Abstract：
PURPOSE:To describe the prevalence and signs of early and late age-related macular degeneration (AMD) in an old cohort. DESIGN:Population-based cohort study. PARTICIPANTS:We included 5272 persons aged ≥66 years, randomly sampled from the Reykjavik area. METHODS:Fundus images were taken through dilated pupils using a 45-degree digital camera and graded for drusen size, type, area, increased retinal pigment, retinal pigment epithelial depigmentation, neovascular lesions, and geographic atrophy (GA) using the modified Wisconsin Age-Related Maculopathy Grading System. MAIN OUTCOME MEASURES:Age-related macular degeneration in an elderly cohort. RESULTS:The mean age of participants was 76 years. The prevalence of early AMD was 12.4% (95% confidence interval [CI], 11.0-13.9) for those aged 66 to 74 years and 36% (95% CI, 30.9-41.1) for those aged ≥85 years. The prevalence of exudative AMD was 3.3% (95% CI, 2.8-3.8). The prevalence of pure GA was 2.4% (95% CI, 2.0-2.8). The highest prevalence of late AMD was among those aged ≥85 years: 11.4% (95% CI, 8.2-14.5) for exudative AMD and 7.6% (95% CI, 4.8-10.4) for pure GA. CONCLUSIONS:Persons aged ≥85 years have a 10-fold higher prevalence of late AMD than those aged 70 to 74 years. The high prevalence of late AMD in the oldest age group and expected increase of elderly people in the western world in coming years call for improved preventive measures and novel treatments.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Jonasson F,Arnarsson A,Eiríksdottir G,Harris TB,Launer LJ,Meuer SM,Klein BE,Klein R,Gudnason V,Cotch MFdoi
10.1016/j.ophtha.2010.08.044subject
Has Abstractpub_date
2011-05-01 00:00:00pages
825-30issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(10)00931-0journal_volume
118pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract：PURPOSE:To characterize the visual prognosis of patients with multifocal choroiditis and panuveitis (MCP), punctate inner choroidopathy (PIC), and the diffuse subretinal fibrosis (DSF) syndrome. METHODS:Forty-one patients with MCP, 16 with PIC, and 5 with DSF syndrome were evaluated. The mean follow-up was approximate...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30561-7
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:Sterile corneal ulceration is a rare complication of rheumatoid arthritis and may lead to corneal perforation. Surgical management for visual restoration frequently is unsuccessful. The authors analyze the factors that may determine the failure of corneal surgery in perforations associated with rheumatoid ar...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)30867-6
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVE:To report the clinical outcome and long-term follow-up of 10 patients with progressive ocular-cicatricial pemphigoid (OCP), nonresponsive to conventional therapy and treated with IV immunoglobulin (IVIg) therapy, reported earlier as a preliminary study. DESIGN:Noncomparative, prospective, interventional case...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.11.012
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To determine whether glaucoma patients with progressive optic disc change have subsequent visual field progression earlier and at a faster rate compared with those without disc change. DESIGN:Prospective, longitudinal, cohort study. PARTICIPANTS AND CONTROLS:Eighty-one patients with open-angle glaucoma. ME...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2009.04.031
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:To determine the independent, relative, and combined impact of reduced distance and near vision on the vision-specific quality of life (VS QOL) of adults in Timor-Leste. DESIGN:A population-based cross-sectional eye health survey was conducted in urban and rural areas in Timor-Leste. PARTICIPANTS:Participants...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2010.03.041
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:To assess perifoveal capillary blood flow velocity (BFV), capillary occlusion, and retinal thickness at the central fovea in diabetic patients with or without clinically significant macular edema; to examine the relationships of these variables with visual acuity (VA); and to identify their contributions to vis...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2007.01.003
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:Photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) outcomes were compared at 1, 3, 6, and 12 months after surgery. DESIGN:Retrospective, nonrandomized, comparative study. PARTICIPANTS:One hundred seven LASIK-treated eyes (58 patients) and 107 PRK-treated eyes (91 patients) having myo...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(99)00043-3
更新日期：2000-02-01 00:00:00
abstract：PURPOSE:To assess the long-term efficacy and stability of LASIK for hyperopia (+0.75 to +7.00 diopters [D]). DESIGN:Retrospective follow-up study of a previous phase III multicenter clinical trial (unpublished data). PARTICIPANTS:Patients who had been treated for hyperopia (33 individuals, 47 eyes) attended follow-up...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2004.09.017
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:To determine the protective action of hyaluronidase on peribulbar anesthesia-related diplopia in patients undergoing cataract surgery. DESIGN:Single-center observational case series. PARTICIPANTS:All patients undergoing elective phacoemulsification and intraocular lens implantation under peribulbar anesthes...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2004.11.059
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To study the anatomic and visual outcomes of a surgical procedure in which tissue plasminogen activator and air are injected subretinally to displace massive submacular hemorrhages secondary to age-related macular degeneration. DESIGN:Prospective, consecutive, interventional case series. PARTICIPANTS:Thirte...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2014.07.027
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To describe the histopathology of Molteno implant capsules in cases of primary and secondary glaucoma and to correlate them with surgical technique and clinical outcomes in quiet eyes. DESIGN:Human tissue study with clinicopathological correlation. MATERIALS:Seventy-five autopsy eyes or surgical pathology s...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(03)00803-0
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:To investigate the rate and risk factors of developing suprachoroidal hemorrhage (SCH) after pars plana vitrectomy (PPV) and the outcomes as a result. DESIGN:Retrospective, comparative consecutive series. PARTICIPANTS:A total of 5459 patients who underwent pars plana vitrectomies over 10 years in 3 surgical c...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2013.06.021
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:To determine 5-year outcomes of Descemet stripping endothelial keratoplasty (DSEK) for Fuchs' endothelial corneal dystrophy (FECD). DESIGN:Prospective cohort study. PARTICIPANTS:Fifty-two eyes of 45 subjects with FECD undergoing primary DSEK. METHODS:Subjects were examined before and at fixed intervals throu...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2015.09.023
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:To report a patient with bilateral symmetrical epibulbar osseous choristoma. DESIGN:Retrospective observational case report. PARTICIPANT:One patient with bilateral symmetrical epibulbar osseous choristoma. METHOD:Retrospective review of stored office records, photographs, computed tomography (CT), and histop...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.12.002
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:This study aimed to develop a protocol to screen and monitor patients with diabetic macular thickening using optical coherence tomography (OCT), a technique for high-resolution cross-sectional imaging of the retina. DESIGN:A cross-sectional pilot study was conducted. PARTICIPANTS:A total of 182 eyes of 107 ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(98)93601-6
更新日期：1998-02-01 00:00:00
abstract：PURPOSE:To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV). DESIGN:Cross-sectional, case-control association study. PARTICIPANTS:Fifty-five patients with PCV, 368 patients with...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2009.12.018
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To analyze the association between retinoblastoma (Rb) and sebaceous carcinoma (SC) of the eyelid to improve surveillance of survivors of RB: DESIGN:Case report and systematic literature review. METHODS:Ten patients who had SC develop after Rb were identified by systematic literature review, and a child who...
journal_title：Ophthalmology
pub_type： 杂志文章,评审
doi：10.1016/s0161-6420(01)00555-3
更新日期：2001-06-01 00:00:00
abstract：PURPOSE:To study the peripheral angiographic features of branch retinal vein occlusions (BRVO) and hemicentral retinal vein occlusions (HRVO) and explore associations with macular edema and neovascularization. DESIGN:Retrospective observational case series. PARTICIPANTS:Seventy-eight outpatients. METHODS:An imaging ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2009.09.019
更新日期：2010-04-01 00:00:00
abstract：:Conventional teaching states that the spiral of Tillaux marks the location of the ora serrata. On literature review, no source for this was found. This study explores this anatomic relationship. In 20 cadaver eyes, narrow-gauge needles were placed penetrating the center of each rectus muscle insertion, and distance to...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(89)32866-1
更新日期：1989-04-01 00:00:00
abstract：:The Prospective Evaluation of Radial Keratotomy (PERK) study is a nine-center clinical trial of a standardized technique of radial keratotomy in 435 patients who had simple myopia with a preoperative refractive error between -2.00 and -8.00 diopters (D). The authors report results for one eye of each patient. The surg...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(87)80021-0
更新日期：1987-10-01 00:00:00
abstract：PURPOSE:To examine the normative profile and determinants of macular ganglion cell-inner plexiform layer (GCIPL) thickness based on spectral-domain OCT (SD-OCT) in a nonglaucoma, multi-ethnic Asian population. DESIGN:Population-based, cross-sectional study. PARTICIPANTS:Ethnic Chinese, Malay, and Indian adults aged ≥...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ophtha.2020.01.055
更新日期：2020-08-01 00:00:00
abstract：PURPOSE:The one-and-a-half syndrome is an eye movement disorder characterized by a unilateral gaze palsy and an ipsilateral internuclear ophthalmoplegia. The authors describe a previously unrecognized association between the one-and-a-half syndrome and oculopalatal myoclonus (OPM). METHODS:Five clinical cases are pres...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(96)30743-4
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:To investigate the possible persistence and characteristics of infrared fluorescence of the fundus for several months after surgery with intraocular injection of indocyanine green (ICG). DESIGN:Interventional, noncomparative, prospective case series. PARTICIPANTS:Seventeen patients operated on in our departme...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(02)01761-X
更新日期：2003-03-01 00:00:00
abstract：PURPOSE:To examine predisposing factors, treatment costs, and visual outcome of microbial keratitis in an ophthalmic casualty and inpatient population. DESIGN:Retrospective medical records review. PARTICIPANTS:Fifteen- to 64-year-olds with microbial keratitis treated at the Royal Victorian Eye and Ear Hospital betwee...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.08.013
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To identify safety and effectiveness outcomes of office-based cataract surgery. Each year, approximately 3.7 million cataract surgeries in the United States are performed in Ambulatory Surgery Center (ASC) and Hospital Outpatient Department (HOPD) locations. Medicare in July 2015 published a solicitation for ex...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2015.12.020
更新日期：2016-04-01 00:00:00
abstract：:Myopia is not a cause of serious disease, although the two are sometimes associated. In contrast to hyperopia, it is a symptom and is easily understood. Myopia can have social as well as physical effects. Myopic patients often fear that they have increased their refractive error by their own behavior. This belief is e...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:There is increasing suspicion that topical ocular miotic therapy in selected persons may precipitate retinal detachments. This is a rare event and probably does not occur in patients free of retinal pathology. Data supporting a possible cause and effect relationship, obtained from the National Registry of Drug-Induced...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(79)35529-4
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVE:To assess the effectiveness of intravitreal aflibercept in patients with neovascular age-related macular degeneration (AMD) previously resistant to treatment with other anti-vascular endothelial growth factor agents. DESIGN:Prospective, open-label, noncontrolled, registered clinical trial. PARTICIPANTS:Fort...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ophtha.2013.08.035
更新日期：2014-01-01 00:00:00
abstract：:Rhabdomyosarcoma is the most common malignant orbital tumor of childhood. It has twice been reported to arise within the globe from the iris. In addition, teratoid medulloepithelioma, a tumor arising from the ciliary epithelium, can contain a rhabdomyoblastic component, often in combination with other heteroplastic el...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(90)32386-2
更新日期：1990-11-01 00:00:00
abstract：:Since its description in 1950, numerous surgical techniques have been advocated to treat Brown's superior oblique tendon sheath syndrome. Of these, a tenectomy of the homolateral superior oblique has emerged as the most effective method. However, an iatrogenically produced superior oblique paralysis has been found to ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(82)34787-9
更新日期：1982-04-01 00:00:00
