Abstract:
OBJECTIVE:Sphingosine 1-phosphate is a naturally occurring biologically active lysophospholipid. Recent studies suggested that sphingosine 1-phosphate is released into the blood flow from activated platelets upon stimulation to exert multiple biological phenomenon. The purpose of this study was to assess the effects of sphingosine 1-phosphate on sinus automaticity, ventricular contraction and coronary blood flow. METHODS:The canine isolated, blood-perfused sinoatrial node and papillary muscle preparations were used. RESULTS:Sphingosine 1-phosphate increased the sinoatrial rate, while it decreased the coronary blood flow, which was followed by a weak negative inotropic effect. These positive chronotropic and coronary vasoconstrictor effects were not attenuated by the beta- and alpha-adrenoceptor antagonists atenolol and prazosin, respectively. Furthermore, sphingosine 1-phosphate did not affect the adenylate cyclase activity of the membrane preparations made from the canine right atrium and right ventricle, indicating the involvement of a novel signaling pathway in sphingosine 1-phosphate-induced cardiac effects. CONCLUSIONS:These results may provide a clue to better understanding the physiological as well as the pathophysiological regulation of sphingosine 1-phosphate in the heart.
journal_name
Cardiovasc Resjournal_title
Cardiovascular researchauthors
Sugiyama A,Yatomi Y,Ozaki Y,Hashimoto Kdoi
10.1016/s0008-6363(00)00013-4subject
Has Abstractpub_date
2000-04-01 00:00:00pages
119-25issue
1eissn
0008-6363issn
1755-3245pii
S0008-6363(00)00013-4journal_volume
46pub_type
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