM,Martyn CN,de Swiet M

    更新日期:2002-03-05 00:00:00

  • An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome.

    abstract:BACKGROUND:Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have been reported to cause this condition and are routinely tested in patients. Because of dramatic changes in our understanding of human genetic variation, reappraisal of reported gen...


    pub_type: 杂志文章


    authors: Adler A,Novelli V,Amin AS,Abiusi E,Care M,Nannenberg EA,Feilotter H,Amenta S,Mazza D,Bikker H,Sturm AC,Garcia J,Ackerman MJ,Hershberger RE,Perez MV,Zareba W,Ware JS,Wilde AAM,Gollob MH

    更新日期:2020-02-11 00:00:00

  • Intrinsic tone as potential vascular reserve in conductance and resistance vessels.

    abstract:BACKGROUND:The purpose of this study was to define the degree of intrinsic tone in conductance and resistance vessels, to define the calcium dependency of intrinsic tone in these vascular preparations, and to investigate the efficacy of vasodilatory agents on the level of intrinsic tone in these vascular preparations. ...


    pub_type: 杂志文章


    authors: Jain M,Dai HB,Carrozza JP,Sellke FW,Morgan KG

    更新日期:1996-09-01 00:00:00

  • Time-series analysis of heart rate variability during submaximal exercise. Evidence for reduced cardiac vagal tone in animals susceptible to ventricular fibrillation.

    abstract::Periodic fluctuations in the R-R interval have been used as noninvasive measures of cardiac autonomic tone. For example, a reduced heart rate variability has been shown to correlate with an increased mortality in patients recovering from myocardial infarction. The effects that physiologic perturbations such as exercis...


    pub_type: 杂志文章


    authors: Billman GE,Hoskins RS

    更新日期:1989-07-01 00:00:00

  • Long-term survival after acute myocardial infarction is lower in more deprived neighborhoods.

    abstract:BACKGROUND:As part of the Worcester Heart Attack Study, a community-wide study examining changes over time in the incidence and long-term case-fatality rates of greater Worcester, Mass, residents hospitalized with confirmed acute myocardial infarction (AMI), we investigated the hypothesis that census tract-level socioe...


    pub_type: 杂志文章


    authors: Tonne C,Schwartz J,Mittleman M,Melly S,Suh H,Goldberg R

    更新日期:2005-06-14 00:00:00

  • Real-time three-dimensional echocardiography: a novel technique to quantify global left ventricular mechanical dyssynchrony.

    abstract:BACKGROUND:Left ventricular (LV) mechanical dyssynchrony (LVMD) has emerged as a therapeutic target using cardiac resynchronization therapy (CRT) in selected patients with chronic heart failure. Current methods used to evaluate LVMD are technically difficult and do not assess LVMD of the whole LV simultaneously. We dev...


    pub_type: 杂志文章


    authors: Kapetanakis S,Kearney MT,Siva A,Gall N,Cooklin M,Monaghan MJ

    更新日期:2005-08-16 00:00:00

  • Reduced mortality and strokes with off-pump coronary artery bypass grafting surgery in octogenarians.

    abstract:BACKGROUND:Off-pump coronary artery bypass surgery (OPCAB) has been revived and has gained popularity, although the exact subsets of patients who might benefit most from this technique are unknown. The aim of this retrospective study was to compare the results of coronary artery bypass grafting surgery (CABG) in octoge...


    pub_type: 杂志文章


    authors: Demaria RG,Carrier M,Fortier S,Martineau R,Fortier A,Cartier R,Pellerin M,Hébert Y,Bouchard D,Pagé P,Perrault LP

    更新日期:2002-09-24 00:00:00

  • Clinical Profile and Consequences of Atrial Fibrillation in Hypertrophic Cardiomyopathy.

    abstract:BACKGROUND:Atrial fibrillation (AF), the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), is capable of producing symptoms that impact quality of life and is associated with risk for embolic stroke. However, the influence of AF on clinical course and outcome in HCM remains incompletely resolved. ...


    pub_type: 杂志文章


    authors: Rowin EJ,Hausvater A,Link MS,Abt P,Gionfriddo W,Wang W,Rastegar H,Estes NAM,Maron MS,Maron BJ

    更新日期:2017-12-19 00:00:00

  • Transplantation of fetal myocardial tissue into the infarcted myocardium of rat. A potential method for repair of infarcted myocardium?

    abstract:BACKGROUND:Unlike skeletal myocytes, mammalian adult cardiomyocytes cannot regenerate after injury. A possible strategy to increase viability and augment ventricular function after myocardial injury is fetal myocardial tissue transplantation. The engrafted fetal cells are a potential source of growth factors and can be...


    pub_type: 杂志文章


    authors: Leor J,Patterson M,Quinones MJ,Kedes LH,Kloner RA

    更新日期:1996-11-01 00:00:00

  • Ghrelin improves endothelial function in patients with metabolic syndrome.

    abstract:BACKGROUND:Metabolic syndrome importantly accelerates the atherosclerotic process, the earliest event of which is endothelial dysfunction. Ghrelin, a gastric peptide with cardiovascular actions, has been shown to inhibit proatherogenic changes in experimental models. This study therefore investigated whether ghrelin ad...


    pub_type: 临床试验,杂志文章


    authors: Tesauro M,Schinzari F,Iantorno M,Rizza S,Melina D,Lauro D,Cardillo C

    更新日期:2005-11-08 00:00:00

  • Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.

    abstract:BACKGROUND:Cystic kidneys and vascular aneurysms are clinical manifestations seen in patients with polycystic kidney disease, a cilia-associated pathology (ciliopathy). Survivin overexpression is associated with cancer, but the clinical pathology associated with survivin downregulation or knockout has never been studie...


    pub_type: 杂志文章


    authors: Aboualaiwi WA,Muntean BS,Ratnam S,Joe B,Liu L,Booth RL,Rodriguez I,Herbert BS,Bacallao RL,Fruttiger M,Mak TW,Zhou J,Nauli SM

    更新日期:2014-02-11 00:00:00

  • Immediate diagnosis of acute myocardial infarction by two-dimensional echocardiography.

    abstract::To define the role of portable two-dimensional echocardiography (2-D echo) in the immediate diagnosis of acute chest pain syndrome, 80 consecutive patients were studied. Adequate 2-D echo studies were obtained in 65 (81%). Thirty-three patients had clinical evidence of transmural or nontransmural acute myocardial infa...


    pub_type: 杂志文章


    authors: Horowitz RS,Morganroth J,Parrotto C,Chen CC,Soffer J,Pauletto FJ

    更新日期:1982-02-01 00:00:00

  • Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries. Patterns of use and outcomes.

    abstract:BACKGROUND:Although aspirin is an effective, inexpensive, and safe treatment of acute myocardial infarction, the frequency of use of aspirin in actual medical practice is not known. Elderly patients, a group with low rates of utilization of effective therapies such as thrombolytic therapy, also may be at risk of not re...


    pub_type: 杂志文章


    authors: Krumholz HM,Radford MJ,Ellerbeck EF,Hennen J,Meehan TP,Petrillo M,Wang Y,Kresowik TF,Jencks SF

    更新日期:1995-11-15 00:00:00

  • Quantitative coronary arteriography: estimation of dimensions, hemodynamic resistance, and atheroma mass of coronary artery lesions using the arteriogram and digital computation.

    abstract::More accurate characterization of coronary artery lesions is needed for evaluation of short and long-term interventions in coronary disease. A method of segmental artery analysis has been developed to maximize the information obtained from coronary arteriograms. Coronary lesions are traced from two projected, perpendi...


    pub_type: 杂志文章


    authors: Brown BG,Bolson E,Frimer M,Dodge HT

    更新日期:1977-02-01 00:00:00

  • A prospective randomized study of a modified technique of ultrafiltration during pediatric open-heart surgery.

    abstract::Conventional ultrafiltration (UF) fails to reverse satisfactorily hemodilution and the rise in total body water (TBW) seen after cardiopulmonary bypass (CPB). We have modified the technique, timing, and placement of UF in the CPB circuit and in pilot studies observed controlled elevation of hematocrit and a significan...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Naik SK,Knight A,Elliott M

    更新日期:1991-11-01 00:00:00

  • Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome.

    abstract:BACKGROUND:Mutations in the gene G4.5 result in a wide spectrum of severe infantile cardiomyopathic phenotypes, including isolated left ventricular noncompaction (LVNC), as well as Barth syndrome (BTHS) with dilated cardiomyopathy (DCM). The purpose of this study was to investigate patients with LVNC or BTHS for mutati...


    pub_type: 杂志文章


    authors: Ichida F,Tsubata S,Bowles KR,Haneda N,Uese K,Miyawaki T,Dreyer WJ,Messina J,Li H,Bowles NE,Towbin JA

    更新日期:2001-03-06 00:00:00

  • Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium.

    abstract:BACKGROUND:Prolonged metabolic abnormalities have been demonstrated previously in postischemic myocardium, including relative increases in glucose uptake and abnormal fatty acid kinetics. However, quantitative metabolic information is limited, and the time course of changes in MVO2 in postischemic myocardium is unknown...


    pub_type: 杂志文章


    authors: Buxton DB,Mody FV,Krivokapich J,Phelps ME,Schelbert HR

    更新日期:1992-05-01 00:00:00

  • High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men.

    abstract:BACKGROUND:Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients. METHODS AND RESULTS:We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoprotein...


    pub_type: 杂志文章


    authors: Deguchi H,Pecheniuk NM,Elias DJ,Averell PM,Griffin JH

    更新日期:2005-08-09 00:00:00

  • Long-term cardiac pro-B-type natriuretic peptide gene delivery prevents the development of hypertensive heart disease in spontaneously hypertensive rats.

    abstract:BACKGROUND:Diastolic dysfunction associated with high blood pressure (BP) leads to cardiac remodeling and fibrosis and progression to congestive heart failure. B-type natriuretic peptide (BNP) has BP-lowering, antifibrotic, and antihypertrophic properties, which makes BNP an attractive agent for attenuating the adverse...


    pub_type: 杂志文章


    authors: Cataliotti A,Tonne JM,Bellavia D,Martin FL,Oehler EA,Harders GE,Campbell JM,Peng KW,Russell SJ,Malatino LS,Burnett JC Jr,Ikeda Y

    更新日期:2011-03-29 00:00:00

  • Reentry within the atrioventricular node: surgical cure with preservation of atrioventricular conduction.

    abstract::Paroxysmal supraventricular tachycardia (PSVT) is commonly caused by reentry within the atrioventricular (AV) node. This arrhythmia was abolished by operative dissection of the AV junction in a patient with disabling tachycardia that was not controlled by drugs. The operation was intended to create complete AV block, ...


    pub_type: 杂志文章


    authors: Pritchett EL,Anderson RW,Benditt DG,Kasell J,Harrison L,Wallace AG,Sealy WC,Gallagher JJ

    更新日期:1979-08-01 00:00:00

  • Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity.

    abstract::Background- Cardiovagal baroreflex sensitivity (BRS) declines with age but is favorably modulated by habitual aerobic exercise. We tested the hypothesis that compliance (transducing capacity) of an elastic artery in which baroreceptors are located is associated with these age-exercise interactions. Methods and Results...


    pub_type: 杂志文章


    authors: Monahan KD,Tanaka H,Dinenno FA,Seals DR

    更新日期:2001-10-02 00:00:00

  • Active and passive tobacco exposure: a serious pediatric health problem. A statement from the Committee on Atherosclerosis and Hypertension in Children, Council on Cardiovascular Disease in the Young, American Heart Association.

    abstract::This review defines the substantial pediatric morbidity from tobacco use, including health effects on the cardiovascular system, the respiratory system, the fetus and newborn, and risk-taking behaviors of adolescents. More recent research suggests effects may extend to other areas, including reports that cigarette smo...


    pub_type: 杂志文章,评审



    更新日期:1994-11-01 00:00:00

  • Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats.

    abstract:BACKGROUND:Estrogen may increase the long-term survival of women who have suffered from a myocardial infarction (MI). We examined the acute and chronic influence of estrogen on MI in the rat left coronary artery ligation model. METHODS AND RESULTS:Female Sprague-Dawley rats (10 to 12 weeks, n=93), divided into 3 group...


    pub_type: 杂志文章


    authors: Smith PJ,Ornatsky O,Stewart DJ,Picard P,Dawood F,Wen WH,Liu PP,Webb DJ,Monge JC

    更新日期:2000-12-12 00:00:00

  • Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans.

    abstract:BACKGROUND:Although long-term lipid-lowering therapy improves endothelium-dependent vasodilatation in humans, it remains unknown whether the short-term removal of LDL per se ameliorates endothelial dysfunction. METHODS AND RESULTS:To examine the effects of a single session of LDL apheresis on endothelial function in p...


    pub_type: 杂志文章


    authors: Tamai O,Matsuoka H,Itabe H,Wada Y,Kohno K,Imaizumi T

    更新日期:1997-01-07 00:00:00

  • Hyperkalemia enhances the effect of adenosine on IK,ADO in rabbit isolated AV nodal myocytes and on AV nodal conduction in guinea pig isolated heart.

    abstract:BACKGROUND:The atrioventricular (AV) node is insensitive to changes in extracellular potassium concentration, [K+]o, because of the absence of the inward rectifier potassium current (IK1). However, we propose that in the presence of adenosine, elevated [K+]o should increase the adenosine-activated inward rectifier pota...


    pub_type: 杂志文章


    authors: Martynyuk AE,Morey TE,Belardinelli L,Dennis DM

    更新日期:1999-01-19 00:00:00