Reduced excretion of a melatonin metabolite in workers exposed to 60 Hz magnetic fields.

Abstract:

:The effects of occupational 60 Hz magnetic field and ambient light exposures on the pineal hormone, melatonin, were studied in 142 male electric utility workers in Colorado, 1995-1996. Melatonin was assessed by radioimmunoassay of its metabolite, 6-hydroxymelatonin sulfate (6-OHMS), in post-work shift urine samples. Personal magnetic field and light exposures were measured over 3 consecutive days using EMDEX C meters adapted with light sensors. Two independent components of magnetic field exposure, intensity (geometric time weighted average) and temporal stability (standardized rate of change metric or RCMS), were analyzed for their effects on creatinine-adjusted 6-OHMS concentrations (6-OHMS/cr) after adjustment for age, month, and light exposure. Geometric mean magnetic field exposures were not associated with 6-OHMS/cr excretion. Men in the highest quartile of temporally stable magnetic field exposure had lower 6-OHMS/cr concentrations on the second and third days compared with those in the lowest quartile. Light exposure modified the magnetic field effect. A progressive decrease in mean 6-OHMS/cr concentrations in response to temporally stable magnetic fields was observed in subjects with low workplace light exposures (predominantly office workers), whereas those with high ambient light exposure showed negligible magnetic field effects. Melatonin suppression may be useful for understanding human biologic responses to magnetic field exposures.

journal_name

Am J Epidemiol

authors

Burch JB,Reif JS,Yost MG,Keefe TJ,Pitrat CA

doi

10.1093/oxfordjournals.aje.a009914

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

27-36

issue

1

eissn

0002-9262

issn

1476-6256

journal_volume

150

pub_type

杂志文章
  • Overcoming ecologic bias using the two-phase study design.

    abstract::Ecologic (aggregate) data are widely available and widely utilized in epidemiologic studies. However, ecologic bias, which arises because aggregate data cannot characterize within-group variability in exposure and confounder variables, can only be removed by supplementing ecologic data with individual-level data. Here...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm386

    authors: Wakefield J,Haneuse SJ

    更新日期:2008-04-15 00:00:00

  • Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies.

    abstract::In prospective studies, disease rates during follow-up are typically analyzed with respect to the values of factors measured during an initial baseline survey. However, because of "regression dilution," this generally tends to underestimate the real associations of disease rates with the "usual" levels of such risk fa...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a010013

    authors: Clarke R,Shipley M,Lewington S,Youngman L,Collins R,Marmot M,Peto R

    更新日期:1999-08-15 00:00:00

  • Invited commentary: variable selection versus shrinkage in the control of multiple confounders.

    abstract::After screening out inappropriate or doubtful covariates on the basis of background knowledge, one may still be left with many potential confounders. It is then tempting to use statistical variable-selection methods to reduce the number used for adjustment. Nonetheless, there is no agreement on how selection should be...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwm355

    authors: Greenland S

    更新日期:2008-03-01 00:00:00

  • General Relative Rate Models for the Analysis of Studies Using Case-Cohort Designs.

    abstract::A standard approach to analysis of case-cohort data involves fitting log-linear models. In this paper, we describe how standard statistical software can be used to fit a broad class of general relative rate models to case-cohort data and derive confidence intervals. We focus on a case-cohort design in which a roster h...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwy223

    authors: Richardson DB,Langholz B,Kelly-Reif K

    更新日期:2019-02-01 00:00:00

  • Social and cultural factors in pregnancy complications among Navajo women.

    abstract::A population of 968 pregnant Navajo women was followed in a prospective study conducted from 1980 to 1983 at the Indian Health Service Hospitals in Gallup and Crownpoint, New Mexico. The purpose of the study was to examine social and cultural influences on obstetric and neonatal complications. The extent of traditiona...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a114382

    authors: Boyce WT,Schaefer C,Harrison HR,Haffner WH,Lewis M,Wright AL

    更新日期:1986-08-01 00:00:00

  • A Population-Based Matched-Sibling Analysis Estimating the Associations Between First Interpregnancy Interval and Birth Outcomes.

    abstract::The association between a single interpregnancy interval (IPI) and birth outcomes has not yet been explored using matched methods. We modeled the odds of preterm birth, being small for gestational age, and having low birth weight in a second, live-born infant in a cohort of 192,041 sibling pairs born in Western Austra...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwy188

    authors: Regan AK,Ball SJ,Warren JL,Malacova E,Padula A,Marston C,Nassar N,Stanley F,Leonard H,de Klerk N,Pereira G

    更新日期:2019-01-01 00:00:00

  • Family caregiving and all-cause mortality: findings from a population-based propensity-matched analysis.

    abstract::Previous studies have provided conflicting evidence on whether being a family caregiver is associated with increased or decreased risk for all-cause mortality. This study examined whether 3,503 family caregivers enrolled in the national Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study showed dif...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwt225

    authors: Roth DL,Haley WE,Hovater M,Perkins M,Wadley VG,Judd S

    更新日期:2013-11-15 00:00:00

  • Combined analysis of Women's Health Initiative observational and clinical trial data on postmenopausal hormone treatment and cardiovascular disease.

    abstract::Circumstances in which both randomized controlled trial and observational study data are available provide an important opportunity to identify biases and improve study design and analysis procedures. In addition, joint analyses of data from the two sources can extend clinical trial findings. The US Women's Health Ini...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwj079

    authors: Prentice RL,Langer RD,Stefanick ML,Howard BV,Pettinger M,Anderson GL,Barad D,Curb JD,Kotchen J,Kuller L,Limacher M,Wactawski-Wende J,Women's Health Initiative Investigators.

    更新日期:2006-04-01 00:00:00

  • Diet and cancer mortality in the counties of Sweden.

    abstract::The association between standardized cancer mortality rate ratios from 1969-1978 and dietary practices was examined in an ecologic study of the 24 counties of Sweden by means of several independent data sources. The study supports the hypothesis that a high intake of cereal fiber protects against colorectal cancer (r ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.aje.a114789

    authors: Rosén M,Nyström L,Wall S

    更新日期:1988-01-01 00:00:00

  • Genetic test evaluation: information needs of clinicians, policy makers, and the public.

    abstract::Growing knowledge about gene-disease associations will lead to new opportunities for genetic testing. Many experts predict that genetic testing will become increasingly important as a guide to prevention, clinical management, and drug treatment based on genetic susceptibilities. As part of a Human Genetic Epidemiology...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/aje/kwf055

    authors: Burke W,Atkins D,Gwinn M,Guttmacher A,Haddow J,Lau J,Palomaki G,Press N,Richards CS,Wideroff L,Wiesner GL

    更新日期:2002-08-15 00:00:00

  • Who is more affected by ozone pollution? A systematic review and meta-analysis.

    abstract::Ozone is associated with adverse health; however, less is known about vulnerable/sensitive populations, which we refer to as sensitive populations. We systematically reviewed epidemiologic evidence (1988-2013) regarding sensitivity to mortality or hospital admission from short-term ozone exposure. We performed meta-an...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/aje/kwu115

    authors: Bell ML,Zanobetti A,Dominici F

    更新日期:2014-07-01 00:00:00

  • Instrumental-Variables Simultaneous Equations Model of Physical Activity and Body Mass Index: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

    abstract::We used full-system-estimation instrumental-variables simultaneous equations modeling (IV-SEM) to examine physical activity relative to body mass index (BMI; weight (kg)/height (m)(2)) using 25 years of data (1985/1986 to 2010/2011) from the Coronary Artery Risk Development in Young Adults (CARDIA) Study (n = 5,115; a...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kww010

    authors: Meyer KA,Guilkey DK,Tien HC,Kiefe CI,Popkin BM,Gordon-Larsen P

    更新日期:2016-09-15 00:00:00

  • On the definition of gestational-age-specific mortality.

    abstract::The "fetuses at risk" concept of gestational-age-specific mortality proposed by Yudkin et al. (Lancet 1987;1:1192-4) and extended by various researchers is becoming popular in perinatal and pediatric epidemiology. However, the definitions using this concept have led to a puzzling phenomenon in which mortality rates ap...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/aje/kwh202

    authors: Cheung YB

    更新日期:2004-08-01 00:00:00

  • Prospective study of diet and pancreatic cancer in male smokers.

    abstract::There have been few prospective studies relating diet to pancreatic cancer, with most having fewer than 100 cases and only one examining dietary nutrients. The authors prospectively examined dietary factors hypothesized to be associated with exocrine pancreatic cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prev...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/155.9.783

    authors: Stolzenberg-Solomon RZ,Pietinen P,Taylor PR,Virtamo J,Albanes D

    更新日期:2002-05-01 00:00:00

  • "If it isn't ultimately aimed at policy, it's not worth doing": interview of George W. Comstock by Alfredo Morabia.

    abstract::George W. Comstock (1915-2007), MD, MPH, DrPH, was lecturer and then professor of epidemiology at the Johns Hopkins University School of Hygiene and Public Health from 1956 to 2007 and served as editor-in-chief of the American Journal of Epidemiology from 1979 to 1988. This interview of George W. Comstock took place i...

    journal_title:American journal of epidemiology

    pub_type: 传,历史文章,面试

    doi:10.1093/aje/kwt027

    authors: Morabia A

    更新日期:2013-04-01 00:00:00

  • Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.

    abstract::The authors hypothesized that genetic predisposition to diabetes complications would be more evident among low-risk individuals and aimed to identify genes related to developing complications (confirmed distal symmetric polyneuropathy, overt nephropathy, or coronary artery disease) in low-risk groups. Participants in ...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwj287

    authors: Costacou T,Chang Y,Ferrell RE,Orchard TJ

    更新日期:2006-11-01 00:00:00

  • Simple Estimation of Patient-Oriented Effects From Randomized Trials: An Open and Shut CACE.

    abstract::In randomized controlled trials, the intention-to-treat estimator provides an unbiased estimate of the causal effect of treatment assignment on the outcome. However, patients often want to know what the effect would be if they were to take the treatment as prescribed (the patient-oriented effect), and several research...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/aje/kwv065

    authors: Steele RJ,Shrier I,Kaufman JS,Platt RW

    更新日期:2015-09-15 00:00:00

  • Life dissatisfactions, job dissatisfaction and illness of married men over time.

    abstract::This study examines the degree to which job and marital satisfaction and participation in leisure activities could predict concurrent and future health status relative to ethnicity, class and occupational factors, and mental health. Data were obtained from a longitudinal study of a random sample of 1034 Manhattan fami...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a112231

    authors: Gersten JC,Friis R,Langner TS

    更新日期:1976-03-01 00:00:00

  • Availability of driver's license master lists for use in government-sponsored public health research.

    abstract::Although the percentage of US drivers with valid driver's licenses varies from state to state, it has historically been high enough to constitute a useful sampling frame for many public health purposes. Over the past decade, states have had to restrict access to this information to comply with the Driver's Privacy Pro...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwr018

    authors: Walsh MC,Trentham-Dietz A,Palta M

    更新日期:2011-06-15 00:00:00

  • Do interviewers' health beliefs and habits modify responses to sensitive questions? A study using data Collected from pregnant women by means of computer-assisted telephone interviews.

    abstract::If interviewers' personal habits or attitudes influence respondents' answers to given questions, this may lead to bias, which should be taken into consideration when analyzing data. The authors examined a potential interviewer effect in a study of pregnant women in which exposure data were obtained through computer-as...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/155.1.95

    authors: Nybo Andersen AM,Olsen J

    更新日期:2002-01-01 00:00:00

  • Congenital Abnormalities of the Male Reproductive System and Risk of Autism Spectrum Disorders.

    abstract::Androgens have an extensive influence on brain development in regions of the brain that are relevant for autism spectrum disorder (ASD), yet their etiological involvement remains unclear. Hypospadias (abnormal positioning of the urethral opening) and cryptorchidism (undescended testes) are 2 relatively common male bir...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwx367

    authors: Rotem RS,Chodick G,Davidovitch M,Hauser R,Coull BA,Weisskopf MG

    更新日期:2018-04-01 00:00:00

  • Association of Chlamydia trachomatis and Mycoplasma hominis with intrauterine growth retardation and preterm delivery. The John Hopkins Study of Cervicitis and Adverse Pregnancy Outcome.

    abstract::The authors conducted a prospective study of risk factors for intrauterine growth retardation (birth weight less than a standard (race- and sex-adjusted) 10th percentile for gestational age) and preterm birth (birth prior to 37 weeks gestation) in a high-risk, inner-city, obstetric population, with special interest in...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.aje.a115244

    authors:

    更新日期:1989-06-01 00:00:00

  • Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004.

    abstract::The Mendelian randomization approach exploits genetic variants to improve causal inference when using observational data. The authors examined the relation between long-term obesity and common mental disorders (CMD) by utilizing the known relation between fat mass and obesity-associated (FTO) genotype and body mass in...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwq444

    authors: Kivimäki M,Jokela M,Hamer M,Geddes J,Ebmeier K,Kumari M,Singh-Manoux A,Hingorani A,Batty GD

    更新日期:2011-02-15 00:00:00

  • Genetics of leptin and obesity: a HuGE review.

    abstract::Leptin is an important regulator of the mass of adipose tissue and of body weight; it operates by inhibiting food intake and stimulating energy expenditure. Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisom...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/aje/kwi174

    authors: Paracchini V,Pedotti P,Taioli E

    更新日期:2005-07-15 00:00:00

  • Maternal and fetal genetic contributions to postterm birth: familial clustering in a population-based sample of 475,429 Swedish births.

    abstract::This study examines the familial clustering and relative influence of genetic and environmental effects on postterm birth in the Swedish population by considering all full- and half-siblings born in Sweden between 1992 and 2004. Of the eligible 475,429 births, 21% occurred after 41 completed weeks and 5.5% occurred af...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kws244

    authors: Oberg AS,Frisell T,Svensson AC,Iliadou AN

    更新日期:2013-03-15 00:00:00

  • Regression toward the mean in a two-stage selection program.

    abstract::A model for a two-stage selection program based upon normally distributed variables is examined. Subjects in the upper part of the distribution of first-stage observations are retained and subsequently observed an additional number of times in a second stage. Subjects in the upper part of the distribution of second-st...

    journal_title:American journal of epidemiology

    pub_type: 临床试验,杂志文章

    doi:10.1093/oxfordjournals.aje.a113423

    authors: McMahan CA

    更新日期:1982-08-01 00:00:00

  • Analgesic drug use and risk of epithelial ovarian cancer.

    abstract::Analgesic use may reduce ovarian cancer risk, possibly through antiinflammatory or antigonadotropic effects. The authors conducted a population-based, case-control study in Washington State that included 812 women aged 35-74 years who were diagnosed with epithelial ovarian cancer between 2002 and 2005 and 1,313 contro...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwn082

    authors: Hannibal CG,Rossing MA,Wicklund KG,Cushing-Haugen KL

    更新日期:2008-06-15 00:00:00

  • Personality and all-cause mortality: individual-participant meta-analysis of 3,947 deaths in 76,150 adults.

    abstract::Personality may influence the risk of death, but the evidence remains inconsistent. We examined associations between personality traits of the five-factor model (extraversion, neuroticism, agreeableness, conscientiousness, and openness to experience) and the risk of death from all causes through individual-participant...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,meta分析

    doi:10.1093/aje/kwt170

    authors: Jokela M,Batty GD,Nyberg ST,Virtanen M,Nabi H,Singh-Manoux A,Kivimäki M

    更新日期:2013-09-01 00:00:00

  • Model of risk of cortical cataract in the US population with exposure to increased ultraviolet radiation due to stratospheric ozone depletion.

    abstract::The authors modeled the possible consequences for US cataract incidence of increases in ultraviolet B radiation due to ozone depletion. Data on the dose-response relation between ocular exposure to ultraviolet B radiation and cortical cataract were derived from a population-based study (the Salisbury Eye Evaluation Pr...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/aje/kwi329

    authors: West SK,Longstreth JD,Munoz BE,Pitcher HM,Duncan DD

    更新日期:2005-12-01 00:00:00

  • Genital chlamydial infections.

    abstract::The isolation of chlamydial trachomatis in sera of patients with gon ococcal urethritis (GU), non-gonococcal urethritis (NGU), post-gonococca l urethritis (PGU) and trachomainclusion conjunctivitis (TRIC) is discussed. Chlamydiae were isolated in 40% of men with NGU, 20-30% with GU and 0-7% of men with symptomatic or...

    journal_title:American journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.aje.a112243

    authors: Richmond SJ,Sparling PF

    更新日期:1976-05-01 00:00:00