Prevalence of age-related macular degeneration in old persons: Age, Gene/environment Susceptibility Reykjavik Study.


PURPOSE:To describe the prevalence and signs of early and late age-related macular degeneration (AMD) in an old cohort. DESIGN:Population-based cohort study. PARTICIPANTS:We included 5272 persons aged ≥66 years, randomly sampled from the Reykjavik area. METHODS:Fundus images were taken through dilated pupils using a 45-degree digital camera and graded for drusen size, type, area, increased retinal pigment, retinal pigment epithelial depigmentation, neovascular lesions, and geographic atrophy (GA) using the modified Wisconsin Age-Related Maculopathy Grading System. MAIN OUTCOME MEASURES:Age-related macular degeneration in an elderly cohort. RESULTS:The mean age of participants was 76 years. The prevalence of early AMD was 12.4% (95% confidence interval [CI], 11.0-13.9) for those aged 66 to 74 years and 36% (95% CI, 30.9-41.1) for those aged ≥85 years. The prevalence of exudative AMD was 3.3% (95% CI, 2.8-3.8). The prevalence of pure GA was 2.4% (95% CI, 2.0-2.8). The highest prevalence of late AMD was among those aged ≥85 years: 11.4% (95% CI, 8.2-14.5) for exudative AMD and 7.6% (95% CI, 4.8-10.4) for pure GA. CONCLUSIONS:Persons aged ≥85 years have a 10-fold higher prevalence of late AMD than those aged 70 to 74 years. The high prevalence of late AMD in the oldest age group and expected increase of elderly people in the western world in coming years call for improved preventive measures and novel treatments.






Jonasson F,Arnarsson A,Eiríksdottir G,Harris TB,Launer LJ,Meuer SM,Klein BE,Klein R,Gudnason V,Cotch MF




Has Abstract


2011-05-01 00:00:00














  • Automated Identification of Lesion Activity in Neovascular Age-Related Macular Degeneration.

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    pub_type: 杂志文章


    authors: Chakravarthy U,Goldenberg D,Young G,Havilio M,Rafaeli O,Benyamini G,Loewenstein A

    更新日期:2016-08-01 00:00:00

  • Amputation neuroma of the orbit. Report of two cases and review of the literature.

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    pub_type: 杂志文章


    authors: Messmer EP,Camara J,Boniuk M,Font RL

    更新日期:1984-11-01 00:00:00

  • Migraine and Risk of Ocular Motor Cranial Nerve Palsies: A Nationwide Cohort Study.

    abstract:PURPOSE:To determine whether migraine is associated with an increased risk of developing ocular motor cranial nerve palsies (OMCNP). DESIGN:Nationwide retrospective cohort study. PARTICIPANTS:Medical records of patients with migraine who were entered in the National Health Insurance Research Database (NHIRD) between ...


    pub_type: 杂志文章,多中心研究


    authors: Yang CP,Chen YT,Fuh JL,Wang SJ

    更新日期:2016-01-01 00:00:00

  • Subconjunctival hemorrhage and conjunctivochalasis.

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    pub_type: 杂志文章


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    更新日期:2009-10-01 00:00:00

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    abstract:OBJECTIVE:To describe the presentation and the clinical course of a patient with consecutive central sterile corneal perforations associated with common variable immunodeficiency. DESIGN:Case report. METHODS:Multiple corneal cultures and scrapings were performed in an effort to identify an infectious cause and all we...


    pub_type: 杂志文章


    authors: Akpek EK,Haddad RS,Winkelstein JA,Gottsch JD

    更新日期:2000-01-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2015-10-01 00:00:00

  • Herbert Herbert: his corneal pits and scleral slits.

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    pub_type: 传,历史文章,杂志文章


    authors: Feibel RM

    更新日期:2014-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Dua HS,Faraj LA,Said DG,Gray T,Lowe J

    更新日期:2013-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Vonthein R,Rauscher S,Paetzold J,Nowomiejska K,Krapp E,Hermann A,Sadowski B,Chaumette C,Wild JM,Schiefer U

    更新日期:2007-06-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Li S,Xu J,He M,Wu K,Munoz SR,Ellwein LB

    更新日期:1999-08-01 00:00:00

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    pub_type: 杂志文章,多中心研究


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    更新日期:2017-10-01 00:00:00

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    authors: Sung KR,Sun JH,Na JH,Lee JY,Lee Y

    更新日期:2012-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Rasmussen A,Bloch SB,Fuchs J,Hansen LH,Larsen M,LaCour M,Lund-Andersen H,Sander B

    更新日期:2013-12-01 00:00:00

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    authors: Arrowsmith PN,Marks RG

    更新日期:1985-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Newman NJ,Capone A,Leeper HF,O'Day DG,Mandell B,Lambert SR,Thoft RA

    更新日期:1994-06-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1979-08-01 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验


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    authors: O'Hanley GP,Canny CL

    更新日期:1985-04-01 00:00:00

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    更新日期:1987-07-01 00:00:00

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    pub_type: 杂志文章,评审



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  • The effect of neodymium: YAG capsulotomy on contrast sensitivity and the evaluation of methods for its assessment.

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    authors: Tan JC,Spalton DJ,Arden GB

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    pub_type: 杂志文章,多中心研究


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    更新日期:2013-01-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 临床试验,杂志文章,随机对照试验


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Beck RW,Messner DK,Musch DC,Martonyi CL,Lichter PR

    更新日期:1985-07-01 00:00:00