Abstract：
:Transient changes in the corneal endothelium were the earliest detectable response to low atmospheric oxygen in experimental animals. Similar changes have been reported after hard and soft contact lens wear. We describe widespread transient cell changes by wide-field specular microscopy in the normal corneal endothelium after 12 hours of a light eye patch. The relative anoxia of lid closure during normal sleep appears to be the cause of observable changes. This observation questions the safety of extended wear contact lens over a prolonged period of time, and its significance to age-related endothelial cell density reduction and cornea guttata remains to be seen.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Khodadoust AA,Hirst LWdoi
10.1016/s0161-6420(84)34169-0subject
Has Abstractpub_date
1984-10-01 00:00:00pages
1125-8issue
10eissn
0161-6420issn
1549-4713pii
S0161-6420(84)34169-0journal_volume
91pub_type
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