Abstract:
OBJECTIVE:The purpose of the study is to examine the association between cardiovascular disease and its risk factors and the incidence of age-related maculopathy. PARTICIPANTS:A population of 3583 adults (range, 43-86 years of age at baseline) living in Beaver Dam, Wisconsin, was studied at baseline and 5 years later. METHODS:Standardized protocols for physical examination, blood collection, administration of a questionnaire, and stereoscopic color fundus photography to determine age-related maculopathy were used. Standard univariate and multivariate analyses were performed. MAIN OUTCOME MEASURES:Incidence and progression of age-related maculopathy were measured. RESULTS:After controlling for age and gender, the authors found both higher systolic blood pressure (odds ratio [OR] per 10 mmHg, 1.16; 95% confidence interval [CI] 1.05, 1.27) and uncontrolled treated hypertension (OR 1.98, 95% CI 1.00, 3.94) were related to the incidence of retinal pigment epithelial depigmentation. After controlling for age and gender, the authors found that both blood pressure and uncontrolled treated hypertension were not significantly associated with an increased risk of having exudative macular degeneration develop (for systolic blood pressure, OR 1.18, 95% CI 0.95, 1.45; for uncontrolled treated hypertension, OR 2.10, 95% CI 0.54, 8.11). After controlling for age and gender, the authors found higher pulse pressure was significantly associated with increased incidence of retinal pigment epithelial depigmentation (OR per 10 mmHg 1.27, 95% CI 1.14, 1.42) and exudative macular degeneration (OR per 10 mmHg 1.29, 95% CI 1.02, 1.65). These relations remained significant after controlling for other risk factors in multivariable analyses. CONCLUSIONS:These findings indicate modest relations between higher pulse pressure (a presumed indicator of atherosclerotic vascular disease) and uncontrolled hypertension with increased 5-year incidence of retinal pigment epithelial depigmentation. Overall, however, data from this study show neither consistent nor strong relations between cardiovascular disease and most of its risk factors with the incidence of lesions associated with age-related maculopathy.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Klein R,Klein BE,Jensen SCdoi
10.1016/s0161-6420(97)30023-2subject
Has Abstractpub_date
1997-11-01 00:00:00pages
1804-12issue
11eissn
0161-6420issn
1549-4713pii
S0161-6420(97)30023-2journal_volume
104pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:OBJECTIVE:To determine if instrument cleaning techniques affect the rate of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK). DESIGN:Retrospective case series. PARTICIPANTS:Two hundred ten eyes of 109 patients. METHODS:A record review was performed of all patients who underwent LASIK at th...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00876-4
更新日期:2002-02-01 00:00:00
abstract:PURPOSE:The aim of this study was to describe a new technique for transscleral suturing of posterior chamber intraocular lenses (PCIOLs) without intraocular knots. DESIGN:Retrospective noncomparative case series. PARTICIPANTS:Twenty-four eyes underwent implantation of PCIOLs with this new technique. METHODS:Suture f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00467-6
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:To investigate the efficacy of alcohol delamination in the management of recurrent corneal erosions (RCEs). DESIGN:Prospective single-center consecutive descriptive case series. PARTICIPANTS:Twelve patients with RCEs who did not respond to conservative management were treated with alcohol delamination. METHO...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2005.10.049
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To determine the long-term reproducibility of the retinal nerve fiber layer (RNFL) thickness deviation map in glaucoma patients. DESIGN:Retrospective, longitudinal study. PARTICIPANTS:One hundred two eyes of 102 glaucoma patients. METHODS:From a total of 318 screened glaucoma patients who had undergone at ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.11.008
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To investigate the associations of genetic variants in the high-density lipoprotein (HDL) metabolism pathway with neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). DESIGN:Cross-sectional, case-control association study. PARTICIPANTS:A Chinese case-control group of...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.10.042
更新日期:2014-04-01 00:00:00
abstract::One hundred twelve patients with vitiligo were examined for ocular abnormalities. Discrete areas of depigmentation with associated pigment hyperplasia clinically appearing to involve the choroid and retinal pigment epithelium were observed in 44 patients, and active uveitis was seen in nine patients. The changes obser...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35413-6
更新日期:1979-06-01 00:00:00
abstract:PURPOSE:To report the long-term outcomes of patients with iridocorneal endothelial (ICE) syndrome who required surgery for glaucoma. DESIGN:Retrospective, noncomparative case series. PARTICIPANTS:Twenty-six patients with ICE syndrome who underwent surgery for glaucoma at one institution between January 1987 and Janua...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(01)00725-4
更新日期:2001-10-01 00:00:00
abstract::In a prospective, double-masked clinical study, the authors evaluated the efficacy and safety of topically applied tretinoin ophthalmic ointment (0.01%) versus placebo in the treatment of squamous metaplasia associated with various ocular surface disorders involving dry eyes. Study parameters consisted of graded sympt...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0161-6420(88)33009-5
更新日期:1988-10-01 00:00:00
abstract::The present paper documents the clinical characteristics and ocular pathology in a patient with abetalipoproteinemia. Noteworthy were: the predominant involvement of the posterior fundus characterized by a loss of photoreceptors; loss or attenuation of the pigment epithelium (producing a sharply demarcated white appea...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(84)34203-8
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVE:To report the effects of intravenous immunoglobulin treatment of ten patients with progressive ocular cicatricial pemphigoid who did not respond to conventional immunomodulatory regimens. DESIGN:Noncomparative, interventional case series. PARTICIPANTS:Ten patients with biopsy-proven progressive cicatricial ...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/S0161-6420(99)90496-7
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To determine agreement between spectral-domain (SD) and time-domain (TD) optical coherence tomography (OCT) image assessments by certified readers in eyes treated for neovascular age-related macular degeneration (AMD). DESIGN:Cross-sectional study within the Comparison of AMD Treatments Trials (CATT). PARTI...
journal_title:Ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ophtha.2014.04.020
更新日期:2014-10-01 00:00:00
abstract::The age distribution, frequency, and correlation among histologic macular changes, including formation of a basal laminar deposit, drusen, and thickening and calcification of Bruch's membrane, were studied by light microscopy. The authors studied 182 unpaired postmortem human maculae from patients between 8 and 100 ye...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31982-7
更新日期:1992-02-01 00:00:00
abstract:PURPOSE:To evaluate treatment of juxtapapillary choroidal melanoma with plaque radiotherapy and to investigate the role of supplemental transpupillary thermotherapy (TTT). DESIGN:Retrospective, comparative case series. PARTICIPANTS:We included 650 consecutive eyes with juxtapapillary choroidal melanoma within 1 mm of...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.06.007
更新日期:2011-02-01 00:00:00
abstract:PURPOSE:To study the adherence of rheumatologists to the hydroxychloroquine (HCQ) dosing guidelines established by the American Academy of Ophthalmology in 2011 and 2016. DESIGN:Retrospective review of electronic medical records (EMRs) in an integrated health care system. PARTICIPANTS:All rheumatology patients starte...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.12.021
更新日期:2017-05-01 00:00:00
abstract::Isolated involvement of the optic nerve with metastatic tumor is uncommon. A 19-year-old man had a midline cerebellar medulloblastoma; a gross total removal was performed. He received postoperative radiation therapy to the whole brain, posterior fossa, and craniospinal axis. A progressive optic neuropathy developed 28...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32912-5
更新日期:1989-02-01 00:00:00
abstract::The authors report seven patients in whom the acute retinal necrosis (ARN) syndrome developed shortly after cutaneous varicella zoster infection. The length of time between the skin infection and ARN varied from 5 days to 3 months. Both eyes were affected in one of seven cases. The ophthalmic branch of cranial nerve V...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(87)33405-0
更新日期:1987-06-01 00:00:00
abstract:OBJECTIVE:The goal of the study was to assess the affect of early surgical resection of capillary hemangiomas on the induced astigmatism of infants. DESIGN:Cohort study. PARTICIPANTS:Three infants younger than 9 months of age are included. INTERVENTION:Total resection of the astigmatism-inducing hemangiomas was perf...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(97)30178-x
更新日期:1997-07-01 00:00:00
abstract::Evaluation of 200 consecutive pars plana vitrectomies shows delayed corneal epithelial healing after intentional scraping and formation of a posterior subcapsular cataract, presumably due to exposure to inadequate infusion fluids. Posterior retinal holes occur frequently, whereas entrance site complications have been ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35684-0
更新日期:1978-02-01 00:00:00
abstract:PURPOSE:To evaluate outcomes of bilateral cataract surgery in children aged 7 to 24 months and compare rates of adverse events (AEs) with other Toddler Aphakia and Pseudophakia Study (TAPS) registry outcomes. DESIGN:Retrospective clinical study at 10 Infant Aphakia Treatment Study (IATS) sites. Statistical analyses co...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.07.020
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of intravitreal sirolimus in the management of noninfectious uveitis of the posterior segment (NIU-PS). DESIGN:Combined analysis of 2 phase 3, randomized, double-masked, multinational, 6-month studies. PARTICIPANTS:Adults with active NIU-PS (intermediate uveitis, posterior ...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2020.03.033
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To use in vivo confocal microscopy (IVCM) to quantitatively analyze microstructural changes over time, after corneal collagen cross-linking for keratoconus. DESIGN:Prospective cohort study. PARTICIPANTS:A total of 38 eyes of 38 patients undergoing collagen cross-linking for keratoconus. METHODS:Prospective, ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.09.014
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Malignant glaucoma (ciliary block glaucoma; aqueous misdirection glaucoma) is an incompletely understood, rare and serious complication of intraocular surgery. METHODS:A woman with pseudophakic malignant glaucoma underwent successful neodymium: YAG (Nd:YAG) laser photodisruption of the anterior hyaloid face...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31479-x
更新日期:1993-09-01 00:00:00
abstract:PURPOSE:To review the clinical characteristics, prevalence, and severity of retinopathy in diabetics with cranial nerve (CN) 3, 4, and/or 6 palsies, and to determine the relationship between type and duration of diabetes mellitus (DM), presence of retinopathy, and occurrence of CN palsy. DESIGN:Retrospective, comparat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00542-6
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the surgical management and visual acuity outcomes in a large series of patients with dislocated intraocular lenses (IOLs). DESIGN:Retrospective consecutive noncomparative case series. PARTICIPANTS:All patients who underwent surgical management of dislocated IOLs by two vitreoretinal surgeons at...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(99)00017-2
更新日期:2000-01-01 00:00:00
abstract::Proton irradiation was used in the treatment of uveal melanomas in 36 eyes. The average follow-up period was 16 months. One patient developed metastatic disease and died. No eye has been enucleated and tumor regression has been observed in all 22 eyes with a follow-up of more than 12 months. This type of treatment off...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35212-3
更新日期:1980-06-01 00:00:00
abstract:PURPOSE:To describe the prevalence and signs of early and late age-related macular degeneration (AMD) in an old cohort. DESIGN:Population-based cohort study. PARTICIPANTS:We included 5272 persons aged ≥66 years, randomly sampled from the Reykjavik area. METHODS:Fundus images were taken through dilated pupils using a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.08.044
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the specific characteristics and management of internal orbital fractures in the pediatric population. DESIGN:Retrospective observational case series. PARTICIPANTS:Thirty-four pediatric patients between the ages of 1 and 18 years with internal orbital ("blowout") fractures. METHODS:Records of p...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00015-4
更新日期:2000-05-01 00:00:00
abstract:PURPOSE:To evaluate the growth of geographic atrophy (GA) during anti-vascular endothelial growth factor (VEGF) therapy. DESIGN:Cohort within a clinical trial. PARTICIPANTS:Patients included in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). METHODS:Participants were randomly assigned to...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2014.11.007
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:To investigate the incidence and outcomes of retinal detachment (RD) associated with retained lens fragments removed by pars plana vitrectomy (PPV). DESIGN:Retrospective, noncomparative, interventional consecutive case series. PARTICIPANTS:All patients who underwent PPV for retained lens material after catara...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(03)00020-4
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to characterize the contemporary clinical presentation and treatment results of patients with dislocated intraocular lenses (IOLs). DESIGN:Retrospective, noncomparative, single-surgeon interventional case series. PARTICIPANTS:Two hundred eighty-four eyes of 277 patients operated ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.04.016
更新日期:2008-10-01 00:00:00