Abstract：
BACKGROUND:Regression and undertreatment after initial photorefractive keratectomy (PRK) in higher myopes is not unusual. Patients frequently desire 20/20 uncorrected vision, which necessitates retreatments or enhancements. However, the safest and most efficacious way to treat these patients has not yet been established. This study evaluates two techniques of PRK enhancements, comparing two different methods of laser epithelial removal. DESIGN:Retrospective, nonrandomized, comparative trial. PARTICIPANTS:A total of 224 eyes. METHODS:Eyes were identified that had 6-month follow-up after a PRK enhancement from February 1995 through February 1997. Two methods of treatment were identified. The same VISX 20/20B laser in the same clinic was used for all retreatments. Group I patients had a total removal of the epithelium in a mode phototherapeutic keratectomy (PTK) prior to the refractive ablation. Group II patients had a total laser epithelial removal in two steps prior to the refractive ablation. The first step was a PRK and then a PTK. MAIN OUTCOME MEASURE:The disappearance of epithelial fluorescence was the end point for the PTK ablation in groups I and II. RESULTS:There were 131 eyes in group I and 93 eyes in group II. The mean spherical equivalent (SE) prior to the original PRK in group I was -7.5 diopters (D) +/- 3 D and in group II was -7.75 D +/- 2.34 D. The mean SE prior to the PRK retreatment in group I was -2.22 D +/- 1.29 D and in group II was -1.89 D +/- 0.83 D. The mean postoperative 6-month SE after the PRK enhancement in group I was -0.05 D +/- 0.80 D and in group II was 0.01 D +/- 1.08 D. A greater proportion of group I eyes (7.8%) had arcuate haze and a hyperopic shift from the 1- to 6-month postoperative visit (P = 0.03). CONCLUSIONS:A two-step laser epithelial removal compared with a one-step PTK epithelial laser removal in PRK retreatments provides a more even and confluent epithelial removal, less risk of arcuate haze development, and less risk of a hyperopic shift from 1 to 6 months after the retreatment.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
George SP,Johnson DGdoi
10.1016/S0161-6420(99)90439-6subject
Has Abstractpub_date
1999-08-01 00:00:00pages
1469-79; discussion 1479-80issue
8eissn
0161-6420issn
1549-4713pii
S0161-6420(99)90439-6journal_volume
106pub_type
临床试验,杂志文章相关文献
OPHTHALMOLOGY文献大全abstract：:*Subspecialty synopses are intended to present major clinical developments and innovations in diagnosis, treatment, surgical technique, and recent clinical research. Each synopsis, written by a recognized knowledgeable subspecialist, is co-sponsored by a major subspecialty society or organization. This subspecialty sy...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0161-6420(89)32789-8
更新日期：1989-07-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between retinal sensitivity and the photoreceptor inner segment/outer segment (IS/OS) layer status in patients with diabetic macular edema (DME). DESIGN:Cross-sectional study. PARTICIPANTS:Twenty-five adult patients (37 eyes) diagnosed with DME and managed at the Wilmer Eye Instit...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.12.003
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:To expand understanding of presentation, diagnosis, and outcomes of hemorrhagic occlusive retinal vasculitis (HORV). DESIGN:Retrospective case series. PARTICIPANTS:Thirty-six eyes of 23 patients. METHODS:The American Society of Cataract and Refractive Surgery (ASCRS) and the American Society of Retina Specia...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2016.11.042
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:To compare the rotational stability of the 2 most commonly used toric intraocular lenses (TIOLs). DESIGN:Retrospective cohort study in a single private practice. SUBJECTS:The study included all patients receiving an Acrysof (n = 626) or Tecnis TIOL (n = 647) over an 18-month period from April 2015 to Septembe...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2018.02.012
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:To identify ophthalmologic manifestations of the blue rubber bleb nevus syndrome, a rare cutaneovisceral hemangiomatosis. METHODS:The authors report two patients with a diagnosis of blue rubber bleb nevus syndrome with orbital hemangiomas. RESULTS:In one patient, the orbital lesion presented with signs and sy...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30584-8
更新日期：1996-06-01 00:00:00
abstract：PURPOSE:To describe the clinical and cytopathologic characteristics in patients with vitreous opacity of unknown cause or preceding inflammation, diagnosed cytopathologically as inflammation. DESIGN:Retrospective case series. PARTICIPANTS:Forty-three consecutive patients (61 eyes) who underwent vitrectomy for vitreou...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2011.10.020
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To describe the presentation and the clinical course of a patient with consecutive central sterile corneal perforations associated with common variable immunodeficiency. DESIGN:Case report. METHODS:Multiple corneal cultures and scrapings were performed in an effort to identify an infectious cause and all we...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(99)00005-6
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:Corneal and ocular wavefront aberrations were recorded together with clinical examination results and patient-reported vision-related quality-of-life evaluation results to define the relevance of dynamic optical analysis of the eye in dry eye disease (DED). DESIGN:Prospective and comparative clinical study. ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2012.03.004
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:To assess the relationship between cardiovascular disease and cardiovascular risk factors, other than smoking, and risk of long-term incident age-related macular degeneration (AMD). DESIGN:Population-based cohort study. PARTICIPANTS:There were 3654 baseline (1992-1994) participants aged > or = 49 years includ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2006.09.033
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:To characterize the clinicopathologic phenotype as well as the molecular genetic basis of an autosomal dominant form of corneal amyloidosis. DESIGN:Clinicopathologic and molecular genetic study of a family with a form of corneal amyloidosis. PARTICIPANTS:Forty-nine individuals from one family were studied. M...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.09.043
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy of a combination of 5-fluorouracil and low-molecular-weight heparin (LMWH) to improve the outcome of surgery for established proliferative vitreoretinopathy (PVR). DESIGN:Double-masked, prospective, randomized, placebo-controlled clinical trial. SETTING:Three tertiary-referral teac...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2004.05.036
更新日期：2004-12-01 00:00:00
abstract：:Recent studies have suggested that diffuse field loss and localized visual field loss in glaucomatous patients may have different pathophysiologic mechanisms. Testing that hypothesis requires that some patients present with purely localized field loss and other patients with purely diffuse loss. This article describes...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32092-x
更新日期：1991-10-01 00:00:00
abstract：OBJECTIVE:To study early direct effects of transpupillary thermotherapy (TTT) on choroidal neovascularization (CNV) and choroid. DESIGN:Retrospective, noncomparative interventional case series. PARTICIPANTS:Sixty-four eyes with subfoveal CNV. INTERVENTION:TTT was delivered using a diode laser at 810 nm through a con...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(02)01034-5
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:Orbital extraocular extension of choroidal melanoma is well known and is usually detected in eyes with medium and large tumors, but it is very rare with small melanomas. It is particularly unusual for choroidal melanomas of any size to invade the optic nerve or its meninges. DESIGN:Two case reports. PARTIC...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(99)00723-X
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:The effect of severing the check ligaments and intermuscular membranes on the dose-response curve for medial rectus recessions in patients with infantile esotropia has not been previously studied by randomized assignment techniques using contemporary control and experimental groups and masked precautions. M...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0161-6420(93)31550-2
更新日期：1993-06-01 00:00:00
abstract：PURPOSE:To determine 5-year outcomes of Descemet stripping endothelial keratoplasty (DSEK) for Fuchs' endothelial corneal dystrophy (FECD). DESIGN:Prospective cohort study. PARTICIPANTS:Fifty-two eyes of 45 subjects with FECD undergoing primary DSEK. METHODS:Subjects were examined before and at fixed intervals throu...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2015.09.023
更新日期：2016-01-01 00:00:00
abstract：:In a long-term study of 252 eyes that had initial glaucoma filtration surgery, there was an overall success rate of 85%. Rigid criteria for success included an intraocular pressure equal to or less than 19 mmHg, no further visual field loss or disc damage, and no glaucomatous etiology for a decrease in visual acuity. ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(86)33771-0
更新日期：1986-01-01 00:00:00
abstract：:Twenty-five ambulatory patients with acquired immunodeficiency syndrome (AIDS) were studied over a 6-month period. Fourteen (56%) of the patients were heterosexuals with a history of intravenous drug abuse. Ocular involvement was seen in 40% of patients, cotton-wool spots being the major manifestation. Findings consis...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：
更新日期：1983-08-01 00:00:00
abstract：BACKGROUND:Opportunistic infections frequently involve the anterior and posterior segments of the eye but rarely occur in the orbit in patients with human immunodeficiency virus (HIV) infection. The authors managed eight patients with HIV and unilateral orbital infections who presented between July 1988 and March 1995....
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0161-6420(96)30479-x
更新日期：1996-09-01 00:00:00
abstract：PURPOSE:To describe the clinical features and to present results of new diagnostic methods to help define the cause of the clinical syndrome of intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage (IHAPSH). DESIGN:Retrospective review of patients with IHAPSH at presentation seen in 3 centers in ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.08.040
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:Droperidol and the new serotonin-3 antagonists are effective drugs for the prophylaxis of postoperative nausea and vomiting (PONV). The aim of this trial was to evaluate whether dolasetron could be a substitute for droperidol, because the Food and Drug Administration has required a Black Box warning on the drop...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.ophtha.2004.01.031
更新日期：2004-08-01 00:00:00
abstract：:Trabeculotomy ab externo and goniotomy seem to be in many ways equivalent, and both are particularly successful in previously unoperated cases of primary infantile glaucoma that become apparent postnatally but before the age of 1 year. It may be more difficult to achieve a technically perfect procedure with trabeculot...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(83)34484-5
更新日期：1983-07-01 00:00:00
abstract：PURPOSE:To estimate retinal ganglion cell (RGC) losses associated with the earliest development of visual field defects in glaucoma. DESIGN:Observational cohort study. PARTICIPANTS:The study group included 53 eyes of 53 patients with suspected glaucoma who were followed as part of the Diagnostic Innovations in Glauco...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2012.09.039
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:Cataract and glaucoma commonly coexist in elderly patients and present complex treatment options. This study investigates the results of simultaneous treatment of both conditions using phacoemulsification with posterior chamber lens implant and mitomycin-augmented trabeculectomy (combined surgery). METHODS:A r...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30571-x
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVE:To describe characteristics of participants in the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) at baseline and to investigate associations among visual function, fundus features, and vision-related quality of life. DESIGN:Cross-sectional study. PARTICIPANTS:The 1052 participant...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2003.10.031
更新日期：2004-07-01 00:00:00
abstract：:Radial keratotomy was performed in 33 rabbits using an eight-incision technique. At various postoperative intervals up to 90 days, these eyes were enucleated and subjected to increasing quantitated trauma until ocular rupture occurred. Control animals (13 eyes) were subjected to similar trauma. The eyes that had surge...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(83)34502-4
更新日期：1983-06-01 00:00:00
abstract：PURPOSE:To evaluate whether confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph II [HRT II], Heidelberg Engineering, Heidelberg, Germany) is a valid tool for the detection of glaucomatous optic nerve damage. DESIGN:Observational, cross-sectional, nonconsecutive study in Montreal, Canada. PARTICIPANTS:...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.09.009
更新日期：2005-12-01 00:00:00
abstract：:The authors used the Humphrey Retinal Analyzer to study the effect of acute changes in intraocular pressure (IOP) on the topography of the optic nerve head in normotensive and hypertensive eyes of cynomolgus monkeys. Chronically elevated IOP was produced monocularly in monkeys by argon laser angle treatment. In 8 hype...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(91)32345-5
更新日期：1991-01-01 00:00:00
abstract：:The authors' experience over the past five years in the cryosurgical management of retinal detachment in ten eyes of eight premature infants with retrolental fibroplasia, whose ages at the time of detachment surgery ranged from 2 1/2 months to 11 months with an average of 5 1/2 months, is reported. Postoperative follo...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(79)35436-7
更新日期：1979-05-01 00:00:00
abstract：OBJECTIVE:To characterize optic nerve head (ONH) anatomy related to the clinical optic disc margin with spectral domain-optical coherence tomography (SD-OCT). DESIGN:Cross-sectional study. PARTICIPANTS:Patients with open-angle glaucoma with focal, diffuse, and sclerotic optic disc damage, and age-matched normal contr...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2011.09.054
更新日期：2012-04-01 00:00:00
