Recurrence of posterior uveal melanoma after 60Co episcleral plaque therapy.

Abstract:

:The authors analyzed the clinical and follow-up data on 277 selected patients with primary choroidal or ciliochoroidal melanoma who were treated with 60Co plaque radiotherapy between 1976 and 1982. Local recurrence of the irradiated melanoma developed in 39 (14%) patients during the follow-up interval. The 5-year tumor recurrence rate (Kaplan-Meier) was estimated to be 12%. Multivariate prognostic factor analysis (Cox proportional hazards modeling) identified the largest linear tumor dimension and proximity of the posterior margin of the tumor to the optic nerve head as predictors of recurrence. The 5-year survival rate of patients whose tumors recurred (58%) was significantly (log-rank test P = 0.0023) worse than that of patients whose tumor remained clinically controlled (82%).

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Karlsson UL,Augsburger JJ,Shields JA,Markoe AM,Brady LW,Woodleigh R

doi

10.1016/s0161-6420(89)32882-x

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

382-8

issue

3

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(89)32882-X

journal_volume

96

pub_type

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