Transient rise in serum soluble Fas (APO-1/CD95) in patients undergoing cardiac surgery.


:The Fas molecule, also designated APO-1/CD95, belongs to the tumor necrosis factor (TNF) receptor family. It is a widely expressed membrane-anchored protein that induces apoptosis by Fas/Fas ligand (Fas-L) mediation. It was reported that Fas-mediated apoptosis plays an important role in regulation of the immune system, systemic inflammatory response, and ischemia/reperfusion injury. A soluble form of Fas (sFas) is produced either through the proteolytic cleavage of membrane-bound receptors or by alternative splicing, and sFas is thought to be implicated in apoptosis. In addition, sFas released damaged cells, and elevated serum levels of sFas reflect systemic tissue damage. To examine the specificity of sFas production during cardiac surgery with cardiopulmonary bypass, we serially measured the serum sFas levels in 13 patients during and after surgery. Blood samples were obtained before surgery, at the end of cardiopulmonary bypass, at the end of surgery, and at 12 h after surgery. Levels of serum sFas were determined by sandwich ELISA. Seven patients undergoing other types of surgeries served as controls. Although increased sFas was not observed in the control group, a significantly higher sFas level was detected in cardiac surgical patients at the end of surgery than before surgery (p = 0. 028), and the level decreased at 12 h after surgery. A significant correlation was observed between the maximum sFas values and the length of surgery (r = 0.659, p = 0.012) and cardioplegic arrest (r = 0.559, p = 0.046). Elevated serum sFas levels were observed in patients undergoing cardiac surgery, and these serum sFas levels reflect the severity of a surgery. sFas may play an important role in the pathophysiology of surgical damage caused by cardiac surgery with cardiopulmonary bypass.


Artif Organs


Artificial organs


Kawahito K,Misawa Y,Fuse K




Has Abstract


2000-08-01 00:00:00














  • Pre- and postoperative magnetic resonance imaging in neonatal arterial switch operation using warm perfusion.

    abstract::Neurological morbidity is a major concern in pediatric cardiac surgery. Cardiopulmonary bypass is one of the few modifiable factors affecting neurodevelopmental outcome. This study aimed to measure the incidence of abnormalities apparent by magnetic resonance imaging (MRI) after neonatal arterial switch operation usin...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Durandy Y,Rubatti M,Couturier R,Rohnean A

    更新日期:2011-11-01 00:00:00

  • Circulatory support for patients experiencing postcardiotomy cardiogenic shock: analysis of risk factors for death and long-term follow-up.

    abstract::Over the last 5 years, 12 patients received ventricular assist devices (VADs) while in postcardiotomy cardiogenic shock. There were 7 male and 5 female patients ranging in age from 22 to 73 years (average age, 54). Eight patients underwent surgery for valve replacements, 3 for coronary artery bypass graftings, and 1 f...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Murakami T,Nakayama H,Irie H,Kino K,Hisamochi K,Koomoto T,Takagaki M,Sugawara E,Senoo Y,Teramoto S

    更新日期:1993-07-01 00:00:00

  • Effects of atrial arrhytmias on the regurgitation of a monoleaflet prosthetic heart valve.

    abstract::Many patients who receive a prosthetic heart valve also have or acquire cardiac arrhythmias. However, most in vitro studies of prosthetic valves examine them under normal rhythms. In this study, a monoleaflet prosthetic heart valve was tested in vitro under conditions that simulated normal sinus rhythm, first degree a...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Zapanta CM

    更新日期:2005-08-01 00:00:00

  • Uremic neuropathy: evidence of middle molecule toxicity.

    abstract::Ten dialysis patients were followed in a prospective study to determine the neurotoxicity of metabolites in the middle molecule (MM) molecular weight (mol wt) range of 500-200 daltons/molecule. In the absence of readily available direct serum measurements of MM concentrations, a theoretically calculated dialysis index...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Milutinovic J,Babb AL,Eschbach JW,Follette WC,Graefe U,Strand MJ,Scribner BH

    更新日期:1978-02-01 00:00:00

  • Microbial and endotoxin contamination in water and dialysate in the central United States.

    abstract::The purified water supplies and randomly selected dialysates of 51 chronic and acute dialysis centers in the central United States were surveyed to assess the relative risks to dialysis patients from microbial and endotoxin contamination. A culture medium more sensitive than those generally employed in routine quality...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Klein E,Pass T,Harding GB,Wright R,Million C

    更新日期:1990-04-01 00:00:00

  • Peritoneal dialysis solutions for the 21st century.

    abstract::Existing peritoneal dialysis (PD) solutions were formulated for the maintenance of fluid and electrolyte balance, correction of metabolic acidosis, and the removal of metabolic waste products. Solutions currently in development are designed to improve biocompatibility by neutralizing pH and reducing glucose degradatio...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审


    authors: Martis L,Chen C,Moberly JB

    更新日期:1998-01-01 00:00:00

  • Outcome analysis for prediction of intraaortic balloon pump support failure and long-term survival in high-risk patients undergoing mitral valve surgery.

    abstract::The outcome predictors of intra-aortic balloon pump (IABP) in patients who undergo mitral valve surgery remain unknown. This study aimed to retrospectively review valvular surgery in patients who received an IABP to identify the predictors of failure of IABP support and anticipate the necessary therapy. This retrospec...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Liang M,Wang C,Feng K,Chen G,Wang K,Wu Z

    更新日期:2020-08-01 00:00:00

  • Acquired Von Willebrand Syndrome and Blood Pump Design.

    abstract::The existence of acquired von Willebrand syndrome (AVWS) in patients with continuous flow left ventricular assist devices (LVADs) is well documented and has been verified by numerous investigators. AVWS has not been observed to occur in pulsatile devices such as the SynCardia total artificial heart (TAH), the HeartMat...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审


    authors: Rosenberg G,Siedlecki CA,Jhun CS,Weiss WJ,Manning K,Deutsch S,Pierce W

    更新日期:2018-12-01 00:00:00

  • Stent treatment of inferior vena cava compression in an ovine with a total artificial heart.

    abstract::Although current continuous-flow total artificial hearts (CFTAHs) are much smaller than previous models, venous kinking may still occur after device implantation, especially in smaller animals. By inserting a self-expanding stent at the site of venous narrowing in a sheep model implanted with a CFTAH, we were able to ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Tuzun E,Parnis S,Rios J,Winkler JA,Cohn WE

    更新日期:2011-07-01 00:00:00

  • Single-center experience with partial support device in destination therapy for end-stage heart failure.

    abstract::Ventricular assist devices (VADs) are considered the standard of care for end-stage heart failure (HF) patients. Despite increasing confidence in the technology, evidence data, endorsement by scientific societies and guidelines, the number of implants reached a steady state and is not increasing at the expected pace. ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Barbone A,Pagliaro B,Basciu A,Iaccarino A,Droandi G,Romano G,Citterio E,Fumero A,Torracca L,Pini D

    更新日期:2020-04-23 00:00:00

  • Antimicrobial Wound Dressing Containing Silver Sulfadiazine With High Biocompatibility: In Vitro Study.

    abstract::Many patients all over the world suffer from acute wounds caused by traumas or burns. In most crucial cases, skin regeneration cannot be promoted spontaneously, and skin grafts are applied as the main treatment. However, this therapy has some drawbacks which motivate researchers to develop wound dressings. In this stu...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Mohseni M,Shamloo A,Aghababaei Z,Vossoughi M,Moravvej H

    更新日期:2016-08-01 00:00:00

  • Short hemodialysis: long-term mortality and morbidity.

    abstract::Individualized short hemodialysis treatment schedules, approximately three 3-h treatments per week, were introduced in a nephrology unit in 1976. In May 1985, 259 patients had been treated, which corresponds to approximately 60 new patients per million inhabitants per year. Ages at start of therapy ranged between 17 a...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Wauters JP,Bercini-Pansiot S,Gilliard N,Stauffer JC

    更新日期:1986-06-01 00:00:00

  • Magnevad status of design improvements human blood results and preliminary sheep trial.

    abstract::Magnevad II is an improved version of Magnevad I and both are fourth-generation axial flow left ventricular assist devices. A major simplification has been implemented and tested. Magnevad I used a magnetically suspended rotor requiring active axial control. Magnevad II is completely passive but otherwise similar. A s...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Goldowsky M,Lafaro R,Reed G

    更新日期:2005-10-01 00:00:00

  • Quantification of Shear-Induced Platelet Activation: High Shear Stresses for Short Exposure Time.

    abstract::Thrombosis and thromboembolism are the life-threatening clinical complications for patients supported or treated with prosthetic cardiovascular devices. The high mechanical shear stress within these devices is believed to be the major contributing factor to cause platelet activation (PA) and function alteration, leadi...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ding J,Chen Z,Niu S,Zhang J,Mondal NK,Griffith BP,Wu ZJ

    更新日期:2015-07-01 00:00:00

  • First experiences with outpatient care of patients with implanted axial flow pumps.

    abstract::As known from patients with pulsatile ventricular assist devices (VADs), early mobilization, physical exercise, and return to normal life are essential for optimal recovery. Recently, implantable rotary pumps became available for extended left ventricular support as bridges to transplantation. Modified procedures are ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Wieselthaler GM,Schima H,Dworschak M,Quittan M,Nuhr M,Czerny M,Seebacher G,Huber L,Grimm M,Wolner E

    更新日期:2001-05-01 00:00:00

  • Flow through an outlet cannula of a rotary ventricular assist device.

    abstract::Rotary ventricular assist devices (VADs) are primarily used during surgery and short-term postoperative assistance. There are issues involving the use of rotary VADs including the behavior of flow emanating from the assist device which might induce flow irregularities that could potentially lead to stroke or cerebrova...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Manning KB,Miller GE

    更新日期:2002-08-01 00:00:00

  • Paracorporeal assistance system for restoring cardiac activity.

    abstract::Two series of experiments were conducted to assess the potential of artificial ventricular bypass in restoring cardiac activity. One series evaluated use of a paracorporeal left ventricle in 17 calves; the other evaluated biventricular bypass in 11 calves. Module pumps with a seamless blood chamber of polyurethane wer...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Tolpekin VE,Koblov LF,Kuvaev AE,Gasanov EK

    更新日期:1987-02-01 00:00:00

  • A novel technique to produce tubular scaffolds based on collagen and elastin.

    abstract::Tubular polymer scaffolds based on tissue engineering techniques have been studied as potential alternatives for vascular regeneration implants. The blood vessels of the cardiovascular system are mainly fibrous, composed of collagen (Col) and elastin (El), and its inner layer consists of endothelial cells. In this wor...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Rodrigues ICP,Pereira KD,Woigt LF,Jardini AL,Luchessi AD,Lopes ÉSN,Webster TJ,Gabriel LP

    更新日期:2020-11-10 00:00:00

  • Testosterone and hemoglobin in hemodialysis male and female patients.

    abstract::It has been speculated that testosterone stimulates erythropoiesis. We hypothesized that hemoglobin levels in hemodialysis (HD) patients are associated with serum testosterone concentrations. Testosterone, hemoglobin, and other biochemical parameters were measured in a representative sample of 98 chronic HD patients (...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ekart R,Taskovska M,Hojs N,Bevc S,Hojs R

    更新日期:2014-07-01 00:00:00

  • Technical feasibility of umbilical cannulation in midgestation lambs supported by the EXTra-uterine Environment for Neonatal Development (EXTEND).

    abstract::EXTEND (EXTra-uterine Environment for Neonatal Development) is a novel system for supporting extremely premature infants that replicates in utero conditions by maintaining a sterile fluid environment and providing gas exchange via a pumpless arteriovenous oxygenator circuit connected to the umbilical vessels. Target g...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Hornick MA,Mejaddam AY,McGovern PE,Hwang G,Han J,Peranteau WH,Partridge EA,Davey MG,Flake AW

    更新日期:2019-12-01 00:00:00

  • Transcutaneous monitoring of blood gas tensions in patients on intermittent peritoneal dialysis.

    abstract::A relative contraindication to intermittent peritoneal dialysis (IPD) is chronic lung disease. To evaluate whether the instillation of 2 L of fluid into the peritoneal cavity affects respiratory function, five IPD patients were studied in the supine position during the first 4 h of a routine IPD session. Blood gas ten...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Korzets Z,Pomeranz A,Shachor Y,Bernheim J

    更新日期:1988-06-01 00:00:00

  • Numerical Simulation of Nonpulsatile Left Ventricular Bypass.

    abstract::A computer simulation was carried out to investigate the influence of nonpulsatile left ventricular assistance on hemodynamics. A simulation circuit was constructed to represent the circulatory system. A source of current was added to denote the nonpulsatile blood pump. The left and right ventricles were replaced by v...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Mitsui N,Fukunaga S,Koura Y,Morita S,Hotei H,Sueshiro M,Sueda T,Matsuura Y

    更新日期:1996-05-01 00:00:00

  • Cell exclusion in couette flow: evaluation through flow visualization and mechanical forces.

    abstract::Cell exclusion is the phenomenon whereby the hematocrit and viscosity of blood decrease in areas of high stress. While this is well known in naturally occurring Poiseuille flow in the human body, it has never previously been shown in Couette flow, which occurs in implantable devices including blood pumps. The high-she...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Leslie LJ,Marshall LJ,Devitt A,Hilton A,Tansley GD

    更新日期:2013-03-01 00:00:00

  • Double filtration plasmapheresis for the treatment of rheumatoid arthritis: a study of 21 cases.

    abstract::The treatment of rheumatoid arthritis remains difficult and often controversial. Plasma exchange has been advocated in some cases. In the present study 71 sessions of double filtration plasmapheresis (DFPP) were performed in 21 patients with rheumatoid arthritis in an average of 3.7 +/- 1.1 sessions per patient within...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Liu JD,Zhang C,Li WS,Lun LD

    更新日期:1997-02-01 00:00:00

  • A computerized model to analyze transcellular fluid shift during hemofiltration.

    abstract::Using urea and inulin as markers, we have developed a simple method to calculate intracellular and extracellular fluid volume in patients before and after hemofiltration therapy. During conventional hemofiltration using substitution fluid with a Na+ concentration of 140 mEq/L, a decrease in extracellular fluid volume ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Kimura G,Satani M,Kojima S,Kuroda K,Itoh K,Ikeda M

    更新日期:1982-02-01 00:00:00

  • Hemodynamic Evaluation of a Biological and Mechanical Aortic Valve Prosthesis Using Patient-Specific MRI-Based CFD.

    abstract::Modeling different treatment options before a procedure is performed is a promising approach for surgical decision making and patient care in heart valve disease. This study investigated the hemodynamic impact of different prostheses through patient-specific MRI-based CFD simulations. Ten time-resolved MRI data sets w...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Hellmeier F,Nordmeyer S,Yevtushenko P,Bruening J,Berger F,Kuehne T,Goubergrits L,Kelm M

    更新日期:2018-01-01 00:00:00

  • Clinical long-term results of vascular prosthesis sealed with fragmented autologous adipose tissue.

    abstract::Tissue engineering can improve the former limitations of artificial organs. This article reports the long-term clinical results of grafts constructed with fragmented autologous adipose tissue. We did a retrospective analysis of a series of 53 patients with lower leg ischemia that received 69 fragmented adipose tissue ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Karube N,Soma T,Noishiki Y,Yamazaki I,Kosuge T,Ichikawa Y,Takanashi Y

    更新日期:2001-03-01 00:00:00

  • Low-intensity ultrasound stimulation enhances chondrogenic differentiation in alginate culture of mesenchymal stem cells.

    abstract::Mesenchymal stem cells (MSCs) are regarded as a potential autologous source for cartilage repair, because they can differentiate into chondrocytes by transforming growth factor-beta (TGF-beta) treatment under the 3-dimensional (3-D) culture condition. However, more efficient and versatile methods for chondrogenic diff...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Lee HJ,Choi BH,Min BH,Son YS,Park SR

    更新日期:2006-09-01 00:00:00

  • An In Vitro Feasibility Study of the Influence of Configurations and Leaflet Thickness on the Hydrodynamics of Deformed Transcatheter Aortic Valve.

    abstract::Clinically, the percutaneous transcatheter aortic valve (TAV) has been reported to be deformed in a noncircular configuration after its implant. The deformation is universal and various, and it leads to serious leakage and durability problems. Even in the same deformation, the leaflets made in different tissue thickne...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Feng W,Yang X,Liu Y,Fan Y

    更新日期:2017-08-01 00:00:00

  • Electrotactile stimulator for artificial proprioception.

    abstract::With the goal of investigating artificial proprioception elicited by electrical stimulation, we have developed a tactile phi phenomenon-based stimulator. This two-channel microprocessed pulse amplitude modulation system generates two different envelope waveforms (triangular and elliptical) and allows programming and v...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Nohama P,Lopes AV,Cliquet Júnior A

    更新日期:1995-03-01 00:00:00