Abstract:
PURPOSE:To investigate the frequency of sneezing among patients receiving intravenous sedation and periocular local anesthetic for oculoplastic procedures in a single center. To identify potential risk factors involved. DESIGN:Prospective, consecutive, interventional case series in a single tertiary-referral oculoplastic unit. PARTICIPANTS:A total of 294 patients undergoing 314 isolated oculoplastic procedures, performed under intravenous sedation with periocular local anesthetic from November 2007 to November 2008. METHODS:Prospective data collection on patient demographics, history of photic sneezing, intravenous sedative, depth of sedation, nasal oxygen, and periocular infiltration site. Standard local anesthetic was used in all cases, but the intravenous sedation was at the discretion of the attending anesthesiologist (7 in total). MAIN OUTCOME MEASURES:Sneezing or attempted sneezing within 5 minutes of injection of the local anesthetic, as determined by agreed observation between attending staff. RESULTS:Sneezing was observed in 16% of cases. No association was found between sneezing and patient age or presence of nasal oxygen. A weakly positive association was observed with male gender (55% sneezers vs. 37% non-sneezers, P = 0.03, relative risk [RR] = 1.5, confidence interval [CI], 1.1-2.0), bilateral infiltration (65% vs. 40%, P = 0.005, RR = 1.6, CI, 1.2-2.1), and upper eyelid infiltration (73% vs. 54%, P = 0.01, RR = 1.4, CI, 1.1-1.7). Photic sneezing was described in 47% of sneezers and 19% of non-sneezers (P = 0.0004, RR = 2.6, CI, 1.6-4.0). Because propofol was given to 95% of patients, no association with sneezing could be ascertained. However, opioid derivatives were found to be protective (12% vs. 43%, P<0.0001, RR = 0.3, CI, 0.1-0.6), whereas midazolam doubled the risk of sneezing (45% vs. 22%, P = 0.0008, RR = 2.1, CI, 1.4-3.0). Deep sedation (Ramsay score 5-6) also strongly increased the sneeze risk (65% vs. 23%, P<0.0001, RR = 2.8, CI, 2.1-3.8). CONCLUSIONS:Propofol-based intravenous sedation, in combination with periocular local anesthetic injections, induces sneezing in approximately one sixth of general oculoplastic cases. Male gender, a history of photic sneezing, bilateral or upper eyelid infiltration, deep sedation, and the concurrent administration of midazolam all increased the risk, whereas adjunctive opioid use reduced the risk.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Morley AM,Jazayeri F,Ali S,Malhotra Rdoi
10.1016/j.ophtha.2009.09.007subject
Has Abstractpub_date
2010-05-01 00:00:00pages
1032-6issue
5eissn
0161-6420issn
1549-4713pii
S0161-6420(09)00999-3journal_volume
117pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract:PURPOSE:To report the prevalence of retinal detachment (RD) and results of prophylaxis against detachment from a giant retinal tear in a large cohort of patients with type 1 Stickler syndrome. DESIGN:Retrospective study. PARTICIPANTS:Two hundred four type 1 Stickler syndrome patients. METHOD:Pedigrees and individual...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.03.059
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To report quantitative changes in the anterior segment configuration after clear corneal incision phacoemulsification and foldable intraocular lens (IOL) implantation by means of ultrasound biomicroscopy (UBM). DESIGN:Prospective, nonrandomized, comparative (self-controlled) trial. PARTICIPANTS:Twenty-one eye...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/S0161-6420(03)00623-7
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:To compare diabetic retinopathy (DR) identification and ungradable image rates between nonmydriatic ultrawide field (UWF) imaging and nonmydriatic multifield fundus photography (NMFP) in a large multistate population-based DR teleophthalmology program. DESIGN:Multiple-site, nonrandomized, consecutive, cross-se...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2016.01.043
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:To investigate the possible persistence and characteristics of infrared fluorescence of the fundus for several months after surgery with intraocular injection of indocyanine green (ICG). DESIGN:Interventional, noncomparative, prospective case series. PARTICIPANTS:Seventeen patients operated on in our departme...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(02)01761-X
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:This study aimed to provide a comparative analysis of American population-based prevalence of uncorrected binocular distance visual acuity in Hispanics and non-Hispanics. DESIGN:The study design was a population-based survey. PARTICIPANTS:Data from the Hispanic Health and Nutrition Examination Survey betwee...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(98)93042-1
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Transconjunctival cryopexy of the vitreous base is clinically effective in patients with steroid nonresponsive pars planitis who have peripheral neovascularization. Cryoablation of the region previously has been thought to eliminate the areas of permeable neovascular tissue, thus removing the focus of exudat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(13)31726-6
更新日期:1994-07-01 00:00:00
abstract:PURPOSE:To use optical coherence tomography (OCT) to evaluate the femtosecond laser intrastromal incisions made during cataract surgery to reduce corneal astigmatism. DESIGN:Retrospective case series. PARTICIPANTS:Seventy-seven eyes of 77 patients. METHODS:Paired intrastromal incisions were created using the Catalys...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2017.03.022
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To evaluate the learning curve in Descemet's membrane endothelial keratoplasty (DMEK) in the management of corneal endothelial disorders. DESIGN:Retrospective, nonrandomized, clinical study at a tertiary referral center. PARTICIPANTS:We included 135 eyes of 118 patients with Fuchs' endothelial dystrophy. MET...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ophtha.2011.03.037
更新日期:2011-11-01 00:00:00
abstract:PURPOSE/BACKGROUND:Retinal arteriovenous malformations can be seen in a variety of ways and have multiple, associated, ocular changes that can affect vision. The authors report two cases of retinal arteriovenous malformation. In each case, a central retinal vein occlusion developed. METHODS:Each patient underwent clin...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31701-x
更新日期:1993-01-01 00:00:00
abstract::Reductions in flicker sensitivity in ocular hypertension are thought to precede manifest glaucomatous damage, but the proportion of patients with ocular hypertension reported to have losses in flicker sensitivity (50-90%) is far out of step with the proportion of ocular hypertensive patients in whom clinically defined...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(90)32630-1
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:Autosomal-dominant optic atrophy (DOA) is one of the most common inherited optic neuropathies, and it is genetically heterogeneous, with mutations in both OPA1 and OPA3 known to cause disease. Approximately 60% of cases harbor OPA1 mutations, whereas OPA3 mutations have been reported in only 2 pedigrees with DO...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.07.029
更新日期:2011-03-01 00:00:00
abstract::A prospective, randomized, double-masked, placebo-controlled clinical trial was conducted to study the effects of oral acyclovir on 55 patients with acute herpes zoster ophthalmicus. Treatment with oral acyclovir resulted in more prompt resolution of signs and symptoms, particularly in patients treated within 72 hours...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(85)33842-3
更新日期:1985-11-01 00:00:00
abstract:PURPOSE:A trabeculectomy is frequently combined with extracapsular cataract surgery to minimize the risks of further optic nerve damage associated with intraocular pressure (IOP) elevations after cataract surgery in eyes with glaucoma. Acute IOP elevations still occur after this combined surgery. The author evaluated t...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(93)31603-9
更新日期:1993-05-01 00:00:00
abstract:PURPOSE:To develop a classification of parapapillary atrophy (PPA) based on its relationship with the location of Bruch's membrane (BM) termination in primary open-angle glaucoma (POAG) patients. DESIGN:Cross-sectional observational study. PARTICIPANTS:This study analyzed 161 eyes from 161 POAG patients who had tempo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.02.011
更新日期:2013-09-01 00:00:00
abstract::The authors present five cases of severe retinal ischemia associated with gentamicin injection. In three of the cases massive doses of gentamicin were erroneously injected into the eye; in two of the cases the authors presume that gentamicin toxicity occurred. The sequence of clinical findings was similar in all five ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33648-0
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVE:Correctable vision impairment caused by refractive error is common in the United States population. We estimated the direct costs of providing eyeglasses to all Americans (age> or =12) who need refractive correction to achieve good distance vision. DESIGN:Cross-sectional study of a nationally representative ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2006.06.033
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:To assess the status of choriocapillaris in eyes with macular atrophy secondary to age-related macular degeneration (AMD) (geographic atrophy [GA]) and Stargardt disease (STGD) using optical coherence tomography angiography (OCTA). DESIGN:Prospective, observational case series. PARTICIPANTS:A total of 14 pati...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.05.041
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of partial surgical excision of enlarged lacrimal caruncles, termed megalocaruncles, in patients with epiphora from functional lacrimal drainage obstruction. DESIGN:Retrospective, noncomparative, interventional case series. PARTICIPANTS:From May 1995 through December 1999, 88 patients...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(00)00637-0
更新日期:2001-04-01 00:00:00
abstract:PURPOSE:To examine the safety and efficacy of anterior ciliary sclerotomy to restore accommodation in the presbyopic eye. DESIGN:Prospective nonrandomized comparative single-center clinical trial. PARTICIPANTS:Nine presbyopic subjects with no prior ocular surgery except corneal refractive procedures were enrolled. M...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1016/s0161-6420(02)01252-6
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To establish an objective ophthalmic surgical evaluation protocol to assess residents' surgical competency and improve residents' surgical outcomes. PARTICIPANTS:Eight experts in resident education from comprehensive ophthalmology, cornea, glaucoma, and retina services; 2 chief residents (postgraduate year 5...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.01.045
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To compare the long-term safety and ocular-hypotensive efficacy of brimonidine tartrate 0.2% with timolol maleate 0.5% administered twice daily in patients with glaucoma or ocular hypertension. DESIGN:A double-masked, parallel-group, active-controlled, multicenter clinical trial of 12 months' duration. PART...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0161-6420(98)91048-x
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To develop and validate a predictive model to estimate the probability of being nonadherent to topical glaucoma medications. DESIGN:Prospective cohort study. PARTICIPANTS:Patients being treated with once-daily prostaglandin eye drops. METHODS:A predictive model for nonadherence was developed from the Trava...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.01.002
更新日期:2013-07-01 00:00:00
abstract::Triamcinolone acetonide (TA) was injected subconjunctivally in nine human eyes one week before trabeculectomy. A biopsy specimen of conjunctiva and subconjunctiva was obtained from the site of drug injection, as well as a site 6 mm from the injection at the time of trabeculectomy. The tissue was evaluated by electron ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:Oral trans-retinoic acid has recently been shown to be an effective treatment modality for acute promyelocytic leukemia. This type of drug differs from traditional tumoricidal agents by promoting differentiation of the malignant, immature cells. METHODS:The authors describe a patient with optic nerve infilt...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(92)31783-x
更新日期:1992-09-01 00:00:00
abstract::The authors studied 50 eyes with atrophic (dry) macular degeneration (geographic atrophy of age-related macular degeneration [GAMD], in 50 consecutive patients for 2 to 6 years (average, 3.4 years). There were 35 women and 15 men ranging in age from 60 to 89 years (average, 73 years). The areas of atrophy tended to fo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32694-7
更新日期:1989-10-01 00:00:00
abstract::A computer program designed according to the needs of clinical investigators has recently been implemented. This ambitious undertaking allows the ophthalmologist direct interfacing and control over all his data, presently 3,252 diabetic patient records, and thus harnesses his hypothesis-testing intuitions with the mem...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(81)34974-4
更新日期:1981-07-01 00:00:00
abstract:OBJECTIVE:To examine phenotypes of age-related macular degeneration (AMD) patients with the complement factor H (CFH) variant (Y402H, C allele at rs1061170). DESIGN:Clinic-based case series study. PARTICIPANTS:The data set contained a total of 956 unrelated cases of AMD. METHODS:Age-related macular degeneration phen...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.06.021
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:Diabetic patients have a greater risk of nonarteritic anterior ischemic optic neuropathy (NAION) than nondiabetic patients. We compare visual outcomes, prevalence of bilateral/sequential ION, and predictors of visual outcomes in NAION between diabetic and nondiabetic patients. DESIGN:Case-control study. PARTI...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2016.11.029
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:The spaceflight-associated neuro-ocular syndrome (SANS) affects astronauts on missions to the International Space Station (ISS). The SANS has blurred vision and ocular changes as typical features. The objective of this study was to investigate if microgravity can create deformations or movements of the eye or o...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.07.007
更新日期:2021-02-01 00:00:00
abstract::One hundred twelve patients with vitiligo were examined for ocular abnormalities. Discrete areas of depigmentation with associated pigment hyperplasia clinically appearing to involve the choroid and retinal pigment epithelium were observed in 44 patients, and active uveitis was seen in nine patients. The changes obser...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(79)35413-6
更新日期:1979-06-01 00:00:00