Abstract：
PURPOSE:Transvascular leakage occurs in diabetic retinopathy. The tight junction proteins occludin and zonula occludens-1 (ZO-1) and adherens junction protein cadherin-5 are critical to the maintenance of endothelial barrier. We report a comparison of junction protein expression in the normal and diabetic retina. METHOD:Case report. Postmortem retinal cryosections were prepared from the left eye of a 73-year-old woman with diabetic retinopathy. Cryosections were immunostained for cadherin-5, occludin, and ZO-1 and compared with retinal cryosections from the right eye of a 72-year-old man with no progression of retinal disease. RESULTS:Immunofluorescence showed positive retinal vessel staining for occludin and ZO-1 in both eyes and cadherin-5 in the normal eye but reduced cadherin-5 staining in the retinal vessels of the diabetic eye. CONCLUSION:Increases in transvascular leakage observed in diabetic retinal vasculature may be associated with reduction in the expression of the critical adherens junction protein, cadherin-5.
journal_name
Am J Ophthalmoljournal_title
American journal of ophthalmologyauthors
Davidson MK,Russ PK,Glick GG,Hoffman LH,Chang MS,Haselton FRdoi
10.1016/s0002-9394(99)00323-2subject
Has Abstractpub_date
2000-02-01 00:00:00pages
267-9issue
2eissn
0002-9394issn
1879-1891pii
S0002939499003232journal_volume
129pub_type
杂志文章abstract：PURPOSE:To determine whether polymorphisms in the Complement Factor H (CFH) gene and the Hemicentin-1 gene at the ARMD1 locus are associated with dry age-related macular degeneration (AMD) in Japanese patients. DESIGN:Clinically relevant laboratory investigation. METHODS:Eighty unrelated Japanese patients with dry AM...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
abstract：PURPOSE:To investigate the characteristics, mergers, and risk factors of different types of myopic maculopathy (MM) in a highly myopic population. DESIGN:Population-based, cross-sectional study. METHODS:A total of 1086 eyes (762 patients) were enrolled. Each participant underwent detailed ocular examinations. Combini...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1976-10-01 00:00:00
abstract：PURPOSE:To evaluate the safety and potential efficacy of gevokizumab, an anti-interleukin 1β (IL-1β) monoclonal antibody, in the treatment of active, noninfectious, non-necrotizing anterior scleritis. DESIGN:Phase 1/2, open label, nonrandomized, prospective, single-arm pilot trial. METHODS:Eight patients with active,...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章
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更新日期：2016-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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abstract：PURPOSE:To determine the population-based incidence and cause of cranial nerve palsies affecting ocular motility in children in the circumscribed population of Olmsted County, Minnesota. METHODS:The Rochester Epidemiology Project medical records linkage system captures virtually all medical care provided to Olmsted Co...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：1976-04-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2011-08-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2013-05-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2014.10.015
更新日期：2015-02-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0002-9394(99)00107-5
更新日期：1999-07-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1997-08-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ajo.2010.08.034
更新日期：2011-02-01 00:00:00
abstract：:We studied a new method for photographing cataractous lens opacaities by retroillumination. The slit-lamp microscope was modified with an adaptor to eliminate the specular reflection from the corneal surface. We construcated two kinds of adaptors for the Zeiss and Goldmann-type slit-lamp microscopes. The cataractous l...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(14)71005-0
更新日期：1997-01-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2002-10-01 00:00:00
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journal_title：American journal of ophthalmology
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更新日期：2013-12-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2021-01-22 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1987-07-15 00:00:00
abstract：PURPOSE:To report a case of congenital superior oblique palsy with an unusually large Bielschowsky head-tilt phenomenon (BHP) and disproportional inconspicuous vertical deviation. METHODS:Case report. RESULTS:An 18-year-old woman presented with slight compensatory head tilting and a Bielschowsky head-tilt phenomenon ...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
doi：10.1016/s0002-9394(00)00639-5
更新日期：2000-12-01 00:00:00
abstract：PURPOSE:To report the prevalence rates of anisometropia in a school population and determine the relative contribution of refractive power and axial length to the measured anisometropia. DESIGN:Population-based cross-sectional study. METHODS:Autorefraction, keratometry, and ultrasonography studies were made. SETTING...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：2004-03-01 00:00:00
abstract：:Ciprofloxacin is a potent fluoroquinolone antibiotic with in vitro activity against many significant gram-positive and gram-negative ocular pathogens. A review of the experimental studies of this antibiotic shows bactericidal activity, a broad antimicrobial spectrum, and a low incidence of resistance. The growing body...
journal_title：American journal of ophthalmology
pub_type： 杂志文章,评审
doi：
更新日期：1991-10-01 00:00:00
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journal_title：American journal of ophthalmology
pub_type： 杂志文章,多中心研究
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更新日期：2017-10-01 00:00:00
abstract：:We studied the behavior of intraocular pressure in glaucoma suspects randomly selected to receive either topical timolol or no treatment over the course of a long-term prospective follow-up study. All patients who after six years of follow-up showed no localized field defects or disk changes, or whose pressures were n...
journal_title：American journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1989-05-15 00:00:00
abstract：:A 59-year-old woman with no evidence of glaucoma developed secondary open-angle glaucoma after an intracapsular cataract extraction complicated by vitreous and iris incarceration. Histopathologic and scanning and electron microscopic studies of the enucleated eye 22 years later revealed extensive proliferation of iris...
journal_title：American journal of ophthalmology
pub_type： 杂志文章
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更新日期：1979-09-01 00:00:00
