Abstract：
:The Fas molecule, also designated APO-1/CD95, belongs to the tumor necrosis factor (TNF) receptor family. It is a widely expressed membrane-anchored protein that induces apoptosis by Fas/Fas ligand (Fas-L) mediation. It was reported that Fas-mediated apoptosis plays an important role in regulation of the immune system, systemic inflammatory response, and ischemia/reperfusion injury. A soluble form of Fas (sFas) is produced either through the proteolytic cleavage of membrane-bound receptors or by alternative splicing, and sFas is thought to be implicated in apoptosis. In addition, sFas released damaged cells, and elevated serum levels of sFas reflect systemic tissue damage. To examine the specificity of sFas production during cardiac surgery with cardiopulmonary bypass, we serially measured the serum sFas levels in 13 patients during and after surgery. Blood samples were obtained before surgery, at the end of cardiopulmonary bypass, at the end of surgery, and at 12 h after surgery. Levels of serum sFas were determined by sandwich ELISA. Seven patients undergoing other types of surgeries served as controls. Although increased sFas was not observed in the control group, a significantly higher sFas level was detected in cardiac surgical patients at the end of surgery than before surgery (p = 0. 028), and the level decreased at 12 h after surgery. A significant correlation was observed between the maximum sFas values and the length of surgery (r = 0.659, p = 0.012) and cardioplegic arrest (r = 0.559, p = 0.046). Elevated serum sFas levels were observed in patients undergoing cardiac surgery, and these serum sFas levels reflect the severity of a surgery. sFas may play an important role in the pathophysiology of surgical damage caused by cardiac surgery with cardiopulmonary bypass.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Kawahito K,Misawa Y,Fuse Kdoi
10.1046/j.1525-1594.2000.06591.xsubject
Has Abstractpub_date
2000-08-01 00:00:00pages
628-31issue
8eissn
0160-564Xissn
1525-1594pii
aor6591journal_volume
24pub_type
杂志文章abstract：:This paper discussed issues of ethical assessment and moral concern associated with organ replacement and physical enhancement: research, allocation, organ donation, artificial organs, xenografts, biomaterials, and neuromaterials. While emphasizing the medical and moral benefits over associated risks, it calls for a b...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1995.tb02362.x
更新日期：1995-05-01 00:00:00
abstract：:The blood flow through the hemofilter device is the key point for ultrafiltrate production during continuous arteriovenous hemofiltration. It mainly depends on arteriovenous pressure gradient and vascular access, which is the major problem for arteriovenous hemofiltration in infants and small children. In infants, we ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1988.tb01518.x
更新日期：1988-02-01 00:00:00
abstract：:The thrombogenicity of membrane oxygenators as well as clotting parameters profiles, using standard human clotting tests, was analyzed in calves and pigs during 6 h perfusion. Three calves and 3 pigs were connected to extracorporeal circulation with standard heparinization. Blood samples were taken for coagulation var...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2001.025007579.x
更新日期：2001-07-01 00:00:00
abstract：:For the last few years we have attempted to separate and isolate from biological fluids the uremic Middle Molecules (MM). The first step in the treatment of plasma is an ultrafiltration through AN69 membrane. The samples are fractionated by Sephadex G-15 chromatography into 9 peaks "a" to "i' under precise conditions ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:The aim of this study was to investigate whether the use of a medically approved biodegradable scaffold as a solid support system would enhance graft survival following transplantation into the omental pouch in a preclinical large animal model. Six beagle dogs underwent total pancreatectomy followed by islet autotrans...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2008.00688.x
更新日期：2008-12-01 00:00:00
abstract：:Plasma levels of granulocyte elastase in complex with alpha 1-proteinase inhibitor (E-alpha 1-PI) increased during hemodialysis from 110 +/- 10 to 506 +/- 66 micrograms/L using dialyzers made of polyamide, from 95 +/- 2.2 to 211 +/- 54 micrograms/ml with hemophane and from 114 +/- 10 to 203 +/- 25 using dialyzers made...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1989.tb02842.x
更新日期：1989-04-01 00:00:00
abstract：:To elucidate the precise mechanism of carpal tunnel syndrome (CTS), serum hyaluronic acid (HA), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were measured in 71 chronic hemodialysis patients with or without CTS and/or shoulder pain. Patients were divided into two gr...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1994.tb02227.x
更新日期：1994-06-01 00:00:00
abstract：:Our aim was to study the aging effects on the in vitro biological properties of bone marrow-derived mesenchymal stem cells (BMSCs) for construction of tissue-engineered heart valves. BMSCs were taken from teenagers with congenital heart diseases, and middle-aged and elderly patients with valvular diseases. Proliferati...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00824.x
更新日期：2010-03-01 00:00:00
abstract：:One hundred and seventy-two patients at The Methodist Hospital in Houston, Texas, were placed on BioMedicus centrifugal ventricular support. One hundred thirty-nine patients were male and 33 were female with a mean age of 59.7 years. Reasons for support were postcardiotomy cardiac failure (129 patients), cardiac allog...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1995.tb02419.x
更新日期：1995-07-01 00:00:00
abstract：:There has been increasing interest in the development of a hepatocyte bioreactor for the treatment of acute hepatic failure; however, little is known about the effect of hepatocyte byproducts on the viability of the cells in the bioreactor environment. We investigated the effects of increasing concentrations of bile o...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1998.06088.x
更新日期：1998-10-01 00:00:00
abstract：:The aim of the present study was to compare the effects of ProTaper Gold, WaveOne Gold, ProTaper Universal, and WaveOne instruments on the amount of apically extruded debris. Eighty mandibular premolar teeth with straight root canals were selected and assigned to four groups (n = 20). The root canals were instrumented...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12675
更新日期：2016-08-01 00:00:00
abstract：:The efficacy of three flushing techniques on subsequent liver function was assessed using the in vivo isolated liver perfusion model (ILPM). Livers from brain-dead mongrel dogs were flushed with cold Euro-Collins as follows: Group I, rapid in situ flushing (10 min); Group II, regular in situ flushing (45 min); Group I...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1988.tb02760.x
更新日期：1988-06-01 00:00:00
abstract：:Modular hip prostheses are commonly used today. Dedicated surgical auxiliary instrumentation is indispensable. A correct coupling between the prosthesis and the instrument is necessary to avoid damage. Based on a specific commercial design (AnCAFit, Wright Cremascoli Ortho, Toulon, France), the aim of this work was to...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2006.00261.x
更新日期：2006-07-01 00:00:00
abstract：:This study aimed to clarify the role of peritoneal T-lymphocytes in peritoneal immune defense mechanisms. This study was designed to examine the changes in T-cell subpopulations during peritonitis in patients treated with continuous ambulatory peritoneal dialysis (CAPD). Our observations were correlated to responses t...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00802.x
更新日期：2009-12-01 00:00:00
abstract：:The effectiveness of the blood substitute neo red cells (NRC) on hemorrhagic shock was evaluated in dogs. Shock was induced by bloodletting, and NRC was infused immediately until the dogs recovered from shock; the process was repeated 3 times (mild shock), or NRC was infused after shock was maintained for 30 min, and ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
abstract：:Patients with end-stage renal disease have a very high prevalence and extent of arterial calcification. A number of studies suggest that similar pathophysiologic mechanisms are responsible for development and progression of calcification of atherosclerotic plaque and bone formation. Fetuin-A is a potent calcification ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00814.x
更新日期：2009-10-01 00:00:00
abstract：:This study assessed the efficacy of multiarterial bypass in coronary artery bypass grafting (CABG) in dialysis patients. Eighty dialysis patients who underwent CABG were divided into 2 groups. Group A consisted of 38 patients in whom the left internal thoracic artery and additional saphenous vein graft (SVG) had been ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:Plasma, in an amount corresponding to 0.05 gm fibrinogen/Kg of body weight, was administered during one hour to defibrinogenated dogs subjected to extracorporeal circulation. Four blood filters included in the extracorporeal circuit were removed one by one at 30-minute intervals. The prefilter pressures rose gradually...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1979.tb03809.x
更新日期：1979-02-01 00:00:00
abstract：:It has been speculated that testosterone stimulates erythropoiesis. We hypothesized that hemoglobin levels in hemodialysis (HD) patients are associated with serum testosterone concentrations. Testosterone, hemoglobin, and other biochemical parameters were measured in a representative sample of 98 chronic HD patients (...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12218
更新日期：2014-07-01 00:00:00
abstract：:The coronary arteries of the goat heart were studied using angiographic techniques and molds of the coronary vessel trees. Blood supplies to the left and right ventricles, interventricular septum, atrioventricular node, and apex of the caprine heart were studied. The goat possesses a left dominant pattern of coronary ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1983.tb04192.x
更新日期：1983-05-01 00:00:00
abstract：:Tissue-engineered heart valves constructed from a xenogeneic or allogeneic decellularized matrix might overcome the disadvantages of current heart valve substitutes. One major necessity besides effective decellularization is to preserve the biomechanical properties of the valve. Native and decellularized porcine pulmo...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2007.00452.x
更新日期：2008-01-01 00:00:00
abstract：:Different from the existing tissue engineering strategies, rapid prototyping (RP) techniques aim to automatically produce complex organs directly from computer-aided design freeform models with high resolution and sophistication. Analogous to building a nuclear power plant, cell biology (especially, renewable stem cel...
journal_title：Artificial organs
pub_type： 杂志文章,评审
doi：10.1111/j.1525-1594.2012.01499.x
更新日期：2012-11-01 00:00:00
abstract：:Thyrotoxic crisis (thyroid storm) is a life-threatening condition. Standard therapy is based on thiamazole, prednisolone, and nonselective beta-blockers. Extracorporeal plasmapheresis is an additional tool for removing circulating thyroxine in patients who do not respond quickly to conventional standard therapy. As th...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00924.x
更新日期：2010-02-01 00:00:00
abstract：:To remove anti-DNA antibodies from a patient's plasma with systemic lupus erythematosus (SLE), a DNA immunoadsorbent was developed by covalently coupling calf thymus DNA on activated Sepharose 4FF. Sepharose 4FF was activated with 5-norbornene-2,3-dicarboximido carbonochloridate (Cl-CO-ONB), which was proven to be a v...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2000.06618.x
更新日期：2000-11-01 00:00:00
abstract：:In clinical application of rotary blood pumps, flow obstruction as a result of suction of the inflow cannula, kinking of tubing, or thrombus formation occurs quite frequently. Early detection of such problems is essential to avoid hemolysis, tissue degradation, or release of thrombi to the patient. A program was devel...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1995.tb02409.x
更新日期：1995-07-01 00:00:00
abstract：:This article reports preliminary results of pilot studies of a new implantable two channel drop foot stimulator. The stimulator consists of an externally worn transmitter inductively coupled to an implanted receiver unit located in the lower leg, lateral and distal to the knee. The receiver is connected to electrodes ...
journal_title：Artificial organs
pub_type： 临床试验,杂志文章
doi：10.1046/j.1525-1594.2002.06949.x
更新日期：2002-03-01 00:00:00
abstract：:The feasibility of extracorporeal adsorption of 1.5-3 L plasma on protein A-Sepharose was investigated in six patients with advanced cancer. Anticoagulation with heparin was associated with respiratory distress syndrome in two patients, most likely caused by complement activation as indicated by a transient leukopenia...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1984.tb04247.x
更新日期：1984-02-01 00:00:00
abstract：:Changes in plasma sodium (Na) concentration during hemodialysis were predicted by changes in Na concentration of the dialysate at equilibrium with the plasma, according to the formula C't = CD - (CD - C'0) [(V0 - QFt)/V0]A/QF, where C'0 and C't are the Na concentration of the dialysate at equilibrium with the plasma a...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1985.tb04365.x
更新日期：1985-05-01 00:00:00
abstract：:Stem cells transplanted to an injured heart affect the host myocardium indirectly. The cytokine hepatocyte growth factor (HGF) may play a key role in this paracrine activity. We hypothesized that HGF-overexpressing stem cells would restore cardiac function after myocardial infarction (MI). Because there is a high rate...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2011.01328.x
更新日期：2012-03-01 00:00:00
abstract：:Although effects of biochemical modulation of stem cells have been widely investigated, only recent advances have been made in the identification of mechanical conditioning on cell signaling pathways. Experimental investigations quantifying the micromechanical environment of mesenchymal stem cells (MSCs) are challengi...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12547
更新日期：2016-03-01 00:00:00
