Abstract：
OBJECTIVE:To describe the presentation and the clinical course of a patient with consecutive central sterile corneal perforations associated with common variable immunodeficiency. DESIGN:Case report. METHODS:Multiple corneal cultures and scrapings were performed in an effort to identify an infectious cause and all were negative. Corneal biopsy did not demonstrate any evidence of micro-organisms. An extended investigation failed to uncover a collagen vascular cause or atopy. RESULTS:Progressive sterile stromal thinning with intact epithelium in the left eye proceeded to perforation despite topical treatment, and cyanoacrylate gluing was performed. However, a secondary Haemophilus influenza endophthalmitis developed, and the eye was eventually lost. The fellow eye proceeded along the same clinical course with sterile stromal thinning. A lamellar patch graft was performed when the central ulceration progressed to a descemetocele. The eye remained quiet with 20/25 vision for 2 years, until the patient died from complications of a liver transplant. CONCLUSIONS:Devastating central sterile corneal thinning leading to perforation may occur in patients with hypogammaglobulinemia.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Akpek EK,Haddad RS,Winkelstein JA,Gottsch JDdoi
10.1016/s0161-6420(99)00005-6subject
Has Abstractpub_date
2000-01-01 00:00:00pages
123-6issue
1eissn
0161-6420issn
1549-4713pii
S0161-6420(99)00005-6journal_volume
107pub_type
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