ERM proteins: from cellular architecture to cell signaling.

Abstract:

:ERM (ezrin/radixin/moesin) proteins, concentrated in actin rich cell-surface structures, cross-link actin filaments with the plasma membrane. They are involved in the formation of microvilli, cell-cell adhesion, maintenance of cell shape, cell motility and membrane trafficking. Recent analyses reveal that they are not only involved in cytoskeleton organization but also in signaling pathway. They play an important role in the activation of members of the Rho family by recruiting their regulators. The functions of ERM proteins are regulated by their conformational charges: the intramolecular interaction between the N- and C-terminal domains of ERM proteins charges masks several binding sites, leading to a dormant protein. Different activation signals regulate ERM proteins functions by modulating these intramolecular interactions. The involvement of ERM proteins in many signaling pathways has led to study their role during development of different species.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

Louvet-Vallée S

doi

10.1016/s0248-4900(00)01078-9

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

305-16

issue

5

eissn

0248-4900

issn

1768-322X

pii

S0248490000010789

journal_volume

92

pub_type

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