Interactions of the monomeric and dimeric flavones apigenin and amentoflavone with the plasma membrane of L929 cells; a fluorescence study.

abstract：:A group of prenyltransferases produce linear lipids by catalyzing consecutive condensation reactions of farnesyl diphosphate (FPP) with specific numbers of isopentenyl diphosphate (IPP), a common building block of isoprenoid compounds. Depending on the stereochemistry of the double bonds formed during IPP condensation...

journal_title：Molecular membrane biology

authors： Teng KH,Liang PH

更新日期：2012-11-01 00:00:00

abstract：:The entry of substrates into, and the export of glururonides from, the lumen of hepatic endoplasmic reticulum (ER) in vitro (sealed microsomes) has been measured using radioactivity-labelled materials and a rapid filtration assay. Analysis of liver microsomes from a jaundiced patient showed the accumulation of bilirub...

journal_title：Molecular membrane biology

authors： Waddell ID,Robertson K,Burchell A,Hume R,Burchell B

更新日期：1995-07-01 00:00:00

abstract：:The eukaryotic endomembrane system (ES) is served by hundreds of dedicated proteins. Experimental characterization of the ES-associated molecular machinery in several model eukaryotes complemented by a recent progress in phylogenomics and comparative genomics have revealed a conserved complex core of the machinery tha...

journal_title：Molecular membrane biology

authors： Elias M

更新日期：2010-11-01 00:00:00

abstract：:A structural characterization of a synthetic peptide corresponding to the fourth transmembrane domain (M4-TMD) of the gamma-subunit of the nicotinic acetylcholine receptor from Torpedo californica has been undertaken. Solid-state NMR and CD spectroscopy studies indicate that upon reconstitution into lipid vesicles or ...

journal_title：Molecular membrane biology

authors： Williamson PT,Zandomeneghi G,Barrantes FJ,Watts A,Meier BH

更新日期：2005-11-01 00:00:00

abstract：:Nanoparticles present a new collection of contrast agents for the field of in vivo molecular imaging. This review focuses on promising molecular imaging probes for optical and magnetic resonance imaging based on four representative nanomaterial(s) platforms: quantum dots, upconversion phosphors, superparamagnetic iron...

journal_title：Molecular membrane biology

authors： Rosenblum LT,Kosaka N,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2010-10-01 00:00:00

abstract：:The serotonin1A (5-HT1A) receptors are members of a superfamily of seven transmembrane domain receptors that couple to G-proteins. They appear to be involved in various behavioural and cognitive functions. This paper reports an efficient strategy to solubilize 5-HT1A receptors from bovine hippocampal membranes using t...

journal_title：Molecular membrane biology

authors： Chattopadhyay A,Harikumar KG,Kalipatnapu S

更新日期：2002-07-01 00:00:00

abstract：:A lactate permease was biochemically identified in Candida albicans RM1000 presenting the following kinetic parameters at pH 5.0: Km 0.33+/-0.09 mM and Vmax 0.85+/-0.06 nmol s(-1) mg dry wt(-1). Lactate uptake was competitively inhibited by pyruvic and propionic acids; acetic acid behaved as a non-competitive substrat...

journal_title：Molecular membrane biology

authors： Soares-Silva I,Paiva S,Kötter P,Entian KD,Casal M

更新日期：2004-11-01 00:00:00

abstract：:Nedd4 family ubiquitin ligases regulate trafficking and degradation of numerous target substrates in different cellular compartments, including at the plasma membrane, in endosomes, in the secretory pathway and in the nucleus. WWP1 is a Nedd4 family protein closely related to mouse Itch and Drosophila Su(dx), both of ...

journal_title：Molecular membrane biology

authors： Flasza M,Nguyen Huu NS,Mazaleyrat S,Clémence S,Villemant C,Clarke R,Baron M

更新日期：2006-05-01 00:00:00

abstract：:The Amt/Mep/Rh family of integral membrane proteins comprises ammonium transporters of bacteria, archaea and eukarya, as well as the Rhesus proteins found in animals. They play a central role in the uptake of reduced nitrogen for biosynthetic purposes, in energy metabolism, or in renal excretion. Recent structural inf...

journal_title：Molecular membrane biology

authors： Andrade SL,Einsle O

更新日期：2007-09-01 00:00:00

abstract：:PagP is a bacterial outer membrane protein consisting of an 8 stranded transmembrane beta-barrel and an N-terminal alpha-helix. It is an enzyme which catalyses transfer of a palmitoyl chain from a phospholipid to lipid A. Molecular dynamics simulations have been used to compare the dynamic behaviour in simulations sta...

journal_title：Molecular membrane biology

authors： Cox K,Sansom MS

更新日期：2009-05-01 00:00:00

abstract：:Loss of epithelial cell polarity, which can arise following disruption of tight junctions (TJs), is a precursor to the care-fully orchestrated removal of moribund cells from epithelia in apoptosis. Ordinarily, this cycle of events has minimally disruptive effects on the function of the epithelial barrier, but some age...

journal_title：Molecular membrane biology

authors： Baker SF,Yin Y,Runswick SK,Stewart GA,Thompson PJ,Garrod DR,Robinson C

更新日期：2003-01-01 00:00:00

abstract：:The cyanelles of the glaucocystophyte alga Cyanophora paradoxa resemble endosymbiotic cyanobacteria in morphology, pigmentation and, especially, in the presence of a peptidoglycan wall situated between the inner and outer envelope membranes. However, it is now clear that cyanelles in fact are primitive plastids. Phylo...

journal_title：Molecular membrane biology

authors： Steiner JM,Löffelhardt W

更新日期：2005-01-01 00:00:00

abstract：:Notch receptor signalling plays a central role in development and its misfunction has been linked to a number of diseases. In the cannonical Notch signalling pathway, ligand binding to Notch activates a series of proteolytic cleavages that release the Notch intracellular domain for trafficking to the nucleus, where it...

journal_title：Molecular membrane biology

authors： Wilkin MB,Baron M

更新日期：2005-07-01 00:00:00

abstract：:Neurotransmitter receptor trafficking in and out synapses has emerged as a key process to regulate synaptic transmission during synaptic development and plasticity both at excitatory and inhibitory synapses. Lateral diffusion of surface neurotransmitter receptors has recently emerged as a key pathway to regulate recep...

journal_title：Molecular membrane biology

authors： Groc L,Choquet D

更新日期：2008-05-01 00:00:00

abstract：:'No cellular organelle has been the subject of as many, as long-lasting or as diverse polemics as the Golgi apparatus'. This statement was made by Whaley almost 30 years ago in the book The Golgi Apparatus and still holds true today, perhaps more then ever. Why is this? How come something as mundane as a series of int...

journal_title：Molecular membrane biology

authors： Elsner M,Hashimoto H,Nilsson T

更新日期：2003-07-01 00:00:00

abstract：:At least four different types of interaction between protein transmembrane helices have been described to date. These include the use of charge-pair interactions that can play a positive or negative role in the assembly of multi-subunit complexes such as the T cell receptor, or recruit signal transducing accessory mol...

journal_title：Molecular membrane biology

authors： Harrison PT

更新日期：1996-04-01 00:00:00

abstract：:This investigation is aimed at defining the structural requirements for aliphatic polyamines to interact with mitochondrial binding sites, which are relevant for the regulation of the permeability transition and for mitochondrial polyamine uptake. The triamines N-aminoethyl-1,2-diaminoethane (dien) and N-aminopropyl-1...

journal_title：Molecular membrane biology

authors： Dalla Via L,Salvi M,Di Noto V,Stefanelli C,Toninello A

更新日期：2004-03-01 00:00:00

abstract：:Amiodarone (AMI) is a low water-solubility drug, which is very useful in the treatment of severe cardiac disease. Its adverse effects are associated with toxicity in different tissues. Several antioxidants have been shown to reduce, and prevent AMI toxicity. The aim of this work was to develop and characterize Dimyris...

journal_title：Molecular membrane biology

authors： Benedini L,Antollini S,Fanani ML,Palma S,Messina P,Schulz P

更新日期：2014-03-01 00:00:00

abstract：:The number of Signal Peptidase I (SPasel) molecules per E. coli cell was determined using western blot techniques. Different strains were found to contain approximately 1000 SPasel molecules per cell during exponential growth. Based on the activity of SPasel in vitro it could be estimated that this amount is sufficien...

journal_title：Molecular membrane biology

authors： van Klompenburg W,Whitley P,Diemel R,von Heijne G,de Kruijff B

更新日期：1995-10-01 00:00:00

abstract：:Homotypic fusion between early endosomes can be reconstituted in vitro. By using wortmannin and LY294002, inhibitors of phosphatidylinositol (Pl) 3-kinase, a requirement for this activity has been established in order for fusion to proceed efficiently. It has been shown that Pl 3-kinase activity is required downstream...

journal_title：Molecular membrane biology

authors： Mills IG,Jones AT,Clague MJ

更新日期：1999-01-01 00:00:00

abstract：:Calpain, an intracellular calcium-dependent protease, is activated at cell membranes and cleaves cytoskeletal and submembranous proteins. Calpain is inferred to be a calcium-dependent regulator for cytoskeletal reorganization. Calpastatin, an endogenous calpain inhibitor, inhibits not only the proteolytic activity of ...

journal_title：Molecular membrane biology

authors： Kawasaki H,Kawashima S

更新日期：1996-10-01 00:00:00

abstract：:Caveolae are approximately 50-100 nm membrane micro-invaginations associated with the plasma membrane of a wide variety of cells. Although they were first identified in transmission electron micrographs approximately 40 years ago, their exact function(s) has remained controversial. Two well-established functions inclu...

journal_title：Molecular membrane biology

authors： Lisanti MP,Tang Z,Scherer PE,Kübler E,Koleske AJ,Sargiacomo M

更新日期：1995-01-01 00:00:00

abstract：:Microorganisms that survive in natural environments form organized multicellular communities, biofilms and colonies with specific properties. During stress and nutrient limitation, slow growing and senescent cells in such communities retain vital processes by maintaining plasma membrane integrity and retaining the abi...

journal_title：Molecular membrane biology

authors： Palková Z,Váchová L,Gásková D,Kucerová H

更新日期：2009-05-01 00:00:00

abstract：:Elucidating the detailed mechanism of activation of membrane protein receptors and their ligand binding is essential for structure-based drug design. Membrane protein crystal structure analysis successfully aids in understanding these fundamental molecular interactions. However, protein crystal structure analysis of t...

journal_title：Molecular membrane biology

authors： Hirozane Y,Motoyaji T,Maru T,Okada K,Tarui N

更新日期：2014-08-01 00:00:00

abstract：:The assessment of the transverse distribution and mobility of NBD-labelled phospholipid analogues in biological membranes by selective chemical destruction of fluorescent label in the outer monolayer with dithionite has been investigated using resealed erythrocyte ghosts as a model system. The distribution of those an...

journal_title：Molecular membrane biology

authors： Pomorski T,Herrmann A,Zachowski A,Devaux PF,Müller P

更新日期：1994-01-01 00:00:00

abstract：:The Signal Recognition Particle (SRP) plays a critical role in the sorting of nascent secretory and membrane proteins. Remarkably, this function has been conserved from bacteria, where SRP delivers proteins to the inner membrane, through to eukaryotes, where SRP is required for targeting of proteins to the endoplasmic...

journal_title：Molecular membrane biology

authors： Pool MR

更新日期：2005-01-01 00:00:00

abstract：:Hereditary spherocytosis (HS), a common human inherited haemolytic anaemia, is associated with partial deficiency of different erythrocyte membrane proteins. In a subset of dominant HS, a partial membrane expression deficiency of band 3, the erythrocyte anion exchanger (AE1), have previously been characterized, and se...

journal_title：Molecular membrane biology

authors： Dhermy D,Burnier O,Bourgeois M,Grandchamp B

更新日期：1999-10-01 00:00:00

abstract：:Modification of proteins with the lipid palmitate, a process called palmitoylation, is important for the normal function of neuronal cells. However, most attention has focused on how palmitoylation regulates the targeting and trafficking of neurotransmitter receptors and non-enzymatic scaffold proteins. In this review...

journal_title：Molecular membrane biology

authors： Montersino A,Thomas GM

更新日期：2015-08-01 00:00:00

abstract：:Ionotropic glutamate receptors belong to the superfamily of P-loop channels as well as K(+), Na(+), and Ca(2+) channels. However, the structural similarity between ion channels of the glutamate receptors and K(+) channels is a matter of discussion. The aim of this study was to analyze differences between the structure...

journal_title：Molecular membrane biology

authors： Tikhonov DB

更新日期：2007-03-01 00:00:00

abstract：:We have previously shown that a mixture of cerebrosides obtained from dried tubers of herb Typhonium giganteum Engl. plays a neuroprotective role in the ischemic brain through its effect on activation of BK(Ca) channels. It is very curious to know whether a single pure cerebroside compound could activate the BK(Ca) ch...

journal_title：Molecular membrane biology

authors： Xu H,Qi J,Wang G,Deng H,Qi Z

更新日期：2011-02-01 00:00:00